Differential Effect of Long‐Term Systemic Exposure of TNFα on Health of the Annulus Fibrosus and Nucleus Pulposus of the Intervertebral Disc

p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence

(2019) Emanuel J. Novais et al.   MATRIX BIOLOGY

A new understanding of the role of IL‐1 in age‐related intervertebral disc degeneration in a murine model

(2019) Deborah J. Gorth et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Chondrocyte‐like nested cells in the aged intervertebral disc are late‐stage nucleus pulposus cells

(2019) Sarthak Mohanty et al.   AGING CELL

COX-2 expression mediated by calcium-TonEBP signaling axis under hyperosmotic conditions serves osmoprotective function in nucleus pulposus cells

(2018) Hyowon Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early onset of disc degeneration in SM/J mice is associated with changes in ion transport systems and fibrotic events

(2018) Ying Zhang et al.   MATRIX BIOLOGY

A novel mouse model of intervertebral disc degeneration shows altered cell fate and matrix homeostasis

(2018) Hyowon Choi et al.   MATRIX BIOLOGY

Transgenic mice overexpressing human TNF-α experience early onset spontaneous intervertebral disc herniation in the absence of overt degeneration

(2018) Deborah J. Gorth et al.   Cell Death & Disease

TNF-α promotes nuclear enrichment of the transcription factor TonEBP/NFAT5 to selectively control inflammatory but not osmoregulatory responses in nucleus pulposus cells

(2017) Zariel I. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diabetes and bone health: latest evidence and clinical implications

(2017) Vikram Sundararaghavan et al.   Therapeutic Advances in Musculoskeletal Disease

Mapping the association between back pain and type 2 diabetes: A cross-sectional and longitudinal study of adult Spanish twins

(2017) Amabile Dario et al.   PLoS One

RNA Sequencing Reveals a Role of TonEBP Transcription Factor in Regulation of Pro-inflammatory Genes in Response to Hyperosmolarity in Healthy Nucleus Pulposus Cells

(2016) Zariel I. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blocking collagen fibril formation in injured knees reduces flexion contracture in a rabbit model

(2016) Andrzej Steplewski et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Prevalence of degenerative and spondyloarthritis-related magnetic resonance imaging findings in the spine and sacroiliac joints in patients with persistent low back pain

(2015) Bodil Arnbak et al.   EUROPEAN RADIOLOGY

Potential roles of cytokines and chemokines in human intervertebral disc degeneration: interleukin-1 is a master regulator of catabolic processes

(2015) K.L.E. Phillips et al.   OSTEOARTHRITIS AND CARTILAGE

Repeated Exposure to High-Frequency Low-Amplitude Vibration Induces Degeneration of Murine Intervertebral Discs and Knee Joints

(2015) Matthew R. McCann et al.   Arthritis & Rheumatology

Tumor Necrosis Factor-α– and Interleukin-1β–Dependent Matrix Metalloproteinase-3 Expression in Nucleus Pulposus Cells Requires Cooperative Signaling via Syndecan 4 and Mitogen-Activated Protein Kinase–NF-κB Axis

(2014) Xin Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Interleukin-1 receptor antagonist deficient mice provide insights into pathogenesis of human intervertebral disc degeneration

(2013) Kate Louise Eve Phillips et al.   ANNALS OF THE RHEUMATIC DISEASES

A role for TNFα in intervertebral disc degeneration: A non-recoverable catabolic shift

(2013) D. Purmessur et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of cytokines in intervertebral disc degeneration: pain and disc content

(2013) Makarand V. Risbud et al.   Nature Reviews Rheumatology

A validated new histological classification for intervertebral disc degeneration

(2013) J.P.H.J. Rutges et al.   OSTEOARTHRITIS AND CARTILAGE

ISSLS Prize Winner

(2013) S. Rajasekaran et al.   SPINE

An organ culture system to model early degenerative changes of the intervertebral disc II: profiling global gene expression changes

(2013) Dessislava Z Markova et al.   ARTHRITIS RESEARCH & THERAPY

A systematic review of the global prevalence of low back pain

(2012) Damian Hoy et al.   ARTHRITIS AND RHEUMATISM

Tumor necrosis factor α- and interleukin-1β-dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1

(2012) Jianru Wang et al.   ARTHRITIS AND RHEUMATISM

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

DNA Methylation of SPARC and Chronic Low Back Pain

(2011) Maral Tajerian et al.   Molecular Pain

Hypoxic Regulation of Nucleus Pulposus Cell Survival

(2010) Makarand V. Risbud et al.   AMERICAN JOURNAL OF PATHOLOGY

Radial and ulnar cortical thickness of the second metacarpal

(2010) Kathleen M. Fox et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Temporal Association of Annular Tears and Nuclear Degeneration: Lessons from the Pediatric Population

(2009) A. Sharma et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Association between Annular Tears and Disk Degeneration: A Longitudinal Study

(2009) A. Sharma et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

The Rising Prevalence of Chronic Low Back Pain

(2009) Janet K. Freburger et al.   ARCHIVES OF INTERNAL MEDICINE

Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain

(2008) Tue Secher Jensen et al.   EUROPEAN SPINE JOURNAL

The Twin Spine Study: Contributions to a changing view of disc degeneration†

(2008) Michele C. Battié et al.   Spine Journal

Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis

(2008) Hui Geng et al.   ARTHRITIS RESEARCH & THERAPY