Defining the phenotype of young healthy nucleus pulposus cells: Recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting

FIH-1-Mint3 Axis Does Not Control HIF-1α Transcriptional Activity in Nucleus Pulposus Cells

(2014) Yuichiro Hirose et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCN2 Suppresses Catabolic Effects of Interleukin-1β through α5β1 and αVβ3 Integrins in Nucleus Pulposus Cells

(2014) Cassie M. Tran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficacy of paracetamol for acute low-back pain: a double-blind, randomised controlled trial

(2014) Christopher M Williams et al.   LANCET

Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: Evolving role of TonEBP

(2014) Zariel I. Johnson et al.   MATRIX BIOLOGY

The biology of Lubricin: Near frictionless joint motion

(2014) Gregory D. Jay et al.   MATRIX BIOLOGY

Wnt Signaling Activates Shh Signaling in Early Postnatal Intervertebral Discs, and Re-Activates Shh Signaling in Old Discs in the Mouse

(2014) Tamara Winkler et al.   PLoS One

Loss of HIF-1α in the Notochord Results in Cell Death and Complete Disappearance of the Nucleus Pulposus

(2014) Christophe Merceron et al.   PLoS One

Effects of hypoxia on differentiation from human placenta-derived mesenchymal stem cells to nucleus pulposus-like cells

(2014) Li Ni et al.   Spine Journal

Growth differentiation factor 6 and transforming growth factor-beta differentially mediate mesenchymal stem cell differentiation, composition, and micromechanical properties of nucleus pulposus constructs

(2014) Louise E Clarke et al.   ARTHRITIS RESEARCH & THERAPY

Novel immortal human cell lines reveal subpopulations in the nucleus pulposus

(2014) Guus GH van den Akker et al.   ARTHRITIS RESEARCH & THERAPY

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Gene expression profile analysis of human intervertebral disc degeneration

(2013) Kai Chen et al.   GENETICS AND MOLECULAR BIOLOGY

Genes associated with disc degeneration identified using microarray gene expression profiling and bioinformatics analysis

(2013) Y. Chen et al.   GENETICS AND MOLECULAR RESEARCH

Integrin-mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral disc

(2013) D. T. Bridgen et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Role of cytokines in intervertebral disc degeneration: pain and disc content

(2013) Makarand V. Risbud et al.   Nature Reviews Rheumatology

Foxa1 and Foxa2 Are Required for Formation of the Intervertebral Discs

(2013) Jennifer A. Maier et al.   PLoS One

Differentiation of Mouse Induced Pluripotent Stem Cells (iPSCs) into Nucleus Pulposus-Like Cells In Vitro

(2013) Jun Chen et al.   PLoS One

Increased Osmolarity and Cell Clustering Preserve Canine Notochordal Cell Phenotype in Culture

(2013) Sandra Spillekom et al.   TISSUE ENGINEERING PART C-METHODS

Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies

(2013) Lucas A Smolders et al.   ARTHRITIS RESEARCH & THERAPY

Dynamic pressurization induces transition of notochordal cells to a mature phenotype while retaining production of important patterning ligands from development

(2013) Devina Purmessur et al.   ARTHRITIS RESEARCH & THERAPY

A systematic review of the global prevalence of low back pain

(2012) Damian Hoy et al.   ARTHRITIS AND RHEUMATISM

Structured Coculture of Mesenchymal Stem Cells and Disc Cells Enhances Differentiation and Proliferation

(2012) Aliza A. Allon et al.   CELLS TISSUES ORGANS

Notochordal Cells in the Adult Intervertebral Disc: New Perspective on an Old Question

(2012) Makarand V. Risbud et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Expression of Prolyl Hydroxylases (PHDs) Is Selectively Controlled by HIF-1 and HIF-2 Proteins in Nucleus Pulposus Cells of the Intervertebral Disc

(2012) Nobuyuki Fujita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Proteomic Analysis of Eight Cartilaginous Tissues Reveals Characteristic Differences as well as Similarities between Subgroups

(2012) Patrik Önnerfjord et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tonicity enhancer binding protein (TonEBP) and hypoxia-inducible factor (HIF) coordinate heat shock protein 70 (Hsp70) expression in hypoxic nucleus pulposus cells: Role of Hsp70 in HIF-1α degradation

(2012) Shilpa S Gogate et al.   JOURNAL OF BONE AND MINERAL RESEARCH

An integrated functional genomics approach identifies the regulatory network directed by brachyury (T ) in chordoma

(2012) Andrew C Nelson et al.   JOURNAL OF PATHOLOGY

Sonic hedgehog in the notochord is sufficient for patterning of the intervertebral discs

(2012) Kyung-Suk Choi et al.   MECHANISMS OF DEVELOPMENT

Genomic Targets of Brachyury (T) in Differentiating Mouse Embryonic Stem Cells

(2012) Amanda L. Evans et al.   PLoS One

Shh Signaling from the Nucleus Pulposus Is Required for the Postnatal Growth and Differentiation of the Mouse Intervertebral Disc

(2012) Chitra Lekha Dahia et al.   PLoS One

Changes in the Molecular Phenotype of Nucleus Pulposus Cells with Intervertebral Disc Aging

(2012) Xinyan Tang et al.   PLoS One

Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc

(2012) Daisuke Sakai et al.   Nature Communications

Identification of cell surface-specific markers to target human nucleus pulposus cells: Expression of carbonic anhydrase XII varies with age and degeneration

(2011) Karen A. Power et al.   ARTHRITIS AND RHEUMATISM

Hypoxic regulation of β-1,3-glucuronyltransferase 1 expression in nucleus pulposus cells of the rat intervertebral disc: Role of hypoxia-inducible factor proteins

(2011) Shilpa S. Gogate et al.   ARTHRITIS AND RHEUMATISM

Is the spinal motion segment a diarthrodial polyaxial joint: What a nice nucleus like you doing in a joint like this?

(2011) Irving M. Shapiro et al.   BONE

Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development

(2011) M. R. McCann et al.   Disease Models & Mechanisms

HIF-1α and HIF-2α degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc

(2011) Nobuyuki Fujita et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Canonical Wnt signaling in the notochordal cell is upregulated in early intervertebral disk degeneration

(2011) Lucas A. Smolders et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discs

(2011) K.-S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells

(2011) Devina Purmessur et al.   ARTHRITIS RESEARCH & THERAPY

Hypoxic Regulation of Nucleus Pulposus Cell Survival

(2010) Makarand V. Risbud et al.   AMERICAN JOURNAL OF PATHOLOGY

Hypoxia-inducible factor regulation of ANK expression in nucleus pulposus cells: Possible implications in controlling dystrophic mineralization in the intervertebral disc

(2010) Renata Skubutyte et al.   ARTHRITIS AND RHEUMATISM

Characterization of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation

(2010) Ben M. Minogue et al.   ARTHRITIS AND RHEUMATISM

Immunohistochemical identification of notochordal markers in cells in the aging human lumbar intervertebral disc

(2010) Christoph Weiler et al.   EUROPEAN SPINE JOURNAL

Quantitative differences in intervertebral disc–matrix composition with age-related degeneration

(2010) Hideki Murakami et al.   MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING

Differential expression level of cytokeratin 8 in cells of the bovine nucleus pulposus complicates the search for specific intervertebral disc cell markers

(2010) Audrey Gilson et al.   ARTHRITIS RESEARCH & THERAPY

Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes

(2010) Ben M Minogue et al.   ARTHRITIS RESEARCH & THERAPY

Expression of Laminin Isoforms, Receptors, and Binding Proteins Unique to Nucleus Pulposus Cells of Immature Intervertebral Disc

(2009) Jun Chen et al.   CONNECTIVE TISSUE RESEARCH

Lubricin Distribution in the Human Intervertebral Disc

(2009) Kristy M Shine et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Injury-induced sequential transformation of notochordal nucleus pulposus to chondrogenic and fibrocartilaginous phenotype in the mouse

(2009) Fan Yang et al.   JOURNAL OF PATHOLOGY

Variations in gene and protein expression in human nucleus pulposus in comparison with annulus fibrosus and cartilage cells: potential associations with aging and degeneration

(2009) J. Rutges et al.   OSTEOARTHRITIS AND CARTILAGE

Differential Phenotype of Intervertebral Disc Cells

(2009) Daisuke Sakai et al.   SPINE

Intercellular Signaling Pathways Active During Intervertebral Disc Growth, Differentiation, and Aging

(2009) Chitra Lekha Dahia et al.   SPINE

Differentiation of Intervertebral Notochordal Cells Through Live Automated Cell Imaging System In Vitro

(2009) Joo Han Kim et al.   SPINE

Cited2 modulates hypoxia-inducible factor-dependent expression of vascular endothelial growth factor in nucleus pulposus cells of the rat intervertebral disc

(2008) Amit Agrawal et al.   ARTHRITIS AND RHEUMATISM

Expression of Integrin Subunits in the Herniated Intervertebral Disc

(2008) Maosheng Xia et al.   CONNECTIVE TISSUE RESEARCH

Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: Implications for disk degeneration and chordoma formation

(2008) Kyung-Suk Choi et al.   DEVELOPMENTAL DYNAMICS

Expression of glucose transporters GLUT-1, GLUT-3, GLUT-9 and HIF-1α in normal and degenerate human intervertebral disc

(2008) S. M. Richardson et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Expenditures and Health Status Among Adults With Back and Neck Problems

(2008) Brook I. Martin   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The role of fibroblast growth factor-8 (FGF8) in animal models of osteoarthritis

(2008) Masako Uchii et al.   ARTHRITIS RESEARCH & THERAPY