Amyloid β: one of three danger-associated molecules that are secondary inducers of the proinflammatory cytokines that mediate Alzheimer's disease

The role of inflammation in age-related disease

(2016) T. Kevin Howcroft et al.   Aging-US

Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model

(2015) Gerhard Leinenga et al.   Science Translational Medicine

Serum high-mobility group box 1 protein correlates with cognitive decline after gastrointestinal surgery

(2014) G.-X. LIN et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

The nature, significance, and glucagon-like peptide-1 analog treatment of brain insulin resistance in Alzheimer's disease

(2014) Konrad Talbot et al.   Alzheimers & Dementia

Analysis of cerebrospinal fluid mitochondrial DNA levels in Alzheimer disease

(2014) Neal Sondheimer et al.   ANNALS OF NEUROLOGY

Heavy metals toxicity: effect of cadmium ions on amyloid beta protein 1–42. Possible implications for Alzheimer’s disease

(2014) Gabriella Notarachille et al.   BIOMETALS

Moving beyond anti-amyloid therapy for the prevention and treatment of Alzheimer’s disease

(2014) Michael A Castello et al.   BMC Neurology

Do Epigenetic Pathways Initiate Late Onset Alzheimer Disease (LOAD): Towards a New Paradigm

(2014) Syed Waseem Bihaqi et al.   Current Alzheimer Research

The distribution of DNA damage is defined by region-specific susceptibility to DNA damage formation rather than repair differences

(2014) Janne M. Strand et al.   DNA REPAIR

Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm-aging”

(2014) Marcello Pinti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Systemic Release of High Mobility Group Box 1 Protein during Severe Murine Influenza

(2014) L. M. Alleva et al.   JOURNAL OF IMMUNOLOGY

TLR Costimulation Causes Oxidative Stress with Unbalance of Proinflammatory and Anti-Inflammatory Cytokine Production

(2014) R. Lavieri et al.   JOURNAL OF IMMUNOLOGY

Inflammation-sleep interface in brain disease: TNF, insulin, orexin

(2014) Ian A Clark et al.   Journal of Neuroinflammation

The impact of single and pairwise Toll-like receptor activation on neuroinflammation and neurodegeneration

(2014) Karen Rosenberger et al.   Journal of Neuroinflammation

GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

(2014) Seonmi Jo et al.   NATURE MEDICINE

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Peripheral administration of an anti-TNF-α receptor fusion protein counteracts the amyloid induced elevation of hippocampal TNF-α levels and memory deficits in mice

(2014) E.R. Detrait et al.   NEUROCHEMISTRY INTERNATIONAL

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-term potentiation of glycinergic synapses triggered by interleukin 1 

(2014) A. M. Chirila et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of TNF-induced apoptosis reveals 550 My of functional conservation

(2014) Steven D. Quistad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exendin-4 promotes the membrane trafficking of the AMPA receptor GluR1 subunit and ADAM10 in the mouse neocortex

(2014) Nobuaki Ohtake et al.   REGULATORY PEPTIDES

Cerebrospinal Fluid Mitochondrial DNA

(2014) Thomas D. Walko et al.   SHOCK

Up-Regulation of miRNA-146a in Progressive, Age-Related Inflammatory Neurodegenerative Disorders of the Human CNS

(2014) Peter N. Alexandrov et al.   Frontiers in Neurology

Low cerebrospinal fluid concentration of mitochondrial DNA in preclinical Alzheimer disease

(2013) Petar Podlesniy et al.   ANNALS OF NEUROLOGY

Treatment implications of the altered cytokine-insulin axis in neurodegenerative disease

(2013) Ian A. Clark et al.   BIOCHEMICAL PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2013/14: Catalytic Receptors

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2013/14: Enzymes

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

(2013) Mychael V. Lourenco et al.   Cell Metabolism

Mercury biomarkers and DNA methylation among michigan dental professionals

(2013) Jaclyn M. Goodrich et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Learning and memory ... and the immune system

(2013) I. Marin et al.   LEARNING & MEMORY

Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease

(2013) Paula L. McClean et al.   NEUROPHARMACOLOGY

A preliminary study of the effects of ulinastatin on early postoperative cognition function in patients undergoing abdominal surgery

(2013) Xu Lili et al.   NEUROSCIENCE LETTERS

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Long-Term Treatment of Thalidomide Ameliorates Amyloid-Like Pathology through Inhibition of β-Secretase in a Mouse Model of Alzheimer’s Disease

(2013) Ping He et al.   PLoS One

S100A8 and S100A9 Induce Cytokine Expression and Regulate the NLRP3 Inflammasome via ROS-Dependent Activation of NF-κB1

(2013) Jean-Christophe Simard et al.   PLoS One

The role of APP and BACE1 trafficking in APP processing and amyloid-β generation

(2013) Xiaojie Zhang et al.   Alzheimers Research & Therapy

Open-heart surgery increases cerebrospinal fluid levels of Alzheimer-associated amyloid β

(2012) B. REINSFELT et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Perioperative inflammatory response and protein S-100β concentrations - relationship with post-operative cognitive dysfunction in elderly patients

(2012) Y-C. LI et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Cerebral β-amyloid deposition predicts HIV-associated neurocognitive disorders in APOE ε4 carriers

(2012) Virawudh Soontornniyomkij et al.   AIDS

Alzheimer's therapeutics: Continued clinical failures question the validity of the amyloid hypothesis—but what lies beyond?

(2012) Kevin Mullane et al.   BIOCHEMICAL PHARMACOLOGY

S100B is increased in Parkinson’s disease and ablation protects against MPTP-induced toxicity through the RAGE and TNF-α pathway

(2012) Kinnari Sathe et al.   BRAIN

At the extreme end of the psychoneuroimmunological spectrum: Delirium as a maladaptive sickness behaviour response

(2012) Colm Cunningham et al.   BRAIN BEHAVIOR AND IMMUNITY

Selective TNF Inhibition for Chronic Stroke and Traumatic Brain Injury

(2012) Edward Tobinick et al.   CNS DRUGS

Surgery Upregulates High Mobility Group Box-1 and Disrupts the Blood-Brain Barrier causing Cognitive Dysfunction in Aged Rats

(2012) Hui-Juan He et al.   CNS Neuroscience & Therapeutics

The Early Involvement of the Innate Immunity in the Pathogenesis of Lateonset Alzheimers Disease: Neuropathological, Epidemiological and Genetic Evidence

(2012) P. Eikelenboom et al.   Current Alzheimer Research

DNA methylation changes in whole blood is associated with exposure to the environmental contaminants, mercury, lead, cadmium and bisphenol A, in women undergoing ovarian stimulation for IVF

(2012) Courtney W. Hanna et al.   HUMAN REPRODUCTION

Changes in plasma and cerebrospinal fluid biomarkers in aged patients with early postoperative cognitive dysfunction following total hip-replacement surgery

(2012) Mu-Huo Ji et al.   Journal of Anesthesia

Alarmins: awaiting a clinical response

(2012) James K. Chan et al.   JOURNAL OF CLINICAL INVESTIGATION

Early intervention with a small molecule inhibitor for tumor nefosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer’s disease

(2012) S Prasad Gabbita et al.   Journal of Neuroinflammation

Tumor necrosis factor-α synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease

(2012) David Tweedie et al.   Journal of Neuroinflammation

Soluble  -Synuclein Is a Novel Modulator of Alzheimer's Disease Pathophysiology

(2012) M. E. Larson et al.   JOURNAL OF NEUROSCIENCE

HMGB1 in Development and Diseases of the Central Nervous System

(2012) Ping Fang et al.   MOLECULAR NEUROBIOLOGY

Regulation of Complement Factor H (CFH) by Multiple miRNAs in Alzheimer’s Disease (AD) Brain

(2012) Walter J. Lukiw et al.   MOLECULAR NEUROBIOLOGY

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

(2012) Sabrina M Lehmann et al.   NATURE NEUROSCIENCE

Genome-scale methylation analysis of Parkinson's disease patients' brains reveals DNA hypomethylation and increased mRNA expression of cytochrome P450 2E1

(2012) Oliver Kaut et al.   NEUROGENETICS

Severe Stroke Induces Long-Lasting Alterations of High-Mobility Group Box 1

(2012) Juliane Schulze et al.   STROKE

Post-Ischemic Inflammation in the Brain

(2012) Takashi Shichita et al.   Frontiers in Immunology

A mitochondrial etiology of Alzheimer and Parkinson disease

(2011) Pinar Coskun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

DNA methylation in neurodegenerative disorders: a missing link between genome and environment?

(2011) S Iraola-Guzmán et al.   CLINICAL GENETICS

High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and Receptor for Advanced Glycation End Products

(2011) Andréy Mazarati et al.   EXPERIMENTAL NEUROLOGY

α-Synuclein Sequesters Dnmt1 from the Nucleus

(2011) Paula Desplats et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis

(2011) Jie Zhao et al.   Journal of Neuroinflammation

The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease

(2011) P. L. McClean et al.   JOURNAL OF NEUROSCIENCE

Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is ‘too big to fail’

(2011) Rudy J Castellani et al.   JOURNAL OF PATHOLOGY

Beneficial Effects of Ethyl Pyruvate through Inhibiting High-Mobility Group Box 1 Expression and TLR4/NF-κB Pathway after Traumatic Brain Injury in the Rat

(2011) Xingfen Su et al.   MEDIATORS OF INFLAMMATION

Amyloid: Little proteins, big clues

(2011) Jim Schnabel   NATURE

Epigenetic mechanisms in Alzheimer's disease

(2011) Diego Mastroeni et al.   NEUROBIOLOGY OF AGING

Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory

(2010) Daniela Puzzo et al.   ANNALS OF NEUROLOGY

Association of Plasma Clusterin Concentration With Severity, Pathology, and Progression in Alzheimer Disease

(2010) Madhav Thambisetty et al.   ARCHIVES OF GENERAL PSYCHIATRY

Tumor necrosis factor-alpha regulates the Hypocretin system via mRNA degradation and ubiquitination

(2010) Shuqin Zhan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The value of serial plasma nuclear and mitochondrial DNA levels in patients with acute ischemic stroke

(2010) Nai-Wen Tsai et al.   CLINICA CHIMICA ACTA

Five-year Survival After Helicobacter pylori Eradication in Alzheimer Disease Patients

(2010) Jannis Kountouras et al.   Cognitive and Behavioral Neurology

Postoperative neurocognitive function and microembolus detection in patients undergoing neck dissection: a pilot study

(2010) Jörn Leiendecker et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways

(2010) Roser Gorina et al.   GLIA

Active Immunization with Amyloid-  1-42 Impairs Memory Performance through TLR2/4-Dependent Activation of the Innate Immune System

(2010) P. Vollmar et al.   JOURNAL OF IMMUNOLOGY

Insulin receptor signaling in the development of neuronal structure and function

(2010) Shu-Ling Chiu et al.   Neural Development

Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia

(2010) K. Hyakkoku et al.   NEUROSCIENCE

The roles of TNF in brain dysfunction and disease

(2010) Ian A. Clark et al.   PHARMACOLOGY & THERAPEUTICS

Tumor necrosis factor-  triggers a cytokine cascade yielding postoperative cognitive decline

(2010) N. Terrando et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MITOCHONDRIAL DNA IS RELEASED BY SHOCK AND ACTIVATES NEUTROPHILS VIA P38 MAP KINASE

(2010) Qin Zhang et al.   SHOCK

Long-term Consequences of Postoperative Cognitive Dysfunction

(2009) Jacob Steinmetz et al.   ANESTHESIOLOGY

Mercury Induces an Unopposed Inflammatory Response in Human Peripheral Blood Mononuclear Cells in Vitro

(2009) Renee M. Gardner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar A -Stimulated Microglial Activation

(2009) E. G. Reed-Geaghan et al.   JOURNAL OF NEUROSCIENCE

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

ROLE OF TOLL-LIKE RECEPTORS 2 AND 4, AND THE RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS IN HIGH-MOBILITY GROUP BOX 1-INDUCED INFLAMMATION IN VIVO

(2009) Marieke A.D. van Zoelen et al.   SHOCK

Tumor Necrosis Factor-α Potentiates Intraneuronal Ca2+Signaling via Regulation of the Inositol 1,4,5-Trisphosphate Receptor

(2008) Keigan M. Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Death after Spinal Cord Injury Is Exacerbated by Rapid TNF -Induced Trafficking of GluR2-Lacking AMPARs to the Plasma Membrane

(2008) A. R. Ferguson et al.   JOURNAL OF NEUROSCIENCE

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

New roles for insulin-like hormones in neuronal signalling and protection: New hopes for novel treatments of Alzheimer’s disease?

(2008) Christian Hölscher et al.   NEUROBIOLOGY OF AGING

Epigenetic changes in Alzheimer's disease: Decrements in DNA methylation

(2008) Diego Mastroeni et al.   NEUROBIOLOGY OF AGING

Insulin Receptor Signaling Regulates Synapse Number, Dendritic Plasticity, and Circuit Function In Vivo

(2008) Shu-Ling Chiu et al.   NEURON

Age-Specific Epigenetic Drift in Late-Onset Alzheimer's Disease

(2008) Sun-Chong Wang et al.   PLoS One

Tumor Necrosis Factor-α Modulates Survival, Proliferation, and Neuronal Differentiation in Neonatal Subventricular Zone Cell Cultures

(2008) Liliana Bernardino et al.   STEM CELLS