Genome Editing Human Pluripotent Stem Cells to Model β-Cell Disease and Unmask Novel Genetic Modifiers

SUR1-mutant iPS cell-derived islets recapitulate the pathophysiology of congenital hyperinsulinism

(2021) Väinö Lithovius et al.   DIABETOLOGIA

The promise of stem cell-derived islet replacement therapy

(2021) Douglas Melton   DIABETOLOGIA

Current and future therapies for type 1 diabetes

(2021) Bernt Johan von Scholten et al.   DIABETOLOGIA

Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells

(2020) Nathaniel J. Hogrebe et al.   NATURE BIOTECHNOLOGY

Insights into pancreatic islet cell dysfunction from type 2 diabetes mellitus genetics

(2020) Nicole A. J. Krentz et al.   Nature Reviews Endocrinology

Trends in Incidence of Type 1 and Type 2 Diabetes Among Youths — Selected Counties and Indian Reservations, United States, 2002–2015

(2020) Jasmin Divers et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

A Non-Coding Disease Modifier of Pancreatic Agenesis Identified by Genetic Correction in a Patient-Derived iPSC Line

(2020) Siddharth Kishore et al.   Cell Stem Cell

COVID-19 in People With Diabetes: Urgently Needed Lessons From Early Reports

(2020) Matthew C. Riddle et al.   DIABETES CARE

Generation of pancreatic β cells from CD177+ anterior definitive endoderm

(2020) Pallavi U. Mahaddalkar et al.   NATURE BIOTECHNOLOGY

Gene-edited human stem cell–derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice

(2020) Kristina G. Maxwell et al.   Science Translational Medicine

Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis

(2020) Jeffrey C. Davis et al.   Cell Reports

Risk factors for COVID-19-related mortality in people with type 1 and type 2 diabetes in England: a population-based cohort study

(2020) Naomi Holman et al.   Lancet Diabetes & Endocrinology

Associations of type 1 and type 2 diabetes with COVID-19-related mortality in England: a whole-population study

(2020) Emma Barron et al.   Lancet Diabetes & Endocrinology

Advances Toward Engineering Functionally Mature Human Pluripotent Stem Cell-Derived β Cells

(2020) Leonardo Velazco-Cruz et al.   Frontiers in Bioengineering and Biotechnology

Epigenetic modification and therapeutic targets of diabetes mellitus

(2020) Rajveer Singh et al.   BIOSCIENCE REPORTS

Overview of Atypical Diabetes

(2020) Jaclyn Tamaroff et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Generation of iPSC-derived insulin-producing cells from patients with type 1 and type 2 diabetes compared with healthy control

(2020) Min Jung Kim et al.   Stem Cell Research

Single-Cell Transcriptome Profiling Reveals β Cell Maturation in Stem Cell-Derived Islets after Transplantation

(2020) Punn Augsornworawat et al.   Cell Reports

Single-Cell RNA-Seq Reveals that CD9 Is a Negative Marker of Glucose-Responsive Pancreatic β-like Cells Derived from Human Pluripotent Stem Cells

(2020) Xisheng Li et al.   Stem Cell Reports

Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?)

(2020) Bart O. Roep et al.   Nature Reviews Endocrinology

Point mutations in the PDX1 transactivation domain impair human β-cell development and function

(2019) Xianming Wang et al.   Molecular Metabolism

Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells

(2019) Gopika G. Nair et al.   NATURE CELL BIOLOGY

Nutrigenetics, epigenetics and gestational diabetes: consequences in mother and child

(2019) Marica Franzago et al.   Epigenetics

Charting cellular identity during human in vitro β-cell differentiation

(2019) Adrian Veres et al.   NATURE

Expression of mutant mRNA and protein in pancreatic cells derived from MODY3- iPS cells

(2019) Shigeharu G. Yabe et al.   PLoS One

Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A

(2019) Fabian L. Cardenas-Diaz et al.   Cell Stem Cell

The supply chain of human pancreatic β cell lines

(2019) Raphael Scharfmann et al.   JOURNAL OF CLINICAL INVESTIGATION

The Genetic Contribution to Type 1 Diabetes

(2019) Marina Bakay et al.   Current Diabetes Reports

Mimicking nature-made beta cells

(2019) Daniel M. Tremmel et al.   Current Opinion in Organ Transplantation

Review: Diabetes, Obesity and Cancer - Pathophysiology and Clinical Implications

(2019) Iliana C Lega et al.   ENDOCRINE REVIEWS

Circadian Entrainment Triggers Maturation of Human In Vitro Islets

(2019) Juan R. Alvarez-Dominguez et al.   Cell Stem Cell

Genetics of Type 1 Diabetes Comes of Age

(2019) Maria J. Redondo et al.   DIABETES CARE

Projected U.S. State-Level Prevalence of Adult Obesity and Severe Obesity

(2019) Zachary J. Ward et al.   NEW ENGLAND JOURNAL OF MEDICINE

Epigenetic Modifications Linked to T2D, the Heritability Gap, and Potential Therapeutic Targets

(2018) Monica Szabó et al.   BIOCHEMICAL GENETICS

Lnc-ing non-coding RNAs with metabolism and diabetes: roles of lncRNAs

(2018) Neha Goyal et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Neonatal Diabetes Mellitus

(2018) Michelle Blanco Lemelman et al.   CLINICS IN PERINATOLOGY

Comparison of the editing patterns and editing efficiencies of TALEN and CRISPR-Cas9 when targeting the human CCR5 gene

(2018) Arildo Nerys-Junior et al.   GENETICS AND MOLECULAR BIOLOGY

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

(2018) Anubha Mahajan et al.   NATURE GENETICS

Animal models of obesity and diabetes mellitus

(2018) Maximilian Kleinert et al.   Nature Reviews Endocrinology

Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 3 (MODY3) carrying a hepatocyte nuclear factor 1-alpha ( HNF1A ) mutation

(2018) Frank Griscelli et al.   Stem Cell Research

Derivation and molecular characterization of pancreatic differentiated MODY1-iPSCs

(2018) Carmel Braverman-Gross et al.   Stem Cell Research

The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates

(2018) Violeta Georgieva Tsonkova et al.   Molecular Metabolism

Human islets expressing HNF1A variant have defective β cell transcriptional regulatory networks

(2018) Rachana Haliyur et al.   JOURNAL OF CLINICAL INVESTIGATION

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

(2018) Anubha Mahajan et al.   NATURE GENETICS

Concise Review: Human Pluripotent Stem Cells for the Modeling of Pancreatic β-Cell Pathology

(2018) Diego Balboa et al.   STEM CELLS

An atlas of human long non-coding RNAs with accurate 5′ ends

(2017) Chung-Chau Hon et al.   NATURE

Incidence Trends of Type 1 and Type 2 Diabetes among Youths, 2002–2012

(2017) Elizabeth J. Mayer-Davis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetics of type 1 diabetes

(2017) Maria J Redondo et al.   PEDIATRIC DIABETES

Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 13 (MODY13) with a the potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) mutation

(2017) Frank Griscelli et al.   Stem Cell Research

Regulatory elements in molecular networks

(2017) Ashley S. Doane et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

LncRNAs: key players and novel insights into diabetes mellitus

(2017) Xiaoyun He et al.   Oncotarget

Using hESCs to Probe the Interaction of the Diabetes-Associated Genes CDKAL1 and MT1E

(2017) Min Guo et al.   Cell Reports

CRISPR/Cas9 Genome-Editing System in Human Stem Cells: Current Status and Future Prospects

(2017) Zhao Zhang et al.   Molecular Therapy-Nucleic Acids

Type 1 diabetes mellitus

(2017) Anastasia Katsarou et al.   Nature Reviews Disease Primers

Mouse Models of Human GWAS Hits for Obesity and Diabetes in the Post Genomic Era: Time for Reevaluation

