Viroporins: structure, function and potential as antiviral targets

Severe Acute Respiratory Syndrome Coronaviruses with Mutations in the E Protein Are Attenuated and Promising Vaccine Candidates

(2015) Jose A. Regla-Nava et al.   JOURNAL OF VIROLOGY

“Too little, too late?” Will inhibitors of the hepatitis C virus p7 ion channel ever be used in the clinic?

(2014) Stephen Griffin   Future Medicinal Chemistry

Easily Accessible Polycyclic Amines that Inhibit the Wild-Type and Amantadine-Resistant Mutants of the M2 Channel of Influenza A Virus

(2014) Matias Rey-Carrizo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Flipping in the Pore: Discovery of Dual Inhibitors That Bind in Different Orientations to the Wild-Type versus the Amantadine-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel

(2014) Yibing Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nuclear Magnetic Resonance Structure Revealed that the Human Polyomavirus JC Virus Agnoprotein Contains an  -Helix Encompassing the Leu/Ile/Phe-Rich Domain

(2014) P. Coric et al.   JOURNAL OF VIROLOGY

Inhibition of the Human Respiratory Syncytial Virus Small Hydrophobic Protein and Structural Variations in a Bicelle Environment

(2014) Y. Li et al.   JOURNAL OF VIROLOGY

The Human Metapneumovirus Small Hydrophobic Protein Has Properties Consistent with Those of a Viroporin and Can Modulate Viral Fusogenic Activity

(2014) C. Masante et al.   JOURNAL OF VIROLOGY

Structural Plasticity of the Coiled-Coil Domain of Rotavirus NSP4

(2014) N. P. Sastri et al.   JOURNAL OF VIROLOGY

The Intraviral Protein Interaction Network of Hepatitis C Virus

(2014) Nicole Hagen et al.   MOLECULAR & CELLULAR PROTEOMICS

Kaempferol Derivatives as Antiviral Drugs against the 3a Channel Protein of Coronavirus

(2014) Silvia Schwarz et al.   PLANTA MEDICA

Two Different Conformations in Hepatitis C Virus p7 Protein Account for Proton Transport and Dye Release

(2014) Siok Wan Gan et al.   PLoS One

Bacteria-Based Analysis of HIV-1 Vpu Channel Activity

(2014) Robert Taube et al.   PLoS One

Structure based computational assessment of channel properties of assembled ORF-8a from SARS-CoV

(2014) Hao-Jen Hsu et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Capsid Protein VP4 of Human Rhinovirus Induces Membrane Permeability by the Formation of a Size-Selective Multimeric Pore

(2014) Anusha Panjwani et al.   PLoS Pathogens

Differential effect of p7 inhibitors on hepatitis C virus cell-to-cell transmission

(2013) L.W. Meredith et al.   ANTIVIRAL RESEARCH

Three-Dimensional Structure and Interaction Studies of Hepatitis C Virus p7 in 1,2-Dihexanoyl-sn-glycero-3-phosphocholine by Solution Nuclear Magnetic Resonance

(2013) Gabriel A. Cook et al.   BIOCHEMISTRY

The ORF4a protein of human coronavirus 229E functions as a viroporin that regulates viral production

(2013) Ronghua Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release

(2013) Toshana L. Foster et al.   HEPATOLOGY

Viroporin activity and membrane topology of classic swine fever virus p7 protein

(2013) Hui-Chen Guo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mutations in hepatitis C virus p7 reduce both the egress and infectivity of assembled particles via impaired proton channel function

(2013) M. J. Bentham et al.   JOURNAL OF GENERAL VIROLOGY

Discovery of Novel Dual Inhibitors of the Wild-Type and the Most Prevalent Drug-Resistant Mutant, S31N, of the M2 Proton Channel from Influenza A Virus

(2013) Jizhou Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

3-Azatetracyclo[5.2.1.15,8.01,5]undecane Derivatives: From Wild-Type Inhibitors of the M2 Ion Channel of Influenza A Virus to Derivatives with Potent Activity against the V27A Mutant

(2013) Matias Rey-Carrizo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drug-Induced Conformational and Dynamical Changes of the S31N Mutant of the Influenza M2 Proton Channel Investigated by Solid-State NMR

(2013) Jonathan K. Williams et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hepatitis C Virus Induces Interleukin-1  (IL-1 )/IL-18 in Circulatory and Resident Liver Macrophages

(2013) S. Shrivastava et al.   JOURNAL OF VIROLOGY

Activation of the Endoplasmic Reticulum Calcium Sensor STIM1 and Store-Operated Calcium Entry by Rotavirus Requires NSP4 Viroporin Activity

