Epigenetic modification and therapeutic targets of diabetes mellitus

circRNAs Signature as Potential Diagnostic and Prognostic Biomarker for Diabetes Mellitus and Related Cardiovascular Complications

(2020) Mohamed Zaiou   Cells

The biogenesis, biology and characterization of circular RNAs

(2019) Lasse S. Kristensen et al.   NATURE REVIEWS GENETICS

Circulating LncRNAs Analysis in Patients with Type 2 Diabetes Reveals Novel Genes Influencing Glucose Metabolism and Islet β-Cell Function

(2018) Yuting Ruan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Mammalian DNA methyltransferases: new discoveries and open questions

(2018) Humaira Gowher et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Two Cases of Mistaken Polyuria and Nephrocalcinosis in Infants with Glucose-Galactose Malabsorption: A Possible Role of 1,25(OH)2D3


(2017) Melissa Fiscaletti et al.   Hormone Research in Paediatrics

The Na+-D-glucose cotransporters SGLT1 and SGLT2 are targets for the treatment of diabetes and cancer

(2017) Hermann Koepsell   PHARMACOLOGY & THERAPEUTICS

Epigenetics and type 1 diabetes: mechanisms and translational applications

(2017) Alberto Zullo et al.   Translational Research

The Genetic Architecture of Type 1 Diabetes

(2017) Samuel Jerram et al.   Genes

Long Noncoding RNAs in Diabetes and Diabetic Complications

(2017) Amy Leung et al.   ANTIOXIDANTS & REDOX SIGNALING

Beyond Genetics: What Causes Type 1 Diabetes

(2016) Zhen Wang et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells

(2016) Mahboubeh Daneshpajooh et al.   DIABETOLOGIA

Are epigenetic drugs for diabetes and obesity at our door step?

(2016) Andrix O. Arguelles et al.   DRUG DISCOVERY TODAY

βlinc1encodes a long noncoding RNA that regulates islet β-cell formation and function

(2016) Luis Arnes et al.   GENES & DEVELOPMENT

Genetic sources of population epigenomic variation

(2016) Aaron Taudt et al.   NATURE REVIEWS GENETICS

The molecular hallmarks of epigenetic control

(2016) C. David Allis et al.   NATURE REVIEWS GENETICS

The biogenesis and emerging roles of circular RNAs

(2016) Ling-Ling Chen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Histone deacetylase inhibitors: Future therapeutics for insulin resistance and type 2 diabetes

(2016) Sorabh Sharma et al.   PHARMACOLOGICAL RESEARCH

Circulating Differentially Methylated Amylin DNA as a Biomarker of β-Cell Loss in Type 1 Diabetes

(2016) John A. Olsen et al.   PLoS One

Metformin-Associated Lactic Acidosis

(2015) Francisco J. Pasquel et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Does epigenetic dysregulation of pancreatic islets contribute to impaired insulin secretion and type 2 diabetes?

(2015) Tasnim Dayeh et al.   Biochemistry and Cell Biology

Downregulation of lncRNA TUG1 Affects Apoptosis and Insulin Secretion in Mouse Pancreatic β Cells

(2015) Dan-dan Yin et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

lncRNA-MIAT Regulates Microvascular Dysfunction by Functioning as a Competing Endogenous RNANovelty and Significance

(2015) Biao Yan et al.   CIRCULATION RESEARCH

Understanding the relationship between DNA methylation and histone lysine methylation

(2014) Nathan R. Rose et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Adverse Epigenetic Signatures by Histone Methyltransferase Set7 Contribute to Vascular Dysfunction in Patients With Type 2 Diabetes MellitusCLINICAL PERSPECTIVE

(2014) Francesco Paneni et al.   Circulation-Cardiovascular Genetics

Diabetic nephropathy—emerging epigenetic mechanisms

(2014) Mitsuo Kato et al.   Nature Reviews Nephrology

A Genome-Wide Association Study for Diabetic Retinopathy in a Japanese Population: Potential Association with a Long Intergenic Non-Coding RNA

(2014) Takuya Awata et al.   PLoS One

Pathogenic role of lncRNA-MALAT1 in endothelial cell dysfunction in diabetes mellitus

(2014) J-Y Liu et al.   Cell Death & Disease

Do epigenetic drug treatments hold the key to killing cancer progenitor cells?