(2017) Samantha Laber et al.   Frontiers in Endocrinology

Long Noncoding RNAs in Diabetes and Diabetic Complications

(2017) Amy Leung et al.   ANTIOXIDANTS & REDOX SIGNALING

Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells

(2017) Heidrun Vethe et al.   Scientific Reports

Co-culture of clonal beta cells with GLP-1 and glucagon-secreting cell line impacts on beta cell insulin secretion, proliferation and susceptibility to cytotoxins

(2016) Alastair D. Green et al.   BIOCHIMIE

Stem Cells: A Renaissance in Human Biology Research

(2016) Jun Wu et al.   CELL

Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes

(2016) Zengrong Zhu et al.   Cell Stem Cell

Induced Pluripotent Stem Cells Meet Genome Editing

(2016) Dirk Hockemeyer et al.   Cell Stem Cell

Functional Investigations of HNF1A Identify Rare Variants as Risk Factors for Type 2 Diabetes in the General Population

(2016) Laeya Abdoli Najmi et al.   DIABETES

The quest to make fully functional human pancreatic beta cells from embryonic stem cells: climbing a mountain in the clouds

(2016) James D. Johnson   DIABETOLOGIA

Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes

(2016) Yisheng Yang et al.   ENDOCRINE REVIEWS

A novel long non-coding RNA CYP4B1-PS1-001 regulates proliferation and fibrosis in diabetic nephropathy

(2016) Min Wang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The genetic architecture of type 2 diabetes

(2016) Christian Fuchsberger et al.   NATURE

A decade of transcription factor-mediated reprogramming to pluripotency

(2016) Kazutoshi Takahashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Generation of human control iPS cell line CHOPWT10 from healthy adult peripheral blood mononuclear cells

(2016) Jean Ann Maguire et al.   Stem Cell Research

Generation of a human induced pluripotent stem cell (iPSC) line from a patient carrying a P33T mutation in the PDX1 gene

(2016) Xianming Wang et al.   Stem Cell Research

Generation of stem cell-derived β-cells from patients with type 1 diabetes

(2016) Jeffrey R. Millman et al.   Nature Communications

Erratum: Erratum: A suppressor locus for MODY3-diabetes

(2016) Miguel A. Garcia-Gonzalez et al.   Scientific Reports

Modeling Cystic Fibrosis Using Pluripotent Stem Cell-Derived Human Pancreatic Ductal Epithelial Cells

(2016) Senem Simsek et al.   Stem Cells Translational Medicine

Experimental Diabetes Mellitus in Different Animal Models

(2016) Amin Al-awar et al.   Journal of Diabetes Research

Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia

(2016) Adrian Kee Keong Teo et al.   Stem Cell Reports

Pancreatic beta cell lines and their applications in diabetes mellitus research

(2016) Masa Skelin   ALTEX-Alternatives to Animal Experimentation

Islet formation in mice and men: lessons for the generation of functional insulin-producing β-cells from human pluripotent stem cells

(2015) Gopika Nair et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Non-coding genetic variants in human disease: Figure 1.

(2015) Feng Zhang et al.   HUMAN MOLECULAR GENETICS

Long Non-Coding RNA Central of Glucose Homeostasis

(2015) Xiangbo Ruan   JOURNAL OF CELLULAR BIOCHEMISTRY

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Therapeutic genome editing: prospects and challenges

(2015) David Benjamin Turitz Cox et al.   NATURE MEDICINE

Establishment of maturity-onset diabetes of the young-induced pluripotent stem cells from a Japanese patient

(2015) Shigeharu G Yabe et al.   Journal of Diabetes Investigation

Induced pluripotent stem cells as a model for diabetes investigation

(2015) J. Stepniewski et al.   Scientific Reports

Genetic Modifiers and Oligogenic Inheritance

(2015) M. Kousi et al.   Cold Spring Harbor Perspectives in Medicine

Type 2 diabetes mellitus

(2015) Ralph A. DeFronzo et al.   Nature Reviews Disease Primers

Bhlhe40, a potential diabetic modifier gene on Dbm1 locus, negatively controls myocyte fatty acid oxidation

(2015) Shigeru Takeshita et al.   GENES & GENETIC SYSTEMS

Novel GATA6 Mutations in Patients with Pancreatic Agenesis and Congenital Heart Malformations

