The Protein Toxins Ricin and Shiga Toxin as Tools to Explore Cellular Mechanisms of Internalization and Intracellular Transport

The Gb3-enriched CD59/flotillin plasma membrane domain regulates host cell invasion by Pseudomonas aeruginosa

(2021) Annette Brandel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Shiga Toxins: An Update on Host Factors and Biomedical Applications

(2021) Yang Liu et al.   Toxins

Unconventional endocytic mechanisms

(2021) Henri-François Renard et al.   CURRENT OPINION IN CELL BIOLOGY

Functional dissection of the retrograde Shiga toxin trafficking inhibitor Retro-2

(2020) Alison Forrester et al.   Nature Chemical Biology

An emerging focus on lipids in extracellular vesicles

(2020) Tore Skotland et al.   ADVANCED DRUG DELIVERY REVIEWS

The role of lipid species in membranes and cancer-related changes

(2020) Tore Skotland et al.   CANCER AND METASTASIS REVIEWS

Diacylglycerol kinase and phospholipase D inhibitors alter the cellular lipidome and endosomal sorting towards the Golgi apparatus

(2020) Anne Berit Dyve Lingelem et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Roles of endogenous ether lipids and associated PUFAs in the regulation of ion channels and their relevance for disease

(2020) Delphine Fontaine et al.   JOURNAL OF LIPID RESEARCH

Targeting the Early Endosome-to-Golgi Transport of Shiga Toxins as a Therapeutic Strategy

(2020) Danyang Li et al.   Toxins

Molecular mechanism of Fast Endophilin-Mediated Endocytosis

(2020) Alessandra Casamento et al.   BIOCHEMICAL JOURNAL

Recognising the signals for endosomal trafficking

(2020) Saroja Weeratunga et al.   CURRENT OPINION IN CELL BIOLOGY

Caveolae: Formation, dynamics, and function

(2020) Robert G. Parton et al.   CURRENT OPINION IN CELL BIOLOGY

Evolving models for assembling and shaping clathrin-coated pits

(2020) Zhiming Chen et al.   JOURNAL OF CELL BIOLOGY

Conserved Functions of Ether Lipids and Sphingolipids in the Early Secretory Pathway

(2020) Noemi Jiménez-Rojo et al.   CURRENT BIOLOGY

Targeting Receptors on Cancer Cells with Protein Toxins

(2020) Antonella Antignani et al.   Biomolecules

Caveolae: Mechanosensing and mechanotransduction devices linking membrane trafficking to mechanoadaptation

(2020) Miguel A. Del Pozo et al.   CURRENT OPINION IN CELL BIOLOGY

Auto-regulation of Secretory Flux by Sensing and Responding to the Folded Cargo Protein Load in the Endoplasmic Reticulum

(2019) Advait Subramanian et al.   CELL

On the road to unraveling the molecular functions of ether lipids

(2019) Noemi Jiménez‐Rojo et al.   FEBS LETTERS

The role of PS 18:0/18:1 in membrane function

(2019) Tore Skotland et al.   Nature Communications

Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling

(2019) Roberta Pascolutti et al.   Cell Reports

Intracellular Transport and Cytotoxicity of the Protein Toxin Ricin

(2019) Natalia Sowa-Rogozińska et al.   Toxins

Shiga Toxin Induces Lipid Compression: A Mechanism for Generating Membrane Curvature

(2019) Erik B. Watkins et al.   NANO LETTERS

Directing Traffic: Regulation of COPI Transport by Post-translational Modifications

(2019) Peter M. Luo et al.   Frontiers in Cell and Developmental Biology

Phosphatidylserine is critical for vesicle fission during clathrin‐mediated endocytosis

(2019) Kelly Varga et al.   JOURNAL OF NEUROCHEMISTRY

Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins

(2019) David W Morgens et al.   eLife

Lysophospholipids Facilitate COPII Vesicle Formation

(2018) Alejandro Melero et al.   CURRENT BIOLOGY

Mechanisms of cellular cholesterol compartmentalization: recent insights

(2018) Elina Ikonen   CURRENT OPINION IN CELL BIOLOGY

Clathrin-independent endocytosis: an increasing degree of complexity

(2018) Kirsten Sandvig et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Formation of COPI-coated vesicles at a glance

(2018) Eric C. Arakel et al.   JOURNAL OF CELL SCIENCE

Lipid-transfer proteins rectify inter-organelle flux and accurately deliver lipids at membrane contact sites

(2018) Kentaro Hanada   JOURNAL OF LIPID RESEARCH

Understanding the diversity of membrane lipid composition

(2018) Takeshi Harayama et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms of clathrin-mediated endocytosis

