Genome Editing Human Pluripotent Stem Cells to Model β-Cell Disease and Unmask Novel Genetic Modifiers
出版年份 2021 全文链接
标题
Genome Editing Human Pluripotent Stem Cells to Model β-Cell Disease and Unmask Novel Genetic Modifiers
作者
关键词
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出版物
Frontiers in Endocrinology
Volume 12, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2021-06-02
DOI
10.3389/fendo.2021.682625
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- SUR1-mutant iPS cell-derived islets recapitulate the pathophysiology of congenital hyperinsulinism
- (2021) Väinö Lithovius et al. DIABETOLOGIA
- The promise of stem cell-derived islet replacement therapy
- (2021) Douglas Melton DIABETOLOGIA
- Current and future therapies for type 1 diabetes
- (2021) Bernt Johan von Scholten et al. DIABETOLOGIA
- Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells
- (2020) Nathaniel J. Hogrebe et al. NATURE BIOTECHNOLOGY
- Insights into pancreatic islet cell dysfunction from type 2 diabetes mellitus genetics
- (2020) Nicole A. J. Krentz et al. Nature Reviews Endocrinology
- Trends in Incidence of Type 1 and Type 2 Diabetes Among Youths — Selected Counties and Indian Reservations, United States, 2002–2015
- (2020) Jasmin Divers et al. MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
- A Non-Coding Disease Modifier of Pancreatic Agenesis Identified by Genetic Correction in a Patient-Derived iPSC Line
- (2020) Siddharth Kishore et al. Cell Stem Cell
- COVID-19 in People With Diabetes: Urgently Needed Lessons From Early Reports
- (2020) Matthew C. Riddle et al. DIABETES CARE
- Generation of pancreatic β cells from CD177+ anterior definitive endoderm
- (2020) Pallavi U. Mahaddalkar et al. NATURE BIOTECHNOLOGY
- Gene-edited human stem cell–derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice
- (2020) Kristina G. Maxwell et al. Science Translational Medicine
- Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis
- (2020) Jeffrey C. Davis et al. Cell Reports
- Risk factors for COVID-19-related mortality in people with type 1 and type 2 diabetes in England: a population-based cohort study
- (2020) Naomi Holman et al. Lancet Diabetes & Endocrinology
- Associations of type 1 and type 2 diabetes with COVID-19-related mortality in England: a whole-population study
- (2020) Emma Barron et al. Lancet Diabetes & Endocrinology
- Advances Toward Engineering Functionally Mature Human Pluripotent Stem Cell-Derived β Cells
- (2020) Leonardo Velazco-Cruz et al. Frontiers in Bioengineering and Biotechnology
- Epigenetic modification and therapeutic targets of diabetes mellitus
- (2020) Rajveer Singh et al. BIOSCIENCE REPORTS
- Overview of Atypical Diabetes
- (2020) Jaclyn Tamaroff et al. ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
- Generation of iPSC-derived insulin-producing cells from patients with type 1 and type 2 diabetes compared with healthy control
- (2020) Min Jung Kim et al. Stem Cell Research
- Single-Cell Transcriptome Profiling Reveals β Cell Maturation in Stem Cell-Derived Islets after Transplantation
- (2020) Punn Augsornworawat et al. Cell Reports
- Single-Cell RNA-Seq Reveals that CD9 Is a Negative Marker of Glucose-Responsive Pancreatic β-like Cells Derived from Human Pluripotent Stem Cells
- (2020) Xisheng Li et al. Stem Cell Reports
- Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?)
- (2020) Bart O. Roep et al. Nature Reviews Endocrinology
- Point mutations in the PDX1 transactivation domain impair human β-cell development and function
- (2019) Xianming Wang et al. Molecular Metabolism
- Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells
- (2019) Gopika G. Nair et al. NATURE CELL BIOLOGY
- Nutrigenetics, epigenetics and gestational diabetes: consequences in mother and child
- (2019) Marica Franzago et al. Epigenetics
- Charting cellular identity during human in vitro β-cell differentiation
- (2019) Adrian Veres et al. NATURE
- Expression of mutant mRNA and protein in pancreatic cells derived from MODY3- iPS cells
- (2019) Shigeharu G. Yabe et al. PLoS One
- Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A
- (2019) Fabian L. Cardenas-Diaz et al. Cell Stem Cell
- The supply chain of human pancreatic β cell lines
- (2019) Raphael Scharfmann et al. JOURNAL OF CLINICAL INVESTIGATION
- The Genetic Contribution to Type 1 Diabetes
- (2019) Marina Bakay et al. Current Diabetes Reports
- Mimicking nature-made beta cells
- (2019) Daniel M. Tremmel et al. Current Opinion in Organ Transplantation
- Review: Diabetes, Obesity and Cancer - Pathophysiology and Clinical Implications
- (2019) Iliana C Lega et al. ENDOCRINE REVIEWS
- Circadian Entrainment Triggers Maturation of Human In Vitro Islets
- (2019) Juan R. Alvarez-Dominguez et al. Cell Stem Cell
- Genetics of Type 1 Diabetes Comes of Age
- (2019) Maria J. Redondo et al. DIABETES CARE
- Projected U.S. State-Level Prevalence of Adult Obesity and Severe Obesity
- (2019) Zachary J. Ward et al. NEW ENGLAND JOURNAL OF MEDICINE
- Epigenetic Modifications Linked to T2D, the Heritability Gap, and Potential Therapeutic Targets
- (2018) Monica Szabó et al. BIOCHEMICAL GENETICS
- Lnc-ing non-coding RNAs with metabolism and diabetes: roles of lncRNAs
- (2018) Neha Goyal et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Neonatal Diabetes Mellitus
- (2018) Michelle Blanco Lemelman et al. CLINICS IN PERINATOLOGY
- Comparison of the editing patterns and editing efficiencies of TALEN and CRISPR-Cas9 when targeting the human CCR5 gene
- (2018) Arildo Nerys-Junior et al. GENETICS AND MOLECULAR BIOLOGY
- Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
- (2018) Anubha Mahajan et al. NATURE GENETICS
- Animal models of obesity and diabetes mellitus
- (2018) Maximilian Kleinert et al. Nature Reviews Endocrinology
- Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 3 (MODY3) carrying a hepatocyte nuclear factor 1-alpha ( HNF1A ) mutation
- (2018) Frank Griscelli et al. Stem Cell Research
- Derivation and molecular characterization of pancreatic differentiated MODY1-iPSCs
- (2018) Carmel Braverman-Gross et al. Stem Cell Research
- The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates
- (2018) Violeta Georgieva Tsonkova et al. Molecular Metabolism
- Human islets expressing HNF1A variant have defective β cell transcriptional regulatory networks
- (2018) Rachana Haliyur et al. JOURNAL OF CLINICAL INVESTIGATION
- Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
- (2018) Anubha Mahajan et al. NATURE GENETICS
- Concise Review: Human Pluripotent Stem Cells for the Modeling of Pancreatic β-Cell Pathology
- (2018) Diego Balboa et al. STEM CELLS
- An atlas of human long non-coding RNAs with accurate 5′ ends
- (2017) Chung-Chau Hon et al. NATURE
- Incidence Trends of Type 1 and Type 2 Diabetes among Youths, 2002–2012
- (2017) Elizabeth J. Mayer-Davis et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genetics of type 1 diabetes
- (2017) Maria J Redondo et al. PEDIATRIC DIABETES
- Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 13 (MODY13) with a the potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) mutation
- (2017) Frank Griscelli et al. Stem Cell Research
- Regulatory elements in molecular networks
- (2017) Ashley S. Doane et al. Wiley Interdisciplinary Reviews-Systems Biology and Medicine
- LncRNAs: key players and novel insights into diabetes mellitus
- (2017) Xiaoyun He et al. Oncotarget
- Using hESCs to Probe the Interaction of the Diabetes-Associated Genes CDKAL1 and MT1E
- (2017) Min Guo et al. Cell Reports
- CRISPR/Cas9 Genome-Editing System in Human Stem Cells: Current Status and Future Prospects
- (2017) Zhao Zhang et al. Molecular Therapy-Nucleic Acids
- Type 1 diabetes mellitus
- (2017) Anastasia Katsarou et al. Nature Reviews Disease Primers
