Stem Cell Therapy for Diabetes: Beta Cells versus Pancreatic Progenitors

A Double Fail-Safe Approach to Prevent Tumorigenesis and Select Pancreatic β Cells from Human Embryonic Stem Cells

(2019) Mirza Muhammad Fahd Qadir et al.   Stem Cell Reports

Chemically defined conditions for long-term maintenance of pancreatic progenitors derived from human induced pluripotent stem cells

(2019) Shuhei Konagaya et al.   Scientific Reports

Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells

(2019) Gopika G. Nair et al.   NATURE CELL BIOLOGY

Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility

(2019) Huaigeng Xu et al.   Cell Stem Cell

Navigating Two Roads to Glucose Normalization in Diabetes: Automated Insulin Delivery Devices and Cell Therapy

(2019) Esther Latres et al.   Cell Metabolism

Charting cellular identity during human in vitro β-cell differentiation

(2019) Adrian Veres et al.   NATURE

Concise Review: Beta-Cell Dedifferentiation in Type 2 Diabetes

(2019) Shimon Efrat   STEM CELLS

Intact pancreatic islets and dispersed beta-cells both generate intracellular calcium oscillations but differ in their responsiveness to glucose

(2019) Rachel T. Scarl et al.   CELL CALCIUM

Decreased α-cell mass and early structural alterations of the exocrine pancreas in patients with type 1 diabetes: An analysis based on the nPOD repository

(2018) Fidéline Bonnet-Serrano et al.   PLoS One

Characterization and Differentiation of Sorted Human Fetal Pancreatic ALDHhi and ALDHhi/CD133+ Cells Toward Insulin-Expressing Cells

(2018) Amanda Oakie et al.   STEM CELLS AND DEVELOPMENT

Differentiation of human pluripotent stem cells into two distinct NKX6.1 populations of pancreatic progenitors

(2018) Idil I. Aigha et al.   Stem Cell Research & Therapy

Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6.1

(2018) Bushra Memon et al.   Stem Cell Research & Therapy

P2RY1/ALK3-Expressing Cells within the Adult Human Exocrine Pancreas Are BMP-7 Expandable and Exhibit Progenitor-like Characteristics

(2018) Mirza Muhammad Fahd Qadir et al.   Cell Reports

Functional Beta Cell Mass from Device-Encapsulated hESC-Derived Pancreatic Endoderm Achieving Metabolic Control

(2018) Thomas Robert et al.   Stem Cell Reports

Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential

(2018) Cindy J.M. Loomans et al.   Stem Cell Reports

Linking a cell-division gene and a suicide gene to define and improve cell therapy safety

(2018) Qin Liang et al.   NATURE

Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors

(2017) Kathryn F. Cogger et al.   Nature Communications

Efficient Generation of Glucose-Responsive Beta Cells from Isolated GP2 + Human Pancreatic Progenitors

(2017) Jacqueline Ameri et al.   Cell Reports

Reconstructing human pancreatic differentiation by mapping specific cell populations during development

(2017) Cyrille Ramond et al.   eLife

Long-Term Culture of Self-renewing Pancreatic Progenitors Derived from Human Pluripotent Stem Cells

(2017) Jamie Trott et al.   Stem Cell Reports

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

(2016) Natalie R. Johnston et al.   Cell Metabolism

Immunogenicity of human embryonic stem cell-derived beta cells

(2016) Cornelis R. van der Torren et al.   DIABETOLOGIA

Increased Frequency of Hormone Negative and Polyhormonal Endocrine Cells in Lean Individuals With Type 2 Diabetes

(2016) Abu Saleh Md Moin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Identification of proliferative and mature β-cells in the islets of Langerhans

(2016) Erik Bader et al.   NATURE

Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates

(2016) Arturo J Vegas et al.   NATURE BIOTECHNOLOGY

Impact of islet architecture on β-cell heterogeneity, plasticity and function

(2016) Sara S. Roscioni et al.   Nature Reviews Endocrinology

Anterior-Posterior Patterning of Definitive Endoderm Generated from Human Embryonic Stem Cells Depends on the Differential Signaling of Retinoic Acid, Wnt-, and BMP-Signaling