(2015) Christina S. Chao et al.   PLoS One

Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases

(2014) Alexander Gusev et al.   AMERICAN JOURNAL OF HUMAN GENETICS

TALEN-mediated genome editing: prospects and perspectives

(2014) David A. Wright et al.   BIOCHEMICAL JOURNAL

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Epigenetic Regulation of the DLK1-MEG3 MicroRNA Cluster in Human Type 2 Diabetic Islets

(2014) Vasumathi Kameswaran et al.   Cell Metabolism

Low Incidence of Off-Target Mutations in Individual CRISPR-Cas9 and TALEN Targeted Human Stem Cell Clones Detected by Whole-Genome Sequencing

(2014) Adrian Veres et al.   Cell Stem Cell

An iCRISPR Platform for Rapid, Multiplexable, and Inducible Genome Editing in Human Pluripotent Stem Cells

(2014) Federico González et al.   Cell Stem Cell

GATA4 Mutations Are a Cause of Neonatal and Childhood-Onset Diabetes

(2014) C. Shaw-Smith et al.   DIABETES

Self-Management in Early Adolescence and Differences by Age at Diagnosis and Duration of Type 1 Diabetes

(2014) Ariana Chao et al.   DIABETES EDUCATOR

Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond

(2014) Niels Grarup et al.   DIABETOLOGIA

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

(2014) Lorenzo Pasquali et al.   NATURE GENETICS

A novel mutation inGATA6causes pancreatic agenesis

(2014) Diana E. Stanescu et al.   PEDIATRIC DIABETES

TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content

(2014) H. Mahdessian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

Mapping of Immune-Mediated Disease Genes

(2013) Isis Ricaño-Ponce et al.   Annual Review of Genomics and Human Genetics

Enhanced Efficiency of Human Pluripotent Stem Cell Genome Editing through Replacing TALENs with CRISPRs

(2013) Qiurong Ding et al.   Cell Stem Cell

 -Cell Dysfunction Due to Increased ER Stress in a Stem Cell Model of Wolfram Syndrome

(2013) L. Shang et al.   DIABETES

A novel GATA6 mutation leading to congenital heart defects and permanent neonatal diabetes: A case report

(2013) G. Catli et al.   DIABETES & METABOLISM

Gene-Environment and Gene-Treatment Interactions in Type 2 Diabetes: Progress, pitfalls, and prospects

(2013) P. W. Franks et al.   DIABETES CARE

Improved genetic testing for monogenic diabetes using targeted next-generation sequencing

(2013) S. Ellard et al.   DIABETOLOGIA

Two Novel GATA6 Mutations Cause Childhood-Onset Diabetes Mellitus, Pancreas Malformation and Congenital Heart Disease

(2013) Maolian Gong et al.   Hormone Research in Paediatrics

Mutations in the Genes Encoding the Transcription Factors Hepatocyte Nuclear Factor 1 Alpha and 4 Alpha in Maturity-Onset Diabetes of the Young and Hyperinsulinemic Hypoglycemia

(2013) Kevin Colclough et al.   HUMAN MUTATION

Derivation of Human Induced Pluripotent Stem Cells from Patients with Maturity Onset Diabetes of the Young

(2013) Adrian K. K. Teo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhancer mutations and phenotype modularity

(2013) Christopher T Gordon et al.   NATURE GENETICS

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Bisphenol A Accelerates Toxic Amyloid Formation of Human Islet Amyloid Polypeptide: A Possible Link between Bisphenol A Exposure and Type 2 Diabetes

(2013) Hao Gong et al.   PLoS One

Environmental Triggers of Type 1 Diabetes

(2013) M. Knip et al.   Cold Spring Harbor Perspectives in Medicine

The lessons of early-onset monogenic diabetes for the understanding of diabetes pathogenesis

(2012) Martine Vaxillaire et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes

(2012) Ignasi Morán et al.   Cell Metabolism

A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models

(2012) Qiurong Ding et al.   Cell Stem Cell

GATA6 inactivating mutations are associated with heart defects and, inconsistently, with pancreatic agenesis and diabetes