- Mouse Models of Human GWAS Hits for Obesity and Diabetes in the Post Genomic Era: Time for Reevaluation
- (2017) Samantha Laber et al. Frontiers in Endocrinology
- Long Noncoding RNAs in Diabetes and Diabetic Complications
- (2017) Amy Leung et al. ANTIOXIDANTS & REDOX SIGNALING
- Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells
- (2017) Heidrun Vethe et al. Scientific Reports
- Co-culture of clonal beta cells with GLP-1 and glucagon-secreting cell line impacts on beta cell insulin secretion, proliferation and susceptibility to cytotoxins
- (2016) Alastair D. Green et al. BIOCHIMIE
- Stem Cells: A Renaissance in Human Biology Research
- (2016) Jun Wu et al. CELL
- Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes
- (2016) Zengrong Zhu et al. Cell Stem Cell
- Induced Pluripotent Stem Cells Meet Genome Editing
- (2016) Dirk Hockemeyer et al. Cell Stem Cell
- Functional Investigations of HNF1A Identify Rare Variants as Risk Factors for Type 2 Diabetes in the General Population
- (2016) Laeya Abdoli Najmi et al. DIABETES
- The quest to make fully functional human pancreatic beta cells from embryonic stem cells: climbing a mountain in the clouds
- (2016) James D. Johnson DIABETOLOGIA
- Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes
- (2016) Yisheng Yang et al. ENDOCRINE REVIEWS
- A novel long non-coding RNA CYP4B1-PS1-001 regulates proliferation and fibrosis in diabetic nephropathy
- (2016) Min Wang et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- The genetic architecture of type 2 diabetes
- (2016) Christian Fuchsberger et al. NATURE
- A decade of transcription factor-mediated reprogramming to pluripotency
- (2016) Kazutoshi Takahashi et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Generation of human control iPS cell line CHOPWT10 from healthy adult peripheral blood mononuclear cells
- (2016) Jean Ann Maguire et al. Stem Cell Research
- Generation of a human induced pluripotent stem cell (iPSC) line from a patient carrying a P33T mutation in the PDX1 gene
- (2016) Xianming Wang et al. Stem Cell Research
- Generation of stem cell-derived β-cells from patients with type 1 diabetes
- (2016) Jeffrey R. Millman et al. Nature Communications
- Erratum: Erratum: A suppressor locus for MODY3-diabetes
- (2016) Miguel A. Garcia-Gonzalez et al. Scientific Reports
- Modeling Cystic Fibrosis Using Pluripotent Stem Cell-Derived Human Pancreatic Ductal Epithelial Cells
- (2016) Senem Simsek et al. Stem Cells Translational Medicine
- Experimental Diabetes Mellitus in Different Animal Models
- (2016) Amin Al-awar et al. Journal of Diabetes Research
- Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia
- (2016) Adrian Kee Keong Teo et al. Stem Cell Reports
- Pancreatic beta cell lines and their applications in diabetes mellitus research
- (2016) Masa Skelin ALTEX-Alternatives to Animal Experimentation
- Islet formation in mice and men: lessons for the generation of functional insulin-producing β-cells from human pluripotent stem cells
- (2015) Gopika Nair et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Non-coding genetic variants in human disease: Figure 1.
- (2015) Feng Zhang et al. HUMAN MOLECULAR GENETICS
- Long Non-Coding RNA Central of Glucose Homeostasis
- (2015) Xiangbo Ruan JOURNAL OF CELLULAR BIOCHEMISTRY
- Integrative analysis of 111 reference human epigenomes
- (2015) Anshul Kundaje et al. NATURE
- Therapeutic genome editing: prospects and challenges
- (2015) David Benjamin Turitz Cox et al. NATURE MEDICINE
- Establishment of maturity-onset diabetes of the young-induced pluripotent stem cells from a Japanese patient
- (2015) Shigeharu G Yabe et al. Journal of Diabetes Investigation
- Induced pluripotent stem cells as a model for diabetes investigation
- (2015) J. Stepniewski et al. Scientific Reports
- Genetic Modifiers and Oligogenic Inheritance
- (2015) M. Kousi et al. Cold Spring Harbor Perspectives in Medicine
- Type 2 diabetes mellitus
- (2015) Ralph A. DeFronzo et al. Nature Reviews Disease Primers
- Bhlhe40, a potential diabetic modifier gene on Dbm1 locus, negatively controls myocyte fatty acid oxidation
- (2015) Shigeru Takeshita et al. GENES & GENETIC SYSTEMS
- Novel GATA6 Mutations in Patients with Pancreatic Agenesis and Congenital Heart Malformations
- (2015) Christina S. Chao et al. PLoS One
- Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases
- (2014) Alexander Gusev et al. AMERICAN JOURNAL OF HUMAN GENETICS
- TALEN-mediated genome editing: prospects and perspectives
- (2014) David A. Wright et al. BIOCHEMICAL JOURNAL
- Generation of Functional Human Pancreatic β Cells In Vitro
- (2014) Felicia W. Pagliuca et al. CELL
- Development and Applications of CRISPR-Cas9 for Genome Engineering
- (2014) Patrick D. Hsu et al. CELL
- Epigenetic Regulation of the DLK1-MEG3 MicroRNA Cluster in Human Type 2 Diabetic Islets
- (2014) Vasumathi Kameswaran et al. Cell Metabolism
- Low Incidence of Off-Target Mutations in Individual CRISPR-Cas9 and TALEN Targeted Human Stem Cell Clones Detected by Whole-Genome Sequencing
- (2014) Adrian Veres et al. Cell Stem Cell
- An iCRISPR Platform for Rapid, Multiplexable, and Inducible Genome Editing in Human Pluripotent Stem Cells
- (2014) Federico González et al. Cell Stem Cell
- GATA4 Mutations Are a Cause of Neonatal and Childhood-Onset Diabetes
- (2014) C. Shaw-Smith et al. DIABETES
- Self-Management in Early Adolescence and Differences by Age at Diagnosis and Duration of Type 1 Diabetes
- (2014) Ariana Chao et al. DIABETES EDUCATOR
- Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond
- (2014) Niels Grarup et al. DIABETOLOGIA
- Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
- (2014) Alireza Rezania et al. NATURE BIOTECHNOLOGY
- Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants
- (2014) Lorenzo Pasquali et al. NATURE GENETICS
- A novel mutation inGATA6causes pancreatic agenesis
- (2014) Diana E. Stanescu et al. PEDIATRIC DIABETES
- TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content
- (2014) H. Mahdessian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The new frontier of genome engineering with CRISPR-Cas9
- (2014) J. A. Doudna et al. SCIENCE
- Mapping of Immune-Mediated Disease Genes
- (2013) Isis Ricaño-Ponce et al. Annual Review of Genomics and Human Genetics
- Enhanced Efficiency of Human Pluripotent Stem Cell Genome Editing through Replacing TALENs with CRISPRs
- (2013) Qiurong Ding et al. Cell Stem Cell
- -Cell Dysfunction Due to Increased ER Stress in a Stem Cell Model of Wolfram Syndrome
- (2013) L. Shang et al. DIABETES
- A novel GATA6 mutation leading to congenital heart defects and permanent neonatal diabetes: A case report
- (2013) G. Catli et al. DIABETES & METABOLISM
- Gene-Environment and Gene-Treatment Interactions in Type 2 Diabetes: Progress, pitfalls, and prospects
- (2013) P. W. Franks et al. DIABETES CARE
- Improved genetic testing for monogenic diabetes using targeted next-generation sequencing
- (2013) S. Ellard et al. DIABETOLOGIA
- Two Novel GATA6 Mutations Cause Childhood-Onset Diabetes Mellitus, Pancreas Malformation and Congenital Heart Disease
- (2013) Maolian Gong et al. Hormone Research in Paediatrics
- Mutations in the Genes Encoding the Transcription Factors Hepatocyte Nuclear Factor 1 Alpha and 4 Alpha in Maturity-Onset Diabetes of the Young and Hyperinsulinemic Hypoglycemia
- (2013) Kevin Colclough et al. HUMAN MUTATION
- Derivation of Human Induced Pluripotent Stem Cells from Patients with Maturity Onset Diabetes of the Young
- (2013) Adrian K. K. Teo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Enhancer mutations and phenotype modularity
- (2013) Christopher T Gordon et al. NATURE GENETICS
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- Bisphenol A Accelerates Toxic Amyloid Formation of Human Islet Amyloid Polypeptide: A Possible Link between Bisphenol A Exposure and Type 2 Diabetes
- (2013) Hao Gong et al. PLoS One
- Environmental Triggers of Type 1 Diabetes
- (2013) M. Knip et al. Cold Spring Harbor Perspectives in Medicine
- The lessons of early-onset monogenic diabetes for the understanding of diabetes pathogenesis
- (2012) Martine Vaxillaire et al. BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
- Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes
- (2012) Ignasi Morán et al. Cell Metabolism
- A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models
- (2012) Qiurong Ding et al. Cell Stem Cell
- GATA6 inactivating mutations are associated with heart defects and, inconsistently, with pancreatic agenesis and diabetes
- (2012) A. Bonnefond et al. DIABETOLOGIA
- Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis
- (2012) Shouhong Xuan et al. JOURNAL OF CLINICAL INVESTIGATION
- GATA4 and GATA6 control mouse pancreas organogenesis