(2013) J. M. Hyser et al.   JOURNAL OF VIROLOGY

Functional Characterization of the Alphavirus TF Protein

(2013) J. E. Snyder et al.   JOURNAL OF VIROLOGY

Unusual architecture of the p7 channel from hepatitis C virus

(2013) Bo OuYang et al.   NATURE

Inhibitors of the Influenza A Virus M2 Proton Channel Discovered Using a High-Throughput Yeast Growth Restoration Assay

(2013) Aruna D. Balgi et al.   PLoS One

Ultrastructural analysis of hepatitis C virus particles

(2013) Maria Teresa Catanese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus

(2013) Jun Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential roles of Leu/Ile/Phe-rich domain of JC virus agnoprotein in dimer/oligomer formation, protein stability and splicing of viral transcripts

(2013) A. Sami Saribas et al.   VIROLOGY

The stability of secreted, acid-labile H77/JFH-1 hepatitis C virus (HCV) particles is altered by patient isolate genotype 1a p7 sequences

(2013) Elizabeth Atkins et al.   VIROLOGY

Evidence suggesting that HCV p7 protects E2 glycoprotein from premature degradation during virus production

(2013) Ali M. Atoom et al.   VIRUS RESEARCH

Hepatitis C Virus p7 is Critical for Capsid Assembly and Envelopment

(2013) Juliane Gentzsch et al.   PLoS Pathogens

Severe diffraction anisotropy, rotational pseudosymmetry and twinning complicate the refinement of a pentameric coiled-coil structure of NSP4 of rotavirus

(2012) Anita R. Chacko et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The dengue virus M protein localises to the endoplasmic reticulum and forms oligomers

(2012) Sook-San Wong et al.   FEBS LETTERS

The Small Hydrophobic Protein of the Human Respiratory Syncytial Virus Forms Pentameric Ion Channels

(2012) Siok-Wan Gan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Viroporin Activity of the Minor Structural Proteins VP2 and VP3 Is Required for SV40 Propagation

(2012) Kristina M. Giorda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-Risk Human Papillomavirus E5 Oncoprotein Displays Channel-Forming Activity Sensitive to Small-Molecule Inhibitors

(2012) L. F. Wetherill et al.   JOURNAL OF VIROLOGY

Quantitative Measurement of Human Papillomavirus Type 16 E5 Oncoprotein Levels in Epithelial Cell Lines by Mass Spectrometry

(2012) Z. Sahab et al.   JOURNAL OF VIROLOGY

Subcellular Localization and Function of an Epitope-Tagged p7 Viroporin in Hepatitis C Virus-Producing Cells

(2012) Gabrielle Vieyres et al.   JOURNAL OF VIROLOGY

Classical Swine Fever Virus p7 Protein Is a Viroporin Involved in Virulence in Swine

(2012) D. P. Gladue et al.   JOURNAL OF VIROLOGY

Genetic Divergence of Rotavirus Nonstructural Protein 4 Results in Distinct Serogroup-Specific Viroporin Activity and Intracellular Punctate Structure Morphologies

(2012) J. M. Hyser et al.   JOURNAL OF VIROLOGY

Viroporins: structure and biological functions

(2012) José Luis Nieva et al.   NATURE REVIEWS MICROBIOLOGY

Structural basis for proton conduction and inhibition by the influenza M2 protein

(2012) Mei Hong et al.   PROTEIN SCIENCE

Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation

(2012) Kathy Triantafilou et al.   THORAX

Coronavirus E protein forms ion channels with functionally and structurally-involved membrane lipids

(2012) Carmina Verdiá-Báguena et al.   VIROLOGY

The p7 protein of the hepatitis C virus induces cell death differently from the influenza A virus viroporin M2

(2012) Jude Juventus Aweya et al.   VIRUS RESEARCH

M2 protein from Influenza A: from multiple structures to biophysical and functional insights

(2012) Timothy A Cross et al.   Current Opinion in Virology

The p7 Protein of Hepatitis C Virus Forms Structurally Plastic, Minimalist Ion Channels

(2012) Danielle E. Chandler et al.   PLoS Computational Biology

A Single Polar Residue and Distinct Membrane Topologies Impact the Function of the Infectious Bronchitis Coronavirus E Protein

(2012) Travis R. Ruch et al.   PLoS Pathogens

Encephalomyocarditis Virus Viroporin 2B Activates NLRP3 Inflammasome

(2012) Minako Ito et al.   PLoS Pathogens

Analysis of Functional Differences between Hepatitis C Virus NS5A of Genotypes 1–7 in Infectious Cell Culture Systems

