Concise Review: Human Pluripotent Stem Cells for the Modeling of Pancreatic β-Cell Pathology

Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men

(2018) Patrik Rorsman et al.   PHYSIOLOGICAL REVIEWS

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

(2018) Emma Ahlqvist et al.   Lancet Diabetes & Endocrinology

The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates

(2018) Violeta Georgieva Tsonkova et al.   Molecular Metabolism

MECHANISMS IN ENDOCRINOLOGY: Towards the clinical translation of stem cell therapy for type 1 diabetes

(2017) Daniel Espes et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity

(2017) Zarah M. Löf-Öhlin et al.   NATURE CELL BIOLOGY

The molecular and morphogenetic basis of pancreas organogenesis

(2017) Hjalte List Larsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors

(2017) Kathryn F. Cogger et al.   Nature Communications

An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation

(2017) Jonna Saarimäki-Vire et al.   Cell Reports

Efficient Generation of Glucose-Responsive Beta Cells from Isolated GP2 + Human Pancreatic Progenitors

(2017) Jacqueline Ameri et al.   Cell Reports

Using hESCs to Probe the Interaction of the Diabetes-Associated Genes CDKAL1 and MT1E

(2017) Min Guo et al.   Cell Reports

Reconstructing human pancreatic differentiation by mapping specific cell populations during development

(2017) Cyrille Ramond et al.   eLife

Single-Cell Gene Expression Analysis of a Human ESC Model of Pancreatic Endocrine Development Reveals Different Paths to β-Cell Differentiation

(2017) Maja Borup Kjær Petersen et al.   Stem Cell Reports

Laser Capture and Deep Sequencing Reveals the Transcriptomic Programmes Regulating the Onset of Pancreas and Liver Differentiation in Human Embryos

(2017) Rachel E. Jennings et al.   Stem Cell Reports

GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells

(2017) Amita Tiyaboonchai et al.   Stem Cell Reports

Interrogating islets in health and disease with single-cell technologies

(2017) Andrea C. Carrano et al.   Molecular Metabolism

Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis

(2017) Chunguang Chen et al.   Molecular Metabolism

β-Cell Replacement Strategies: The Increasing Need for a “β-Cell Dogma”

(2017) Andhira Vieira et al.   Frontiers in Genetics

Modeling Congenital Hyperinsulinism with ABCC8-Deficient Human Embryonic Stem Cells Generated by CRISPR/Cas9

(2017) Dongsheng Guo et al.   Scientific Reports

Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells

(2017) Heidrun Vethe et al.   Scientific Reports

ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells

(2016) Eiji Yoshihara et al.   Cell Metabolism

Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas

(2016) Yue J. Wang et al.   Cell Metabolism

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

(2016) Åsa Segerstolpe et al.   Cell Metabolism

An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study-Identified Diabetes Genes and Drug Discovery

(2016) Hui Zeng et al.   Cell Stem Cell

Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes

(2016) Zengrong Zhu et al.   Cell Stem Cell

Single-Cell Transcriptomics of the Human Endocrine Pancreas

(2016) Yue J. Wang et al.   DIABETES

Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes

(2016) Yisheng Yang et al.   ENDOCRINE REVIEWS

Impact of islet architecture on β-cell heterogeneity, plasticity and function

(2016) Sara S. Roscioni et al.   Nature Reviews Endocrinology

Generation of stem cell-derived β-cells from patients with type 1 diabetes

(2016) Jeffrey R. Millman et al.   Nature Communications

Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia

(2016) Adrian Kee Keong Teo et al.   Stem Cell Reports

A Single-Cell Transcriptome Atlas of the Human Pancreas

(2016) Mauro J. Muraro et al.   Cell Systems

Knowledge Gaps in Rodent Pancreas Biology: Taking Human Pluripotent Stem Cell-Derived Pancreatic Beta Cells into Our Own Hands

