The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

Unique inflammatory profile is associated with higher SARS-CoV-2 acute respiratory distress syndrome (ARDS) mortality

(2021) Joseph Balnis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells

(2021) Shuai Wang et al.   CELL RESEARCH

Relationship between SARS-CoV-2 infection and the incidence of ventilator-associated lower respiratory tract infections: a European multicenter cohort study

(2021) Anahita Rouzé et al.   INTENSIVE CARE MEDICINE

Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia

(2021) Rogan A. Grant et al.   NATURE

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

(2021) Jennifer M. Dan et al.   SCIENCE

Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune Signatures

(2021) Jacob D. Galson et al.   Frontiers in Immunology

Early postmortem mapping of SARS-CoV-2 RNA in patients with COVID-19 and the correlation with tissue damage

(2021) Stefanie Deinhardt-Emmer et al.   eLife

Laboratory abnormalities in patients with COVID-2019 infection

(2020) Giuseppe Lippi et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Evidence for gastrointestinal infection of SARS-CoV-2

(2020) Fei Xiao et al.   GASTROENTEROLOGY

Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China

(2020) Qiurong Ruan et al.   INTENSIVE CARE MEDICINE

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Viral load of SARS-CoV-2 in clinical samples

(2020) Yang Pan et al.   LANCET INFECTIOUS DISEASES

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

(2020) Xiaobo Yang et al.   Lancet Respiratory Medicine

COVID-19 Autopsies, Oklahoma, USA

(2020) Lisa M Barton et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

COVID-19, ACE2, and the cardiovascular consequences

(2020) Andrew M. South et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Airborne transmission of severe acute respiratory syndrome coronavirus‐2 to healthcare workers: a narrative review

(2020) N. M. Wilson et al.   ANAESTHESIA

The Italian coronavirus disease 2019 outbreak: recommendations from clinical practice

(2020) M. Sorbello et al.   ANAESTHESIA

Autopsy Findings and Venous Thromboembolism in Patients With COVID-19

(2020) Dominic Wichmann et al.   ANNALS OF INTERNAL MEDICINE

Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (n=4532)

(2020) M. Montopoli et al.   ANNALS OF ONCOLOGY

The BTK inhibitor ibrutinib may protect against pulmonary injury in COVID-19–infected patients

(2020) Steven P. Treon et al.   BLOOD

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

(2020) Yixuan J. Hou et al.   CELL

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

(2020) Alba Grifoni et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

(2020) Zhuo Zhou et al.   Cell Host & Microbe

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

(2020) Evangelos J. Giamarellos-Bourboulis et al.   Cell Host & Microbe

Favorable Anakinra Responses in Severe Covid-19 Patients with Secondary Hemophagocytic Lymphohistiocytosis

(2020) George Dimopoulos et al.   Cell Host & Microbe

Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes

(2020) Lihua Zhu et al.   Cell Metabolism

Pathological evidence for residual SARS-CoV-2 in pulmonary tissues of a ready-for-discharge patient

(2020) Xiao-Hong Yao et al.   CELL RESEARCH

Comparison of Hospitalized Patients With ARDS Caused by COVID-19 and H1N1

(2020) Xiao Tang et al.   CHEST

Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial Version 7)

(2020)   CHINESE MEDICAL JOURNAL

Using IL‐2R/lymphocytes for predicting the clinical progression of patients with COVID‐19

(2020) H. Hou et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

An inflammatory profile correlates with decreased frequency of cytotoxic cells in COVID-19

(2020) Veronica Bordoni et al.   CLINICAL INFECTIOUS DISEASES

Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients

(2020) Xiaohua Chen et al.   CLINICAL INFECTIOUS DISEASES

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

(2020) Chuan Qin et al.   CLINICAL INFECTIOUS DISEASES

Exploring Diseases/Traits and Blood Proteins Causally Related to Expression of ACE2, the Putative Receptor of SARS-CoV-2: A Mendelian Randomization Analysis Highlights Tentative Relevance of Diabetes-Related Traits

(2020) Shitao Rao et al.   DIABETES CARE

COVID-19, diabetes mellitus and ACE2: The conundrum

(2020) Rimesh Pal et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection

(2020) Paolo Verdecchia et al.   European Journal of Internal Medicine

CT in coronavirus disease 2019 (COVID-19): a systematic review of chest CT findings in 4410 adult patients

(2020) Vineeta Ojha et al.   EUROPEAN RADIOLOGY

Abnormal pulmonary function in COVID-19 patients at time of hospital discharge

(2020) Xiaoneng Mo et al.   EUROPEAN RESPIRATORY JOURNAL

Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals

(2020) Ling Ni et al.   IMMUNITY

Time to consider histologic pattern of lung injury to treat critically ill patients with COVID-19 infection

(2020) Marie-Christine Copin et al.   INTENSIVE CARE MEDICINE

COVID-19 pneumonia: different respiratory treatments for different phenotypes?

(2020) Luciano Gattinoni et al.   INTENSIVE CARE MEDICINE

Postmortem Examination of Patients With COVID-19

(2020) Tina Schaller et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Urgent avenues in the treatment of COVID-19: Targeting downstream inflammation to prevent catastrophic syndrome

(2020) Luca Quartuccio et al.   JOINT BONE SPINE

A possible role for B cells in COVID-19? Lesson from patients with agammaglobulinemia

(2020) Isabella Quinti et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Type I IFN immunoprofiling in COVID-19 patients

(2020) Sophie Trouillet-Assant et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Longitudinal hematologic and immunologic variations associated with the progression of COVID-19 patients in China

(2020) Ruchong Chen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Complement activation in patients with COVID-19: A novel therapeutic target

(2020) Massimo Cugno et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

(2020) Betsy J. Barnes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T cell subset counts in peripheral blood can be used as discriminatory biomarkers for diagnosis and severity prediction of COVID-19

(2020) Mei Jiang et al.   JOURNAL OF INFECTIOUS DISEASES

Characteristics of Peripheral Lymphocyte Subset Alteration in COVID-19 Pneumonia

(2020) Fan Wang et al.   JOURNAL OF INFECTIOUS DISEASES

Diagnostic Utility of Clinical Laboratory Data Determinations for Patients with the Severe COVID‐19

(2020) Yong Gao et al.   JOURNAL OF MEDICAL VIROLOGY

ISTH interim guidance on recognition and management of coagulopathy in COVID‐19

(2020) Jecko Thachil et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China

(2020) Hua Su et al.   KIDNEY INTERNATIONAL

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Hypoxaemia related to COVID-19: vascular and perfusion abnormalities on dual-energy CT

(2020) Min Lang et al.   LANCET INFECTIOUS DISEASES

Human neutralizing antibodies elicited by SARS-CoV-2 infection

(2020) Bin Ju et al.   NATURE

Virological assessment of hospitalized patients with COVID-2019

(2020) Roman Wölfel et al.   NATURE

The proximal origin of SARS-CoV-2

(2020) Kristian G. Andersen et al.   NATURE MEDICINE

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

(2020) Mingfeng Liao et al.   NATURE MEDICINE

Temporal dynamics in viral shedding and transmissibility of COVID-19

(2020) Xi He et al.   NATURE MEDICINE

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neurologic Features in Severe SARS-CoV-2 Infection

(2020) Julie Helms et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical Characteristics of Covid-19 in New York City

(2020) Parag Goyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiorgan and Renal Tropism of SARS-CoV-2

(2020) Victor G. Puelles et al.   NEW ENGLAND JOURNAL OF MEDICINE

Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19

(2020) Yan Zhang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Two X‐linked agammaglobulinemia patients develop pneumonia as COVID‐19 manifestation but recover

(2020) Annarosa Soresina et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

SARS-CoV-2 infection protects against rechallenge in rhesus macaques

(2020) Abishek Chandrashekar et al.   SCIENCE

Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model

(2020) Barry Rockx et al.   SCIENCE

SARS-CoV-2/COVID-19

(2020) Marcin F. Osuchowski et al.   SHOCK

Glycemic Variability in Diabetes Increases the Severity of Influenza

(2020) Rebecca J. Marshall et al.   mBio

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

(2020) Chaomin Wu et al.   JAMA Internal Medicine

Impact of sex and gender on COVID-19 outcomes in Europe

(2020) Catherine Gebhard et al.   Biology of Sex Differences

Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues

(2020) Meng-Yuan Li et al.   Infectious Diseases of Poverty

COVID-19 and the endocrine system: exploring the unexplored

(2020) R. Pal et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients

(2020) Yonggang Zhou et al.   National Science Review

Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients

(2020) Jing Liu et al.   EBioMedicine

Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing

(2020) Wen Wen et al.   Cell Discovery

SARS-CoV-2 Infection–Associated Hemophagocytic Lymphohistiocytosis

(2020) Andrey Prilutskiy et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Why COVID-19 Silent Hypoxemia Is Baffling to Physicians

(2020) Martin J. Tobin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Reduced monocytic HLA-DR expression indicates immunosuppression in critically ill COVID-19 patients

(2020) Thibaud Spinetti et al.   ANESTHESIA AND ANALGESIA

COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection

(2020) Hanny Al-Samkari et al.   BLOOD

Thrombolysis restores perfusion in COVID 19 hypoxia

(2020) Deepa J Arachchillage et al.   BRITISH JOURNAL OF HAEMATOLOGY

Severe COVID-19 is marked by a dysregulated myeloid cell compartment

(2020) Jonas Schulte-Schrepping et al.   CELL

Elevated calprotectin and abnormal myeloid cell subsets discriminate severe from mild COVID-19

(2020) Aymeric Silvin et al.   CELL

Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells

(2020) Yunlong Cao et al.   CELL

Expansion of myeloid-derived suppressor cells in patients with severe coronavirus disease (COVID-19)

(2020) Chiara Agrati et al.   CELL DEATH AND DIFFERENTIATION

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

(2020) Liuliu Yang et al.   Cell Stem Cell

Systemically comparing host immunity between survived and deceased COVID-19 patients

(2020) Feng Wang et al.   Cellular & Molecular Immunology

Selective CD8 cell reduction by SARS-CoV-2 is associated with a worse prognosis and systemic inflammation in COVID-19 patients

(2020) J.M. Urra et al.   CLINICAL IMMUNOLOGY

Impact of SARS-CoV-2 Viral Load on Risk of Intubation and Mortality Among Hospitalized Patients with Coronavirus Disease 2019

(2020) Reed Magleby et al.   CLINICAL INFECTIOUS DISEASES

Airborne transmission of SARS-CoV-2: The world should face the reality

(2020) Lidia Morawska et al.   ENVIRONMENT INTERNATIONAL

High mortality in COVID‐19 patients with mild respiratory disease

(2020) Chiara Masetti et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

A review of the main histopathological findings in the Coronavirus Disease 2019 (COVID-19)

(2020) Walter O. Vasquez-Bonilla et al.   HUMAN PATHOLOGY

Severe COVID-19 is associated with deep and sustained multifaceted cellular immunosuppression

(2020) Robin Jeannet et al.   INTENSIVE CARE MEDICINE

Dying with SARS-CoV-2 infection—an autopsy study of the first consecutive 80 cases in Hamburg, Germany

(2020) Carolin Edler et al.   INTERNATIONAL JOURNAL OF LEGAL MEDICINE

Presence of Genetic Variants Among Young Men With Severe COVID-19

(2020) Caspar I. van der Made et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Persistent Symptoms in Patients After Acute COVID-19

(2020) Angelo Carfì et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Association of Angiotensin-Converting Enzyme Inhibitor or Angiotensin Receptor Blocker Use With COVID-19 Diagnosis and Mortality

(2020) Emil L. Fosbøl et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent

(2020) Alessio Mazzoni et al.   JOURNAL OF CLINICAL INVESTIGATION

SARS-CoV-2 as a Factor to Disbalance the Renin–Angiotensin System: A Suspect in the Case of Exacerbated IL-6 Production

(2020) Rafael Franco et al.   JOURNAL OF IMMUNOLOGY

Cytokine storm and leukocyte changes in mild versus severe SARS‐CoV‐2 infection: Review of 3939 COVID‐19 patients in China and emerging pathogenesis and therapy concepts

(2020) Jin Wang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

COVID‐19: What type of cytokine storm are we dealing with?

