Nanocomposites-based targeted oral drug delivery systems with infliximab in a murine colitis model

Ternary nanocomposite carriers based on organic clay-lipid vesicles as an effective colon-targeted drug delivery system: preparation and in vitro/in vivo characterization

(2020) Hyeon Young Kim et al.   JOURNAL OF NANOBIOTECHNOLOGY

Oral Targeted Delivery by Nanoparticles Enhances Efficacy of an Hsp90 Inhibitor by Reducing Systemic Exposure in Murine Models of Colitis and Colitis-Associated Cancer

(2019) Mei Yang et al.   Journal of Crohns & Colitis

Towards the Oral Treatment of Ileo-Colonic Inflammatory Bowel Disease with Infliximab Tablets: Development and Validation of the Production Process

(2019) Bahez Gareb et al.   Pharmaceutics

Krill Oil-Incorporated Liposomes As An Effective Nanovehicle To Ameliorate The Inflammatory Responses Of DSS-Induced Colitis

(2019) Jin-Hee Kim et al.   International Journal of Nanomedicine

Target-Specific Fluorescence-Mediated Tomography for Non-Invasive and Dynamic Assessment of Early Neutrophil Infiltration in Murine Experimental Colitis

(2019) Tobias M. Nowacki et al.   Cells

Translating Immunology into Therapeutic Concepts for Inflammatory Bowel Disease

(2018) Holm H. Uhlig et al.   Annual Review of Immunology

Restoration of mucosal integrity and epithelial transport function by concomitant anti-TNFα treatment in chronic DSS-induced colitis

(2018) Henrike Lenzen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Dextran sulphate sodium colitis in C57BL/6J mice is alleviated by Lactococcus lactis and worsened by the neutralization of Tumor necrosis Factor α

(2017) Aleš Berlec et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Oral Delivery of Nanoparticles Loaded With Ginger Active Compound, 6-Shogaol, Attenuates Ulcerative Colitis and Promotes Wound Healing in a Murine Model of Ulcerative Colitis

(2017) Mingzhen Zhang et al.   Journal of Crohns & Colitis

Interleukin-33 regulates intestinal inflammation by modulating macrophages in inflammatory bowel disease

(2017) Dong Hyuk Seo et al.   Scientific Reports

Mechanism of Action of Anti-TNF Therapy in Inflammatory Bowel Disease

(2016) Alon D. Levin et al.   Journal of Crohns & Colitis

Beyond endoscopic mucosal healing in UC: histological remission better predicts corticosteroid use and hospitalisation over 6 years of follow-up

(2015) Robert V Bryant et al.   GUT

Liposomes as nanomedical devices

(2015) Giuseppina Bozzuto et al.   International Journal of Nanomedicine

Effects of triglycerides on the hydrophobic drug loading capacity of saturated phosphatidylcholine-based liposomes

(2015) Soon-Seok Hong et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse

(2015) Katharina Maisel et al.   JOURNAL OF CONTROLLED RELEASE

Claudin switching: Physiological plasticity of the Tight Junction

(2015) Christopher T. Capaldo et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

First Multicenter Study of Modified Release Phosphatidylcholine “LT-02” in Ulcerative Colitis: A Randomized, Placebo-Controlled Trial in Mesalazine-Refractory Courses

(2014) Max Karner et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Improved pH-dependent drug release and oral exposure of telmisartan, a poorly soluble drug through the formation of drug-aminoclay complex

(2014) Liang Yang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Association Between Tumor Necrosis Factor-α Antagonists and Risk of Cancer in Patients With Inflammatory Bowel Disease

(2014) Nynne Nyboe Andersen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Longitudinal analysis of inflammation and microbiota dynamics in a model of mild chronic dextran sulfate sodium-induced colitis in mice

(2014) Luigia De Fazio   WORLD JOURNAL OF GASTROENTEROLOGY

Chitosan-coated nano-liposomes for the oral delivery of berberine hydrochloride

(2014) Thanh Xuan Nguyen et al.   Journal of Materials Chemistry B

Reduction of CD68+ Macrophages and Decreased IL-17 Expression in Intestinal Mucosa of Patients with Inflammatory Bowel Disease Strongly Correlate With Endoscopic Response and Mucosal Healing following Infliximab Therapy

(2013) Flavio Caprioli et al.   INFLAMMATORY BOWEL DISEASES

Antibodies to Infliximab and Risk of Infusion Reactions in Patients With Inflammatory Bowel Disease

(2013) Sorcha O’Meara et al.   INFLAMMATORY BOWEL DISEASES

Approaches for enhancing oral bioavailability of peptides and proteins

(2013) Jwala Renukuntla et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Anti-TNF Monoclonal Antibodies in Inflammatory Bowel Disease: Pharmacokinetics-Based Dosing Paradigms

(2012) I Ordás et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Influence of polymorphisms and TNF and IL1β serum concentration on the infliximab response in Crohn’s disease and ulcerative colitis

(2012) Diana Lacruz-Guzmán et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Bioadhesive pellets increase local 5-aminosalicylic acid concentration in experimental colitis

(2012) Tereza Bautzová et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Neutralization of Membrane TNF, but Not Soluble TNF, Is Crucial for the Treatment of Experimental Colitis

(2012) Clémentine Perrier et al.   INFLAMMATORY BOWEL DISEASES

Integrity and stability of oral liposomes containing bile salts studied in simulated and ex vivo gastrointestinal media

(2012) Shunwen Hu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Drug delivery to inflamed colon by nanoparticles: Comparison of different strategies

(2012) Régis Coco et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+Th17 cells

(2012) Margherita Coccia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Blocking Lymphocyte Localization to the Gastrointestinal Mucosa as a Therapeutic Strategy for Inflammatory Bowel Diseases

(2011) Eduardo J. Villablanca et al.   GASTROENTEROLOGY

Antibodies Against Tumor Necrosis Factor (TNF) Induce T-Cell Apoptosis in Patients With Inflammatory Bowel Diseases via TNF Receptor 2 and Intestinal CD14+ Macrophages

(2011) Raja Atreya et al.   GASTROENTEROLOGY

Preparation and characterization of nanocapsules for colon-targeted drug delivery system

(2011) Sanjay J. Kshirsagar et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

Enhand secretion of tumour necrosis factor-alpha, IL-6, and IL-1β by isolated lamina ropria monouclear cells from patients with ulcretive cilitis and Crohn's disease

(2010) H.-C. REINECKER et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Mucoadhesive liposomal delivery systems: the choice of coating material

(2010) Pankaj Ranjan Karn et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Adherence to infliximab maintenance therapy and health care utilization and costs by Crohn’s disease patients

(2009) Sunanda V. Kane et al.   ADVANCES IN THERAPY

Colonic treatments and targets: issues and opportunities

(2009) Emma L. McConnell et al.   JOURNAL OF DRUG TARGETING

CD4 T-cell differentiation and inflammatory bowel disease

(2009) Lauren A. Zenewicz et al.   TRENDS IN MOLECULAR MEDICINE

Adsorptive Depletion of Elevated Proinflammatory CD14+CD16+DR++Monocytes in Patients With Inflammatory Bowel Disease

(2008) Hiroyuki Hanai et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY