Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice
Authors
Keywords
-
Journal
Nature Communications
Volume 12, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-09-03
DOI
10.1038/s41467-021-25453-2
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle
- (2020) Hui Che et al. eLife
- Comparison of inbred mouse strains shows diverse phenotypic outcomes of intervertebral disc aging
- (2020) Emanuel J. Novais et al. AGING CELL
- Hypoxic Regulation of Mitochondrial Metabolism and Mitophagy in Nucleus Pulposus Cells Is Dependent on HIF ‐1α– BNIP3 Axis
- (2020) Vedavathi Madhu et al. JOURNAL OF BONE AND MINERAL RESEARCH
- A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells
- (2020) Masahiro Wakita et al. Nature Communications
- Sox9 deletion causes severe intervertebral disc degeneration characterized by apoptosis, matrix remodeling, and compartment-specific transcriptomic changes
- (2020) Maria Tsingas et al. MATRIX BIOLOGY
- Senotherapeutic drugs for human intervertebral disc degeneration and low back pain
- (2020) Hosni Cherif et al. eLife
- Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
- (2019) Jamie N. Justice et al. EBioMedicine
- Protocol Update for large-scale genome and gene function analysis with the PANTHER classification system (v.14.0)
- (2019) Huaiyu Mi et al. Nature Protocols
- Frailty index as a biomarker of lifespan and healthspan: focus on pharmacological interventions
- (2019) Dushani L. Palliyaguru et al. MECHANISMS OF AGEING AND DEVELOPMENT
- p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence
- (2019) Emanuel J. Novais et al. MATRIX BIOLOGY
- A new understanding of the role of IL‐1 in age‐related intervertebral disc degeneration in a murine model
- (2019) Deborah J. Gorth et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Targeting senescent cells alleviates obesity‐induced metabolic dysfunction
- (2019) Allyson K. Palmer et al. AGING CELL
- Systemic clearance of p16 INK4a ‐positive senescent cells mitigates age‐associated intervertebral disc degeneration
- (2019) Prashanti Patil et al. AGING CELL
- Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model
- (2019) Peisu Zhang et al. NATURE NEUROSCIENCE
- Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro
- (2019) Hosni Cherif et al. Journal of Clinical Medicine
- Chondrocyte‐like nested cells in the aged intervertebral disc are late‐stage nucleus pulposus cells
- (2019) Sarthak Mohanty et al. AGING CELL
- Restored immune cell functions upon clearance of senescence in the irradiated splenic environment
- (2019) Lina Palacio et al. AGING CELL
- Controlled induction and targeted elimination of p16INK4a-expressing chondrocytes in cartilage explant culture
- (2019) Garrett A. Sessions et al. FASEB JOURNAL
- Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
- (2019) LaTonya J. Hickson et al. EBioMedicine
- Transcriptional profiling of the murine intervertebral disc and age-associated changes in the nucleus pulposus
- (2019) Matthew A. Veras et al. CONNECTIVE TISSUE RESEARCH
- TonEBP-deficiency accelerates intervertebral disc degeneration underscored by matrix remodeling, cytoskeletal rearrangements, and changes in proinflammatory gene expression
- (2019) Steven Tessier et al. MATRIX BIOLOGY
- Lactate Efflux From Intervertebral Disc Cells Is Required for Maintenance of Spine Health
- (2019) Elizabeth S Silagi et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Differential Effect of Long‐Term Systemic Exposure of TNFα on Health of the Annulus Fibrosus and Nucleus Pulposus of the Intervertebral Disc
- (2019) Deborah J Gorth et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Expression of p16INK 4a is a biomarker of chondrocyte aging but does not cause osteoarthritis
- (2018) Brian O. Diekman et al. AGING CELL
- A novel mouse model of intervertebral disc degeneration shows altered cell fate and matrix homeostasis
- (2018) Hyowon Choi et al. MATRIX BIOLOGY
- Senolytics improve physical function and increase lifespan in old age
- (2018) Ming Xu et al. NATURE MEDICINE
- Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death
- (2018) Elizabeth S. Silagi et al. Scientific Reports
- Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
- (2018) Spencer L James et al. LANCET
- Transgenic mice overexpressing human TNF-α experience early onset spontaneous intervertebral disc herniation in the absence of overt degeneration
- (2018) Deborah J. Gorth et al. Cell Death & Disease
- Bicarbonate Recycling by HIF-1-Dependent Carbonic Anhydrase Isoforms 9 and 12 Is Critical in Maintaining Intracellular pH and Viability of Nucleus Pulposus Cells
- (2017) Elizabeth S Silagi et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration
- (2017) Oscar Alvarez-Garcia et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype
- (2017) Kevin Ngo et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Targeting cellular senescence prevents age-related bone loss in mice
- (2017) Joshua N Farr et al. NATURE MEDICINE
- Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
- (2017) Ok Hee Jeon et al. NATURE MEDICINE
- Intervertebral Disk Degeneration and Repair
- (2017) James Dowdell et al. NEUROSURGERY
- Cellular senescence mediates fibrotic pulmonary disease
- (2017) Marissa J. Schafer et al. Nature Communications
- Cellular Senescence: A Translational Perspective
- (2017) James L. Kirkland et al. EBioMedicine
- Matrisome Profiling During Intervertebral Disc Development And Ageing
- (2017) Joana Caldeira et al. Scientific Reports
- Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
- (2016) Carolyn M. Roos et al. AGING CELL
- MLL1 is essential for the senescence-associated secretory phenotype
- (2016) Brian C. Capell et al. GENES & DEVELOPMENT
- Dasatinib induces lung vascular toxicity and predisposes to pulmonary hypertension
- (2016) Christophe Guignabert et al. JOURNAL OF CLINICAL INVESTIGATION
- The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
- (2015) Yi Zhu et al. AGING CELL
- Defining the phenotype of young healthy nucleus pulposus cells: Recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting
- (2015) Makarand V. Risbud et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Quercetin intraperitoneal administration ameliorates lipopolysaccharide-induced systemic inflammation in mice
- (2015) Yi-Ru Liao et al. LIFE SCIENCES
- The aging mouse partially models the aging human spine: lumbar and coccygeal disc height, composition, mechanical properties, and Wnt signaling in young and old mice
- (2014) Nilsson Holguin et al. JOURNAL OF APPLIED PHYSIOLOGY
- Cellular senescence: from physiology to pathology
- (2014) Daniel Muñoz-Espín et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Loss of HIF-1α in the Notochord Results in Cell Death and Complete Disappearance of the Nucleus Pulposus
- (2014) Christophe Merceron et al. PLoS One
- Phrenic motor neuron degeneration compromises phrenic axonal circuitry and diaphragm activity in a unilateral cervical contusion model of spinal cord injury
- (2012) Charles Nicaise et al. EXPERIMENTAL NEUROLOGY
- Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc
- (2012) Daisuke Sakai et al. Nature Communications
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
- (2010) Jean-Philippe Coppé et al. Annual Review of Pathology-Mechanisms of Disease
- Accelerated aging of intervertebral discs in a mouse model of progeria
- (2010) Nam Vo et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse
- (2010) S.S. Glasson et al. OSTEOARTHRITIS AND CARTILAGE
- Localized Intervertebral Disc Injury Leads to Organ Level Changes in Structure, Cellularity, and Biosynthesis
- (2009) James C. Iatridis et al. Cellular and Molecular Bioengineering
- Prevalence and Pattern of Lumbar Magnetic Resonance Imaging Changes in a Population Study of One Thousand Forty-Three Individuals
- (2009) Kenneth M. C. Cheung et al. SPINE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now