(2016) Munirah Mohamad Santosa et al.   Frontiers in Endocrinology

Human induced pluripotent stem cells: A disruptive innovation

(2016) J. De Vos et al.   Current Research in Translational Medicine

Differentiation of human pluripotent stem cells into β-cells: Potential and challenges

(2015) Nina Quiskamp et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Human pluripotent stem cell based islet models for diabetes research

(2015) Diego Balboa et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Islet formation in mice and men: lessons for the generation of functional insulin-producing β-cells from human pluripotent stem cells

(2015) Gopika Nair et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas

(2015) Patrick S. McGrath et al.   DIABETES

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

(2015) H. A. Russ et al.   EMBO JOURNAL

MAFA and T3Drive Maturation of Both Fetal Human Islets and Insulin-Producing Cells Differentiated From hESC

(2015) Cristina Aguayo-Mazzucato et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Role of ARX in Human Pancreatic Endocrine Specification

(2015) Blair K. Gage et al.   PLoS One

Efficient Generation of NKX6-1+ Pancreatic Progenitors from Multiple Human Pluripotent Stem Cell Lines

(2015) M. Cristina Nostro et al.   Stem Cell Reports

Endothelial Cells Control Pancreatic Cell Fate at Defined Stages through EGFL7 Signaling

(2015) Der-I Kao et al.   Stem Cell Reports

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Neurotransmitter control of islet hormone pulsatility

(2014) E. Gylfe et al.   DIABETES OBESITY & METABOLISM

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Differentiated human stem cells resemble fetal, not adult, β cells

(2014) Sinisa Hrvatin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The window period of NEUROGENIN3 during human gestation

(2014) Rachel J Salisbury et al.   Islets

New Opportunities: Harnessing Induced Pluripotency for Discovery in Diabetes and Metabolism

(2013) Adrian Kee Keong Teo et al.   Cell Metabolism

Dynamic Chromatin Remodeling Mediated by Polycomb Proteins Orchestrates Pancreatic Differentiation of Human Embryonic Stem Cells

(2013) Ruiyu Xie et al.   Cell Stem Cell

 -Cell Dysfunction Due to Increased ER Stress in a Stem Cell Model of Wolfram Syndrome

(2013) L. Shang et al.   DIABETES

Development of the Human Pancreas From Foregut to Endocrine Commitment

(2013) R. E. Jennings et al.   DIABETES

Derivation of Human Induced Pluripotent Stem Cells from Patients with Maturity Onset Diabetes of the Young

(2013) Adrian K. K. Teo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type 1 diabetes

(2013) Mark A Atkinson et al.   LANCET

Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells

(2013) Jennifer E. Bruin et al.   Stem Cell Research

Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo

(2013) Alireza Rezania et al.   STEM CELLS

Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity

(2013) Ashleigh E. Schaffer et al.   PLoS Genetics

Efficient Derivation of Purified Lung and Thyroid Progenitors from Embryonic Stem Cells

(2012) Tyler A. Longmire et al.   Cell Stem Cell

Pancreas organogenesis: From bud to plexus to gland

(2011) Fong Cheng Pan et al.   DEVELOPMENTAL DYNAMICS

The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells

(2011) C. L. Basford et al.   DIABETOLOGIA

Nkx6 Transcription Factors and Ptf1a Function as Antagonistic Lineage Determinants in Multipotent Pancreatic Progenitors

(2010) Ashleigh E. Schaffer et al.   DEVELOPMENTAL CELL

Quantitative analysis of cell composition and purity of human pancreatic islet preparations

(2010) Anna Pisania et al.   LABORATORY INVESTIGATION

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Neonatal Diabetes Mellitus

(2008) Lydia Aguilar-Bryan et al.   ENDOCRINE REVIEWS

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY

Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling

(2008) D. C. Hay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical implications of a molecular genetic classification of monogenic β-cell diabetes

(2008) Rinki Murphy et al.   Nature clinical practice. Endocrinology & metabolism