- (2012) Manuel Carrasco et al. JOURNAL OF CLINICAL INVESTIGATION
- The long-range interaction landscape of gene promoters
- (2012) Amartya Sanyal et al. NATURE
- Landscape of transcription in human cells
- (2012) Sarah Djebali et al. NATURE
- The accessible chromatin landscape of the human genome
- (2012) Robert E. Thurman et al. NATURE
- Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes
- (2012) Amélie Bonnefond et al. NATURE GENETICS
- TALENs: a widely applicable technology for targeted genome editing
- (2012) J. Keith Joung et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The Past 200 Years in Diabetes
- (2012) Kenneth S. Polonsky NEW ENGLAND JOURNAL OF MEDICINE
- Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers
- (2012) Sebastian Bultmann et al. NUCLEIC ACIDS RESEARCH
- Exome Sequencing and Genetic Testing for MODY
- (2012) Stefan Johansson et al. PLoS One
- A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
- (2012) M. Jinek et al. SCIENCE
- Systematic Localization of Common Disease-Associated Variation in Regulatory DNA
- (2012) M. T. Maurano et al. SCIENCE
- Transgene-Free Disease-Specific Induced Pluripotent Stem Cells from Patients with Type 1 and Type 2 Diabetes
- (2012) Yogish C. Kudva et al. Stem Cells Translational Medicine
- Transcriptional enhancers in development and disease
- (2012) Noboru Sakabe et al. GENOME BIOLOGY
- MODY
- (2011) Stefan S. Fajans et al. DIABETES CARE
- Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses
- (2011) M. N. Cabili et al. GENES & DEVELOPMENT
- Phenotype harmonization and cross-study collaboration in GWAS consortia: the GENEVA experience
- (2011) Siiri N. Bennett et al. GENETIC EPIDEMIOLOGY
- CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
- (2011) Elitza Deltcheva et al. NATURE
- Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription
- (2011) Feng Zhang et al. NATURE BIOTECHNOLOGY
- GATA6 haploinsufficiency causes pancreatic agenesis in humans
- (2011) Hana Lango Allen et al. NATURE GENETICS
- On target? Tracing zinc-finger-nuclease specificity
- (2011) Claudio Mussolino et al. NATURE METHODS
- Review on monogenic diabetes
- (2011) Andrea K. Steck et al. Current Opinion in Endocrinology Diabetes and Obesity
- The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway
- (2010) Michael R. Lieber Annual Review of Biochemistry
- XanthomonasAvrBs3 Family-Type III Effectors: Discovery and Function
- (2010) Jens Boch et al. Annual Review of Phytopathology
- Genetics of Type 1 Diabetes: What's Next?
- (2010) F. Pociot et al. DIABETES
- Genetic investigation in an Italian child with an unusual association of atrial septal defect, attributable to a new familial GATA4 gene mutation, and neonatal diabetes due to pancreatic agenesis
- (2010) E. D’Amato et al. DIABETIC MEDICINE
- A TALE nuclease architecture for efficient genome editing
- (2010) Jeffrey C Miller et al. NATURE BIOTECHNOLOGY
- Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
- (2010) Benjamin F Voight et al. NATURE GENETICS
- Genome editing with engineered zinc finger nucleases
- (2010) Fyodor D. Urnov et al. NATURE REVIEWS GENETICS
- Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene
- (2010) Julie Støy et al. REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
- Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease
- (2010) John P. Driver et al. Seminars in Immunopathology
- Vertebrate Endoderm Development and Organ Formation
- (2009) Aaron M. Zorn et al. Annual Review of Cell and Developmental Biology
- Overview of the Type I Diabetes Genetics Consortium
- (2009) S S Rich et al. GENES AND IMMUNITY
- The DNA-damage response in human biology and disease
- (2009) Stephen P. Jackson et al. NATURE
- Generation of pluripotent stem cells from patients with type 1 diabetes
- (2009) R. Maehr et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Discordant Phenotypes in Fraternal Twins Having an Identical Mutation in Exon ORF15 of the RPGR Gene
- (2008) Saloni Walia ARCHIVES OF OPHTHALMOLOGY
- Progress and prospects: Zinc-finger nucleases as gene therapy agents
- (2008) D Carroll GENE THERAPY
- Identifying modifier genes of monogenic disease: strategies and difficulties
- (2008) Emmanuelle Génin et al. HUMAN GENETICS
- Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo
- (2008) Evert Kroon et al. NATURE BIOTECHNOLOGY
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