VEGF–neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP β2-chimaerin

Small G protein Rac GTPases regulate the maintenance of glioblastoma stem-like cells in vitro and in vivo

(2017) Yun-Ju Lai et al.   Oncotarget

De-repression of the RAC activator ELMO1 in cancer stem cells drives progression of TGFβ-deficient squamous cell carcinoma from transition zones

(2017) Heather A McCauley et al.   eLife

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

Mechanisms of Hippo pathway regulation

(2016) Zhipeng Meng et al.   GENES & DEVELOPMENT

Tyrosine 397 phosphorylation is critical for FAK-promoted Rac1 activation and invasive properties in oral squamous cell carcinoma cells

(2016) Ya-Wen Chiu et al.   LABORATORY INVESTIGATION

Characterization of Hippo Pathway Components by Gene Inactivation

(2016) Steven W. Plouffe et al.   MOLECULAR CELL

RAC-LATS1/2 signaling regulates YAP activity by switching between the YAP-binding partners TEAD4 and RUNX3

(2016) J-W Jang et al.   ONCOGENE

A new role of the Rac-GAP β2-chimaerin in cell adhesion reveals opposite functions in breast cancer initiation and tumor progression

(2016) Victoria Casado-Medrano et al.   Oncotarget

P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer

(2016) Hira Lal Goel et al.   Cell Reports

Tead and AP1 Coordinate Transcription and Motility

(2016) Xiangfan Liu et al.   Cell Reports

WIP Drives Tumor Progression through YAP/TAZ-Dependent Autonomous Cell Growth

(2016) Ricardo Gargini et al.   Cell Reports

Alternative Wnt Signaling Activates YAP/TAZ

(2015) Hyun Woo Park et al.   CELL

Rho-Signaling-Directed YAP/TAZ Activity Underlies the Long-Term Survival and Expansion of Human Embryonic Stem Cells

(2015) Masatoshi Ohgushi et al.   Cell Stem Cell

Rac1-Dependent Phosphorylation and Focal Adhesion Recruitment of Myosin IIA Regulates Migration and Mechanosensing

(2015) Ana M. Pasapera et al.   CURRENT BIOLOGY

A laminin 511 matrix is regulated by TAZ and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells

(2015) Cheng Chang et al.   GENES & DEVELOPMENT

Hippo Component TAZ Functions as a Co-repressor and Negatively Regulates ΔNp63Transcription through TEA Domain (TEAD) Transcription Factor

(2015) Ivette Valencia-Sama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adhesion to fibronectin regulates Hippo signaling via the FAK–Src–PI3K pathway

(2015) Nam-Gyun Kim et al.   JOURNAL OF CELL BIOLOGY

The interplay between TEAD4 and KLF5 promotes breast cancer partially through inhibiting the transcription of p27Kip1

(2015) Chunyan Wang et al.   Oncotarget

Transcriptional Co-repressor Function of the Hippo Pathway Transducers YAP and TAZ

(2015) Minchul Kim et al.   Cell Reports

Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

(2014) Xiaodong Feng et al.   CANCER CELL

Merlin/NF2 Loss-Driven Tumorigenesis Linked to CRL4DCAF1-Mediated Inhibition of the Hippo Pathway Kinases Lats1 and 2 in the Nucleus

(2014) Wei Li et al.   CANCER CELL

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease

(2014) X. Varelas   DEVELOPMENT

NRP1 Presented in trans to the Endothelium Arrests VEGFR2 Endocytosis, Preventing Angiogenic Signaling and Tumor Initiation

(2014) Sina Koch et al.   DEVELOPMENTAL CELL

Sema3C Promotes the Survival and Tumorigenicity of Glioma Stem Cells through Rac1 Activation

(2014) Jianghong Man et al.   Cell Reports

Regulated Splicing of the α6 Integrin Cytoplasmic Domain Determines the Fate of Breast Cancer Stem Cells

(2014) Hira Lal Goel et al.   Cell Reports

Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2

(2013) Feng Yin et al.   CELL

GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation

(2013) Hira Lal Goel et al.   EMBO Molecular Medicine

The Hippo pathway: regulators and regulations

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

Id2 Complexes with the SNAG Domain of Snai1 Inhibiting Snai1-Mediated Repression of Integrin  4

(2013) C. Chang et al.   MOLECULAR AND CELLULAR BIOLOGY

TAZ Expression as a Prognostic Indicator in Colorectal Cancer

(2013) Hiu-Fung Yuen et al.   PLoS One

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

The RacGAP β2-Chimaerin Selectively Mediates Axonal Pruning in the Hippocampus

(2012) Martin M. Riccomagno et al.   CELL

The evolving concept of cancer and metastasis stem cells

(2012) Irène Baccelli et al.   JOURNAL OF CELL BIOLOGY

Cancer stem cells and epithelial–mesenchymal transition: Concepts and molecular links

(2012) Christina Scheel et al.   SEMINARS IN CANCER BIOLOGY

VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer

(2012) Hira Lal Goel et al.   Cancer Discovery

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks

(2011) Suling Liu et al.   CANCER RESEARCH

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma

(2011) K. P. L. Bhat et al.   GENES & DEVELOPMENT

Breast cancer stem cells, cytokine networks, and the tumor microenvironment

(2011) Hasan Korkaya et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion

(2011) D. Iliopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Merlin/NF2 Suppresses Tumorigenesis by Inhibiting the E3 Ubiquitin Ligase CRL4DCAF1 in the Nucleus

(2010) Wei Li et al.   CELL

Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content

(2010) Salvatore Pece et al.   CELL

The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCPE3 Ligase

(2010) Chen-Ying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-10b Targets Tiam1

(2010) Charlotte H. Moriarty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition

(2009) Heng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer stem cells: mirage or reality?

(2009) Piyush B Gupta et al.   NATURE MEDICINE

Blocking Neuropilin-2 Function Inhibits Tumor Cell Metastasis

(2008) Maresa Caunt et al.   CANCER CELL

An essential role for Rac1 in endothelial cell function and vascular development

(2008) Wenfu Tan et al.   FASEB JOURNAL

Neuropilins: a versatile partner of extracellular molecules that regulate development and disease

(2008) Katarzyna Adela Uniewicz   Frontiers in Bioscience-Landmark

Therapeutic Targeting of Neuropilin-2 on Colorectal Carcinoma Cells Implanted in the Murine Liver

(2008) M. J. Gray et al.   JNCI-Journal of the National Cancer Institute

TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway

(2008) Q.-Y. Lei et al.   MOLECULAR AND CELLULAR BIOLOGY