Neuropilin-1 mediates neutrophil elastase uptake and cross-presentation in breast cancer cells

A novel TCR-like CAR with specificity for PR1/HLA-A2 effectively targets myeloid leukemia in vitro when expressed in human adult peripheral blood and cord blood T cells

(2016) Qing Ma et al.   CYTOTHERAPY

Neuropilin-1 is associated with clinicopathology of gastric cancer and contributes to cell proliferation and migration as multifunctional co-receptors

(2016) Linhao Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

PR1 peptide vaccine induces specific immunity with clinical responses in myeloid malignancies

(2016) M H Qazilbash et al.   LEUKEMIA

Activity of 8F4, a T-cell receptor-like anti-PR1/HLA-A2 antibody, against primary human AML in vivo

(2016) A Sergeeva et al.   LEUKEMIA

Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain

(2015) Peishen Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

Interactions between neutrophils and non-small cell lung cancer cells: enhancement of tumor proliferation and inflammatory mediator synthesis

(2014) Katja Hattar et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

NRP-1 expression in bladder cancer and its implications for tumor progression

(2014) Wen Cheng et al.   TUMOR BIOLOGY

Supercritical fluid chromatography/mass spectrometry in metabolite analysis

(2014) Kaori Taguchi et al.   Bioanalysis

Neuropilin 1: function and therapeutic potential in cancer

(2013) Belal Chaudhary et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The potential of neutrophil elastase inhibitors as anti-inflammatory therapies

(2013) Peter A. Henriksen   CURRENT OPINION IN HEMATOLOGY

Sequence dependence of C-end rule peptides in binding and activation of neuropilin-1 receptor

(2013) David Zanuy et al.   JOURNAL OF STRUCTURAL BIOLOGY

Breast Cancer Cell Uptake of the Inflammatory Mediator Neutrophil Elastase Triggers an Anticancer Adaptive Immune Response

(2012) E. A. Mittendorf et al.   CANCER RESEARCH

Targeting VEGF signalling via the neuropilin co-receptor

(2012) Snezana Djordjevic et al.   DRUG DISCOVERY TODAY

Clathrin Pit-mediated Endocytosis of Neutrophil Elastase and Cathepsin G by Cancer Cells

(2012) Alyssa D. Gregory et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Broad Cross-Presentation of the Hematopoietically Derived PR1 Antigen on Solid Tumors Leads to Susceptibility to PR1-Targeted Immunotherapy

(2012) G. Alatrash et al.   JOURNAL OF IMMUNOLOGY

The Role of Antigen Cross-presentation From Leukemia Blasts on Immunity to the Leukemia-associated Antigen PR1

(2012) Gheath Alatrash et al.   JOURNAL OF IMMUNOTHERAPY

Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex

(2012) Bert J C Janssen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An anti-PR1/HLA-A2 T-cell receptor-like antibody mediates complement-dependent cytotoxicity against acute myeloid leukemia progenitor cells

(2011) A. Sergeeva et al.   BLOOD

Intratumoral neutrophils and plasmacytoid dendritic cells indicate poor prognosis and are associated with pSTAT3 expression in AJCC stage I/II melanoma

(2011) Trine O. Jensen et al.   CANCER

Neuropilins: A New Target for Cancer Therapy

(2011) Camille Grandclement et al.   Cancers

Low Molecular Weight Cyclin E Overexpression Shortens Mitosis, Leading to Chromosome Missegregation and Centrosome Amplification

(2010) Rozita Bagheri-Yarmand et al.   CANCER RESEARCH

Neuropilin-1 exerts co-receptor function for TGF-beta-1 on the membrane of cancer cells and enhances responses to both latent and active TGF-beta

(2010) Yelena Glinka et al.   CARCINOGENESIS

Insulin Receptor Substrate Regulation of Phosphoinositide 3-Kinase

(2010) H. E. Metz et al.   CLINICAL CANCER RESEARCH

Repeated PR1 and WT1 peptide vaccination in Montanide-adjuvant fails to induce sustained high-avidity, epitope-specific CD8+ T cells in myeloid malignancies

(2010) K. Rezvani et al.   HAEMATOLOGICA

Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth

(2010) A McGarry Houghton et al.   NATURE MEDICINE

Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases

(2010) B. Korkmaz et al.   PHARMACOLOGICAL REVIEWS

C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration

(2009) T. Teesalu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High levels of vascular endothelial growth factor and its receptors (VEGFR-1, VEGFR-2, neuropilin-1) are associated with worse outcome in breast cancer

(2008) Sriparna Ghosh et al.   HUMAN PATHOLOGY