(2018) Marko Kaksonen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transverse distribution of plasma membrane bilayer cholesterol: Picking sides

(2018) Theodore L. Steck et al.   TRAFFIC

Small GTPases and BAR domain proteins regulate branched actin polymerisation for clathrin and dynamin-independent endocytosis

(2018) Mugdha Sathe et al.   Nature Communications

GM1 ganglioside-independent intoxication by Cholera toxin

(2018) Jakob Cervin et al.   PLoS Pathogens

Moxetumomab Pasudotox: First Global Approval

(2018) Sohita Dhillon   DRUGS

Colocalization of receptors for Shiga toxins with lipid rafts in primary human renal glomerular endothelial cells and influence of D-PDMP on synthesis and distribution of glycosphingolipid receptors

(2017) Nadine Legros et al.   GLYCOBIOLOGY

Lipids in exosomes: Current knowledge and the way forward

(2017) Tore Skotland et al.   PROGRESS IN LIPID RESEARCH

Exogenous lysophospholipids with large head groups perturb clathrin-mediated endocytosis

(2017) Ieva Ailte et al.   TRAFFIC

Structural and functional roles of ether lipids

(2017) John M. Dean et al.   Protein & Cell

Protection against Shiga Toxins

(2017) Simona Kavaliauskiene et al.   Toxins

Shiga Toxin—A Model for Glycolipid-Dependent and Lectin-Driven Endocytosis

(2017) Ludger Johannes   Toxins

The biophysical properties of ethanolamine plasmalogens revealed by atomistic molecular dynamics simulations

(2016) Tomasz Rog et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Interdigitation of long-chain sphingomyelin induces coupling of membrane leaflets in a cholesterol dependent manner

(2016) Tomasz Róg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

How We Read Oncologic FDG PET/CT

(2016) Michael S. Hofman et al.   CANCER IMAGING

Cellular effects of fluorodeoxyglucose: Global changes in the lipidome and alteration in intracellular transport

(2016) Simona Kavaliauskiene et al.   Oncotarget

The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport

(2016) Maria L. Torgersen et al.   Oncotarget

Addition of lysophospholipids with large head groups to cells inhibits Shiga toxin binding

(2016) Ieva Ailte et al.   Scientific Reports

Novel actions of 2-deoxy-D-glucose: protection against Shiga toxins and changes in cellular lipids

(2015) Simona Kavaliauskiene et al.   BIOCHEMICAL JOURNAL

Cross-linking of glycosphingolipids at the plasma membrane: consequences for intracellular signaling and traffic

(2015) Tove Irene Klokk et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lateral organization, bilayer asymmetry, and inter-leaflet coupling of biological membranes

(2015) Jonathan D. Nickels et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Asna1/TRC40 controls beta cell function and ER homeostasis by ensuring retrograde transport

(2015) Stefan Norlin et al.   DIABETES

Inhibition of Rab prenylation by statins induces cellular glycosphingolipid remodeling

(2015) Beth Binnington et al.   GLYCOBIOLOGY

Biosynthesis of GPI-anchored proteins: special emphasis on GPI lipid remodeling

(2015) Taroh Kinoshita et al.   JOURNAL OF LIPID RESEARCH

Cell-intrinsic adaptation of lipid composition to local crowding drives social behaviour

(2015) Mathieu Frechin et al.   NATURE

Fucosylation and protein glycosylation create functional receptors for cholera toxin

(2015) Amberlyn M Wands et al.   eLife

The ether lipid precursor hexadecylglycerol protects against Shiga toxins

(2014) Jonas Bergan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cholesterol, sphingolipids, and glycolipids: What do we know about their role in raft-like membranes?

(2014) Tomasz Róg et al.   CHEMISTRY AND PHYSICS OF LIPIDS

The Ether Lipid Precursor Hexadecylglycerol Stimulates the Release and Changes the Composition of Exosomes Derived from PC-3 Cells

(2014) Santosh Phuyal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid requirements for entry of protein toxins into cells

(2014) Kirsten Sandvig et al.   PROGRESS IN LIPID RESEARCH

Specificity and Commonality of the Phosphoinositide-Binding Proteome Analyzed by Quantitative Mass Spectrometry

(2014) Stephanie Jungmichel et al.   Cell Reports

Endocytic Crosstalk: Cavins, Caveolins, and Caveolae Regulate Clathrin-Independent Endocytosis

(2014) Natasha Chaudhary et al.   PLOS BIOLOGY

Ceramide synthases as potential targets for therapeutic intervention in human diseases

(2013) Joo-Won Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility

(2013) Michael C. Bassik et al.   CELL

Cell density-induced changes in lipid composition and intracellular trafficking

(2013) Simona Kavaliauskiene et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Retrograde transport of protein toxins through the Golgi apparatus