(2014) Shannon Byler et al.   Epigenomics

Sodium–Glucose Cotransporter 2 Inhibitors for Type 2 Diabetes

(2013) Despoina Vasilakou et al.   ANNALS OF INTERNAL MEDICINE

DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets

(2013) Elin Hall et al.   BMC Medical Genetics

Defining the Role of GLP-1 in the Enteroinsulinar Axis in Type 2 Diabetes Using DPP-4 Inhibition and GLP-1 Receptor Blockade

(2013) B. A. Aulinger et al.   DIABETES

A Critical Analysis of the Clinical Use of Incretin-Based Therapies: The benefits by far outweigh the potential risks

(2013) M. A. Nauck   DIABETES CARE

Is Incretin-Based Therapy Ready for the Care of Hospitalized Patients With Type 2 Diabetes?: The time has come for GLP-1 receptor agonists!

(2013) S. Schwartz et al.   DIABETES CARE

Safety and Efficacy of Sitagliptin Therapy for the Inpatient Management of General Medicine and Surgery Patients With Type 2 Diabetes: A pilot, randomized, controlled study

(2013) G. E. Umpierrez et al.   DIABETES CARE

Canagliflozin Lowers Postprandial Glucose and Insulin by Delaying Intestinal Glucose Absorption in Addition to Increasing Urinary Glucose Excretion: Results of a randomized, placebo-controlled study

(2013) D. Polidori et al.   DIABETES CARE

A Critical Analysis of the Clinical Use of Incretin-Based Therapies: Are the GLP-1 therapies safe?

(2013) P. C. Butler et al.   DIABETES CARE

Glucose Variability is an Independent Predictor of Mortality in Hospitalized Patients Treated with Total Parenteral Nutrition

(2013) Farnoosh Farrokhi et al.   Endocrine Practice

Cancer Development, Progression, and Therapy: An Epigenetic Overview

(2013) Sibaji Sarkar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

High-throughput sequencing for biology and medicine

(2013) W. W. Soon et al.   Molecular Systems Biology

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

Pleiotropy in complex traits: challenges and strategies

(2013) Nadia Solovieff et al.   NATURE REVIEWS GENETICS

Genome wide association studies for diabetes: perspective on results and challenges

(2013) JM Torres et al.   PEDIATRIC DIABETES

Mechanisms of Diabetic Complications

(2013) Josephine M. Forbes et al.   PHYSIOLOGICAL REVIEWS

CpG Methylation Changes within the IL2RA Promoter in Type 1 Diabetes of Childhood Onset

(2013) Marie-Pierre Belot et al.   PLoS One

Effect of exercise on DNA methylation and metabolism in human adipose tissue and skeletal muscle

(2013) Tina Rönn et al.   Epigenomics

Metformin: an old but still the best treatment for type 2 diabetes

(2013) Lilian Beatriz Aguayo Rojas et al.   Diabetology & Metabolic Syndrome

LX4211, a Dual SGLT1/SGLT2 Inhibitor, Improved Glycemic Control in Patients With Type 2 Diabetes in a Randomized, Placebo-Controlled Trial

(2012) B Zambrowicz et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Efficacy and Safety Profile Evaluation of Acarbose Alone and in Association With Other Antidiabetic Drugs: A Systematic Review

(2012) Giuseppe Derosa et al.   CLINICAL THERAPEUTICS

What Will Diabetes Genomes Tell Us?

(2012) Karen L. Mohlke et al.   Current Diabetes Reports

What have we learned from six years of GWAS in autoimmune diseases, and what is next?

