Cell Death in Coronavirus Infections: Uncovering Its Role during COVID-19

Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages

(2021) Els Wauters et al.   CELL RESEARCH

Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19

(2021) Can Liu et al.   CELL

SARS-Cov-2 ORF3a: Mutability and function

(2021) Martina Bianchi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Metabolic programs define dysfunctional immune responses in severe COVID-19 patients

(2021) Elizabeth A. Thompson et al.   Cell Reports

Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features

(2021) Anastasia Gangaev et al.   Nature Communications

Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy

(2021) Sara De Biasi et al.   Nature Communications

The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

(2021) Marcin F Osuchowski et al.   Lancet Respiratory Medicine

Cell-Type Apoptosis in Lung during SARS-CoV-2 Infection

(2021) Yakun Liu et al.   Pathogens

Dissecting DISC regulation via pharmacological targeting of caspase-8/c-FLIPL heterodimer

(2020) Laura K. Hillert et al.   CELL DEATH AND DIFFERENTIATION

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

(2020) Michael Letko et al.   Nature Microbiology

The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

(2020)   Nature Microbiology

SARS-CoV-2 perturbs the Renin-Angiotensin System and energy metabolism

(2020) Jun Mori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application

(2020) Stephen A. Lauer et al.   ANNALS OF INTERNAL MEDICINE

Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis

(2020) Ting Zhang et al.   CELL

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

(2020) Alba Grifoni et al.   CELL

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

(2020) Evangelos J. Giamarellos-Bourboulis et al.   Cell Host & Microbe

Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment

(2020) Mehmet Soy et al.   CLINICAL RHEUMATOLOGY

Characteristics of Peripheral Lymphocyte Subset Alteration in COVID-19 Pneumonia

(2020) Fan Wang et al.   JOURNAL OF INFECTIOUS DISEASES

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

(2020) Mingfeng Liao et al.   NATURE MEDICINE

Olfactory Dysfunction: A Highly Prevalent Symptom of COVID-19 With Public Health Significance

(2020) Ahmad R. Sedaghat et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Smell and taste alterations in Covid‐19: a cross‐sectional analysis of different cohorts

(2020) Alberto Paderno et al.   International Forum of Allergy & Rhinology

Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)

(2020) Shelbi Christgen et al.   Frontiers in Cellular and Infection Microbiology

COVID-19 cytokine storm: the interplay between inflammation and coagulation

(2020) Ricardo J Jose et al.   Lancet Respiratory Medicine

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)

(2020) Bo Diao et al.   Frontiers in Immunology

SARS-CoV-2 and ORF3a: Nonsynonymous Mutations, Functional Domains, and Viral Pathogenesis

(2020) Elio Issa et al.   mSystems

COVID-19: The first documented coronavirus pandemic in history

(2020) Yen-Chin Liu et al.   Biomedical Journal

Increased CD95 (Fas) and PD‐1 expression in peripheral blood T lymphocytes in COVID‐19 patients

(2020) Silvia Bellesi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Elevated calprotectin and abnormal myeloid cell subsets discriminate severe from mild COVID-19

(2020) Aymeric Silvin et al.   CELL

The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

(2020) Yujie Ren et al.   Cellular & Molecular Immunology

Expansion of plasmablasts and loss of memory B cells in peripheral blood from COVID‐19 patients with pneumonia

(2020) Sara De Biasi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inflammasomes and Pyroptosis as Therapeutic Targets for COVID-19

(2020) Jeremy K. Y. Yap et al.   JOURNAL OF IMMUNOLOGY

COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis

(2020) Robert Lorenz Chua et al.   NATURE BIOTECHNOLOGY

A single-cell atlas of the peripheral immune response in patients with severe COVID-19

(2020) Aaron J. Wilk et al.   NATURE MEDICINE

Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia

(2020) Sara De Biasi et al.   Nature Communications

Association of chemosensory dysfunction and COVID‐19 in patients presenting with influenza‐like symptoms

(2020) Carol H. Yan et al.   International Forum of Allergy & Rhinology

Comprehensive mapping of immune perturbations associated with severe COVID-19

(2020) Leticia Kuri-Cervantes et al.   Science Immunology

Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: Structural genomics approach

(2020) Ahmad Abu Turab Naqvi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Natural history of COVID-19 and current knowledge on treatment therapeutic options

