Protection against Shiga Toxins

Management and monitoring recommendations for the use of eliglustat in adults with type 1 Gaucher disease in Europe

(2017) Nadia Belmatoug et al.   European Journal of Internal Medicine

Time to use a dose of Chloroquine as an adjuvant to anti-cancer chemotherapies

(2016) Steve Pascolo   EUROPEAN JOURNAL OF PHARMACOLOGY

Statin Use for the Primary Prevention of Cardiovascular Disease in Adults

(2016) et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Determining the Turnover of Glycosphingolipid Species by Stable-Isotope Tracer Lipidomics

(2016) Tore Skotland et al.   JOURNAL OF MOLECULAR BIOLOGY

Cellular effects of fluorodeoxyglucose: Global changes in the lipidome and alteration in intracellular transport

(2016) Simona Kavaliauskiene et al.   Oncotarget

Shiga Toxins as Multi-Functional Proteins: Induction of Host Cellular Stress Responses, Role in Pathogenesis and Therapeutic Applications

(2016) Moo-Seung Lee et al.   Toxins

Retrograde Trafficking Inhibitor of Shiga Toxins Reduces Morbidity and Mortality of Mice Infected with Enterohemorrhagic Escherichia coli

(2015) T. Secher et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel actions of 2-deoxy-D-glucose: protection against Shiga toxins and changes in cellular lipids

(2015) Simona Kavaliauskiene et al.   BIOCHEMICAL JOURNAL

Cross-linking of glycosphingolipids at the plasma membrane: consequences for intracellular signaling and traffic

(2015) Tove Irene Klokk et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Novel Furin Inhibitors with Potent Anti-infectious Activity

(2015) Kornelia Hardes et al.   ChemMedChem

Protective Efficacy and Pharmacokinetics of Human/Mouse Chimeric Anti-Stx1 and Anti-Stx2 Antibodies in Mice

(2015) Angela R. Melton-Celsa et al.   Clinical and Vaccine Immunology

Inhibition of Rab prenylation by statins induces cellular glycosphingolipid remodeling

(2015) Beth Binnington et al.   GLYCOBIOLOGY

Antibiotic treatment of verocytotoxin-producingEscherichia coli(VTEC) infection: a systematic review and a proposal

(2015) Morten Agger et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Chloroquine analogues in drug discovery: new directions of uses, mechanisms of actions and toxic manifestations from malaria to multifarious diseases

(2015) M. A. A. Al-Bari   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A Conserved Structural Motif Mediates Retrograde Trafficking of Shiga Toxin Types 1 and 2

(2015) Andrey S. Selyunin et al.   TRAFFIC

The effect of statins on cancer cells—review

(2015) Lucyna Matusewicz et al.   TUMOR BIOLOGY

Different roles of the C-terminal end of Stx1A and Stx2A for AB5complex integrity and retrograde transport of Stx in HeLa cells

(2015) Linn Kymre et al.   Pathogens and Disease

Structural optimization of a retrograde trafficking inhibitor that protects cells from infections by human polyoma- and papillomaviruses

(2014) Daniel W. Carney et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The ether lipid precursor hexadecylglycerol protects against Shiga toxins

(2014) Jonas Bergan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Eliglustat: First Global Approval

(2014) Raewyn M. Poole   DRUGS

Manganese induces oligomerization to promote down-regulation of the intracellular trafficking receptor used by Shiga toxin

(2014) Ritika Tewari et al.   MOLECULAR BIOLOGY OF THE CELL

Lipid requirements for entry of protein toxins into cells

(2014) Kirsten Sandvig et al.   PROGRESS IN LIPID RESEARCH

Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKKβ leading to autophagy

(2013) Haibin Xi et al.   BIOCHEMICAL PHARMACOLOGY

Comparative Analysis of the Expression Patterns of UPR-Target Genes Caused by UPR-Inducing Compounds

(2013) Satoko SHINJO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Cell density-induced changes in lipid composition and intracellular trafficking

(2013) Simona Kavaliauskiene et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Statins in Heart Failure

