Insulin Resistance Exacerbates Alzheimer Disease via Multiple Mechanisms

Broader Insights into Understanding Tumor Necrosis Factor and Neurodegenerative Disease Pathogenesis Infer New Therapeutic Approaches

(2021) Ian Albert Clark et al.   JOURNAL OF ALZHEIMERS DISEASE

Computer-Aided Drug Design of β-Secretase, γ-Secretase and Anti-Tau Inhibitors for the Discovery of Novel Alzheimer’s Therapeutics

(2020) Varnavas D. Mouchlis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Liraglutide Suppresses Tau Hyperphosphorylation, Amyloid Beta Accumulation through Regulating Neuronal Insulin Signaling and BACE-1 Activity

(2020) Salinee Jantrapirom et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

GSK3β is a key regulator of the ROS-dependent necrotic death induced by the quinone DMNQ

(2020) Sonia Ciotti et al.   Cell Death & Disease

Effect of Aβ oligomers on neuronal APP triggers a vicious cycle leading to the propagation of synaptic plasticity alterations to healthy neurons

(2020) Marta Rolland et al.   JOURNAL OF NEUROSCIENCE

Tumor Necrosis Factor (TNF) blocking agents are associated with lower risk for Alzheimer’s disease in patients with rheumatoid arthritis and psoriasis

(2020) Mengshi Zhou et al.   PLoS One

Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia

(2020) Suzanne Craft et al.   JAMA Neurology

Amyloid-β Immunotherapy for Alzheimer's Disease - Is It Now A Long Shot…?

(2019) Francesco Panza et al.   ANNALS OF NEUROLOGY

Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior

(2019) Marion Soto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear factor‐kappa β as a therapeutic target for Alzheimer's disease

(2019) Niraj Kumar Jha et al.   JOURNAL OF NEUROCHEMISTRY

Rosiglitazone has a neutral effect on the risk of dementia in type 2 diabetes patients

(2019) Chin-Hsiao Tseng   Aging-US

Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer’s disease: study protocol for a randomised controlled trial (ELAD study)

(2019) Grazia Daniela Femminella et al.   Trials

α-synuclein in the pathophysiology of Alzheimer’s disease

(2019) Daniel Twohig et al.   Molecular Neurodegeneration

Altered Insulin Signaling in Alzheimer’s Disease Brain – Special Emphasis on PI3K-Akt Pathway

(2019) Sami Gabbouj et al.   Frontiers in Neuroscience

Amyloid Beta Oligomers Target to Extracellular and Intracellular Neuronal Synaptic Proteins in Alzheimer's Disease

(2019) Yu Ding et al.   Frontiers in Neurology

Phosphorylation Signaling in APP Processing in Alzheimer’s Disease

(2019) Tao Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The cost of Alzheimer's disease in China and re-estimation of costs worldwide

(2018) Jianping Jia et al.   Alzheimers & Dementia

Time-response studies on development of cognitive deficits in an experimental model of insulin resistance

(2018) Anand Kamal Sachdeva et al.   CLINICAL NUTRITION

The cell biology of systemic insulin function

(2018) Victoria L. Tokarz et al.   JOURNAL OF CELL BIOLOGY

The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease

(2018) Andre F Batista et al.   JOURNAL OF PATHOLOGY

Insulin-degrading enzyme is not secreted from cultured cells

(2018) Eun Suk Song et al.   Scientific Reports

NSAID Exposure and Risk of Alzheimer's Disease: An Updated Meta-Analysis From Cohort Studies

(2018) Caixia Zhang et al.   Frontiers in Aging Neuroscience

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease

(2018) Fuyuki Kametani et al.   Frontiers in Neuroscience

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Therapeutic implications of how TNF links apolipoprotein E, phosphorylated tau, α-synuclein, amyloid-β and insulin resistance in neurodegenerative diseases

(2018) I A Clark et al.   BRITISH JOURNAL OF PHARMACOLOGY

Current progress on peroxisome proliferator-activated receptor gamma agonist as an emerging therapeutic approach for the treatment of Alzheimer's disease: An update

(2018) Mahmood Ahmad Khan et al.   Current Neuropharmacology

Metformin Use Associated with Reduced Risk of Dementia in Patients with Diabetes: A Systematic Review and Meta-Analysis

(2018) Jared M. Campbell et al.   JOURNAL OF ALZHEIMERS DISEASE

The effects of insulin on the inflammatory activity of BV2 microglia

(2018) Fiona Brabazon et al.   PLoS One

Evaluation of Metformin on Cognitive Improvement in Patients With Non-dementia Vascular Cognitive Impairment and Abnormal Glucose Metabolism

(2018) Yufeng Lin et al.   Frontiers in Aging Neuroscience

Questions concerning the role of amyloid-β in the definition, aetiology and diagnosis of Alzheimer’s disease