(2012) Troels K. H. Scheel et al.   PLoS Pathogens

A new pentameric structure of rotavirus NSP4 revealed by molecular replacement

(2011) Anita R. Chacko et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Emodin inhibits current through SARS-associated coronavirus 3a protein

(2011) Silvia Schwarz et al.   ANTIVIRAL RESEARCH

DIDS blocks a chloride-dependent current that is mediated by the 2B protein of enterovirus 71

(2011) Shiqi Xie et al.   CELL RESEARCH

Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel

(2011) Toshana L. Foster et al.   HEPATOLOGY

HIV-1 Vpu Protein Antagonizes Innate Restriction Factor BST-2 via Lipid-embedded Helix-Helix Interactions

(2011) Mark Skasko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploring the Size Limit of Templates for Inhibitors of the M2 Ion Channel of Influenza A Virus

(2011) María D. Duque et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular Dynamics Simulation Directed Rational Design of Inhibitors Targeting Drug-Resistant Mutants of Influenza A Virus M2

(2011) Jun Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development and Application of Hepatitis C Reporter Viruses with Genotype 1 to 7 Core-Nonstructural Protein 2 (NS2) Expressing Fluorescent Proteins or Luciferase in Modified JFH1 NS5A

(2011) J. M. Gottwein et al.   JOURNAL OF VIROLOGY

Novel Pentameric Structure of the Diarrhea-Inducing Region of the Rotavirus Enterotoxigenic Protein NSP4

(2011) A. R. Chacko et al.   JOURNAL OF VIROLOGY

The influence of different lipid environments on the structure and function of the hepatitis C virus p7 ion channel protein

(2011) Thomas Whitfield et al.   MOLECULAR MEMBRANE BIOLOGY

The HIV-1 Vpu Viroporin Inhibitor BIT225 Does Not Affect Vpu-Mediated Tetherin Antagonism

(2011) Björn D. Kuhl et al.   PLoS One

Sublingual Immunization with M2-Based Vaccine Induces Broad Protective Immunity against Influenza

(2011) Byoung-Shik Shim et al.   PLoS One

Structural Investigation of Rimantadine Inhibition of the AM2-BM2 Chimera Channel of Influenza Viruses

(2011) Rafal M. Pielak et al.   STRUCTURE

Dengue virus PrM/M proteins fail to show pH-dependent ion channel activity in Xenopus oocytes

(2011) Sook-San Wong et al.   VIROLOGY

Human polyomavirus JC small regulatory agnoprotein forms highly stable dimers and oligomers: Implications for their roles in agnoprotein function

(2011) A. Sami Saribas et al.   VIROLOGY

Ion channel activity of HIV-1 Vpu is dispensable for counteraction of CD317

(2011) Sebastian Bolduan et al.   VIROLOGY

Genetic and functional heterogeneity of the hepatitis C virus p7 ion channel during natural chronic infection

(2011) Hui Li et al.   VIROLOGY

Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in Inhibitors of M2 from Influenza A Virus

(2011) Jun Wang et al.   ACS Medicinal Chemistry Letters

The SV40 Late Protein VP4 Is a Viroporin that Forms Pores to Disrupt Membranes for Viral Release

(2011) Smita Raghava et al.   PLoS Pathogens

A Concerted Action of Hepatitis C Virus P7 and Nonstructural Protein 2 Regulates Core Localization at the Endoplasmic Reticulum and Virus Assembly

(2011) Bertrand Boson et al.   PLoS Pathogens

NS2 Protein of Hepatitis C Virus Interacts with Structural and Non-Structural Proteins towards Virus Assembly

(2011) Costin-Ioan Popescu et al.   PLoS Pathogens

A novel Hepatitis C virus p7 ion channel inhibitor, BIT225, inhibits bovine viral diarrhea virus in vitro and shows synergism with recombinant interferon-α-2b and nucleoside analogues

(2010) Carolyn A. Luscombe et al.   ANTIVIRAL RESEARCH

Drug sensitivity, drug-resistant mutations, and structures of three conductance domains of viral porins

(2010) Mukesh Sharma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

ORF8a of SARS-CoV forms an ion channel: Experiments and molecular dynamics simulations

(2010) Cheng-Chang Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Secondary structure, dynamics, and architecture of the p7 membrane protein from hepatitis C virus by NMR spectroscopy