(2012) Xinli Hu et al.   CURRENT OPINION IN IMMUNOLOGY

Changes in MicroRNA Expression Contribute to Pancreatic  -Cell Dysfunction in Prediabetic NOD Mice

(2012) E. Roggli et al.   DIABETES

Circulating Levels of MicroRNA from Children with Newly Diagnosed Type 1 Diabetes and Healthy Controls: Evidence That miR-25 Associates to Residual Beta-Cell Function and Glycaemic Control during Disease Progression

(2012) Lotte B. Nielsen et al.   Experimental Diabetes Research

Profiles of Epigenetic Histone Post-translational Modifications at Type 1 Diabetes Susceptible Genes

(2012) Feng Miao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Management of Hyperglycemia in Hospitalized Patients in Non-Critical Care Setting: An Endocrine Society Clinical Practice Guideline

(2012) Guillermo E. Umpierrez et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Choosing a blood-glucose-lowering agent after metformin

(2012) Michaela Diamant   LANCET

Increased DNA Methylation and Decreased Expression ofPDX-1in Pancreatic Islets from Patients with Type 2 Diabetes

(2012) Beatrice T. Yang et al.   MOLECULAR ENDOCRINOLOGY

SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects

(2012) Ele Ferrannini et al.   Nature Reviews Endocrinology

Association of the CpG Methylation Pattern of the Proximal Insulin Gene Promoter with Type 1 Diabetes

(2012) Delphine Fradin et al.   PLoS One

Emerging patterns of genetic overlap across autoimmune disorders

(2012) Corinne Richard-Miceli et al.   Genome Medicine

Transcriptome Analysis of Human Diabetic Kidney Disease

(2011) K. I. Woroniecka et al.   DIABETES

Randomized Study of Basal-Bolus Insulin Therapy in the Inpatient Management of Patients With Type 2 Diabetes Undergoing General Surgery (RABBIT 2 Surgery)

(2011) G. E. Umpierrez et al.   DIABETES CARE

Genome-wide association studies (GWAS): impact on elucidating the aetiology of diabetes

(2011) Hakon Hakonarson et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

DNA methylation dysregulates and silences the HLA-DQ locus by altering chromatin architecture

(2011) P Majumder et al.   GENES AND IMMUNITY

Glucose handling by the kidney

(2011) Amanda Mather et al.   KIDNEY INTERNATIONAL

Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1

(2011) Sara Fröjdö et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

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(2011) Dan Christensen et al.   MOLECULAR MEDICINE

The epidemic of type 1 diabetes

(2011) Gregory P. Forlenza et al.   Current Opinion in Endocrinology Diabetes and Obesity

Pervasive Sharing of Genetic Effects in Autoimmune Disease

(2011) Chris Cotsapas et al.   PLoS Genetics

A Genome-Wide Meta-Analysis of Six Type 1 Diabetes Cohorts Identifies Multiple Associated Loci

(2011) Jonathan P. Bradfield et al.   PLoS Genetics

Involvement of MicroRNAs in the Cytotoxic Effects Exerted by Proinflammatory Cytokines on Pancreatic  -Cells

(2010) E. Roggli et al.   DIABETES

Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA1c levels in human pancreatic islets

(2010) B. T. Yang et al.   DIABETOLOGIA

Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines

(2010) M. Lundh et al.   DIABETOLOGIA

Can the Genetics of Type 1 and Type 2 Diabetes Shed Light on the Genetics of Latent Autoimmune Diabetes in Adults?