(2016) Claudia Davenport et al.   STEM CELLS

Escape Mutations, Ganciclovir Resistance, and Teratoma Formation in Human iPSCs Expressing an HSVtk Suicide Gene

(2016) Andriana G Kotini et al.   Molecular Therapy-Nucleic Acids

Multiple mechanisms determine the sensitivity of human-induced pluripotent stem cells to the inducible caspase-9 safety switch

(2016) Shigeki Yagyu et al.   Molecular Therapy-Methods & Clinical Development

Design of a Bioartificial Pancreas+

(2016) Emmanuel C. Opara et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Alginate Encapsulant Incorporating CXCL12 Supports Long-Term Allo- and Xenoislet Transplantation Without Systemic Immune Suppression

(2015) T. Chen et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Insulin secretion from beta cells within intact islets: Location matters

(2015) Oanh Hoang Do et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

(2015) H. A. Russ et al.   EMBO JOURNAL

Development of an encapsulated stem cell-based therapy for diabetes

(2015) Alice Anna Tomei et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

β-Cell-targeted blockage of PD1 and CTLA4 pathways prevents development of autoimmune diabetes and acute allogeneic islets rejection

(2015) M M El Khatib et al.   GENE THERAPY

An Inducible Caspase-9 Suicide Gene to Improve the Safety of Therapy Using Human Induced Pluripotent Stem Cells

(2015) Shigeki Yagyu et al.   MOLECULAR THERAPY

Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion

(2015) Talitha van der Meulen et al.   NATURE MEDICINE

Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate

(2015) Danielle L. Gomez et al.   PLoS One

Cell aggregation optimizes the differentiation of human ESCs and iPSCs into pancreatic bud-like progenitor cells

(2015) Taro Toyoda et al.   Stem Cell Research

Insulin-Producing Endocrine Cells Differentiated In Vitro From Human Embryonic Stem Cells Function in Macroencapsulation Devices In Vivo

(2015) Alan D. Agulnick et al.   Stem Cells Translational Medicine

Efficient Generation of NKX6-1+ Pancreatic Progenitors from Multiple Human Pluripotent Stem Cell Lines

(2015) M. Cristina Nostro et al.   Stem Cell Reports

Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes

(2015) Laura Marroqui et al.   EBioMedicine

Advances and challenges in the differentiation of pluripotent stem cells into pancreatic β cells

(2015) Essam M Abdelalim   World Journal of Stem Cells

Functional Proteomics Screen Enables Enrichment of Distinct Cell Types from Human Pancreatic Islets

(2015) Revital Sharivkin et al.   PLoS One

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Reprogramming of human pancreatic exocrine cells to β-like cells

(2014) M Lemper et al.   CELL DEATH AND DIFFERENTIATION

β-Cell Differentiation of Human Pancreatic Duct–Derived Cells After In Vitro Expansion

(2014) Elisa Corritore et al.   Cellular Reprogramming

Membranes to achieve immunoprotection of transplanted islets

(2014) Julien Schweicher   Frontiers in Bioscience-Landmark

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Differentiated human stem cells resemble fetal, not adult, β cells

(2014) Sinisa Hrvatin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human embryonic stem cell derived islet progenitors mature inside an encapsulation device without evidence of increased biomass or cell escape

(2014) Kaitlyn Kirk et al.   Stem Cell Research

Pluripotent Stem Cells as a Potential Tool for Disease Modelling and Cell Therapy in Diabetes

(2014) Essam M. Abdelalim et al.   Stem Cell Reviews and Reports

Pancreatic Stem Cells Remain Unresolved

(2014) Fang-Xu Jiang et al.   STEM CELLS AND DEVELOPMENT

Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin

(2014) Guisheng Zhou et al.   Frontiers in Physiology

Development of the Human Pancreas From Foregut to Endocrine Commitment

(2013) R. E. Jennings et al.   DIABETES

Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

(2013) Jennifer E. Bruin et al.   DIABETOLOGIA

Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells

(2013) Jennifer E. Bruin et al.   Stem Cell Research

Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo

(2013) Alireza Rezania et al.   STEM CELLS

Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells

(2013) Brandon L. Taylor et al.   Cell Reports

Reversible immortalization of Nestin-positive precursor cells from pancreas and differentiation into insulin-secreting cells

(2012) Pei Wei et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation

(2012) H. P. Shih et al.   DEVELOPMENT

Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

(2012) A. Rezania et al.   DIABETES

Paracrine Interactions Within Islets of Langerhans

(2012) Duk-Su Koh et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Stage-specific signaling through TGF  family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells

(2011) M. C. Nostro et al.   DEVELOPMENT

Pancreatic alpha cell mass in European subjects with type 2 diabetes

(2011) J. C. Henquin et al.   DIABETOLOGIA

Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas

(2011) M. J. Riedel et al.   DIABETOLOGIA

Gap junctions and other mechanisms of cell-cell communication regulate basal insulin secretion in the pancreatic islet

(2011) R. K. P. Benninger et al.   JOURNAL OF PHYSIOLOGY-LONDON

Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells

(2011) Xiaofang Xu et al.   MECHANISMS OF DEVELOPMENT

Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells

(2011) Olivia G Kelly et al.   NATURE BIOTECHNOLOGY

Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans

(2011) Rayner Rodriguez-Diaz et al.   NATURE MEDICINE

CD24: A Novel Surface Marker for PDX1-Positive Pancreatic Progenitors Derived from Human Embryonic Stem Cells

(2011) Wei Jiang et al.   STEM CELLS

Glucose-Dependent Insulinotropic Polypeptide Is Expressed in Pancreatic Islet α-Cells and Promotes Insulin Secretion

(2010) Yukihiro Fujita et al.   GASTROENTEROLOGY

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Direct effect of alginate purification on the survival of islets immobilized in alginate-based microcapsules

(2009) Geneviève Langlois et al.   Acta Biomaterialia

Oxygen: a master regulator of pancreatic development?

(2009) Christopher A. Fraker et al.   BIOLOGY OF THE CELL

Safety and Viability of Microencapsulated Human Islets Transplanted Into Diabetic Humans

(2009) B. E. Tuch et al.   DIABETES CARE

Cell-cell interactions in the endocrine pancreas

(2009) R. Jain et al.   DIABETES OBESITY & METABOLISM

Teratoma formation by human embryonic stem cells: Evaluation of essential parameters for future safety studies

(2009) Hannes Hentze et al.   Stem Cell Research

Human β-cell Precursors Mature Into Functional Insulin-producing Cells in an Immunoisolation Device: Implications for Diabetes Cell Therapies

(2009) Seung-Hee Lee et al.   TRANSPLANTATION

Insulin as a physiological modulator of glucagon secretion

(2008) Pritpal Bansal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Optimal implantation site for pancreatic islet transplantation

(2008) S. Merani et al.   BRITISH JOURNAL OF SURGERY

Insulin secretion from human beta cells is heterogeneous and dependent on cell-to-cell contacts

(2008) A. Wojtusciszyn et al.   DIABETOLOGIA

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY

Isolation of major pancreatic cell types and long-term culture-initiating cells using novel human surface markers

(2008) Craig Dorrell et al.   Stem Cell Research

Alginate Modification Improves Long-Term Survival and Function of Transplanted Encapsulated Islets

(2008) Aaron G. Mallett et al.   TISSUE ENGINEERING PART A

Clinical implications of a molecular genetic classification of monogenic β-cell diabetes

(2008) Rinki Murphy et al.   Nature clinical practice. Endocrinology & metabolism