(2013) Michele Correale et al.   Current Vascular Pharmacology

N-Methyldihydroquinazolinone Derivatives of Retro-2 with Enhanced Efficacy against Shiga Toxin

(2013) Romain Noel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Shiga toxin–binding site for host cell receptor GPP130 reveals unexpected divergence in toxin-trafficking mechanisms

(2013) Somshuvra Mukhopadhyay et al.   MOLECULAR BIOLOGY OF THE CELL

The Ether Lipid Precursor Hexadecylglycerol Causes Major Changes in the Lipidome of HEp-2 Cells

(2013) Jonas Bergan et al.   PLoS One

Failure of Manganese to Protect from Shiga Toxin

(2013) Marsha A. Gaston et al.   PLoS One

Action of Shiga Toxin Type-2 and Subtilase Cytotoxin on Human Microvascular Endothelial Cells

(2013) María M. Amaral et al.   PLoS One

(S)-N-Methyldihydroquinazolinones are the Active Enantiomers of Retro-2 Derived Compounds against Toxins

(2013) Neetu Gupta et al.   ACS Medicinal Chemistry Letters

A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors

(2012) Luis E. Raez et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Highly Potent Inhibitors of Proprotein Convertase Furin as Potential Drugs for Treatment of Infectious Diseases

(2012) Gero L. Becker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multicenter Evaluation of a Sequence-Based Protocol for Subtyping Shiga Toxins and Standardizing Stx Nomenclature

(2012) F. Scheutz et al.   JOURNAL OF CLINICAL MICROBIOLOGY

The biology and therapeutic targeting of the proprotein convertases

(2012) Nabil G. Seidah et al.   NATURE REVIEWS DRUG DISCOVERY

Best supportive care and therapeutic plasma exchange with or without eculizumab in Shiga-toxin-producing E. coli O104:H4 induced haemolytic–uraemic syndrome: an analysis of the German STEC-HUS registry

(2012) Jan T. Kielstein et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Annexin A1 and A2: Roles in Retrograde Trafficking of Shiga Toxin

(2012) Lionel Tcatchoff et al.   PLoS One

Anti-Gb3 Monoclonal Antibody Inhibits Angiogenesis and Tumor Development

(2012) Ariane Desselle et al.   PLoS One

Manganese Blocks Intracellular Trafficking of Shiga Toxin and Protects Against Shiga Toxicosis

(2012) S. Mukhopadhyay et al.   SCIENCE

Shiga toxins

(2012) Jonas Bergan et al.   TOXICON

Chemical Structure of Retro-2, a Compound That Protects Cells against Ribosome-Inactivating Proteins

(2012) Jewn Giew Park et al.   Scientific Reports

Postmortem Hydroxychloroquine Concentrations in Nontoxic Cases

(2011) D. Kimberley Molina   AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY

Genome-Wide RNAi Screens Identify Genes Required for Ricin and PE Intoxications

(2011) Dimitri Moreau et al.   DEVELOPMENTAL CELL

The role of statins in stroke

(2011) Ugo Paliani et al.   Internal and Emergency Medicine

Deaths Associated With Bacterial Pathogens Transmitted Commonly Through Food: Foodborne Diseases Active Surveillance Network (FoodNet), 1996–2005

(2011) Casey Barton Behravesh et al.   JOURNAL OF INFECTIOUS DISEASES

Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study

(2011) Martina Bielaszewska et al.   LANCET INFECTIOUS DISEASES

Cholesterol modulates glycolipid conformation and receptor activity

(2011) Daniel Lingwood et al.   Nature Chemical Biology

Pathophysiology of manganese-associated neurotoxicity

(2011) Brad A. Racette et al.   NEUROTOXICOLOGY

Epidemic Profile of Shiga-Toxin–ProducingEscherichia coliO104:H4 Outbreak in Germany

(2011) Christina Frank et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Glucosylceramide Synthase Inhibitor Protects Rats Against the Cytotoxic Effects of Shiga Toxin 2

(2011) CLAUDIA SILBERSTEIN et al.   PEDIATRIC RESEARCH

Inhibitors of Intravesicular Acidification Protect Against Shiga Toxin in a pH-Independent Manner

(2011) Anne Berit Dyve Lingelem et al.   TRAFFIC

A phase 2 study of eliglustat tartrate (Genz-112638), an oral substrate reduction therapy for Gaucher disease type 1

(2010) E. Lukina et al.   BLOOD

2-Deoxy-d-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion

(2010) Haibin Xi et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Inhibition of Retrograde Transport Protects Mice from Lethal Ricin Challenge

(2010) Bahne Stechmann et al.   CELL

Human Intestinal Tissue and Cultured Colonic Cells Contain Globotriaosylceramide Synthase mRNA and the Alternate Shiga Toxin Receptor Globotetraosylceramide

(2010) S. D. Zumbrun et al.   INFECTION AND IMMUNITY

A Major Fraction of Glycosphingolipids in Model and Cellular Cholesterol-containing Membranes Is Undetectable by Their Binding Proteins

(2010) Radhia Mahfoud et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple Beneficial Health Effects of Natural Alkylglycerols from Shark Liver Oil

(2010) Anne-Laure Deniau et al.   Marine Drugs

An Update on the Therapeutic Role of Alkylglycerols

(2010) Tommaso Iannitti et al.   Marine Drugs

Shiga toxin and its use in targeted cancer therapy and imaging

(2010) Nikolai Engedal et al.   Microbial Biotechnology

Hemolytic Uremic Syndrome and Death in Persons withEscherichia coliO157:H7 Infection, Foodborne Diseases Active Surveillance Network Sites, 2000–2006

(2009) L. Hannah Gould et al.   CLINICAL INFECTIOUS DISEASES

Hemolytic uremic syndrome: pathogenesis and update of interventions

(2009) Marina S Palermo et al.   Expert Review of Anti-Infective Therapy

A novel, promoter-based, target-specific assay identifies 2-deoxy-d-glucose as an inhibitor of globotriaosylceramide biosynthesis

(2009) Tetsuya Okuda et al.   FEBS Journal

Globotriaosyl ceramide receptor function - Where membrane structure and pathology intersect

(2009) C.A. Lingwood et al.   FEBS LETTERS

Shiga Toxin Activates Complement and Binds Factor H: Evidence for an Active Role of Complement in Hemolytic Uremic Syndrome

(2009) Dorothea Orth et al.   JOURNAL OF IMMUNOLOGY

Detergent-resistant globotriaosyl ceramide may define verotoxin/glomeruli-restricted hemolytic uremic syndrome pathology

(2009) Fahima Khan et al.   KIDNEY INTERNATIONAL

Retrograde Shiga Toxin Trafficking Is Regulated by ARHGAP21 and Cdc42

(2009) Heidi Hehnly et al.   MOLECULAR BIOLOGY OF THE CELL

Shiga toxins — from cell biology to biomedical applications

(2009) Ludger Johannes et al.   NATURE REVIEWS MICROBIOLOGY

Manganese and its Role in Parkinson’s Disease: From Transport to Neuropathology

(2009) Michael Aschner et al.   NEUROMOLECULAR MEDICINE

Glycosphingolipid Requirements for Endosome-to-Golgi Transport of Shiga Toxin

(2009) Hilde Raa et al.   TRAFFIC

Differential intracellular transport and binding of verotoxin 1 and verotoxin 2 to globotriaosylceramide‐containing lipid assemblies

(2008) Patty Tam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Shiga Toxin 2 Affects the Central Nervous System through Receptor Globotriaosylceramide Localized to Neurons

(2008) Fumiko Obata et al.   JOURNAL OF INFECTIOUS DISEASES

Fatty acid-dependent globotriaosyl ceramide receptor function in detergent resistant model membranes

(2008) Radhia Mahfoud et al.   JOURNAL OF LIPID RESEARCH

The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel

(2008) A. A. Rodriguez-Menchaca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mitogen-activated Protein Kinase p38 Links Shiga Toxin-dependent Signaling and Trafficking

(2007) Sébastien Wälchli et al.   MOLECULAR BIOLOGY OF THE CELL