(2010) Struan F. A. Grant et al.   ENDOCRINE REVIEWS

Myeloid Deletion of SIRT1 Induces Inflammatory Signaling in Response to Environmental Stress

(2010) T. T. Schug et al.   MOLECULAR AND CELLULAR BIOLOGY

Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1

(2010) Masato Iwabu et al.   NATURE

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease

(2010) Steve Eyre et al.   ARTHRITIS RESEARCH & THERAPY

SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity

(2009) Takeshi Yoshizaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

microRNA-342, microRNA-191 and microRNA-510 are differentially expressed in T regulatory cells of type 1 diabetic patients

(2009) Renata Hezova et al.   CELLULAR IMMUNOLOGY

Dapagliflozin, a Novel, Selective SGLT2 Inhibitor, Improved Glycemic Control Over 2 Weeks in Patients With Type 2 Diabetes Mellitus

(2009) B Komoroski et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

SIRT1 Genetic Variation Is Related to BMI and Risk of Obesity

(2009) M.Carola Zillikens et al.   DIABETES

Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail

(2009) D. Brasacchio et al.   DIABETES

American Association of Clinical Endocrinologists and American Diabetes Association Consensus Statement on Inpatient Glycemic Control

(2009) E. S. Moghissi et al.   DIABETES CARE

Sliding Scale Insulin—Time to Stop Sliding

(2009) Irl B. Hirsch   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes

(2009) Chris Wallace et al.   NATURE GENETICS

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

Linking DNA methylation and histone modification: patterns and paradigms

(2009) Howard Cedar et al.   NATURE REVIEWS GENETICS

The diagnosis and management of monogenic diabetes in children and adolescents

(2009) Andrew Hattersley et al.   PEDIATRIC DIABETES

Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

(2009) S. Nejentsev et al.   SCIENCE

Autoimmune Disease Classification by Inverse Association with SNP Alleles

(2009) Marina Sirota et al.   PLoS Genetics

Transcriptional regulation of the insulin-responsive glucose transporter GLUT4 gene: from physiology to pathology

(2008) Eddy Karnieli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glucose regulation of insulin gene expression in pancreatic β-cells

(2008) Sreenath S. Andrali et al.   BIOCHEMICAL JOURNAL

Methyl-CpG binding proteins: specialized transcriptional repressors or structural components of chromatin?

(2008) T. Clouaire et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Genetic determinants and molecular pathways in the pathogenesis of Type 2 diabetes

(2008) Wanzhu Jin et al.   CLINICAL SCIENCE

Glycemic variability: A strong independent predictor of mortality in critically ill patients*

(2008) James S. Krinsley   CRITICAL CARE MEDICINE

Follow-Up Analysis of Genome-Wide Association Data Identifies Novel Loci for Type 1 Diabetes

(2008) S. F.A. Grant et al.   DIABETES

HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk: Analysis of the Type 1 Diabetes Genetics Consortium Families

(2008) H. Erlich et al.   DIABETES

Lymphocytes From Patients With Type 1 Diabetes Display a Distinct Profile of Chromatin Histone H3 Lysine 9 Dimethylation: An Epigenetic Study in Diabetes

(2008) F. Miao et al.   DIABETES

Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes

(2008) D. M. Nathan et al.   DIABETES CARE

Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion

(2008) C. Ling et al.   DIABETOLOGIA

PDX-1 and MafA Play a Crucial Role in Pancreatic β-Cell Differentiation and Maintenance of Mature β-Cell Function

(2008) Hideaki KANETO et al.   ENDOCRINE JOURNAL

Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus

(2008) E Y M G Fung et al.   GENES AND IMMUNITY

Histone Code Modifications Repress Glucose Transporter 4 Expression in the Intrauterine Growth-restricted Offspring

(2008) Nupur Raychaudhuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Genetics of Type 2 Diabetes: A Realistic Appraisal in 2008

(2008) Jose C. Florez   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

SIRT1 Exerts Anti-Inflammatory Effects and Improves Insulin Sensitivity in Adipocytes

(2008) T. Yoshizaki et al.   MOLECULAR AND CELLULAR BIOLOGY

Pancreatic transcription factors and their role in the birth, life and survival of the pancreatic β cell

(2008) Andreia S. Bernardo et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

DNA methylation in development and human disease

(2008) Suhasni Gopalakrishnan et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Detecting shared pathogenesis from the shared genetics of immune-related diseases

(2008) Alexandra Zhernakova et al.   NATURE REVIEWS GENETICS