(2020) Guillaume Monneret et al.   JOURNAL OF MEDICAL VIROLOGY

SARS‐CoV‐2‐reactive interferon‐γ‐producing CD8+ T cells in patients hospitalized with coronavirus disease 2019

(2020) Estela Giménez et al.   JOURNAL OF MEDICAL VIROLOGY

Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study

(2020) Luca Carsana et al.   LANCET INFECTIOUS DISEASES

Crucial laboratory parameters in COVID-19 diagnosis and prognosis: An updated meta-analysis

(2020) Gita Vita Soraya et al.   MEDICINA CLINICA

In situ detection of SARS-CoV-2 in lungs and airways of patients with COVID-19

(2020) Inga-Marie Schaefer et al.   MODERN PATHOLOGY

The protein expression profile of ACE2 in human tissues

(2020) Feria Hikmet et al.   Molecular Systems Biology

Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis

(2020) Julien Carvelli et al.   NATURE

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

(2020) Nina Le Bert et al.   NATURE

Convergent antibody responses to SARS-CoV-2 in convalescent individuals

(2020) Davide F. Robbiani et al.   NATURE

A single-cell atlas of the peripheral immune response in patients with severe COVID-19

(2020) Aaron J. Wilk et al.   NATURE MEDICINE

Extrapulmonary manifestations of COVID-19

(2020) Aakriti Gupta et al.   NATURE MEDICINE

Multisystem Inflammatory Syndrome in U.S. Children and Adolescents

(2020) Leora R. Feldstein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rapid Decay of Anti–SARS-CoV-2 Antibodies in Persons with Mild Covid-19

(2020) F. Javier Ibarrondo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multisystem Inflammatory Syndrome in Children in New York State

(2020) Elizabeth M. Dufort et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomewide Association Study of Severe Covid-19 with Respiratory Failure

(2020) David Ellinghaus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

(2020) Matthias Thoms et al.   SCIENCE

Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans

(2020) Jose Mateus et al.   SCIENCE

Incidence of thrombotic complications in critically ill ICU patients with COVID-19

(2020) F.A. Klok et al.   THROMBOSIS RESEARCH

The evolution of pulmonary pathology in fatal COVID-19 disease: an autopsy study with clinical correlation

(2020) Hans Bösmüller et al.   VIRCHOWS ARCHIV

The inhibition of IL-2/IL-2R gives rise to CD8+ T cell and lymphocyte decrease through JAK1-STAT5 in critical patients with COVID-19 pneumonia

(2020) Hongbo Shi et al.   Cell Death & Disease

Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia

(2020) Sara De Biasi et al.   Nature Communications

Cross-reactive Antibody Response between SARS-CoV-2 and SARS-CoV Infections

(2020) Huibin Lv et al.   Cell Reports

Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells

(2020) Megan L. Stanifer et al.   Cell Reports

Is a “Cytokine Storm” Relevant to COVID-19?

(2020) Pratik Sinha et al.   JAMA Internal Medicine

Caution about early intubation and mechanical ventilation in COVID-19

(2020) Martin J. Tobin et al.   Annals of Intensive Care

COVID-19 in people with diabetes: understanding the reasons for worse outcomes

(2020) Matteo Apicella et al.   Lancet Diabetes & Endocrinology

Anti-CD20 immunosuppressive disease-modifying therapies and COVID-19

(2020) Gavin Giovannoni   Multiple Sclerosis and Related Disorders

Anti-CD20 and COVID-19 in multiple sclerosis and related disorders: A case series of 60 patients from Madrid, Spain

(2020) Paloma Montero-Escribano et al.   Multiple Sclerosis and Related Disorders

Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients

(2020) Chaofu Wang et al.   EBioMedicine

Comprehensive mapping of immune perturbations associated with severe COVID-19

(2020) Leticia Kuri-Cervantes et al.   Science Immunology

The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

(2020) Lakshmanane Premkumar et al.   Science Immunology

SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection

(2020) Daniel M. Altmann et al.   Science Immunology

Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19

(2020) Jeong Seok Lee et al.   Science Immunology

Severe immunosuppression and not a cytokine storm characterize COVID-19 infections

(2020) Kenneth E. Remy et al.   JCI Insight

IL-6 and CD8+ T cell counts combined are an early predictor of in-hospital mortality of patients with COVID-19

(2020) Miao Luo et al.   JCI Insight

The laboratory tests and host immunity of COVID-19 patients with different severity of illness

(2020) Feng Wang et al.   JCI Insight

Immune-Inflammatory Parameters in COVID-19 Cases: A Systematic Review and Meta-Analysis

(2020) Xudong Feng et al.   Frontiers in Medicine

Clinical and Immune Features of Hospitalized Pediatric Patients With Coronavirus Disease 2019 (COVID-19) in Wuhan, China

