Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 65, Issue -, Pages 17-27Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2020.02.005
Keywords
Commander; Endosome; ESCRT; Retriever; Retromer; Sorting nexin; SNX
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Funding
- National Health and Medical Research Council Senior Research Fellowship [APP1136021]
- NHMRC [APP1156493]
- Bright-Focus Foundation [A2018627S]
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The endosomal compartment is a major sorting station controlling the balance between endocytic recycling and lysosomal degradation, and its homeostasis is emerging as a central factor in various neurodegenerative diseases such as Alzheimer's and Parkinson's. Membrane trafficking is generally coordinated by the recognition of specific signals in transmembrane protein cargos by different transport machineries. A number of different protein trafficking complexes are essential for sequence-specific recognition and retrieval of endosomal cargos, recycling them to other compartments and acting to counter-balance the default endosomal sorting complex required for transport-mediated degradation pathway. In this review, we provide a summary of the key endosomal transport machineries, and the molecular mechanisms by which different cargo sequences are specifically recognised.
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