Caveolae: Mechanosensing and mechanotransduction devices linking membrane trafficking to mechanoadaptation

The role of membrane-shaping BAR domain proteins in caveolar invagination: from mechanistic insights to pathophysiological consequences

(2020) Michael M. Kessels et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The caveolar-mitochondrial interface: regulation of cellular metabolism in physiology and pathophysiology

(2020) Cerrone R. Foster et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Caveolae and lipid sorting: Shaping the cellular response to stress

(2020) Robert G. Parton et al.   JOURNAL OF CELL BIOLOGY

Caveolae in CNS arterioles mediate neurovascular coupling

(2020) Brian W. Chow et al.   NATURE

Membrane tension buffering by caveolae: a role in cancer?

(2020) Vibha Singh et al.   CANCER AND METASTASIS REVIEWS

Non-caveolar caveolins – duties outside the caves

(2020) Albert Pol et al.   JOURNAL OF CELL SCIENCE

Sphingomyelin Effects in Caveolin-1 Mediated Membrane Curvature

(2020) Anjali Krishna et al.   JOURNAL OF PHYSICAL CHEMISTRY B

EphB1 interaction with caveolin-1 in endothelial cells modulates caveolae biogenesis

(2020) Chinnaswamy Tiruppathi et al.   MOLECULAR BIOLOGY OF THE CELL

EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake

(2020) Claudia Matthaeus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid accumulation controls the balance between surface connection and scission of caveolae

(2020) Madlen Hubert et al.   eLife

Cav-1 (Caveolin-1) Deficiency Increases Autophagy in the Endothelium and Attenuates Vascular Inflammation and Atherosclerosis

(2020) Xinbo Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Caveolae: Formation, dynamics, and function

(2020) Robert G. Parton et al.   CURRENT OPINION IN CELL BIOLOGY

Caveolae Control Contractile Tension for Epithelia to Eliminate Tumor Cells

(2020) Jessica L. Teo et al.   DEVELOPMENTAL CELL

Stromal CAVIN1 Controls Prostate Cancer Microenvironment and Metastasis by Modulating Lipid Distribution and Inflammatory Signaling

(2020) Jin-Yih Low et al.   MOLECULAR CANCER RESEARCH

Coupling of melanocyte signaling and mechanics by caveolae is required for human skin pigmentation

(2020) Lia Domingues et al.   Nature Communications

ECM deposition is driven by caveolin-1–dependent regulation of exosomal biogenesis and cargo sorting

(2020) Lucas Albacete-Albacete et al.   JOURNAL OF CELL BIOLOGY

Caveolin1 and YAP drive mechanically induced mesothelial to mesenchymal transition and fibrosis

(2020) Raffaele Strippoli et al.   Cell Death & Disease

Membrane Curvature and Tension Control the Formation and Collapse of Caveolar Superstructures

(2019) Gonen Golani et al.   DEVELOPMENTAL CELL

Caveolin-1α regulates primary cilium length by controlling RhoA GTPase activity

(2019) Laura Rangel et al.   Scientific Reports

Stimulation of Caveolin-1 Signaling Improves Arteriovenous Fistula Patency

(2019) Takuya Hashimoto et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Caveolin-1 Regulates Atherogenesis by Attenuating Low-Density Lipoprotein Transcytosis and Vascular Inflammation Independently of Endothelial Nitric Oxide Synthase Activation

(2019) Cristina M. Ramírez et al.   CIRCULATION

The plasma membrane as a mechanochemical transducer

(2019) Anabel-Lise Le Roux et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells

(2019) Melissa Dewulf et al.   Nature Communications

Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis

(2019) Kerrie-Ann McMahon et al.   Nature Communications

Super-resolution modularity analysis shows polyhedral caveolin-1 oligomers combine to form scaffolds and caveolae

(2019) Ismail M. Khater et al.   Scientific Reports

Caveolin-1 Endows Order in Cholesterol-Rich Detergent Resistant Membranes

(2019) Raggi et al.   Biomolecules

Caveolae: The FAQs

(2019) Robert G. Parton et al.   TRAFFIC

Ascidian caveolin induces membrane curvature and protects tissue integrity and morphology during embryogenesis

(2019) Punit Bhattachan et al.   FASEB JOURNAL

Endothelial EphB4 maintains vascular integrity and transport function in adult heart

(2019) Guillermo Luxán et al.   eLife

Caveolin-1 dictates ferroptosis in the execution of acute immune-mediated hepatic damage by attenuating nitrogen stress

(2019) Guanghui Deng et al.   FREE RADICAL BIOLOGY AND MEDICINE

An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation

(2019) Asier Echarri et al.   Nature Communications

Modulation of caveolae by insulin/IGF‐1 signaling regulates aging of Caenorhabditis elegans

(2018) Noa Roitenberg et al.   EMBO REPORTS

The Hippo Pathway: Biology and Pathophysiology

(2018) Shenghong Ma et al.   Annual Review of Biochemistry

Interplay between Membrane Curvature and Cholesterol: Role of Palmitoylated Caveolin-1

(2018) Anjali Krishna et al.   BIOPHYSICAL JOURNAL

The Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae

(2018) Valentina Rausch et al.   CURRENT BIOLOGY

EHD2 is a mechanotransducer connecting caveolae dynamics with gene transcription

(2018) Stéphanie Torrino et al.   JOURNAL OF CELL BIOLOGY

Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells

(2018) Joseph Jose Thottacherry et al.   Nature Communications

Caveolin-1 Modulates Mechanotransduction Responses to Substrate Stiffness through Actin-Dependent Control of YAP

(2018) Roberto Moreno-Vicente et al.   Cell Reports

Phosphatidylserine dictates the assembly and dynamics of caveolae in the plasma membrane

(2017) Takashi Hirama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis

(2017) Benjamin J. Andreone et al.   NEURON

InducibleFgf13ablation enhances caveolae-mediated cardioprotection during cardiac pressure overload

(2017) Eric Q. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caveolin1 Is Required for Th1 Cell Infiltration, but Not Tight Junction Remodeling, at the Blood-Brain Barrier in Autoimmune Neuroinflammation

(2017) Sarah E. Lutz et al.   Cell Reports

Deciphering caveolar functions by syndapin III KO-mediated impairment of caveolar invagination

(2017) Eric Seemann et al.   eLife

Src-dependent phosphorylation of caveolin-1 Tyr-14 promotes swelling and release of caveolae

(2016) Adriana M. Zimnicka et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanisms of ephrin–Eph signalling in development, physiology and disease

(2016) Artur Kania et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells

(2016) Jan R. Kraehling et al.   Nature Communications

PTRF/Cavin-1 promotes efficient ribosomal RNA transcription in response to metabolic challenges

(2016) Libin Liu et al.   eLife

Critical role of CAV1/caveolin-1 in cell stress responses in human breast cancer cells via modulation of lysosomal function and autophagy

(2015) Yin Shi et al.   Autophagy

Caveolin-1 deficiency induces a MEK-ERK1/2-Snail-1-dependent epithelial-mesenchymal transition and fibrosis during peritoneal dialysis

(2015) R. Strippoli et al.   EMBO Molecular Medicine

Caveolae protect endothelial cells from membrane rupture during increased cardiac output

(2015) Jade P.X. Cheng et al.   JOURNAL OF CELL BIOLOGY

The caveolin–cavin system plays a conserved and critical role in mechanoprotection of skeletal muscle

(2015) Harriet P. Lo et al.   JOURNAL OF CELL BIOLOGY

Phosphorylation of PACSIN2 by protein kinase C triggers the removal of caveolae from the plasma membrane

(2015) Y. Senju et al.   JOURNAL OF CELL SCIENCE

Caveolae - mechanosensitive membrane invaginations linked to actin filaments

(2015) A. Echarri et al.   JOURNAL OF CELL SCIENCE

Cavin family proteins and the assembly of caveolae

(2015) O. Kovtun et al.   JOURNAL OF CELL SCIENCE

Feedback regulation between plasma membrane tension and membrane-bending proteins organizes cell polarity during leading edge formation

(2015) Kazuya Tsujita et al.   NATURE CELL BIOLOGY

Membrane tension controls the assembly of curvature-generating proteins

(2015) Mijo Simunovic et al.   Nature Communications

Dynamic caveolae exclude bulk membrane proteins and are required for sorting of excess glycosphingolipids

(2015) Elena Shvets et al.   Nature Communications

Caveolae regulate the nanoscale organization of the plasma membrane to remotely control Ras signaling

(2014) Nicholas Ariotti et al.   JOURNAL OF CELL BIOLOGY

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

Appreciating force and shape — the rise of mechanotransduction in cell biology

(2014) Thomas Iskratsch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dynamic Shaping of Cellular Membranes by Phospholipids and Membrane-Deforming Proteins

(2014) Shiro Suetsugu et al.   PHYSIOLOGICAL REVIEWS

Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae

(2014) Yann Gambin et al.   eLife

Caveolae as plasma membrane sensors, protectors and organizers

(2013) Robert G. Parton et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of Phosphatidylinositol 4,5-Bisphosphate in Regulating EHD2 Plasma Membrane Localization

(2013) Laura C. Simone et al.   PLoS One

EHD2 shuttles to the nucleus and represses transcription

(2012) Olga Pekar et al.   BIOCHEMICAL JOURNAL

Constitutive Formation of Caveolae in a Bacterium

(2012) Piers J. Walser et al.   CELL

Caveolae

(2012) Asier Echarri et al.   CURRENT BIOLOGY

Caveolar domain organization and trafficking is regulated by Abl kinases and mDia1

(2012) Asier Echarri et al.   JOURNAL OF CELL SCIENCE

EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization

(2012) Björn Morén et al.   MOLECULAR BIOLOGY OF THE CELL

Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae

(2011) Bidisha Sinha et al.   CELL

Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis

(2011) Jacky G. Goetz et al.   CELL

Signaling from the Living Plasma Membrane

(2011) Hernán E. Grecco et al.   CELL

Caveolin-1 Deficiency Causes Cholesterol-Dependent Mitochondrial Dysfunction and Apoptotic Susceptibility

(2011) Marta Bosch et al.   CURRENT BIOLOGY

High-resolution mapping reveals topologically distinct cellular pools of phosphatidylserine

(2011) Gregory D. Fairn et al.   JOURNAL OF CELL BIOLOGY

SDPR induces membrane curvature and functions in the formation of caveolae

(2009) Carsten G. Hansen et al.   NATURE CELL BIOLOGY

Caveolae Act as Membrane Reserves Which Limit Mechanosensitive ICl,swell Channel Activation during Swelling in the Rat Ventricular Myocyte

(2009) Lukasz Kozera et al.   PLoS One

A distinct pool of phosphatidylinositol 4,5-bisphosphate in caveolae revealed by a nanoscale labeling technique

(2009) A. Fujita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PTRF-Cavin, a Conserved Cytoplasmic Protein Required for Caveola Formation and Function

(2008) Michelle M. Hill et al.   CELL

Deletion of Cavin/PTRF Causes Global Loss of Caveolae, Dyslipidemia, and Glucose Intolerance

(2008) Libin Liu et al.   Cell Metabolism