(2010) Gabriel A. Cook et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Membrane Potential Depolarization as a Triggering Mechanism for Vpu-Mediated HIV-1 Release

(2010) Kate Hsu et al.   BIOPHYSICAL JOURNAL

Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability

(2010) Stephen D. Carter et al.   FEBS LETTERS

NMR Structure and Ion Channel Activity of the p7 Protein from Hepatitis C Virus

(2010) Roland Montserret et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The subcellular localization of the hepatitis C virus non-structural protein NS2 is regulated by an ion channel-independent function of the p7 protein

(2010) P. Tedbury et al.   JOURNAL OF GENERAL VIROLOGY

Proton Transport through the Influenza A M2 Channel: Three-Dimensional Reference Interaction Site Model Study

(2010) Saree Phongphanphanee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kinetic Analysis of the M2 Proton Conduction of the Influenza Virus

(2010) Rafal M. Pielak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Human Papillomavirus Type 16 E5 Oncoprotein Inhibits Epidermal Growth Factor Trafficking Independently of Endosome Acidification

(2010) Frank A. Suprynowicz et al.   JOURNAL OF VIROLOGY

Hepatitis C Virus NS2 Coordinates Virus Particle Assembly through Physical Interactions with the E1-E2 Glycoprotein and NS3-NS4A Enzyme Complexes

(2010) K. A. Stapleford et al.   JOURNAL OF VIROLOGY

Hepatitis C Virus NS2 Protein Serves as a Scaffold for Virus Assembly by Interacting with both Structural and Nonstructural Proteins

(2010) Y. Ma et al.   JOURNAL OF VIROLOGY

Influence of pr-M Cleavage on the Heterogeneity of Extracellular Dengue Virus Particles

(2010) J. Junjhon et al.   JOURNAL OF VIROLOGY

Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers

(2010) Sarah D. Cady et al.   NATURE

Influenza virus activates inflammasomes via its intracellular M2 ion channel

(2010) Takeshi Ichinohe et al.   NATURE IMMUNOLOGY

Coexistence of two adamantane binding sites in the influenza A M2 ion channel

(2010) M. R. Rosenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligomerization state and supramolecular structure of the HIV-1 Vpu protein transmembrane segment in phospholipid bilayers

(2010) Jun-Xia Lu et al.   PROTEIN SCIENCE

Insight into the Mechanism of the Influenza A Proton Channel from a Structure in a Lipid Bilayer

(2010) M. Sharma et al.   SCIENCE

Mechanisms of Proton Conduction and Gating in Influenza M2 Proton Channels from Solid-State NMR

(2010) F. Hu et al.   SCIENCE

Immunization with an attenuated severe acute respiratory syndrome coronavirus deleted in E protein protects against lethal respiratory disease

(2010) Jason Netland et al.   VIROLOGY

The human papillomavirus type 16 E5 oncoprotein synergizes with EGF-receptor signaling to enhance cell cycle progression and the down-regulation of p27Kip1

(2010) Adolfo Pedroza-Saavedra et al.   VIROLOGY

Rotavirus Disrupts Calcium Homeostasis by NSP4 Viroporin Activity

(2010) J. M. Hyser et al.   mBio

Intracellular Proton Conductance of the Hepatitis C Virus p7 Protein and Its Contribution to Infectious Virus Production

(2010) Ann L. Wozniak et al.   PLoS Pathogens

Structural and Functional Studies of Nonstructural Protein 2 of the Hepatitis C Virus Reveal Its Key Role as Organizer of Virion Assembly

(2010) Vlastimil Jirasko et al.   PLoS Pathogens

The Human Polyoma JC Virus Agnoprotein Acts as a Viroporin

(2010) Tadaki Suzuki et al.   PLoS Pathogens

Antiviral Efficacy of the Novel Compound BIT225 against HIV-1 Release from Human Macrophages

(2009) G. Khoury et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Determination of Pore-Lining Residues in the Hepatitis C Virus p7 Protein

(2009) Chee Foong Chew et al.   BIOPHYSICAL JOURNAL

NMR studies of p7 protein from hepatitis C virus

(2009) Gabriel A. Cook et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

The ion channel activity of the SARS-coronavirus 3a protein is linked to its pro-apoptotic function

(2009) Chak-Ming Chan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Discovery of Spiro-Piperidine Inhibitors and Their Modulation of the Dynamics of the M2 Proton Channel from Influenza A Virus

(2009) Jun Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Energetic analysis of the two controversial drug binding sites of the M2 proton channel in influenza A virus

(2009) Qi-Shi Du et al.   JOURNAL OF THEORETICAL BIOLOGY

Reverse genetic analysis of a putative, influenza virus M2 HXXXW-like motif in the p7 protein of hepatitis C virus

(2009) Z. Meshkat et al.   JOURNAL OF VIRAL HEPATITIS

The Open Reading Frame 3a Protein of Severe Acute Respiratory Syndrome-Associated Coronavirus Promotes Membrane Rearrangement and Cell Death

(2009) E. C. Freundt et al.   JOURNAL OF VIROLOGY

Membrane Orientation of the Human Papillomavirus Type 16 E5 Oncoprotein

(2009) E. Krawczyk et al.   JOURNAL OF VIROLOGY

Characterization of Determinants Important for Hepatitis C Virus p7 Function in Morphogenesis by Using trans-Complementation

(2009) C. Brohm et al.   JOURNAL OF VIROLOGY

Determinants of Hepatitis C Virus p7 Ion Channel Function and Drug Sensitivity Identified In Vitro

(2009) C. StGelais et al.   JOURNAL OF VIROLOGY

Model generation of viral channel forming 2B protein bundles from polio and coxsackie viruses

(2009) George Patargias et al.   MOLECULAR MEMBRANE BIOLOGY

The SARS Coronavirus 3a Protein Causes Endoplasmic Reticulum Stress and Induces Ligand-Independent Downregulation of the Type 1 Interferon Receptor

(2009) Rinki Minakshi et al.   PLoS One

Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus

(2009) E. Khurana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An amantadine-sensitive chimeric BM2 ion channel of influenza B virus has implications for the mechanism of drug inhibition

(2009) Y. Ohigashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel

(2009) C. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of drug inhibition and drug resistance of influenza A M2 channel

(2009) R. M. Pielak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy

(2009) P. Luik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional and Structural Characterization of 2B Viroporin Membranolytic Domains†

(2008) Silvia Sánchez-Martínez et al.   BIOCHEMISTRY

Poliovirus 2b insertion into lipid monolayers and pore formation in vesicles modulated by anionic phospholipids

(2008) Aitziber Agirre et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel

(2008) Stephen Griffin et al.   HEPATOLOGY

Structural and Functional Characterization of Nonstructural Protein 2 for Its Role in Hepatitis C Virus Assembly

(2008) Vlastimil Jirasko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the Membrane-active Regions of Hepatitis C Virus p7 Protein

(2008) Ana J. Pérez-Berná et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Severe acute respiratory syndrome coronavirus 3a protein activates the mitochondrial death pathway through p38 MAP kinase activation

(2008) K. Padhan et al.   JOURNAL OF GENERAL VIROLOGY

Structure of Amantadine-Bound M2 Transmembrane Peptide of Influenza A in Lipid Bilayers from Magic-Angle-Spinning Solid-State NMR: The Role of Ser31 in Amantadine Binding

(2008) Sarah D. Cady et al.   JOURNAL OF MOLECULAR BIOLOGY

Recombinant VP4 of Human Rhinovirus Induces Permeability in Model Membranes

(2008) M. P. Davis et al.   JOURNAL OF VIROLOGY

The Influenza Virus M2 Protein Cytoplasmic Tail Interacts with the M1 Protein and Influences Virus Assembly at the Site of Virus Budding

(2008) B. J. Chen et al.   JOURNAL OF VIROLOGY

Differential Modulation of prM Cleavage, Extracellular Particle Distribution, and Virus Infectivity by Conserved Residues at Nonfurin Consensus Positions of the Dengue Virus pr-M Junction

(2008) J. Junjhon et al.   JOURNAL OF VIROLOGY

Structure and mechanism of the M2 proton channel of influenza A virus

(2008) Jason R. Schnell et al.   NATURE

Structural basis for the function and inhibition of an influenza virus proton channel

(2008) Amanda L. Stouffer et al.   NATURE

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

(2008) Stuart J. D. Neil et al.   NATURE

Structure and ion channel activity of the human respiratory syncytial virus (hRSV) small hydrophobic protein transmembrane domain

(2008) Siok Wan Gan et al.   PROTEIN SCIENCE

Structure of the Immature Dengue Virus at Low pH Primes Proteolytic Maturation

(2008) I-M. Yu et al.   SCIENCE

Phosphorylation of human polyomavirus BK agnoprotein at Ser-11 is mediated by PKC and has an important regulative function

(2008) Mona Johannessen et al.   VIROLOGY

Structure of the transmembrane region of the M2 protein H+ channel

(2002) Junfeng Wang et al.   PROTEIN SCIENCE