Effects of Citrus Fruit Juices and Their Bioactive Components on Inflammation and Immunity: A Narrative Review

Nutrition and immunity: lessons for COVID-19

(2021) Philip C. Calder   EUROPEAN JOURNAL OF CLINICAL NUTRITION

A Review of Micronutrients and the Immune System–Working in Harmony to Reduce the Risk of Infection

(2020) Adrian F. Gombart et al.   Nutrients

Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

(2020) Canrong Wu et al.   Acta Pharmaceutica Sinica B

Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections

(2020) Philip C. Calder et al.   Nutrients

Patients with Community Acquired Pneumonia Exhibit Depleted Vitamin C Status and Elevated Oxidative Stress

(2020) Anitra C. Carr et al.   Nutrients

Review of Evidence Available on Hesperidin-Rich Products as Potential Tools against COVID-19 and Hydrodynamic Cavitation-Based Extraction as a Method of Increasing Their Production

(2020) Francesco Meneguzzo et al.   Processes

Blood Orange Juice Consumption Increases Flow-Mediated Dilation in Adults with Overweight and Obesity: A Randomized Controlled Trial

(2020) Lu Li et al.   JOURNAL OF NUTRITION

Naringenin, a flavanone with antiviral and anti‐inflammatory effects: A promising treatment strategy against COVID ‐19

(2020) Helda Tutunchi et al.   PHYTOTHERAPY RESEARCH

Fruit-Based Beverages Contain a Wide Range of Phytochemicals and Intervention Targets Should Account for the Individual Compounds Present and Their Availability

(2020) Charles Bestwick et al.   Foods

Molecular docking study of potential phytochemicals and their effects on the complex of SARS-CoV2 spike protein and human ACE2

(2020) Anamika Basu et al.   Scientific Reports

Impact of orange juice consumption on cardiovascular disease risk factors: a systematic review and meta-analysis of randomized-controlled trials

(2020) Habeeb Alhabeeb et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Activation of Resolution Pathways to Prevent and Fight Chronic Inflammation: Lessons From Asthma and Inflammatory Bowel Disease

(2019) Cindy Barnig et al.   Frontiers in Immunology

Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial

(2018) Fatemeh Homayouni et al.   PHYTOTHERAPY RESEARCH

Immune Function and Micronutrient Requirements Change over the Life Course

(2018) Silvia Maggini et al.   Nutrients

Folate deficiency affects dendritic cell function and subsequent T helper cell differentiation

(2017) Chi-Heng Wu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Caveolin-1–mediated internalization of the vitamin C transporter SVCT2 in microglia triggers an inflammatory phenotype

(2017) Camila C. Portugal et al.   Science Signaling

Vitamin C and Infections

(2017) Harri Hemilä   Nutrients

Vitamin C and Immune Function

(2017) Anitra Carr et al.   Nutrients

Orange juice as dietary source of antioxidants for patients with hepatitis C under antiviral therapy

(2017) Danielle Gonçalves et al.   Food & Nutrition Research

Caveolin-1–mediated internalization of the vitamin C transporter SVCT2 in microglia triggers an inflammatory phenotype

(2017) Camila C. Portugal et al.   Science Signaling

Alloantigen-Induced Regulatory T Cells Generated in Presence of Vitamin C Display Enhanced Stability of Foxp3 Expression and Promote Skin Allograft Acceptance

(2017) Eirini Nikolouli et al.   Frontiers in Immunology

Ozone-induced damage in 3D-Skin Model is prevented by topical vitamin C and vitamin E compound mixtures application

(2016) Giuseppe Valacchi et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Vitamin C Facilitates Demethylation of theFoxp3Enhancer in a Tet-Dependent Manner

(2016) Varun Sasidharan Nair et al.   JOURNAL OF IMMUNOLOGY

A serum metabolomics-driven approach predicts orange juice consumption and its impact on oxidative stress and inflammation in subjects from the BIONAOS study