(2012) A. Bonnefond et al.   DIABETOLOGIA

Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis

(2012) Shouhong Xuan et al.   JOURNAL OF CLINICAL INVESTIGATION

GATA4 and GATA6 control mouse pancreas organogenesis

(2012) Manuel Carrasco et al.   JOURNAL OF CLINICAL INVESTIGATION

The long-range interaction landscape of gene promoters

(2012) Amartya Sanyal et al.   NATURE

Landscape of transcription in human cells

(2012) Sarah Djebali et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

The accessible chromatin landscape of the human genome

(2012) Robert E. Thurman et al.   NATURE

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

(2012) Amélie Bonnefond et al.   NATURE GENETICS

TALENs: a widely applicable technology for targeted genome editing

(2012) J. Keith Joung et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Past 200 Years in Diabetes

(2012) Kenneth S. Polonsky   NEW ENGLAND JOURNAL OF MEDICINE

Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers

(2012) Sebastian Bultmann et al.   NUCLEIC ACIDS RESEARCH

Exome Sequencing and Genetic Testing for MODY

(2012) Stefan Johansson et al.   PLoS One

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

Transgene-Free Disease-Specific Induced Pluripotent Stem Cells from Patients with Type 1 and Type 2 Diabetes

(2012) Yogish C. Kudva et al.   Stem Cells Translational Medicine

Transcriptional enhancers in development and disease

(2012) Noboru Sakabe et al.   GENOME BIOLOGY

MODY

(2011) Stefan S. Fajans et al.   DIABETES CARE

Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses

(2011) M. N. Cabili et al.   GENES & DEVELOPMENT

Phenotype harmonization and cross-study collaboration in GWAS consortia: the GENEVA experience

(2011) Siiri N. Bennett et al.   GENETIC EPIDEMIOLOGY

CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III

(2011) Elitza Deltcheva et al.   NATURE

Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription

(2011) Feng Zhang et al.   NATURE BIOTECHNOLOGY

GATA6 haploinsufficiency causes pancreatic agenesis in humans

(2011) Hana Lango Allen et al.   NATURE GENETICS

On target? Tracing zinc-finger-nuclease specificity

(2011) Claudio Mussolino et al.   NATURE METHODS

Review on monogenic diabetes

(2011) Andrea K. Steck et al.   Current Opinion in Endocrinology Diabetes and Obesity

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

XanthomonasAvrBs3 Family-Type III Effectors: Discovery and Function

(2010) Jens Boch et al.   Annual Review of Phytopathology

Genetics of Type 1 Diabetes: What's Next?

(2010) F. Pociot et al.   DIABETES

Genetic investigation in an Italian child with an unusual association of atrial septal defect, attributable to a new familial GATA4 gene mutation, and neonatal diabetes due to pancreatic agenesis

(2010) E. D’Amato et al.   DIABETIC MEDICINE

A TALE nuclease architecture for efficient genome editing

(2010) Jeffrey C Miller et al.   NATURE BIOTECHNOLOGY

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

Genome editing with engineered zinc finger nucleases

(2010) Fyodor D. Urnov et al.   NATURE REVIEWS GENETICS

Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene

(2010) Julie Støy et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease

(2010) John P. Driver et al.   Seminars in Immunopathology

Vertebrate Endoderm Development and Organ Formation

(2009) Aaron M. Zorn et al.   Annual Review of Cell and Developmental Biology

Overview of the Type I Diabetes Genetics Consortium

(2009) S S Rich et al.   GENES AND IMMUNITY

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Generation of pluripotent stem cells from patients with type 1 diabetes

(2009) R. Maehr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discordant Phenotypes in Fraternal Twins Having an Identical Mutation in Exon ORF15 of the RPGR Gene

(2008) Saloni Walia   ARCHIVES OF OPHTHALMOLOGY

Progress and prospects: Zinc-finger nucleases as gene therapy agents

(2008) D Carroll   GENE THERAPY

Identifying modifier genes of monogenic disease: strategies and difficulties

(2008) Emmanuelle Génin et al.   HUMAN GENETICS

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY