Mitochondrial Metabolic Signatures in Hepatocellular Carcinoma

Differential roles of GDF15 and FGF21 in systemic metabolic adaptation to the mitochondrial integrated stress response

(2021) Seul Gi Kang et al.   iScience

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

An adipocyte-specific defect in oxidative phosphorylation increases systemic energy expenditure and protects against diet-induced obesity in mouse models

(2020) Min Jeong Choi et al.   DIABETOLOGIA

PGC1α suppresses metastasis of HCC by inhibiting Warburg effect via PPARγ‐dependent WNT/β‐catenin/PDK1 axis

(2020) Qiaozhu Zuo et al.   HEPATOLOGY

CRIF1 overexpression facilitates tumor growth and metastasis through inducing ROS/NFκB pathway in hepatocellular carcinoma

(2020) Hulin Chang et al.   Cell Death & Disease

Growth differentiation factor 15 protects against the aging‐mediated systemic inflammatory response in humans and mice

(2020) Ji Sun Moon et al.   AGING CELL

Analysis of Key Genes Regulating the Warburg Effect in Patients with Gastrointestinal Cancers and Selective Inhibition of This Metabolic Pathway in Liver Cancer Cells

(2020) Xinyue Zhang et al.   OncoTargets and Therapy

Mitochondrial uncoupling and the disruption of the metabolic network in hepatocellular carcinoma

(2020) Lilia Turcios et al.   Oncotarget

Mitoribosome Defect in Hepatocellular Carcinoma Promotes an Aggressive Phenotype with Suppressed Immune Reaction

(2020) So Mee Kwon et al.   iScience

Mitochondrial Respiratory Defect Enhances Hepatoma Cell Invasiveness via STAT3/NFE2L1/STX12 Axis

(2020) Young-Kyoung Lee et al.   Cancers

A Novel Biomarker Driving Poor-Prognosis Liver Cancer: Overexpression of the Mitochondrial Calcium Gatekeepers

(2020) Chia-Jung Li et al.   Biomedicines

Mitochondrial stress and GDF15 in the pathophysiology of sepsis

(2020) Yasunori Fujita et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Hepatic stellate cells in hepatocellular carcinoma promote tumor growth via growth differentiation factor 15 production

(2020) Yuta Myojin et al.   GASTROENTEROLOGY

MCUR1 facilitates epithelial-mesenchymal transition and metastasis via the mitochondrial calcium dependent ROS/Nrf2/Notch pathway in hepatocellular carcinoma

(2019) Mingpeng Jin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

SIRT 1/ MRPS 5 axis enhances the metabolic flexibility of liver cancer stem cells

(2019) Zhihao Wei et al.   HEPATOLOGY

Mitohormesis Primes Tumor Invasion and Metastasis

(2019) Timothy C. Kenny et al.   Cell Reports

Inhibition of hepatocellular carcinoma by metabolic normalization

(2019) Huabo Wang et al.   PLoS One

Mitochondrial fusion is required for regulation of mitochondrial DNA replication

(2019) Eduardo Silva Ramos et al.   PLoS Genetics

MSTO1 mutations cause mtDNA depletion, manifesting as muscular dystrophy with cerebellar involvement

(2019) S. Donkervoort et al.   ACTA NEUROPATHOLOGICA

MiR-885-5p Negatively Regulates Warburg Effect by Silencing Hexokinase 2 in Liver Cancer

(2019) Fei Xu et al.   Molecular Therapy-Nucleic Acids

Hypoxia regulates the mitochondrial activity of hepatocellular carcinoma cells through HIF/HEY1/PINK1 pathway

(2019) David Kung-Chun Chiu et al.   Cell Death & Disease

MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation

(2018) Tingting Ren et al.   ANTIOXIDANTS & REDOX SIGNALING

CTGF mediates tumor-stroma interactions between hepatoma cells and hepatic stellate cells to accelerate HCC progression.