(2016) Oscar D. Rangel-Huerta et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Urinary excretion ofCitrusflavanones and their major catabolites after consumption of fresh oranges and pasteurized orange juice: A randomized cross-over study

(2016) Julian K. Aschoff et al.   MOLECULAR NUTRITION & FOOD RESEARCH

A Mixed Flavonoid-Fish Oil Supplement Induces Immune-Enhancing and Anti-Inflammatory Transcriptomic Changes in Adult Obese and Overweight Women—A Randomized Controlled Trial

(2016) Lynn Cialdella-Kam et al.   Nutrients

Red-fleshed sweet orange juice improves the risk factors for metabolic syndrome

(2015) Jacqueline Q. Silveira et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

In Vitro Bioaccessibility of Carotenoids, Flavonoids, and Vitamin C from Differently Processed Oranges and Orange Juices [Citrus sinensis (L.) Osbeck]

(2015) Julian K. Aschoff et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

In the eye of the neutrophil swarm-navigation signals that bring neutrophils together in inflamed and infected tissues

(2015) Tim Lämmermann   JOURNAL OF LEUKOCYTE BIOLOGY

Mechanism of folic acid radiolysis in aqueous solution

(2015) Michel M. Araújo et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Gastrointestinal absorption and metabolism of hesperetin-7-O-rutinoside and hesperetin-7-O-glucoside in healthy humans

(2015) Lucas Actis-Goretta et al.   MOLECULAR NUTRITION & FOOD RESEARCH

In vitro colonic catabolism of orange juice (poly)phenols

(2015) Gema Pereira-Caro et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Vitamin C Compound Mixtures Prevent Ozone-Induced Oxidative Damage in Human Keratinocytes as Initial Assessment of Pollution Protection

(2015) Giuseppe Valacchi et al.   PLoS One

Vitamin C promotes wound healing through novel pleiotropic mechanisms

(2015) Bassem M Mohammed et al.   International Wound Journal

Enhanced Human Neutrophil Vitamin C Status, Chemotaxis and Oxidant Generation Following Dietary Supplementation with Vitamin C-Rich SunGold Kiwifruit

(2015) Stephanie Bozonet et al.   Nutrients

Investigation of cytokines, oxidative stress, metabolic, and inflammatory biomarkers after orange juice consumption by normal and overweight subjects

(2015) Grace K. Z. S. Dourado et al.   Food & Nutrition Research

Effects of Nutritional Supplementation on Fatigue, and Autonomic and Immune Dysfunction in Patients with End-Stage Renal Disease: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial

(2015) Sanae Fukuda et al.   PLoS One

Orange juice (poly)phenols are highly bioavailable in humans

(2014) Gema Pereira-Caro et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Vitamin C supplementation modulates gene expression in peripheral blood mononuclear cells specifically upon an inflammatory stimulus: a pilot study in healthy subjects

(2014) Raffaella Canali et al.   Genes and Nutrition

Comparative effect of fucoxanthin and vitamin C on oxidative and functional parameters of human lymphocytes

(2014) Nathalia Molina et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Pharmacokinetics of Flavanone Glycosides after Ingestion of Single Doses of Fresh-Squeezed Orange Juice versus Commercially Processed Orange Juice in Healthy Humans

(2014) Jacqueline Q. Silveira et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells

(2014) Sidonia B.G. Eckle et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Technical Advance: Ascorbic acid induces development of double-positive T cells from human hematopoietic stem cells in the absence of stromal cells

(2014) Mirelle J. A. J. Huijskens et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Vitamin C Mitigates Oxidative Stress and Tumor Necrosis Factor-Alpha in Severe Community-Acquired Pneumonia and LPS-Induced Macrophages

(2014) Yuanyuan Chen et al.   MEDIATORS OF INFLAMMATION

A dual character of flavonoids in influenza A virus replication and spread through modulating cell-autonomous immunity by MAPK signaling pathways

(2014) Wenjuan Dong et al.   Scientific Reports

Monitoring immune modulation by nutrition in the general population: identifying and substantiating effects on human health

(2013) Ruud Albers et al.   BRITISH JOURNAL OF NUTRITION

A Consideration of Biomarkers to be Used for Evaluation of Inflammation in Human Nutritional Studies

(2013) P.C. Calder et al.   BRITISH JOURNAL OF NUTRITION

Orange juice and its major polyphenol hesperidin consumption do not induce immunomodulation in healthy well-nourished humans

(2013) Olivier Perche et al.   CLINICAL NUTRITION

Red Orange: Experimental Models and Epidemiological Evidence of Its Benefits on Human Health

(2013) Giuseppe Grosso et al.   Oxidative Medicine and Cellular Longevity

Feeding the immune system

(2013) Philip C. Calder   PROCEEDINGS OF THE NUTRITION SOCIETY

Dose-Dependent Vitamin C Uptake and Radical Scavenging Activity in Human Skin Measured with in vivo Electron Paramagnetic Resonance Spectroscopy

(2013) Anna-Christina Lauer et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY

Recognition of vitamin B metabolites by mucosal-associated invariant T cells

(2013) Onisha Patel et al.   Nature Communications

Bioavailability of dietary (poly)phenols: a study with ileostomists to discriminate between absorption in small and large intestine

(2013) Gina Borges et al.   Food & Function

Vitamin-Mediated Regulation of Intestinal Immunity

(2013) Jun Kunisawa et al.   Frontiers in Immunology

Vitamin C Is an Essential Factor on the Anti-viral Immune Responses through the Production of Interferon-α/β at the Initial Stage of Influenza A Virus (H3N2) Infection

(2013) Yejin Kim et al.   Immune Network

Effect of fruit and vegetable consumption on immune function in older people: a randomized controlled trial

(2012) Andrew Gibson et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Effects of red orange juice intake on endothelial function and inflammatory markers in adult subjects with increased cardiovascular risk

(2012) Silvio Buscemi et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Vitamin C Promotes Maturation of T-Cells

(2012) Jared Manning et al.   ANTIOXIDANTS & REDOX SIGNALING

Ascorbic acid enhances the expression of type 1 and type 4 collagen and SVCT2 in cultured human skin fibroblasts

(2012) Yuki Kishimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Naringenin attenuates the release of pro-inflammatory mediators from lipopolysaccharide-stimulated BV2 microglia by inactivating nuclear factor-κB and inhibiting mitogen-activated protein kinases

(2012) Yung Hyun Choi   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Citrus Flavanones: What Is Their Role in Cardiovascular Protection?

(2012) Audrey Chanet et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Dietary Folic Acid Promotes Survival of Foxp3+ Regulatory T Cells in the Colon

(2012) M. Kinoshita et al.   JOURNAL OF IMMUNOLOGY

MR1 presents microbial vitamin B metabolites to MAIT cells

(2012) Lars Kjer-Nielsen et al.   NATURE

A Pivotal Role of Vitamin B9 in the Maintenance of Regulatory T Cells In Vitro and In Vivo

(2012) Jun Kunisawa et al.   PLoS One

Naringin ameliorates metabolic syndrome by activating AMP-activated protein kinase in mice fed a high-fat diet

(2011) Peng Pu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Flavonoids inhibit high glucose-induced up-regulation of ICAM-1 via the p38 MAPK pathway in human vein endothelial cells

(2011) Sung-Whan Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Up-regulation of PPARγ, heat shock protein-27 and -72 by naringin attenuates insulin resistance, β-cell dysfunction, hepatic steatosis and kidney damage in a rat model of type 2 diabetes

(2011) Ashok Kumar Sharma et al.   BRITISH JOURNAL OF NUTRITION

Dietary factors and low-grade inflammation in relation to overweight and obesity

(2011) Philip C. Calder et al.   BRITISH JOURNAL OF NUTRITION

Citrus Polyphenol Hesperidin Stimulates Production of Nitric Oxide in Endothelial Cells while Improving Endothelial Function and Reducing Inflammatory Markers in Patients with Metabolic Syndrome

(2011) Stefano Rizza et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Hesperidin Partially Restores Impaired Immune and Nutritional Function in Irradiated Mice

(2011) Yu-Rim Lee et al.   JOURNAL OF MEDICINAL FOOD

Naringin, the major grapefruit flavonoid, specifically affects atherosclerosis development in diet-induced hypercholesterolemia in mice

(2011) Audrey Chanet et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Hesperidin Displays Relevant Role in the Nutrigenomic Effect of Orange Juice on Blood Leukocytes in Human Volunteers: A Randomized Controlled Cross-Over Study

(2011) Dragan Milenkovic et al.   PLoS One

Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers

(2010) Christine Morand et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression

(2010) Husam Ghanim et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Reduction of common cold symptoms by encapsulated juice powder concentrate of fruits and vegetables: a randomised, double-blind, placebo-controlled trial

(2010) Stephanie Roll et al.   BRITISH JOURNAL OF NUTRITION

Absorption, conjugation and excretion of the flavanones, naringenin and hesperetin from α-rhamnosidase-treated orange juice in human subjects

(2010) Lea Bredsdorff et al.   BRITISH JOURNAL OF NUTRITION

Effects of hesperetin on the production of inflammatory mediators in IL-1β treated human synovial cells

(2010) Eun Mi Choi et al.   CELLULAR IMMUNOLOGY

Differential Effects of Cream, Glucose, and Orange Juice on Inflammation, Endotoxin, and the Expression of Toll-Like Receptor-4 and Suppressor of Cytokine Signaling-3

(2010) R. Deopurkar et al.   DIABETES CARE

Concentration and Solubility of Flavanones in Orange Beverages Affect Their Bioavailability in Humans

(2010) Fernando Vallejo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Blood Folate Status and Expression of Proteins Involved in Immune Function, Inflammation, and Coagulation: Biochemical and Proteomic Changes in the Plasma of Humans in Response to Long-Term Synthetic Folic Acid Supplementation

(2010) Susan J. Duthie et al.   JOURNAL OF PROTEOME RESEARCH

Inflammatory Disease Processes and Interactions with Nutrition

(2009) P. C. Calder et al.   BRITISH JOURNAL OF NUTRITION

Regulatory T cells: how do they suppress immune responses?

(2009) S. Sakaguchi et al.   INTERNATIONAL IMMUNOLOGY

In vivo vitamin C supplementation increases phosphoinositol transfer protein expression in peripheral blood mononuclear cells from healthy individuals

(2008) Helen R. Griffiths et al.   BRITISH JOURNAL OF NUTRITION

Absorption, metabolism and excretion of flavanones from single portions of orange fruit and juice and effects of anthropometric variables and contraceptive pill use on flavanone excretion

(2008) Gary M. Brett et al.   BRITISH JOURNAL OF NUTRITION

Orange juice is a good folate source in respect to folate content and stability during storage and simulated digestion

(2008) Veronica Öhrvik et al.   EUROPEAN JOURNAL OF NUTRITION

Gene expression profiling reveals new protective roles for vitamin C in human skin cells

(2008) T DUARTE et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hesperidin, hesperidin methyl chalone and phellopterin from Poncirus trifoliata (Rutaceae) differentially regulate the expression of adhesion molecules in tumor necrosis factor-α-stimulated human umbilical vein endothelial cells

(2008) Irina Tsoy Nizamutdinova et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Naringenin has anti-inflammatory properties in macrophage and ex vivo human whole-blood models

(2008) C. Bodet et al.   JOURNAL OF PERIODONTAL RESEARCH