Article
Pharmacology & Pharmacy
Anthony Cunha, Alexandra Gaubert, Julien Verget, Marie-Laure Thiolat, Philippe Barthelemy, Benjamin Dehay
Summary: This study proposes a new pharmaceutical technology that delivers trehalose using nanotechnology to restore autophagy function and treat neurodegenerative diseases.
Article
Pharmacology & Pharmacy
Meenakshi Goel, Dennis Leung, Amin Famili, Debby Chang, Purnendu Nayak, Mohammad Al-Sayah
Summary: An accelerated in vitro release testing method was developed to predict the real-time in vitro release of a synthetic peptide from a 6-month CR PLGA implant formulation, focusing on the release behavior of an aggregation-prone peptide. The method optimized a combination of release conditions involving co-solvent, surfactant, elevated temperature, and neutral buffer to achieve complete peptide release within 14-21 days, compared to 3- to 6-months of real-time release.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Sajid Khan Sadozai, Saeed Ahmad Khan, Abdul Baseer, Rooh Ullah, Alam Zeb, Marc Schneider
Summary: An optimized topical antifungal gel was developed to prolong the release of ketoconazole, reduce systemic absorption, enhance therapeutic effect and improve patient compliance. The gel formulation, containing PLGA nanoparticles loaded with ketoconazole, showed excellent physical characteristics, controlled drug release, reduced skin permeation, and effective treatment of the infection.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Musaed Alkholief, Mohd Abul Kalam, Md Khalid Anwer, Aws Alshamsan
Summary: The study shows that using different ratios of stabilizers and solvents to prepare PLGA-NPs can affect the physical and chemical properties of the nanoparticles, while optimal drug encapsulation can be achieved by combining 40 mg PLGA and 4 mg IND in 1 mL DCM/chloroform with PVA/PVP (1-3%).
Article
Pharmacology & Pharmacy
Dan Yun, Dengyuan Liu, Jinlin Liu, Yanyi Feng, Hongyu Chen, Simiao Chen, Qingchun Xie
Summary: This study proposes a simplified surface modification strategy using cRGDyK peptide (RGD)-modified PLGA nanoparticles (NPs) loaded with paclitaxel. The results show that the modified NPs have excellent in vitro drug release properties and cellular uptake ability, leading to increased efficacy and reduced toxicity of the antitumor drug. In a mouse model experiment, the RGD-modified NPs exhibit a higher tumor weight suppression rate, demonstrating their promising potential in cancer therapy.
Article
Pharmacology & Pharmacy
Ruifeng Wang, Quanying Bao, Andrew G. Clark, Yan Wang, Shawn Zhang, Diane J. Burgess
Summary: This study focused on microencapsulation of small molecule drugs using coacervation techniques and aimed to establish a reliable apparatus, investigate the impact of silicone oil viscosity on microsphere performance, and develop a reproducible in vitro release testing method. The results showed that the viscosity of silicone oil used during the coacervation process affected the physicochemical properties and release characteristics of the microspheres.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Nanoscience & Nanotechnology
Seham Elsayed, Germeen N. S. Girgis, Marwa S. El-Dahan
Summary: In this study, PVS-loaded PLGA nanoparticles were prepared to improve the hypolipidemic and hepatoprotective activities of PVS. The optimized nanoparticles showed suitable particle size, entrapment efficiency, and stability, and demonstrated significant hypolipidemic and hepatoprotective activities in vivo.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Jiayu Zhou, Yishu Zhai, Jumei Xu, Tian Zhou, Lian Cen
Summary: This study investigated the feasibility of microfluidic preparation of PLGA composite microspheres with mesoporous silica nanoparticles (MSNs) to finely manipulate drug release behaviors. The results showed that PLGA-MSNs achieved sustained release for 4 months without any burst release, while PLGA microspheres encountered a burst release in the mid-term of the studied duration. Incorporating MSNs into PLGA microspheres via microfluidics could be an efficient strategy to finely tune drug release behavior.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Engineering, Chemical
Md Khalid Anwer, Essam A. Ali, Muzaffar Iqbal, Mohammed Muqtader Ahmed, Mohammed F. Aldawsari, Ahmed Al Saqr, Ahmed Alalaiwe, Gamal A. Soliman
Summary: In this study, OLP-loaded PLGA nanoparticles and OLP-CS-PLGA nanoparticles were successfully prepared to improve the dissolution rate and bioavailability of Olaparib. The results showed that OLP-CS-PLGA nanoparticles could be an effective approach for enhancing the bioavailability of Olaparib.
Article
Materials Science, Multidisciplinary
Estefania V. R. Campos, Patricia L. F. Proenca, Tais Germano da Costa, Renata de Lima, Sarah Hedtrich, Leonardo Fernandes Fraceto, Daniele Ribeiro de Araujo
Summary: The study demonstrated that nanoparticles and hydrogels can alter the release kinetics of budesonide (BUD), leading to more effective treatment of atopic dermatitis (AD) and facilitating the skin absorption of BUD; while nanoparticles were unable to penetrate the stratum corneum, they were effective in promoting BUD absorption into the skin.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Instruments & Instrumentation
Jennifer Walker, Jason Albert, Desheng Liang, Jing Sun, Richard Schutzman, Raj Kumar, Cameron White, Moritz Beck-Broichsitter, Steven P. Schwendeman
Summary: Copolymers of lactic and glycolic acids are commonly used in biomedical applications. This study compared PLGAs from different manufacturers and revealed differences in their properties, providing recommendations for selecting suitable PLGAs.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Bangqing Wu, Lijun Wu, Yingju He, Zongning Yin, Li Deng
Summary: PLGA microspheres loaded with brexpiprazole were successfully developed to achieve controlled and sustained release in vivo, showing potential for extended-release of therapeutics for schizophrenia treatment.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2021)
Article
Chemistry, Applied
Xiaodong Xie, Shuqi Li, Yanling Liu, Zhigang Huang, Jun Yi, Xiaofang Li, Chongkai Gao, Fang Wu, Bohong Guo
Summary: In this study, PLGA was used as a carrier to synthesize florfenicol nanoparticles (FF-PLGA NPs) for improved water solubility and controlled drug release. The FF-PLGA NPs showed high antibacterial activity, sustained drug release, and stability. The addition of hydrophilic materials significantly enhanced drug solubility.
REACTIVE & FUNCTIONAL POLYMERS
(2022)
Article
Pharmacology & Pharmacy
Jan Kozak, Miloslava Rabiskova, Alf Lamprecht
Summary: The study proposed a method of using a thin agarose hydrogel layer to simulate tissue environment for drug-release testing of implantable formulations, showing significantly different release profiles compared with traditional testing in release medium alone, due to the physical restriction to swelling and deformation provided by the gel layer.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Ruben Varela-Fernandez, Carlos Bendicho-Lavilla, Manuel Martin-Pastor, Rocio Herrero Vanrell, Maria Isabel Lema-Gesto, Miguel Gonzalez-Barcia, Francisco Javier Otero-Espinar
Summary: Biodegradable PLGA microspheres are attractive delivery systems for sustained release of therapeutic substances into the eye. Idebenone-loaded PLGA microspheres were successfully developed using an emulsion/solvent evaporation method, with appropriate production yield and drug encapsulation efficiency. The microspheres exhibited desirable properties and showed no cytotoxic effects in vitro. These findings suggest that PLGA microspheres could be a promising intraocular system for long-term idebenone administration in the treatment of Leber's Hereditary Optic Neuropathy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