(2020) Wagner Gouvea dos Santos   BIOMEDICINE & PHARMACOTHERAPY

Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity

(2020) Carolyn Rydyznski Moderbacher et al.   CELL

Altered bioenergetics and mitochondrial dysfunction of monocytes in patients with COVID‐19 pneumonia

(2020) Lara Gibellini et al.   EMBO Molecular Medicine

Monocytopenia, monocyte morphological anomalies and hyperinflammation characterise severe COVID ‐19 in type 2 diabetes

(2020) Fawaz Alzaid et al.   EMBO Molecular Medicine

Quantitative and qualitative alterations of circulating myeloid cells and plasmacytoid DC in SARS‐CoV‐2 infection

(2020) Benedetta Peruzzi et al.   IMMUNOLOGY

Molecular basis of the potential interaction of SARS-CoV-2 spike protein to CD147 in COVID-19 associated-lymphopenia

(2020) Mohamed A. Helal et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

COVID-19 severity associates with pulmonary redistribution of CD1c+ DCs and inflammatory transitional and nonclassical monocytes

(2020) Ildefonso Sánchez-Cerrillo et al.   JOURNAL OF CLINICAL INVESTIGATION

Substantial induction of non-apoptotic CD4 T-cell death during the early phase of HIV-1 infection in a humanized mouse model

(2020) Kazutaka Terahara et al.   MICROBES AND INFECTION

A dynamic COVID-19 immune signature includes associations with poor prognosis

(2020) Adam G. Laing et al.   NATURE MEDICINE

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

(2020) Prabhu S. Arunachalam et al.   SCIENCE

Coronaviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines

(2020) SangJoon Lee et al.   TRENDS IN IMMUNOLOGY

Two distinct immunopathological profiles in autopsy lungs of COVID-19

(2020) Ronny Nienhold et al.   Nature Communications

The role of death domain proteins in host response upon SARS-CoV-2 infection: modulation of programmed cell death and translational applications

(2020) Nikita V. Ivanisenko et al.   Cell Death Discovery

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

(2020) Rajendra Karki et al.   CELL

Necrostatin-1 and necroptosis inhibition: Pathophysiology and therapeutic implications

(2020) Liyuan Cao et al.   PHARMACOLOGICAL RESEARCH

Lymphopenia predicted illness severity and recovery in patients with COVID-19: A single-center, retrospective study

(2020) Jiheng Liu et al.   PLoS One

SARS-CoV-2: Structure, Biology, and Structure-Based Therapeutics Development

(2020) Mei-Yue Wang et al.   Frontiers in Cellular and Infection Microbiology

Comparative Transcriptome Analysis Reveals the Intensive Early Stage Responses of Host Cells to SARS-CoV-2 Infection

(2020) Jiya Sun et al.   Frontiers in Microbiology

Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2

(2020) Francesca Salamanna et al.   Frontiers in Medicine

Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome

(2019) I-Yin Chen et al.   Frontiers in Microbiology

Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC

(2019) Kam-Leung Siu et al.   FASEB JOURNAL

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Necroptosis in the Pathophysiology of Disease

(2019) Mitri K. Khoury et al.   AMERICAN JOURNAL OF PATHOLOGY

Collateral Damage: Necroptosis in the Development of Lung Injury

(2019) Hilary Faust et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis)

(2019) R. K. Subbarao Malireddi et al.   Frontiers in Cellular and Infection Microbiology

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Recent advances in inflammasome biology

(2018) David E Place et al.   CURRENT OPINION IN IMMUNOLOGY

Necroptosis: a regulated inflammatory mode of cell death

(2018) Yogesh K. Dhuriya et al.   Journal of Neuroinflammation

Role of Severe Acute Respiratory Syndrome Coronavirus Viroporins E, 3a, and 8a in Replication and Pathogenesis

(2018) Carlos Castaño-Rodriguez et al.   mBio

Epstein-Barr virus encoded latent membrane protein 1 suppresses necroptosis through targeting RIPK1/3 ubiquitination

(2018) Xiaolan Liu et al.   Cell Death & Disease

Necroptosis in anti-viral inflammation

(2018) Himani Nailwal et al.   CELL DEATH AND DIFFERENTIATION

Modulation of the immune response by Middle East respiratory syndrome coronavirus

(2018) Somayeh Shokri et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

(2018) Daniel Frank et al.   CELL DEATH AND DIFFERENTIATION

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Virus Infection and Death Receptor-Mediated Apoptosis