(2018) Yuki Makino et al.   CANCER RESEARCH

Treatment-damaged hepatocellular carcinoma promotes activities of hepatic stellate cells and fibrosis through GDF15

(2018) Gang Dong et al.   EXPERIMENTAL CELL RESEARCH

The mitochondrial unfolded protein response and mitohormesis: a perspective on metabolic diseases

(2018) Hyon-Seung Yi et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

MiR-3662 suppresses hepatocellular carcinoma growth through inhibition of HIF-1α-mediated Warburg effect

(2018) Zhiqiang Chen et al.   Cell Death & Disease

Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin

(2018) Dannielle DeWaal et al.   Nature Communications

Metabolite profiling identifies a signature of tumorigenicity in hepatocellular carcinoma

(2018) Shamir Cassim et al.   Oncotarget

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly

(2018) Elizabeth C Hinchy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-517a promotes Warburg effect in HCC by directly targeting FBP1

(2018) Delin Zhang et al.   OncoTargets and Therapy

Lactate-mediated mitoribosomal defects impair mitochondrial oxidative phosphorylation and promote hepatoma cell invasiveness

(2017) Young-Kyoung Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ANGPTL6 expression is coupled with mitochondrial OXPHOS function to regulate adipose FGF21

(2017) Seul Gi Kang et al.   JOURNAL OF ENDOCRINOLOGY

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

(2017) Paul J Emmerson et al.   NATURE MEDICINE

Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPRmt to promote metastasis

(2017) T C Kenny et al.   ONCOGENE

High MRPS23 expression contributes to hepatocellular carcinoma proliferation and indicates poor survival outcomes

(2017) Meng Pu et al.   TUMOR BIOLOGY

Growth differentiation factor 15 induces growth and metastasis of human liver cancer stem-like cells via AKT/GSK-3β/β-catenin signaling

(2017) Qiong Xu et al.   Oncotarget

Inhibition of HSF1 suppresses the growth of hepatocarcinoma cell lines in vitro and AKT-driven hepatocarcinogenesis in mice

(2017) Antonio Cigliano et al.   Oncotarget

AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species

(2017) Rebecca C. Rabinovitch et al.   Cell Reports

The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma

(2017) Eun-Ran Park et al.   Cancer Medicine

The Mitochondrial Unfolded Protein Response as a Non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond

(2017) Timothy C. Kenny et al.   Frontiers in Oncology

GDF15 deficiency exacerbates chronic alcohol- and carbon tetrachloride-induced liver injury

(2017) Hyo Kyun Chung et al.   Scientific Reports

Loss of FBP1 facilitates aggressive features of hepatocellular carcinoma cells through the Warburg effect

(2016) Juan Yang et al.   CARCINOGENESIS

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

(2016) Christopher J. Fiorese et al.   CURRENT BIOLOGY

c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src

(2016) Sanda Win et al.   HEPATOLOGY

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

(2016) Hyo Kyun Chung et al.   JOURNAL OF CELL BIOLOGY

Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response

(2016) Yi-Fan Lin et al.   NATURE

microRNA-129-5p, a c-Myc negative target, affects hepatocellular carcinoma progression by blocking the Warburg effect

(2016) Han Han et al.   Journal of Molecular Cell Biology

NUPR1, a new target in liver cancer: implication in controlling cell growth, migration, invasion and sorafenib resistance

(2016) M R Emma et al.   Cell Death & Disease

SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1α-mediated mitochondrial biogenesis

(2016) Yuming Li et al.   Oncotarget

Nrf2 is a potential prognostic marker and promotes proliferation and invasion in human hepatocellular carcinoma

(2015) Mingxin Zhang et al.   BMC CANCER

Identification of a mitochondrial defect gene signature revealsNUPR1as a key regulator of liver cancer progression

(2015) Young-Kyoung Lee et al.   HEPATOLOGY

MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer

(2015) Weijie Guo et al.   HEPATOLOGY

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Glycolytic inhibitors 2-deoxyglucose and 3-bromopyruvate synergize with photodynamic therapy respectively to inhibit cell migration

(2015) Xiaolan Feng et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Mitochondrial Respiratory Dysfunction Induces Claudin-1 Expression via Reactive Oxygen Species-mediated Heat Shock Factor 1 Activation, Leading to Hepatoma Cell Invasiveness

(2015) Jong-Hyuk Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity

(2015) Sanda Win et al.   JOURNAL OF HEPATOLOGY

Minireview: Roles of Fibroblast Growth Factors 19 and 21 in Metabolic Regulation and Chronic Diseases

(2015) Fangfang Zhang et al.   MOLECULAR ENDOCRINOLOGY

Energy metabolism determines the sensitivity of human hepatocellular carcinoma cells to mitochondrial inhibitors and biguanide drugs

