Linking a cell-division gene and a suicide gene to define and improve cell therapy safety

Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration

(2017) Michiko Mandai et al.   NEW ENGLAND JOURNAL OF MEDICINE

Teratomas produced from human pluripotent stem cells xenografted into immunodeficient mice - a histopathology atlas

(2016) Ivan Damjanov et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Multiple mechanisms determine the sensitivity of human-induced pluripotent stem cells to the inducible caspase-9 safety switch

(2016) Shigeki Yagyu et al.   Molecular Therapy-Methods & Clinical Development

Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies

(2015) Steven D Schwartz et al.   LANCET

Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts

(2014) James J. H. Chong et al.   NATURE

An estimation of the number of cells in the human body

(2013) Eva Bianconi et al.   ANNALS OF HUMAN BIOLOGY

Directed Differentiation of Human Embryonic Stem Cells into Thymic Epithelial Progenitor-like Cells Reconstitutes the Thymic Microenvironment In Vivo

(2013) Xiaoning Sun et al.   Cell Stem Cell

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Safeguarding clinical translation of pluripotent stem cells with suicide genes

(2013) Weiqiang Li et al.   Organogenesis

Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration

(2012) M. K. Diril et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The in vitro survival of human monosomies and trisomies as embryonic stem cells

(2012) Juan Carlos Biancotti et al.   Stem Cell Research

Harnessing the potential of induced pluripotent stem cells for regenerative medicine

(2011) Sean M. Wu et al.   NATURE CELL BIOLOGY

Leptin Receptor Signaling Supports Cancer Cell Metabolism through Suppression of Mitochondrial Respiration in Vivo

(2010) Jiyoung Park et al.   AMERICAN JOURNAL OF PATHOLOGY

TK.007: A Novel, Codon-Optimized HSVtk(A168H) Mutant for Suicide Gene Therapy

(2010) Ellen Preuß et al.   HUMAN GENE THERAPY

Efficient Generation of Germ Line Transmitting Chimeras from C57BL/6N ES Cells by Aggregation with Outbred Host Embryos

(2010) Marina Gertsenstein et al.   PLoS One

Genetic substitution of Cdk1 by Cdk2 leads to embryonic lethality and loss of meiotic function of Cdk2

(2008) A. Satyanarayana et al.   DEVELOPMENT