Neuropilin-1: A Key Protein to Consider in the Progression of Pediatric Brain Tumors

Advances in the molecular classification of pediatric brain tumors: A guide to the galaxy

(2020) Chantel Cacciotti et al.   JOURNAL OF PATHOLOGY

Neuropilins, as Relevant Oncology Target: Their Role in the Tumoral Microenvironment

(2020) Aurore Dumond et al.   Frontiers in Cell and Developmental Biology

Ablation of neuropilin-1 improves the therapeutic response in conventional drug-resistant glioblastoma multiforme

(2020) Ramcharan Singh Angom et al.   ONCOGENE

Childhood brain tumors: current management, biological insights, and future directions

(2019) Ian F. Pollack et al.   Journal of Neurosurgery-Pediatrics

VEGF/Neuropilin Signaling in Cancer Stem Cells

(2019) Arthur Mercurio   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuropilins in the Context of Tumor Vasculature

(2019) Stephan Niland et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Survival and functional outcomes of molecularly defined childhood posterior fossa ependymoma: Cure at a cost

(2019) Michal Zapotocky et al.   CANCER

Insights into new mechanisms and models of cancer stem cell multidrug resistance

(2019) Y. Garcia-Mayea et al.   SEMINARS IN CANCER BIOLOGY

Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1

(2019) Marine Leclerc et al.   Nature Communications

Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse

(2019) Liguo Zhang et al.   CANCER CELL

Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1–2 trials

(2019) Robert C Doebele et al.   LANCET ONCOLOGY

miRNA-124-3p/neuropilin-1(NRP-1) axis plays an important role in mediating glioblastoma growth and angiogenesis

(2018) Guilong Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

NRP1 knockdown promotes the migration and invasion of human neuroblastoma-derived SK‑N‑AS cells via the activation of β1�integrin expression

(2018) Yoshiaki Ishizuka et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

B7-H4 Modulates Regulatory CD4+T Cell Induction and Function via Ligation of a Semaphorin 3a/Plexin A4/Neuropilin-1 Complex

(2018) Joseph R. Podojil et al.   JOURNAL OF IMMUNOLOGY

Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells

(2018) Jonathan Powell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Infant medulloblastoma — learning new lessons from old strata

(2018) Marc Remke et al.   Nature Reviews Clinical Oncology

NRP-1 interacts with GIPC1 and α6/β4-integrins to increase YAP1/∆Np63α-dependent epidermal cancer stem cell survival

(2018) Daniel Grun et al.   ONCOGENE

Stimulation of medulloblastoma stem cells differentiation by a peptidomimetic targeting neuropilin-1

(2018) Caifeng Gong et al.   Oncotarget

Subgroup-specific immune and stromal microenvironment in medulloblastoma

(2018) Michael Bockmayr et al.   OncoImmunology

Macrophage-derived Neuropilin-2 exhibits novel tumor-promoting functions

(2018) Sohini Roy et al.   CANCER RESEARCH

VEGF–neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP β2-chimaerin

(2018) Ameer L. Elaimy et al.   Science Signaling

Targeting Cancer Stem Cells to Overcome Chemoresistance

(2018) Toni Nunes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Late vertebral side effects in long-term survivors of irradiated childhood brain tumor

(2018) Miro-Pekka Jussila et al.   PLoS One

Neuropilin-1 mediates neutrophil elastase uptake and cross-presentation in breast cancer cells

(2017) Celine Kerros et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pediatric Gliomas: Current Concepts on Diagnosis, Biology, and Clinical Management

(2017) Dominik Sturm et al.   JOURNAL OF CLINICAL ONCOLOGY

Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas

(2017) Alvaro Lassaletta et al.   JOURNAL OF CLINICAL ONCOLOGY

Multifaceted Role of Neuropilins in the Immune System: Potential Targets for Immunotherapy

(2017) Sohini Roy et al.   Frontiers in Immunology

Neuropilin-1 modulates TGFβ signaling to drive glioblastoma growth and recurrence after anti-angiogenic therapy