(2017) Xingchen Zhou et al.   Viruses-Basel

Exploitation of necroptosis for treatment of caspase-compromised cancers

(2017) Young Sik Cho et al.   Oncology Letters

Mir-21 Mediates the Inhibitory Effect of Ang (1–7) on AngII-induced NLRP3 Inflammasome Activation by Targeting Spry1 in lung fibroblasts

(2017) Na-Na Sun et al.   Scientific Reports

Monocyte Conversion During Inflammation and InjuryHighlights

(2016) Rachel M. Kratofil et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

(2016) Michelle A. Hughes et al.   MOLECULAR CELL

HCV-Mediated Apoptosis of Hepatocytes in Culture and Viral Pathogenesis

(2016) Erica Silberstein et al.   PLoS One

Hepatitis C Virus Infection of Cultured Human Hepatoma Cells Causes Apoptosis and Pyroptosis in Both Infected and Bystander Cells

(2016) H. M. Kofahi et al.   Scientific Reports

Suppression of RIP3-dependent Necroptosis by Human Cytomegalovirus

(2015) Shinya Omoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Viroporins: structure, function and potential as antiviral targets

(2015) Claire Scott et al.   JOURNAL OF GENERAL VIROLOGY

Latent infection of myeloid progenitors by human cytomegalovirus protects cells from FAS-mediated apoptosis through the cellular IL-10/PEA-15 pathway

(2015) Emma Poole et al.   JOURNAL OF GENERAL VIROLOGY

Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways

(2015) Hin Chu et al.   JOURNAL OF INFECTIOUS DISEASES

Viruses, apoptosis, and neuroinflammation—a double-edged sword

(2015) Peter G. E. Kennedy   JOURNAL OF NEUROVIROLOGY

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

(2015) Kate E. Lawlor et al.   Nature Communications

Human cytomegalovirus suppresses Fas expression and function

(2014) S. Seirafian et al.   JOURNAL OF GENERAL VIROLOGY

RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway

(2014) Xiaqiong Wang et al.   NATURE IMMUNOLOGY

Emerging Human Middle East Respiratory Syndrome Coronavirus Causes Widespread Infection and Alveolar Damage in Human Lungs

(2013) Andreas C. Hocke et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Network Modeling Reveals Steps in Angiotensin Peptide Processing

(2013) John H. Schwacke et al.   HYPERTENSION

Inhibition of NF- B-Mediated Inflammation in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice Increases Survival

(2013) M. L. DeDiego et al.   JOURNAL OF VIROLOGY

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

(2013) Gilad Doitsh et al.   NATURE

Proteomic analysis reveals that CD147/EMMPRIN confers chemoresistance in cancer stem cell-like cells

(2013) Min Jueng Kang et al.   PROTEOMICS

Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome

(2012) Tae-Bong Kang et al.   IMMUNITY

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-1β Signaling Promotes CNS-Intrinsic Immune Control of West Nile Virus Infection

(2012) Hilario J. Ramos et al.   PLoS Pathogens

Varicella-Zoster Virus Infection Triggers Formation of an Interleukin-1β (IL-1β)-processing Inflammasome Complex

(2011) Adel M. Nour et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis

(2011) Julien van Grevenynghe et al.   JOURNAL OF CLINICAL INVESTIGATION

The NLRP3 Inflammasome Detects Encephalomyocarditis Virus and Vesicular Stomatitis Virus Infection

(2011) J. V. Rajan et al.   JOURNAL OF VIROLOGY

Apoptosis: A Programme of Cell Death or Cell Disposal?

(2011) W. O. Pereira et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Identification of known drugs that act as inhibitors of NF-κB signaling and their mechanism of action

(2010) Susanne C. Miller et al.   BIOCHEMICAL PHARMACOLOGY

Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL

(2010) Nicolai Fricker et al.   JOURNAL OF CELL BIOLOGY

Varicella-zoster virus–induced apoptosis in MeWo cells is accompanied by down-regulation of Bcl-2 expression

(2010) Elizabeth Brazeau et al.   JOURNAL OF NEUROVIROLOGY

Adenovirus Membrane Penetration Activates the NLRP3 Inflammasome

(2010) A. U. Barlan et al.   JOURNAL OF VIROLOGY

The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins

(2009) S. Abu-Hamad et al.   JOURNAL OF CELL SCIENCE

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE