Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type 1 Diabetes

Regulation of extracellular matrix assembly and structure by hybrid M1/M2 macrophages

(2021) Claire E. Witherel et al.   BIOMATERIALS

Oxygen-release microspheres capable of releasing oxygen in response to environmental oxygen level to improve stem cell survival and tissue regeneration in ischemic hindlimbs

(2021) Ya Guan et al.   JOURNAL OF CONTROLLED RELEASE

Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets

(2021) Michael P. Vincent et al.   Nature Communications

Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells

(2020) Nathaniel J. Hogrebe et al.   NATURE BIOTECHNOLOGY

Mesenchymal stem cell-derived exosomes protect beta cells against hypoxia-induced apoptosis via miR-21 by alleviating ER stress and inhibiting p38 MAPK phosphorylation

(2020) Jin Chen et al.   Stem Cell Research & Therapy

Therapeutic vascularization in regenerative medicine: Concise Review

(2020) Roberto Gianni‐Barrera et al.   Stem Cells Translational Medicine

Xiaozhang Tie Improves Intestinal Motility in Rats With Cirrhotic Ascites by Regulating the Stem Cell Factor/c-kit Pathway in Interstitial Cells of Cajal

(2020) Qiang Zhao et al.   Frontiers in Pharmacology

Stem Cell Therapy for Diabetes: Beta Cells versus Pancreatic Progenitors

(2020) Bushra Memon et al.   Cells

Generation of pancreatic β cells from CD177+ anterior definitive endoderm

(2020) Pallavi U. Mahaddalkar et al.   NATURE BIOTECHNOLOGY

Gene-edited human stem cell–derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice

(2020) Kristina G. Maxwell et al.   Science Translational Medicine

A retrievable implant for the long-term encapsulation and survival of therapeutic xenogeneic cells

(2020) Suman Bose et al.   Nature Biomedical Engineering

Therapeutic Resevoirs: Implantable Therapeutic Reservoir Systems for Diverse Clinical Applications in Large Animal Models (Adv. Healthcare Mater. 11/2020)

(2020) Garry P. Duffy et al.   Advanced Healthcare Materials

Immune-evasive human islet-like organoids ameliorate diabetes

(2020) Eiji Yoshihara et al.   NATURE

Single-Cell Transcriptome Profiling Reveals β Cell Maturation in Stem Cell-Derived Islets after Transplantation

(2020) Punn Augsornworawat et al.   Cell Reports

Single-Cell RNA-Seq Reveals that CD9 Is a Negative Marker of Glucose-Responsive Pancreatic β-like Cells Derived from Human Pluripotent Stem Cells

(2020) Xisheng Li et al.   Stem Cell Reports

A scalable device-less biomaterial approach for subcutaneous islet transplantation

(2020) Alexander E. Vlahos et al.   BIOMATERIALS

Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells

(2019) Leonardo Velazco-Cruz et al.   Stem Cell Reports

A Double Fail-Safe Approach to Prevent Tumorigenesis and Select Pancreatic β Cells from Human Embryonic Stem Cells

(2019) Mirza Muhammad Fahd Qadir et al.   Stem Cell Reports

Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells

(2019) Gopika G. Nair et al.   NATURE CELL BIOLOGY

Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients

(2019) Tobias Deuse et al.   NATURE BIOTECHNOLOGY

Biomaterials: Foreign Bodies or Tuners for the Immune Response?

(2019) Erminia Mariani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alginate‐microencapsulation of human stem cell–derived β cells with CXCL 12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression

(2019) David A. Alagpulinsa et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Engineering the Vasculature for Islet Transplantation

(2019) Daniel T. Bowers et al.   Acta Biomaterialia

Oxygenation strategies for encapsulated islet and beta cell transplants

(2019) Klearchos K. Papas et al.   ADVANCED DRUG DELIVERY REVIEWS

Charting cellular identity during human in vitro β-cell differentiation

(2019) Adrian Veres et al.   NATURE

Microporous scaffolds support assembly and differentiation of pancreatic progenitors into β-cell clusters

(2019) Richard L. Youngblood et al.   Acta Biomaterialia

Oxygen generating biomaterial improves the function and efficacy of beta cells within a macroencapsulation device

(2019) M.M. Coronel et al.   BIOMATERIALS

Long-term implant fibrosis prevention in rodents and non-human primates using crystallized drug formulations

(2019) Shady Farah et al.   NATURE MATERIALS

A hydrogel platform for in vitro three dimensional assembly of human stem cell-derived islet cells and endothelial cells

(2019) Punn Augsornworawat et al.   Acta Biomaterialia

An actuatable soft reservoir modulates host foreign body response

(2019) E. B. Dolan et al.   Science Robotics

Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases

(2019) Ankita Nandi et al.   Oxidative Medicine and Cellular Longevity

Conformal Coating of Stem Cell-Derived Islets for β Cell Replacement in Type 1 Diabetes

(2019) Aaron A. Stock et al.   Stem Cell Reports

Isoform-Specific Roles of ERK1 and ERK2 in Arteriogenesis

(2019) Nicolas Ricard et al.   Cells

Cell encapsulation: Overcoming barriers in cell transplantation in diabetes and beyond

(2018) Marco Farina et al.   ADVANCED DRUG DELIVERY REVIEWS

Transplantation of macroencapsulated human islets within the bioartificial pancreas βAir to patients with type 1 diabetes mellitus

(2018) Per-Ola Carlsson et al.   AMERICAN JOURNAL OF TRANSPLANTATION

3D heterogeneous islet organoid generation from human embryonic stem cells using a novel engineered hydrogel platform

(2018) Joseph Candiello et al.   BIOMATERIALS

An important step towards a prevascularized islet macroencapsulation device—effect of micropatterned membranes on development of endothelial cell network

(2018) Katarzyna Skrzypek et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Improvement of islet function and survival by integration of perfluorodecalin into microcapsules in vivo and in vitro

(2018) Sang-Ho Lee et al.   Journal of Tissue Engineering and Regenerative Medicine

The journey of islet cell transplantation and future development

(2018) Anissa Gamble et al.   Islets

Long-term viability and function of transplanted islets macroencapsulated at high density are achieved by enhanced oxygen supply

(2018) Yoav Evron et al.   Scientific Reports

Sustained release of targeted cardiac therapy with a replenishable implanted epicardial reservoir

(2018) William Whyte et al.   Nature Biomedical Engineering

The Effect of Reduced Self-Monitored Blood Glucose Testing After Adoption of Continuous Glucose Monitoring on Hemoglobin A1c and Time in RangeData reported previously in Price, DA, et al. (2017). Glycemic impact of reduced frequency of blood glucose monitoring with continuous glucose monitoring use. Diabetes 66(S1):A239.

(2018) Sarah Puhr et al.   Diabetes Technology & Therapeutics

Oxygen Perfusion (Persufflation) of Human Pancreata Enhances Insulin Secretion and Attenuates Islet Proinflammatory Signaling

(2018) Amy C. Kelly et al.   TRANSPLANTATION

Linking a cell-division gene and a suicide gene to define and improve cell therapy safety

(2018) Qin Liang et al.   NATURE

Glucose Monitoring in Individuals With Diabetes Using a Long-Term Implanted Sensor/Telemetry System and Model

(2017) Joseph Y. Lucisano et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Metabolomics Study of the Effects of Inflammation, Hypoxia, and High Glucose on Isolated Human Pancreatic Islets

(2017) Marta Garcia-Contreras et al.   JOURNAL OF PROTEOME RESEARCH

Laminin and collagen IV inclusion in immunoisolating microcapsules reduces cytokine-mediated cell death in human pancreatic islets

(2017) L. Alberto Llacua et al.   Journal of Tissue Engineering and Regenerative Medicine

Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations

(2017) Florian T. Merkle et al.   NATURE

Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates

(2017) Joshua C. Doloff et al.   NATURE MATERIALS

Oxygen environment and islet size are the primary limiting factors of isolated pancreatic islet survival

(2017) Hirotake Komatsu et al.   PLoS One

Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes

(2017) Barbara Ludwig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Real-time measurement of small molecules directly in awake, ambulatory animals

(2017) Netzahualcóyotl Arroyo-Currás et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2017 Military Supplement

(2017) Anirban Sen Gupta   SHOCK

2017 Military Supplement

(2017) Andres S. Benitez Cardenas et al.   SHOCK

Intraportal islet transplantation: the impact of the liver microenvironment

(2017) Vaihere Delaune et al.   TRANSPLANT INTERNATIONAL

ROCKII inhibition promotes the maturation of human pancreatic beta-like cells

(2017) Zaniar Ghazizadeh et al.   Nature Communications

Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors

(2017) Kathryn F. Cogger et al.   Nature Communications

Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant

(2017) Gaetano Faleo et al.   Stem Cell Reports

Prevascularization in tissue engineering: Current concepts and future directions

(2016) Matthias W. Laschke et al.   BIOTECHNOLOGY ADVANCES

Progress and challenges in macroencapsulation approaches for type 1 diabetes (T1D) treatment: Cells, biomaterials, and devices

(2016) Shang Song et al.   BIOTECHNOLOGY AND BIOENGINEERING

Effective endothelial cell and human pluripotent stem cell interactions generate functional insulin-producing beta cells

(2016) Dodanim Talavera-Adame et al.   DIABETOLOGIA

Extracellular matrix components supporting human islet function in alginate-based immunoprotective microcapsules for treatment of diabetes

(2016) Alberto Llacua et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates

(2016) Arturo J Vegas et al.   NATURE BIOTECHNOLOGY

Advances in islet encapsulation technologies

(2016) Tejal Desai et al.   NATURE REVIEWS DRUG DISCOVERY

Comparison of Perfluorodecalin and HEMOXCell as Oxygen Carriers for Islet Oxygenation in an In Vitro Model of Encapsulation

(2016) Aida Rodriguez-Brotons et al.   TISSUE ENGINEERING PART A

Generation of stem cell-derived β-cells from patients with type 1 diabetes

(2016) Jeffrey R. Millman et al.   Nature Communications

Encapsulation of Insulin-Secreting Cells Expressing a Genetically Encoded Fluorescent Calcium Indicator for Cell-Based Sensing In Vivo

(2016) Christophe Boss et al.   Advanced Healthcare Materials

Large-scale time series microscopy of neovessel growth during angiogenesis

(2015) Urs Utzinger et al.   ANGIOGENESIS

Development of an encapsulated stem cell-based therapy for diabetes

(2015) Alice Anna Tomei et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Prevention of foreign body reaction in a pre-clinical large animal model

(2015) Michail Kastellorizios et al.   JOURNAL OF CONTROLLED RELEASE

Multiple tissue response modifiers to promote angiogenesis and prevent the foreign body reaction around subcutaneous implants

(2015) Michail Kastellorizios et al.   JOURNAL OF CONTROLLED RELEASE

Human Islets Have Fewer Blood Vessels than Mouse Islets and the Density of Islet Vascular Structures Is Increased in Type 2 Diabetes

(2015) Marcela Brissova et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

A prevascularized subcutaneous device-less site for islet and cellular transplantation

(2015) Andrew R Pepper et al.   NATURE BIOTECHNOLOGY

Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates

(2015) Omid Veiseh et al.   NATURE MATERIALS

Endothelial Cells Mediate Islet-Specific Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitor Cells

(2015) Maria Jaramillo et al.   TISSUE ENGINEERING PART A

Diabetes Is Reversed in a Murine Model by Marginal Mass Syngeneic Islet Transplantation Using a Subcutaneous Cell Pouch Device

(2015) Andrew R. Pepper et al.   TRANSPLANTATION

Efficient Generation of NKX6-1+ Pancreatic Progenitors from Multiple Human Pluripotent Stem Cell Lines

(2015) M. Cristina Nostro et al.   Stem Cell Reports

cGMP-Manufactured Human Induced Pluripotent Stem Cells Are Available for Pre-clinical and Clinical Applications

(2015) Behnam Ahmadian Baghbaderani et al.   Stem Cell Reports

Oxygen supply to encapsulated therapeutic cells

(2014) Clark K. Colton   ADVANCED DRUG DELIVERY REVIEWS

Long-Term Allogeneic Islet Graft Survival in Prevascularized Subcutaneous Sites Without Immunosuppressive Treatment

(2014) N. M. Luan et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Macrophage polarization in response to ECM coated polypropylene mesh

(2014) Matthew T. Wolf et al.   BIOMATERIALS

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Membranes to achieve immunoprotection of transplanted islets

(2014) Julien Schweicher   Frontiers in Bioscience-Landmark

Enrichment of chitosan hydrogels with perfluorodecalin promotes gelation and stem cell vitality

(2014) Timothy E.L. Douglas et al.   MATERIALS LETTERS

Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells

(2014) Mitsutoshi Yamada et al.   NATURE

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Differentiated human stem cells resemble fetal, not adult, β cells

(2014) Sinisa Hrvatin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Compliant 3D Microenvironment Improves β-Cell Cluster Insulin Expression Through Mechanosensing and β-Catenin Signaling

(2014) Crystal E. Nyitray et al.   TISSUE ENGINEERING PART A

A novel multilayer immunoisolating encapsulation system overcoming protrusion of cells

(2014) Swapnil V. Bhujbal et al.   Scientific Reports

Encapsulated islets for diabetes therapy: History, current progress, and critical issues requiring solution

(2013) David W. Scharp et al.   ADVANCED DRUG DELIVERY REVIEWS

Porous Implants Modulate Healing and Induce Shifts in Local Macrophage Polarization in the Foreign Body Reaction

(2013) Eric M. Sussman et al.   ANNALS OF BIOMEDICAL ENGINEERING

The TheraCyte™ Device Protects against Islet Allograft Rejection in Immunized Hosts

(2013) Makiko Kumagai-Braesch et al.   CELL TRANSPLANTATION

Enhanced Oxygen Supply Improves Islet Viability in a New Bioartificial Pancreas

(2013) Uriel Barkai et al.   CELL TRANSPLANTATION

Human pluripotent stem cells: an emerging model in developmental biology

(2013) Z. Zhu et al.   DEVELOPMENT

How to make a functional  -cell

(2013) F. W. Pagliuca et al.   DEVELOPMENT

Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

(2013) Jennifer E. Bruin et al.   DIABETOLOGIA

Impairment of pancreatic β-cell function by chronic intermittent hypoxia

(2013) Ning Wang et al.   EXPERIMENTAL PHYSIOLOGY

Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies

(2013) Andrew S Lee et al.   NATURE MEDICINE

The Efficacy of an Immunoisolating Membrane System for Islet Xenotransplantation in Minipigs

(2013) Tova Neufeld et al.   PLoS One

Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo

(2013) Alireza Rezania et al.   STEM CELLS

Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist

(2012) B. Ludwig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage phenotype as a predictor of constructive remodeling following the implantation of biologically derived surgical mesh materials

(2011) Bryan N. Brown et al.   Acta Biomaterialia

Perfluorodecalin-enriched fibrin matrix for human islet culture

(2011) Elisa Maillard et al.   BIOMATERIALS

Perfluorocarbon Emulsions Prevent Hypoxia of Pancreatic β-Cells

(2011) E. Maillard et al.   CELL TRANSPLANTATION

Stage-specific signaling through TGF  family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells

(2011) M. C. Nostro et al.   DEVELOPMENT

Immune complement activation is attenuated by surface nanotopography

(2011) Mats Hulander et al.   International Journal of Nanomedicine

Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells

(2011) Xiaofang Xu et al.   MECHANISMS OF DEVELOPMENT

Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells

(2011) Olivia G Kelly et al.   NATURE BIOTECHNOLOGY

Oxygen-Generating Nanofiber Cell Scaffolds with Antimicrobial Properties

(2010) Junping Wang et al.   ACS Applied Materials & Interfaces

Mesenchymal stem cells protect islets from hypoxia/reoxygenation-induced injury

(2010) Yanrong Lu et al.   CELL BIOCHEMISTRY AND FUNCTION

High Vascular Density and Oxygenation of Pancreatic Islets Transplanted in Clusters into Striated Muscle

(2010) Johanna Svensson et al.   CELL TRANSPLANTATION

A Novel Device for Islet Transplantation Providing Immune Protection and Oxygen Supply

(2010) B. Ludwig et al.   HORMONE AND METABOLIC RESEARCH

The Effect of Surface Nanometre-Scale Morphology on Protein Adsorption

(2010) Pasquale Emanuele Scopelliti et al.   PLoS One

Proangiogenic scaffolds as functional templates for cardiac tissue engineering

(2010) L. R. Madden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Function of an Implanted Tissue Glucose Sensor for More than 1 Year in Animals

(2010) D. A. Gough et al.   Science Translational Medicine

Quantitative Assessment of Islets of Langerhans Encapsulated in Alginate

(2010) Amy S. Johnson et al.   TISSUE ENGINEERING PART C-METHODS

The Role of Perfluorocarbon in Organ Preservation

(2010) Sarah A. Hosgood et al.   TRANSPLANTATION

A New Oxygen Carrier for Improved Long-Term Storage of Human Pancreata Before Islet Isolation

(2010) Heide Brandhorst et al.   TRANSPLANTATION

Small Molecules Efficiently Direct Endodermal Differentiation of Mouse and Human Embryonic Stem Cells

(2009) Malgorzata Borowiak et al.   Cell Stem Cell

Extracellular Matrix in Pancreatic Islets: Relevance to Scaffold Design and Transplantation

(2009) John C. Stendahl et al.   CELL TRANSPLANTATION

Oxygen consumption and diffusion in assemblages of respiring spheres: Performance enhancement of a bioartificial pancreas

(2009) Amy S. Johnson et al.   CHEMICAL ENGINEERING SCIENCE

Are stem cells a cure for diabetes?

(2009) Michael D. McCall et al.   CLINICAL SCIENCE

Preimplantation of an Immunoprotective Device Can Lower the Curative Dose of Islets to That of Free Islet Transplantation—Studies in a Rodent Model

(2009) Anne K. Sörenby et al.   TRANSPLANTATION

Bone Marrow–Derived Mesenchymal Stem Cells Improve Islet Graft Function in Diabetic Rats

(2009) M. Figliuzzi et al.   TRANSPLANTATION PROCEEDINGS

Long-Term Survival of Nonhuman Primate Islets Implanted in an Omental Pouch on a Biodegradable Scaffold

(2008) D. M. Berman et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Oxygen generating scaffolds for enhancing engineered tissue survival

(2008) Se Heang Oh et al.   BIOMATERIALS

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY

Vascularization in tissue engineering

(2008) Jeroen Rouwkema et al.   TRENDS IN BIOTECHNOLOGY

Biomimetic materials for tissue engineering

(2007) Peter X. Ma   ADVANCED DRUG DELIVERY REVIEWS