(2013) Kirsten Sandvig et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Shiga toxin–binding site for host cell receptor GPP130 reveals unexpected divergence in toxin-trafficking mechanisms

(2013) Somshuvra Mukhopadhyay et al.   MOLECULAR BIOLOGY OF THE CELL

The Ether Lipid Precursor Hexadecylglycerol Causes Major Changes in the Lipidome of HEp-2 Cells

(2013) Jonas Bergan et al.   PLoS One

Functions of plasmalogen lipids in health and disease

(2012) Nancy E. Braverman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain

(2012) F.-Xabier Contreras et al.   NATURE

Manganese Blocks Intracellular Trafficking of Shiga Toxin and Protects Against Shiga Toxicosis

(2012) S. Mukhopadhyay et al.   SCIENCE

Shiga toxins

(2012) Jonas Bergan et al.   TOXICON

Retromer Guides STxB and CD8-M6PR from Early to Recycling Endosomes, EHD1 Guides STxB from Recycling Endosome to Golgi

(2012) Jenna E. McKenzie et al.   TRAFFIC

Cholesterol modulates cell signaling and protein networking by specifically interacting with PDZ domain-containing scaffold proteins

(2012) Ren Sheng et al.   Nature Communications

High throughput quantitative molecular lipidomics

(2011) Hye R. Jung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics

(2011) Alfred H. Merrill   CHEMICAL REVIEWS

Plasmalogens the neglected regulatory and scavenging lipid species

(2011) Stefan Wallner et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Genome-Wide RNAi Screens Identify Genes Required for Ricin and PE Intoxications

(2011) Dimitri Moreau et al.   DEVELOPMENTAL CELL

Actin dynamics counteract membrane tension during clathrin-mediated endocytosis

(2011) Steeve Boulant et al.   NATURE CELL BIOLOGY

Cholesterol modulates glycolipid conformation and receptor activity

(2011) Daniel Lingwood et al.   Nature Chemical Biology

Inhibition of Retrograde Transport Protects Mice from Lethal Ricin Challenge

(2010) Bahne Stechmann et al.   CELL

Identification of different itineraries and retromer components for endosome-to-Golgi transport of TGN38 and Shiga toxin

(2010) Zi Zhao Lieu et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Co-regulation of Caveolar and Cdc42-dependent Fluid Phase Endocytosis by Phosphocaveolin-1

(2010) Zhi-Jie Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Revisiting caveolin trafficking: the end of the caveosome: Figure 1.

(2010) Robert G. Parton et al.   JOURNAL OF CELL BIOLOGY

Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradation

(2010) Arnold Hayer et al.   JOURNAL OF CELL BIOLOGY

FIP1/RCP Binding to Golgin-97 Regulates Retrograde Transport from Recycling Endosomes to the trans-Golgi Network

(2010) Jian Jing et al.   MOLECULAR BIOLOGY OF THE CELL

Lipidomics: coming to grips with lipid diversity

(2010) Andrej Shevchenko et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

How Cholesterol Constrains Glycolipid Conformation for Optimal Recognition of Alzheimer's β Amyloid Peptide (Aβ1-40)

(2010) Nouara Yahi et al.   PLoS One

Shiga Toxin Increases Formation of Clathrin-Coated Pits through Syk Kinase

(2010) Audrun Utskarpen et al.   PLoS One

Shiga toxin and its use in targeted cancer therapy and imaging

(2010) Nikolai Engedal et al.   Microbial Biotechnology

New aspects of the regulation of glycosphingolipid receptor function

(2009) Clifford A. Lingwood et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Cross-Linking of GM1 Ganglioside by Galectin-1 Mediates Regulatory T Cell Activity Involving TRPC5 Channel Activation: Possible Role in Suppressing Experimental Autoimmune Encephalomyelitis

(2009) J. Wang et al.   JOURNAL OF IMMUNOLOGY

Population context determines cell-to-cell variability in endocytosis and virus infection

(2009) Berend Snijder et al.   NATURE

Shiga toxins — from cell biology to biomedical applications

(2009) Ludger Johannes et al.   NATURE REVIEWS MICROBIOLOGY

Glycosphingolipid Requirements for Endosome-to-Golgi Transport of Shiga Toxin

(2009) Hilde Raa et al.   TRAFFIC

Cellular Trafficking of Quantum Dot-Ligand Bioconjugates and Their Induction of Changes in Normal Routing of Unconjugated Ligands

(2008) Christina Tekle et al.   NANO LETTERS

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Mitogen-activated Protein Kinase p38 Links Shiga Toxin-dependent Signaling and Trafficking

(2007) Sébastien Wälchli et al.   MOLECULAR BIOLOGY OF THE CELL