(2018) Gary P. Morris et al.   ACTA NEUROPATHOLOGICA

Racial and ethnic estimates of Alzheimer's disease and related dementias in the United States (2015–2060) in adults aged ≥65 years

(2018) Kevin A. Matthews et al.   Alzheimers & Dementia

The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer’s disease

(2018) Daniel Twohig et al.   Acta Neuropathologica Communications

Microglia in Alzheimer’s disease

(2017) Heela Sarlus et al.   JOURNAL OF CLINICAL INVESTIGATION

ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway

(2017) Yang Zhao et al.   Molecular Cancer

Insulin signaling: An opportunistic target to minify the risk of Alzheimer’s disease

(2017) Rohit Pardeshi et al.   PSYCHONEUROENDOCRINOLOGY

Metabolism-Centric Overview of the Pathogenesis of Alzheimer's Disease

(2017) Somang Kang et al.   YONSEI MEDICAL JOURNAL

Apolipoprotein E4 and Insulin Resistance Interact to Impair Cognition and Alter the Epigenome and Metabolome

(2017) Lance A. Johnson et al.   Scientific Reports

Alzheimer’s disease prevention: from risk factors to early intervention

(2017) Marta Crous-Bou et al.   Alzheimers Research & Therapy

Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer’s Disease

(2017) Roger J. Mullins et al.   Frontiers in Aging Neuroscience

The etiology of oxidative stress in insulin resistance

(2017) Samantha Hurrle et al.   Biomedical Journal

Effects of Insulin and Octreotide on Memory and Growth Hormone in Alzheimer's Disease

(2017) G. Stennis Watson et al.   JOURNAL OF ALZHEIMERS DISEASE

Insulin Levels are Decreased in the Cerebrospinal Fluid of Women with Prodomal Alzheimer's Disease

(2017) Francisco J. Gil-Bea et al.   JOURNAL OF ALZHEIMERS DISEASE

Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer’s disease?

(2016) Olga Pivovarova et al.   ANNALS OF MEDICINE

Microglial response to LPS increases in wild-type mice during aging but diminishes in an Alzheimer's mouse model: Implication of TLR4 signaling in disease progression

(2016) Michelle Go et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

c-Jun N-terminal Kinase (JNK) induces phosphorylation of amyloid precursor protein (APP) at Thr668, in okadaic acid-induced neurodegeneration

(2016) Ji-Hwan Ahn et al.   BMB Reports

Pioglitazone and exenatide enhance cognition and downregulate hippocampal beta amyloid oligomer and microglia expression in insulin-resistant rats

(2016) Enas S. Gad et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Primary and Secondary Prevention Trials in Alzheimer Disease: Looking Back, Moving Forward

(2016) David Hsu et al.   Current Alzheimer Research

Targeting Tumor Necrosis Factor Alpha for Alzheimer’s Disease

(2016) Boris Decourt et al.   Current Alzheimer Research

Insulin Resistance and Neurodegeneration: Progress Towards the Development of New Therapeutics for Alzheimer’s Disease

(2016) Suzanne M. de la Monte   DRUGS

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study

(2016) Vanita R. Aroda et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence?

(2016) Molly Stanley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Excess cerebral TNF causing glutamate excitotoxicity rationalizes treatment of neurodegenerative diseases and neurogenic pain by anti-TNF agents

(2016) Ian A. Clark et al.   Journal of Neuroinflammation

Hyperinsulinemia caused by dexamethasone treatment is associated with reduced insulin clearance and lower hepatic activity of insulin-degrading enzyme

(2016) André Otávio Peres Protzek et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus

(2016) Wei-Jen Tang   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models

(2016) Michael J. D. Daniels et al.   Nature Communications

Antioxidants and Dementia Risk: Consideration through a Cerebrovascular Perspective

(2016) Virginie Lam et al.   Nutrients

An Overview of Murine High Fat Diet as a Model for Type 2 Diabetes Mellitus

(2016) Ahlke Heydemann   Journal of Diabetes Research

Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood

(2016) Seung-Hwan Lee et al.   Molecular Metabolism

A specific RAGE-binding peptide biopanning from phage display random peptide library that ameliorates symptoms in amyloid β peptide-mediated neuronal disorder

(2015) Cuizan Cai et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Amyloid β: one of three danger-associated molecules that are secondary inducers of the proinflammatory cytokines that mediate Alzheimer's disease

(2015) I A Clark et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of PI3K/AKT/mTOR axis disrupts oxidative stress-mediated survival of melanoma cells

(2015) Heather G. Hambright et al.   Oncotarget

Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner

(2015) Sandeep K. Sharma et al.   Scientific Reports

Link between type 2 diabetes and Alzheimer’s disease: from epidemiology to mechanism and treatment

(2015) Xiaohua Li et al.   Clinical Interventions in Aging

Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers

(2014) Christiane Reitz et al.   BIOCHEMICAL PHARMACOLOGY

Targeting TNF: a therapeutic strategy for Alzheimer's disease

(2014) Xin Cheng et al.   DRUG DISCOVERY TODAY

Type 3 diabetes is sporadic Alzheimer׳s disease: Mini-review

(2014) Suzanne M. de la Monte   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Etanercept Reduces Neuroinflammation and Lethality in Mouse Model of Japanese Encephalitis

(2014) Jing Ye et al.   JOURNAL OF INFECTIOUS DISEASES

Insulin Receptor Signaling in Normal and Insulin-Resistant States

(2014) J. Boucher et al.   Cold Spring Harbor Perspectives in Biology

Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease

(2014) Gary P Morris et al.   Acta Neuropathologica Communications

Intranasal insulin therapy for cognitive impairment and neurodegeneration: current state of the art

(2013) Suzanne M de la Monte   Expert Opinion on Drug Delivery

Pioglitazone Improves Cognitive Function via Increasing Insulin Sensitivity and Strengthening Antioxidant Defense System in Fructose-Drinking Insulin Resistance Rats

(2013) Qing-Qing Yin et al.   PLoS One

Metformin, Other Antidiabetic Drugs, and Risk of Alzheimer's Disease: A Population-Based Case-Control Study

(2012) Patrick Imfeld et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Methylglyoxal Induces Tau Hyperphosphorylation via Promoting AGEs Formation

(2012) Xiao-Hong Li et al.   NEUROMOLECULAR MEDICINE

Antioxidant Therapies for Alzheimer's Disease

(2012) Ye Feng et al.   Oxidative Medicine and Cellular Longevity

Ablation of TNF-RI/RII Expression in Alzheimer's Disease Mice Leads to an Unexpected Enhancement of Pathology

(2011) Sara L. Montgomery et al.   AMERICAN JOURNAL OF PATHOLOGY

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Possible implications of insulin resistance and glucose metabolism in Alzheimer’s disease pathogenesis

(2011) Domenico Bosco et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

COGNITIVE IMPROVEMENT WITH INTRATHECAL ADMINISTRATION OF INFLIXIMAB IN A WOMAN WITH ALZHEIMER'S DISEASE

(2011) Jian-Quan Shi et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 activation

(2011) Xiao-Hong Li et al.   NEUROBIOLOGY OF AGING

Deletion of Insulin-Degrading Enzyme Elicits Antipodal, Age-Dependent Effects on Glucose and Insulin Tolerance

(2011) Samer O. Abdul-Hay et al.   PLoS One

Rosiglitazone Monotherapy in Mild-to-Moderate Alzheimer’s Disease: Results from a Randomized, Double-Blind, Placebo-Controlled Phase III Study

(2010) Michael Gold et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Oxidative stress, insulin signaling, and diabetes

(2010) Justin L. Rains et al.   FREE RADICAL BIOLOGY AND MEDICINE

Improvement of cognition, a potential benefit of anti-TNF therapy in elderly patients with rheumatoid arthritis

(2010) Yi-Ming Chen et al.   JOINT BONE SPINE

Comparable Sensitivity of Postmenopausal and Young Women to the Effects of Intranasal Insulin on Food Intake and Working Memory

(2010) Rosemarie Krug et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Review Article: Genetics of Alzheimer Disease

(2010) Lynn M. Bekris et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Therapeutic evaluation of etanercept in a model of traumatic brain injury

(2010) Chung-Ching Chio et al.   JOURNAL OF NEUROCHEMISTRY

LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice

(2010) Daniel C Lee et al.   Journal of Neuroinflammation

AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation

(2010) Michela Guglielmotto et al.   NEUROBIOLOGY OF AGING

Uncontrolled diabetes increases the risk of Alzheimer’s disease: a population-based cohort study

(2009) W. L. Xu et al.   DIABETOLOGIA

Molecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading Enzyme

(2009) Marika Manolopoulou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PIOGLITAZONE IMPROVED COGNITION IN A PILOT STUDY ON PATIENTS WITH ALZHEIMER'S DISEASE AND MILD COGNITIVE IMPAIRMENT WITH DIABETES MELLITUS

(2009) Haruo Hanyu et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer disease

(2009) Tomohiko Sato et al.   NEUROBIOLOGY OF AGING

JNK regulates APP cleavage and degradation in a model of Alzheimer's disease

(2009) Alessio Colombo et al.   NEUROBIOLOGY OF DISEASE

Inhaled insulin—Intrapulmonary, intranasal, and other routes of administration: Mechanisms of action

(2009) R.I. Henkin   NUTRITION

Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease

(2008) Wei-Qin Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease

(2008) Leah R Hanson et al.   BMC NEUROSCIENCE

Differential Sensitivity of Men and Women to Anorexigenic and Memory-Improving Effects of Intranasal Insulin

(2008) Christian Benedict et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

(2008) Jae Lee et al.   Journal of Neuroinflammation