(2020) Huan Wu et al.   JAMA Network Open

The Respiratory Drive: An Overlooked Tile of COVID-19 Pathophysiology

(2020) Luciano Gattinoni et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

SARS-CoV-2 Viral Load Predicts Mortality in Patients with and without Cancer Who Are Hospitalized with COVID-19

(2020) Lars F. Westblade et al.   CANCER CELL

The emerging spectrum of cardiopulmonary pathology of the coronavirus disease 2019 (COVID-19): Report of 3 autopsies from Houston, Texas, and review of autopsy findings from other United States cities

(2020) Louis Maximilian Buja et al.   CARDIOVASCULAR PATHOLOGY

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

(2020) Takuya Sekine et al.   CELL

Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2

(2020) Sandra C.A. Nielsen et al.   Cell Host & Microbe

Decreased T cell populations contribute to the increased severity of COVID-19

(2020) Rui Liu et al.   CLINICA CHIMICA ACTA

Comparative analysis of laboratory indexes of severe and non-severe patients infected with COVID-19

(2020) Jinfeng Bao et al.   CLINICA CHIMICA ACTA

COVID-19 pneumonia: CD8+ T and NK cells are decreased in number but compensatory increased in cytotoxic potential

(2020) Yujie Jiang et al.   CLINICAL IMMUNOLOGY

Endothelial to mesenchymal transition: a precursor to post-COVID-19 interstitial pulmonary fibrosis and vascular obliteration?

(2020) Mathew Suji Eapen et al.   EUROPEAN RESPIRATORY JOURNAL

Inflammasome formation in the lungs of patients with fatal COVID-19

(2020) Stefano Toldo et al.   INFLAMMATION RESEARCH

Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions

(2020) Matthijs Kox et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Compartmental immunophenotyping in COVID-19 ARDS: A case series

(2020) Andreas Ronit et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Presence of hyaluronan in lung alveoli in severe Covid-19 - an opening for new treatment options?

(2020) Urban Hellman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

COVID-19 severity associates with pulmonary redistribution of CD1c+ DCs and inflammatory transitional and nonclassical monocytes

(2020) Ildefonso Sánchez-Cerrillo et al.   JOURNAL OF CLINICAL INVESTIGATION

Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis

(2020) Linlin Cheng et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Upper respiratory tract levels of SARS-CoV-2 RNA and duration of viral RNA shedding do not differ between patients with mild and severe/critical COVID-19

(2020) Aylin Yilmaz et al.   JOURNAL OF INFECTIOUS DISEASES

Peripheral immunophenotypes in children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection

(2020) Michael J. Carter et al.   NATURE MEDICINE

A dynamic COVID-19 immune signature includes associations with poor prognosis

(2020) Adam G. Laing et al.   NATURE MEDICINE

Diffuse alveolar damage and thrombotic microangiopathy are the main histopathological findings in lung tissue biopsy samples of COVID-19 patients

(2020) Farahnaz Sadegh Beigee et al.   PATHOLOGY RESEARCH AND PRACTICE

Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients

(2020) Jan C. Holter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

(2020) Ludovico Cantuti-Castelvetri et al.   SCIENCE

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

Mechanisms of SARS-CoV-2 transmission and pathogenesis

(2020) Andrew G. Harrison et al.   TRENDS IN IMMUNOLOGY

Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19

(2020) Guillaume Carissimo et al.   Nature Communications

Two distinct immunopathological profiles in autopsy lungs of COVID-19

(2020) Ronny Nienhold et al.   Nature Communications

Evasion of Type I Interferon by SARS-CoV-2

(2020) Hongjie Xia et al.   Cell Reports

Pathophysiology of COVID-19-associated acute respiratory distress syndrome: a multicentre prospective observational study

(2020) Giacomo Grasselli et al.   Lancet Respiratory Medicine

Ventilation management and clinical outcomes in invasively ventilated patients with COVID-19 (PRoVENT-COVID): a national, multicentre, observational cohort study

(2020) Michela Botta et al.   Lancet Respiratory Medicine

Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes

(2020) Daniel E Leisman et al.   Lancet Respiratory Medicine

Prevalence of phenotypes of acute respiratory distress syndrome in critically ill patients with COVID-19: a prospective observational study