(2017) Sam C. Kwiatkowski et al.   PLoS One

Neuropilin-1 is upregulated by Wnt/β-catenin signaling and is important for mammary stem cells

(2017) Wei Liu et al.   Scientific Reports

Risk stratification of childhood medulloblastoma in the molecular era: the current consensus

(2016) Vijay Ramaswamy et al.   ACTA NEUROPATHOLOGICA

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

VEGF/NRP-1 axis promotes progression of breast cancer via enhancement of epithelial-mesenchymal transition and activation of NF-κB and β-catenin

(2016) Minna Luo et al.   CANCER LETTERS

The expanding role of neuropilin

(2016) Natalie Kofler et al.   CURRENT OPINION IN HEMATOLOGY

Medulloblastoma

(2016) Nathan E. Millard et al.   JOURNAL OF CHILD NEUROLOGY

The immune system and cancer evasion strategies: therapeutic concepts

(2016) S. Muenst et al.   JOURNAL OF INTERNAL MEDICINE

Class 3 semaphorins induce F-actin reorganization in human dendritic cells: Role in cell migration

(2016) Sabrina Curreli et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Combined inhibition of vascular endothelial growth factor receptor signaling with temozolomide enhances cytotoxicity against human glioblastoma cells via downregulation of Neuropilin-1

(2016) Jungwhoi Lee et al.   JOURNAL OF NEURO-ONCOLOGY

Adjunctive everolimus therapy for treatment-resistant focal-onset seizures associated with tuberous sclerosis (EXIST-3): a phase 3, randomised, double-blind, placebo-controlled study

(2016) Jacqueline A French et al.   LANCET

VEGF-A acts via neuropilin-1 to enhance epidermal cancer stem cell survival and formation of aggressive and highly vascularized tumors

(2016) D Grun et al.   ONCOGENE

CD133+ brain tumor-initiating cells are dependent on STAT3 signaling to drive medulloblastoma recurrence

(2016) N Garg et al.   ONCOGENE

Concurrent Expression of VEGF-C and Neuropilin-2 Is Correlated with Poor Prognosis in Glioblastoma

(2016) Haiqing Zhao et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Neuropilin-1 (NRP-1)/GIPC1 pathway mediates glioma progression

(2016) Guilong Zhang et al.   TUMOR BIOLOGY

Inhibition of PlexA1-mediated brain tumor growth and tumor-associated angiogenesis using a transmembrane domain targeting peptide

(2016) Laurent Jacob et al.   Oncotarget

Ablation of Neuropilin 1 from glioma-associated microglia and macrophages slows tumor progression

(2016) Jeremy T. Miyauchi et al.   Oncotarget

Pediatric Brain Tumors: An Update

(2016) Devorah Segal et al.   Current Problems in Pediatric and Adolescent Health Care

Specific Neuropilins Expression in Alveolar Macrophages among Tissue-Specific Macrophages

(2016) Naing Ye Aung et al.   PLoS One

Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity

(2015) Andrey Korshunov et al.   ACTA NEUROPATHOLOGICA

The Immune System in Cancer Prevention, Development and Therapy

(2015) Serge M. Candeias et al.   Anti-Cancer Agents in Medicinal Chemistry

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

(2015) Kristian W. Pajtler et al.   CANCER CELL

Neuropilin 1 balances  8 integrin-activated TGF  signaling to control sprouting angiogenesis in the brain

(2015) S. Hirota et al.   DEVELOPMENT

BRAFMutation andCDKN2ADeletion Define a Clinically Distinct Subgroup of Childhood Secondary High-Grade Glioma

(2015) Matthew Mistry et al.   JOURNAL OF CLINICAL ONCOLOGY

Differential expression of vascular endothelial growth factor A, its receptors VEGFR-1, -2, and -3 and co-receptors neuropilin-1 and -2 does not predict bevacizumab response in human astrocytomas

(2015) Peter Baumgarten et al.   NEURO-ONCOLOGY

A role for cancer stem cells in therapy resistance: Cellular and molecular mechanisms

(2015) Monica Cojoc et al.   SEMINARS IN CANCER BIOLOGY

EMT, CTCs and CSCs in tumor relapse and drug-resistance

(2015) Abhisek Mitra et al.   Oncotarget

Regulation of mTOR Signaling by Semaphorin 3F-Neuropilin 2 Interactions In Vitro and In Vivo

(2015) Hironao Nakayama et al.   Scientific Reports

Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma

(2015) Xuecai Ge et al.   eLife

Neuropilin-1 as Therapeutic Target for Malignant Melanoma

(2015) Grazia Graziani et al.   Frontiers in Oncology

Neuropilin regulation of angiogenesis: Figure 1

(2014) Anastasia Lampropoulou et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma

(2014) Robert J. Vanner et al.   CANCER CELL

Childhood Brain Tumor Epidemiology: A Brain Tumor Epidemiology Consortium Review

(2014) K. J. Johnson et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Novel expression of Neuropilin 1 on human tumor-infiltrating lymphocytes in colorectal cancer liver metastases

(2014) Belal Chaudhary et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A phase I study of the human monoclonal anti-NRP1 antibody MNRP1685A in patients with advanced solid tumors

(2014) Colin D. Weekes et al.   INVESTIGATIONAL NEW DRUGS

Neuropilin Regulation of Angiogenesis, Arteriogenesis, and Vascular Permeability

(2014) Alice Plein et al.   MICROCIRCULATION

C11orf95–RELA fusions drive oncogenic NF-κB signalling in ependymoma

(2014) Matthew Parker et al.   NATURE

High Neuropilin 1 Expression Was Associated With Angiogenesis and Poor Overall Survival in Resected Pancreatic Ductal Adenocarcinoma

(2014) Qiwen Ben et al.   PANCREAS

Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors

(2014) Daniella Arêas Mendes-da-Cruz et al.   PLoS One

Neuropilin-1 Promotes Epithelial-to-Mesenchymal Transition by Stimulating Nuclear Factor-Kappa B and Is Associated with Poor Prognosis in Human Oral Squamous Cell Carcinoma

(2014) Weiming Chu et al.   PLoS One

Sema3C Promotes the Survival and Tumorigenicity of Glioma Stem Cells through Rac1 Activation

(2014) Jianghong Man et al.   Cell Reports

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

(2013) Andrea Casazza et al.   CANCER CELL

Neuropilin 1: function and therapeutic potential in cancer

(2013) Belal Chaudhary et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Targeting Placental Growth Factor/Neuropilin 1 Pathway Inhibits Growth and Spread of Medulloblastoma

(2013) Matija Snuderl et al.   CELL

GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation

(2013) Hira Lal Goel et al.   EMBO Molecular Medicine

Neuropilin-2 contributes to tumorigenicity in a mouse model of Hedgehog pathway medulloblastoma

(2013) Melanie G. Hayden Gephart et al.   JOURNAL OF NEURO-ONCOLOGY

Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis

(2013) Greg M. Delgoffe et al.   NATURE

Signal Transduction by Vascular Endothelial Growth Factor Receptors

(2013) S. Koch et al.   Cold Spring Harbor Perspectives in Medicine

Pediatric glioma stem cells: biologic strategies for oncolytic HSV virotherapy

(2013) Gregory K. Friedman et al.   Frontiers in Oncology

K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

(2012) Dong-Anh Khuong-Quang et al.   ACTA NEUROPATHOLOGICA

A phase I, dose-escalation study of TB-403, a monoclonal antibody directed against PlGF, in patients with advanced solid tumours

(2012) U Lassen et al.   BRITISH JOURNAL OF CANCER

Medulloblastoma stem cells: Modeling tumor heterogeneity

(2012) Branavan Manoranjan et al.   CANCER LETTERS

Neuropilin-1Stimulates Tumor Growth by Increasing Fibronectin Fibril Assembly in the Tumor Microenvironment

(2012) Usman Yaqoob et al.   CANCER RESEARCH

Neuropilins: expression and roles in the epithelium

(2012) Jonathan R. L. Wild et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Neuropilin 1 deficiency on CD4+Foxp3+regulatory T cells impairs mouse melanoma growth

(2012) Wiebke Hansen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autocrine VEGF–VEGFR2–Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth

(2012) Petra Hamerlik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

(2012) Gang Wu et al.   NATURE GENETICS

Expression of dual angiogenic/neurogenic growth factors in human primary brain tumors

(2011) Maud Clemessy et al.   JOURNAL OF NEURO-ONCOLOGY

Clinical Relevance of Tumor Cells with Stem-Like Properties in Pediatric Brain Tumors

(2011) Cécile Thirant et al.   PLoS One

Neuropilin-1 attenuates autoreactivity in experimental autoimmune encephalomyelitis

(2011) Benjamin D. Solomon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropilin-1 regulates platelet-derived growth factor receptor signalling in mesenchymal stem cells

(2010) Stephen G. Ball et al.   BIOCHEMICAL JOURNAL

Neuropilin-1 exerts co-receptor function for TGF-beta-1 on the membrane of cancer cells and enhances responses to both latent and active TGF-beta

(2010) Yelena Glinka et al.   CARCINOGENESIS

A Distinct Spectrum of Copy Number Aberrations in Pediatric High-Grade Gliomas

(2010) D. A. Bax et al.   CLINICAL CANCER RESEARCH

Whole-Genome Profiling of Pediatric Diffuse Intrinsic Pontine Gliomas Highlights Platelet-Derived Growth Factor Receptor α and Poly (ADP-ribose) Polymerase As Potential Therapeutic Targets

(2010) Maryam Zarghooni et al.   JOURNAL OF CLINICAL ONCOLOGY

The Neuroimmune Semaphorin-3A Reduces Inflammation and Progression of Experimental Autoimmune Arthritis

(2010) A. Catalano   JOURNAL OF IMMUNOLOGY

Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II

(2010) Hyota Takamatsu et al.   NATURE IMMUNOLOGY

A multivariate analysis of factors determining tumor progression in childhood low-grade glioma: a population-based cohort study (CCLG CNS9702)

(2010) T. Stokland et al.   NEURO-ONCOLOGY

Identification of CD15 as a Marker for Tumor-Propagating Cells in a Mouse Model of Medulloblastoma

(2009) Tracy-Ann Read et al.   CANCER CELL

Role of Class 3 Semaphorins and Their Receptors in Tumor Growth and Angiogenesis

(2009) P. Gaur et al.   CLINICAL CANCER RESEARCH

Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages

(2009) Jong-Dae Ji et al.   HUMAN IMMUNOLOGY

Neuropilin-1/GIPC1 Signaling Regulates α5β1 Integrin Traffic and Function in Endothelial Cells

(2009) Donatella Valdembri et al.   PLOS BIOLOGY

Neuropilins: structure, function and role in disease

(2008) Caroline Pellet-Many et al.   BIOCHEMICAL JOURNAL

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo

(2008) D. Hambardzumyan et al.   GENES & DEVELOPMENT

Neuropilin-1 Expression on Regulatory T Cells Enhances Their Interactions with Dendritic Cells during Antigen Recognition

(2008) Milka Sarris et al.   IMMUNITY

Neuropilin-1-VEGFR-2 Complexing Requires the PDZ-binding Domain of Neuropilin-1

(2008) Claudia Prahst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemotherapy for Malignant Brain Tumors of Childhood

(2008) Nicholas G. Gottardo et al.   JOURNAL OF CHILD NEUROLOGY

Neuropilin-1 is a receptor for transforming growth factor β-1, activates its latent form, and promotes regulatory T cell activity

(2008) Yelena Glinka et al.   JOURNAL OF LEUKOCYTE BIOLOGY