(2015) CHIA-CHI HSU et al.   ONCOLOGY REPORTS

Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid

(2015) Christian Kukat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation

(2015) Valeria Iansante et al.   Nature Communications

By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice

(2015) Weiqi Dai et al.   Oncotarget

Down-regulation of oxidative phosphorylation in the liver by expression of the ATPase inhibitory factor 1 induces a tumor-promoter metabolic state

(2015) Fulvio Santacatterina et al.   Oncotarget

Dichloroacetate Enhances Adriamycin-Induced Hepatoma Cell Toxicity In Vitro and In Vivo by Increasing Reactive Oxygen Species Levels

(2014) Yunhai Dai et al.   PLoS One

Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21

(2014) M. Cornu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial dysfunction represses HIF-1α protein synthesis through AMPK activation in human hepatoma HepG2 cells

(2013) Chia-Chi Hsu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress

(2013) Chaofeng Yang et al.   BMC GASTROENTEROLOGY

PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells

(2013) L. Sun et al.   JOURNAL OF CELL SCIENCE

CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis

(2013) Brian F. Teske et al.   MOLECULAR BIOLOGY OF THE CELL

Activating oxidative phosphorylation by a pyruvate dehydrogenase kinase inhibitor overcomes sorafenib resistance of hepatocellular carcinoma

(2012) Y-C Shen et al.   BRITISH JOURNAL OF CANCER

CRIF1 Is Essential for the Synthesis and Insertion of Oxidative Phosphorylation Polypeptides in the Mammalian Mitochondrial Membrane

(2012) Soung Jung Kim et al.   Cell Metabolism

Nrf2-induced antiapoptotic Bcl-xL protein enhances cell survival and drug resistance

(2012) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating Glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

(2012) Bo Wang et al.   HEPATOLOGY

Activation of the Farnesoid X Receptor Induces Hepatic Expression and Secretion of Fibroblast Growth Factor 21

(2012) Holly A. Cyphert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat shock factor 1 promotes invasion and metastasis of hepatocellular carcinoma in vitro and in vivo

(2011) Feng Fang et al.   CANCER

The TGF-β superfamily cytokine, MIC-1/GDF15: A pleotrophic cytokine with roles in inflammation, cancer and metabolism

(2011) Samuel N. Breit et al.   GROWTH FACTORS

Liver X receptor negatively regulates fibroblast growth factor 21 in the fatty liver induced by cholesterol-enriched diet

(2011) Takashi Uebanso et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Growth Differentiation Factor 15 Is Induced by Hepatitis C Virus Infection and Regulates Hepatocellular Carcinoma-Related Genes

(2011) Youhui Si et al.   PLoS One

Paradoxical Regulation of Human FGF21 by Both Fasting and Feeding Signals: Is FGF21 a Nutritional Adaptation Factor?

(2011) Takashi Uebanso et al.   PLoS One

Mitochondrial Energetics and Therapeutics

(2010) Douglas C. Wallace et al.   Annual Review of Pathology-Mechanisms of Disease

GDF-15 Contributes to Proliferation and Immune Escape of Malignant Gliomas

(2010) P. Roth et al.   CLINICAL CANCER RESEARCH

Plasma metabolomic profile in nonalcoholic fatty liver disease

(2010) Satish C. Kalhan et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Dynamic regulation of PGC-1α localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response

(2009) Rozalyn M. Anderson et al.   AGING CELL

Mitochondrial DNA Instability and Metabolic Shift in Human Cancers

(2009) Hsin-Chen Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Somatic mutations of mitochondrial genome in hepatocellular carcinoma

(2009) Pen-Hui Yin et al.   MITOCHONDRION

Caspase-independent Mitochondrial Cell Death Results from Loss of Respiration, Not Cytotoxic Protein Release

(2009) Lydia Lartigue et al.   MOLECULAR BIOLOGY OF THE CELL

PGC-1α negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erbα axis

(2009) Jennifer L. Estall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man

(2008) Cecilia Gälman et al.   Cell Metabolism

Effect of in vivo loss of GDF-15 on hepatocellular carcinogenesis

(2008) Teresa A. Zimmers et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Aluminum-induced defective mitochondrial metabolism perturbs cytoskeletal dynamics in human astrocytoma cells

(2008) J. Lemire et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS

The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth

(2008) Ron Firestein et al.   PLoS One