Neuropilin-1 modulates TGFβ signaling to drive glioblastoma growth and recurrence after anti-angiogenic therapy

The expanding role of neuropilin

(2016) Natalie Kofler et al.   CURRENT OPINION IN HEMATOLOGY

Neuropilin 1 balances  8 integrin-activated TGF  signaling to control sprouting angiogenesis in the brain

(2015) S. Hirota et al.   DEVELOPMENT

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch

(2015) Irene Maria Aspalter et al.   Nature Communications

Elucidating the cancer-specific genetic alteration spectrum of glioblastoma derived cell lines from whole exome and RNA sequencing

(2015) Vikas Patil et al.   Oncotarget

NRP1 Presented in trans to the Endothelium Arrests VEGFR2 Endocytosis, Preventing Angiogenic Signaling and Tumor Initiation

(2014) Sina Koch et al.   DEVELOPMENTAL CELL

Neuropilin 1: function and therapeutic potential in cancer

(2013) Belal Chaudhary et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

 1 Integrin Targeting Potentiates Antiangiogenic Therapy and Inhibits the Growth of Bevacizumab-Resistant Glioblastoma

(2013) W. S. Carbonell et al.   CANCER RESEARCH

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Gene Expression Profile Identifies Tyrosine Kinase c-Met as a Targetable Mediator of Antiangiogenic Therapy Resistance

(2013) A. Jahangiri et al.   CLINICAL CANCER RESEARCH

Glioblastoma Resistance to Anti-VEGF Therapy: Has the Challenge Been MET?

(2013) J. H. McCarty   CLINICAL CANCER RESEARCH

Acquired Resistance to Anti-VEGF Therapy in Glioblastoma Is Associated with a Mesenchymal Transition

(2013) Y. Piao et al.   CLINICAL CANCER RESEARCH

αvβ8 integrin interacts with RhoGDI1 to regulate Rac1 and Cdc42 activation and drive glioblastoma cell invasion

(2013) Steve B. Reyes et al.   MOLECULAR BIOLOGY OF THE CELL

Systematic Review of Protein Biomarkers of Invasive Behavior in Glioblastoma

(2013) Eli T. Sayegh et al.   MOLECULAR NEUROBIOLOGY

Signaling by the TGF  Superfamily

(2013) J. L. Wrana   Cold Spring Harbor Perspectives in Biology

VEGF Inhibits Tumor Cell Invasion and Mesenchymal Transition through a MET/VEGFR2 Complex

(2012) Kan V. Lu et al.   CANCER CELL

Neuropilin-1-Dependent Regulation of EGF-Receptor Signaling

(2012) S. Rizzolio et al.   CANCER RESEARCH

Glioblastoma Angiogenesis and Tumor Cell Invasiveness Are Differentially Regulated by  8 Integrin

(2011) J. H. Tchaicha et al.   CANCER RESEARCH

TGF-β Receptor Signaling Pathways in Angiogenesis; Emerging Targets for Anti-Angiogenesis Therapy

(2011) Laurens A. van Meeteren et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Neuropilins are positive regulators of Hedgehog signal transduction

(2011) R. T. Hillman et al.   GENES & DEVELOPMENT

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Neuropilin-1 exerts co-receptor function for TGF-beta-1 on the membrane of cancer cells and enhances responses to both latent and active TGF-beta

(2010) Yelena Glinka et al.   CARCINOGENESIS

Glioma-Associated Cancer-Initiating Cells Induce Immunosuppression

(2010) J. Wei et al.   CLINICAL CANCER RESEARCH

Neuropilin-1 Mediates Divergent R-Smad Signaling and the Myofibroblast Phenotype

(2010) Ying Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A mosaic mouse model of astrocytoma identifies αvβ8 integrin as a negative regulator of tumor angiogenesis

(2010) J H Tchaicha et al.   ONCOGENE

Cell adhesion and signaling networks in brain neurovascular units

(2009) Joseph H McCarty   CURRENT OPINION IN HEMATOLOGY

The nuances of therapy

(2009) Lee M. Ellis et al.   NATURE

New regulatory mechanisms of TGF-β receptor function

(2009) Jong Seok Kang et al.   TRENDS IN CELL BIOLOGY

TGF-β signaling in vascular biology and dysfunction

(2008) Marie-José Goumans et al.   CELL RESEARCH

Neuropilin-1-VEGFR-2 Complexing Requires the PDZ-binding Domain of Neuropilin-1

(2008) Claudia Prahst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuropilin-1 is a receptor for transforming growth factor β-1, activates its latent form, and promotes regulatory T cell activity

(2008) Yelena Glinka et al.   JOURNAL OF LEUKOCYTE BIOLOGY

TGFβ1 and TGFβ3 are partially redundant effectors in brain vascular morphogenesis

(2008) Zhenyu Mu et al.   MECHANISMS OF DEVELOPMENT