(2020) Pratik Sinha et al.   Lancet Respiratory Medicine

A Longitudinal Study of Immune Cells in Severe COVID-19 Patients

(2020) Didier Payen et al.   Frontiers in Immunology

As Plain as the Nose on Your Face: The Case for A Nasal (Mucosal) Route of Vaccine Administration for Covid-19 Disease Prevention

(2020) Craig R. Travis   Frontiers in Immunology

A narrative review of venous thrombosis epidemiology, pathophysiology, and anticoagulant therapies and trials in severe acute respiratory syndrome coronavirus 2 infection

(2020) Andrea T. Obi et al.   Journal of Vascular Surgery-Venous and Lymphatic Disorders

Natural killer cell immunotypes related to COVID-19 disease severity

(2020) Christopher Maucourant et al.   Science Immunology

Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison

(2020) Ioanna-Evdokia Galani et al.   NATURE IMMUNOLOGY

Myocardial injury in severe COVID‐19 is similar to pneumonias of other origin: results from a multicentre study

(2020) Peter Jirak et al.   ESC Heart Failure

Antibody response using six different serological assays in a completely PCR-tested community after a coronavirus disease 2019 outbreak—the CoNAN study

(2020) Sebastian Weis et al.   CLINICAL MICROBIOLOGY AND INFECTION

Influenza A Virus Infection Induces Hyperresponsiveness in Human Lung Tissue-Resident and Peripheral Blood NK Cells

(2019) Marlena Scharenberg et al.   Frontiers in Immunology

Hyperferritinemia in Critically Ill Patients

(2019) Gunnar Lachmann et al.   CRITICAL CARE MEDICINE

Review of clinical practice guidelines on the use of procalcitonin in infections

(2019) Benita Tujula et al.   Infectious Diseases

Mechanisms and treatment of organ failure in sepsis

(2018) Christophe Lelubre et al.   Nature Reviews Nephrology

The CD8 T Cell Response to Respiratory Virus Infections

(2018) Megan E. Schmidt et al.   Frontiers in Immunology

Post-operative immune suppression is mediated via reversible, Interleukin-10 dependent pathways in circulating monocytes following major abdominal surgery

(2018) Hew D. T. Torrance et al.   PLoS One

Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69 − CD56 dim cells

(2017) Nicole Marquardt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Diabetes Exacerbates Infection via Hyperinflammation by Signaling through TLR4 and RAGE

(2017) Travis B. Nielsen et al.   mBio

The Microbiome and the Respiratory Tract

(2016) Robert P. Dickson et al.   Annual Review of Physiology

Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection

(2015) Allison L. Totura et al.   mBio

Validation of the Caprini Venous Thromboembolism Risk Assessment Model in Critically Ill Surgical Patients

(2015) Andrea T. Obi et al.   JAMA Surgery

Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response

(2014) Hin Chu et al.   VIROLOGY

Development and Validation of the HScore, a Score for the Diagnosis of Reactive Hemophagocytic Syndrome

(2014) Laurence Fardet et al.   Arthritis & Rheumatology

Antibodies induced by receptor-binding domain in spike protein of SARS-CoV do not cross-neutralize the novel human coronavirus hCoV-EMC

(2013) Lanying Du et al.   JOURNAL OF INFECTION

Active Replication of Middle East Respiratory Syndrome Coronavirus and Aberrant Induction of Inflammatory Cytokines and Chemokines in Human Macrophages: Implications for Pathogenesis

(2013) Jie Zhou et al.   JOURNAL OF INFECTIOUS DISEASES

Myeloid-Derived Suppressor Cells Evolve during Sepsis and Can Enhance or Attenuate the Systemic Inflammatory Response

(2012) Laura Brudecki et al.   INFECTION AND IMMUNITY

Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future

(2011) Philipp Schuetz et al.   BMC Medicine

Lack of Peripheral Memory B Cell Responses in Recovered Patients with Severe Acute Respiratory Syndrome: A Six-Year Follow-Up Study

(2011) F. Tang et al.   JOURNAL OF IMMUNOLOGY

Functional Disability 5 Years after Acute Respiratory Distress Syndrome

(2011) Margaret S. Herridge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pulmonary fibrosis: pathogenesis, etiology and regulation

(2009) M S Wilson et al.   Mucosal Immunology

Pathogenetic mechanisms of severe acute respiratory syndrome

(2007) Yong Guo et al.   VIRUS RESEARCH