The quest to make fully functional human pancreatic beta cells from embryonic stem cells: climbing a mountain in the clouds

Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation

(2016) Marta Szabat et al.   Cell Metabolism

An insulin signaling feedback loop regulates pancreas progenitor cell differentiation during islet development and regeneration

(2016) Lihua Ye et al.   DEVELOPMENTAL BIOLOGY

Nine-Year Effects of 3.7 Years of Intensive Glycemic Control on Cardiovascular Outcomes

(2016)   DIABETES CARE

Research-Focused Isolation of Human Islets From Donors With and Without Diabetes at the Alberta Diabetes Institute IsletCore

(2016) James Lyon et al.   ENDOCRINOLOGY

A microfluidic array for real-time live-cell imaging of human and rodent pancreatic islets

(2016) Mohammad Nourmohammadzadeh et al.   LAB ON A CHIP

Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice

(2016) Arturo J Vegas et al.   NATURE MEDICINE

Glucose Effectiveness

(2016) Erik Korsgren et al.   TRANSPLANTATION

Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement

(2016) Stephen T. Bartlett et al.   TRANSPLANTATION

The Human Endocrine Pancreas: New Insights on Replacement and Regeneration

(2016) Juan Domínguez-Bendala et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Statistical approaches and software for clustering islet cell functional heterogeneity

(2016) Quin F. Wills et al.   Islets

Process Analytical Utility of Raman Microspectroscopy in the Directed Differentiation of Human Pancreatic Insulin-Positive Cells

(2015) Stanislav O. Konorov et al.   ANALYTICAL CHEMISTRY

Differentiation of human pluripotent stem cells into β-cells: Potential and challenges

(2015) Nina Quiskamp et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Pancreatic β-cell identity, glucose sensing and the control of insulin secretion

(2015) Guy A. Rutter et al.   BIOCHEMICAL JOURNAL

A live-cell, high-content imaging survey of 206 endogenous factors across five stress conditions reveals context-dependent survival effects in mouse primary beta cells

(2015) Yu Hsuan Carol Yang et al.   DIABETOLOGIA

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

(2015) H. A. Russ et al.   EMBO JOURNAL

Integrated perfusion and separation systems for entrainment of insulin secretion from islets of Langerhans

(2015) Lian Yi et al.   LAB ON A CHIP

Guiding pancreatic beta cells to target electrodes in a whole-cell biosensor for diabetes

(2015) Eileen Pedraza et al.   LAB ON A CHIP

Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells

(2015) Anthony N. Vomund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replacing and safeguarding pancreatic β cells for diabetes

(2015) Jennifer E. Bruin et al.   Science Translational Medicine

Treating Diet-Induced Diabetes and Obesity with Human Embryonic Stem Cell-Derived Pancreatic Progenitor Cells and Antidiabetic Drugs

(2015) Jennifer E. Bruin et al.   Stem Cell Reports

Accelerated Maturation of Human Stem Cell-Derived Pancreatic Progenitor Cells into Insulin-Secreting Cells in Immunodeficient Rats Relative to Mice

(2015) Jennifer E. Bruin et al.   Stem Cell Reports

High-content screening identifies a role for Na+channels in insulin production

(2015) Marta Szabat et al.   Royal Society Open Science

Composition and function of macroencapsulated human embryonic stem cell-derived implants: comparison with clinical human islet cell grafts

(2014) Evi Motté et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Systematically labeling developmental stage-specific genes for the study of pancreatic β-cell differentiation from human embryonic stem cells

(2014) Haisong Liu et al.   CELL RESEARCH

Stem Cells to Insulin Secreting Cells: Two Steps Forward and Now a Time to Pause?

(2014) Jake A. Kushner et al.   Cell Stem Cell

Development of a conditionally immortalized human pancreatic β cell line

(2014) Raphaël Scharfmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers

(2014) Simona Chera et al.   NATURE

Closing in on pancreatic beta cells

(2014) Neil Hanley   NATURE BIOTECHNOLOGY

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Differentiated human stem cells resemble fetal, not adult, β cells

(2014) Sinisa Hrvatin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endodermal differentiation of human pluripotent stem cells to insulin-producing cells in 3D culture

(2014) Hiroki Takeuchi et al.   Scientific Reports

How to make a functional  -cell

(2013) F. W. Pagliuca et al.   DEVELOPMENT

Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

(2013) Jennifer E. Bruin et al.   DIABETOLOGIA

The role of aging upon β cell turnover

(2013) Jake A. Kushner   JOURNAL OF CLINICAL INVESTIGATION

Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion

(2013) Y. H. C. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells

(2013) Jennifer E. Bruin et al.   Stem Cell Research

Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

(2012) Arya E. Mehran et al.   Cell Metabolism

The Adult Mouse and Human Pancreas Contain Rare Multipotent Stem Cells that Express Insulin

(2011) Simon R. Smukler et al.   Cell Stem Cell

Stage-specific signaling through TGF  family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells

(2011) M. C. Nostro et al.   DEVELOPMENT

The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells

(2011) C. L. Basford et al.   DIABETOLOGIA

Paracrine signalling loops in adult human and mouse pancreatic islets: netrins modulate beta cell apoptosis signalling via dependence receptors

(2011) Y. H. C. Yang et al.   DIABETOLOGIA

Gap junctions and other mechanisms of cell-cell communication regulate basal insulin secretion in the pancreatic islet

(2011) R. K. P. Benninger et al.   JOURNAL OF PHYSIOLOGY-LONDON

Reduced Progression of Diabetic Microvascular Complications With Islet Cell Transplantation Compared With Intensive Medical Therapy

(2011) David M. Thompson et al.   TRANSPLANTATION

Pancreatic cell immobilization in alginate beads produced by emulsion and internal gelation

(2010) Corinne A. Hoesli et al.   BIOTECHNOLOGY AND BIOENGINEERING

Recurrence of Type 1 Diabetes After Simultaneous Pancreas-Kidney Transplantation, Despite Immunosuppression, Is Associated With Autoantibodies and Pathogenic Autoreactive CD4 T-Cells

(2010) F. Vendrame et al.   DIABETES

Residual Insulin Production and Pancreatic  -Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study

(2010) H. A. Keenan et al.   DIABETES

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Different Effects of FK506, Rapamycin, and Mycophenolate Mofetil on Glucose-Stimulated Insulin Release and Apoptosis in Human Islets

(2009) James D. Johnson et al.   CELL TRANSPLANTATION

Insulin Resistance and Hyperinsulinemia: Is hyperinsulinemia the cart or the horse?

(2008) M. H. Shanik et al.   DIABETES CARE

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY