Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration

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Molecular mechanisms of biological aging in intervertebral discs

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Migration of bone marrow–derived cells for endogenous repair in a new tail-looping disc degeneration model in the mouse: a pilot study

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Structure, function, aging and turnover of aggrecan in the intervertebral disc

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Cell and molecular biology of intervertebral disc degeneration: current understanding and implications for potential therapeutic strategies

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Molecular Basis of Intervertebral Disc Degeneration and Herniations: What Are the Important Translational Questions?

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FOXO3 and Related Transcription Factors in Development, Aging, and Exceptional Longevity

(2014) A. J. Kahn   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Epidemiology of Low Back Pain in Adults

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FOXO transcription factors: key regulators of cellular quality control

(2014) Ashley E. Webb et al.   TRENDS IN BIOCHEMICAL SCIENCES

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Age-Related Carbonylation of Fibrocartilage Structural Proteins Drives Tissue Degenerative Modification

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Biochemical composition and turnover of the extracellular matrix of the normal and degenerate intervertebral disc

(2013) Sarit Sara Sivan et al.   EUROPEAN SPINE JOURNAL

Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration

(2013) Luigi A. Nasto et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Needle puncture injury causes acute and long-term mechanical deficiency in a mouse model of intervertebral disc degeneration

(2013) John T. Martin et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints

(2013) Nam Vo et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

FOXOs: signalling integrators for homeostasis maintenance

(2013) Astrid Eijkelenboom et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of cytokines in intervertebral disc degeneration: pain and disc content

(2013) Makarand V. Risbud et al.   Nature Reviews Rheumatology

Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis

(2013) Y. Akasaki et al.   OSTEOARTHRITIS AND CARTILAGE

The molecular basis of intervertebral disc degeneration

(2013) Christopher K. Kepler et al.   Spine Journal

Investigating the role of DNA damage in tobacco smoking-induced spine degeneration

(2013) Luigi A. Nasto et al.   Spine Journal

Aging changes in lumbar discs and vertebrae and their interaction: a 15-year follow-up study

(2013) Tapio Videman et al.   Spine Journal

Age-related changes in human cervical, thoracal and lumbar intervertebral disc exhibit a strong intra-individual correlation

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Hypoxic Regulation of Nucleus Pulposus Cell Survival

(2010) Makarand V. Risbud et al.   AMERICAN JOURNAL OF PATHOLOGY

FoxO-Mediated Defense against Oxidative Stress in Osteoblasts Is Indispensable for Skeletal Homeostasis in Mice

(2010) Elena Ambrogini et al.   Cell Metabolism

FoxO1 Is a Positive Regulator of Bone Formation by Favoring Protein Synthesis and Resistance to Oxidative Stress in Osteoblasts

(2010) Marie-Therese Rached et al.   Cell Metabolism

FoxOs Inhibit mTORC1 and Activate Akt by Inducing the Expression of Sestrin3 and Rictor

(2010) Chia-Chen Chen et al.   DEVELOPMENTAL CELL

Stressin' Sestrins take an aging fight

(2010) Andrei V. Budanov et al.   EMBO Molecular Medicine

The effect of needle size inducing degeneration in the rat caudal disc: evaluation using radiograph, magnetic resonance imaging, histology, and immunohistochemistry

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Characterization of Intervertebral Disc Aging

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FoxO transcription factors in the maintenance of cellular homeostasis during aging

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A systematic review of low back pain cost of illness studies in the United States and internationally

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