The aging mouse partially models the aging human spine: lumbar and coccygeal disc height, composition, mechanical properties, and Wnt signaling in young and old mice

Low-intensity vibrations partially maintain intervertebral disc mechanics and spinal muscle area during deconditioning

(2013) Nilsson Holguin et al.   Spine Journal

Role of biomechanics in intervertebral disc degeneration and regenerative therapies: what needs repairing in the disc and what are promising biomaterials for its repair?

(2013) James C. Iatridis et al.   Spine Journal

Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue

(2012) Meina Wang et al.   ARTHRITIS AND RHEUMATISM

Notochordal Cells in the Adult Intervertebral Disc: New Perspective on an Old Question

(2012) Makarand V. Risbud et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Shh Signaling from the Nucleus Pulposus Is Required for the Postnatal Growth and Differentiation of the Mouse Intervertebral Disc

(2012) Chitra Lekha Dahia et al.   PLoS One

Comparison of Animal Discs Used in Disc Research to Human Lumbar Disc

(2012) Brent L. Showalter et al.   SPINE

The effects of oxygen tension and antiaging factor Klotho on the Wnt singaling in nucleus pulposus cells

(2012) Akihiko Hiyama et al.   ARTHRITIS RESEARCH & THERAPY

Mouse tail vertebrae adapt to cyclic mechanical loading by increasing bone formation rate and decreasing bone resorption rate as shown by time-lapsed in vivo imaging of dynamic bone morphometry

(2011) Floor M. Lambers et al.   BONE

Brief daily exposure to low-intensity vibration mitigates the degradation of the intervertebral disc in a frequency-specific manner

(2011) Nilsson Holguin et al.   JOURNAL OF APPLIED PHYSIOLOGY

Effects of a glycogen synthase kinase-3β inhibitor (LiCl) on c-myc protein in intervertebral disc cells

(2011) Akihiko Hiyama et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Age-related expression of MCP-1 and MMP-3 in mouse intervertebral disc in relation to TWEAK and TNF-α stimulation

(2011) Koji Fujita et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Canonical Wnt signaling in the notochordal cell is upregulated in early intervertebral disk degeneration

(2011) Lucas A. Smolders et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

TNF is required for the induction but not the maintenance of compression-induced BME signals in murine tail vertebrae: Limitations of anti-TNF therapy for degenerative disc disease

(2011) M. Owen Papuga et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Intercellular Signaling Pathways Active During and After Growth and Differentiation of the Lumbar Vertebral Growth Plate

(2011) Chitra Lekha Dahia et al.   SPINE

Intervertebral Disc Development Is Regulated by Wnt/β-catenin Signaling

(2011) Naoki Kondo et al.   SPINE

Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration

(2011) W Erwin et al.   ARTHRITIS RESEARCH & THERAPY

Enhancement of intervertebral disc cell senescence by WNT/β-catenin signaling-induced matrix metalloproteinase expression

(2010) Akihiko Hiyama et al.   ARTHRITIS AND RHEUMATISM

Rat Intervertebral Disc Health During Hindlimb Unloading: Brief Ambulation With or Without Vibration

(2010) Nilsson Holguin et al.   AVIATION SPACE AND ENVIRONMENTAL MEDICINE

Age-Related Changes in Bone Structure and Strength in Female and Male BALB/c Mice

(2010) Mark D. Willinghamm et al.   CALCIFIED TISSUE INTERNATIONAL

Effects of enzymatic digestion on compressive properties of rat intervertebral discs

(2010) Ana Barbir et al.   JOURNAL OF BIOMECHANICS

The relationship between the Wnt/β-catenin and TGF-β/BMP signals in the intervertebral disc cell

(2010) Akihiko Hiyama et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Accelerated aging of intervertebral discs in a mouse model of progeria

(2010) Nam Vo et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels

(2009) Rong Yuan et al.   AGING CELL

Measurement of geometric deformation of lumbar intervertebral discs under in-vivo weightbearing condition

(2009) Shaobai Wang et al.   JOURNAL OF BIOMECHANICS

Comparison of Animal Discs Used in Disc Research to Human Lumbar Disc

(2009) Jesse C. Beckstein et al.   SPINE

Absence of Biglycan Accelerates the Degenerative Process in Mouse Intervertebral Disc

(2009) Takashi Furukawa et al.   SPINE

Intercellular Signaling Pathways Active During Intervertebral Disc Growth, Differentiation, and Aging

(2009) Chitra Lekha Dahia et al.   SPINE

Short applications of very low-magnitude vibrations attenuate expansion of the intervertebral disc during extended bed rest

(2009) Nilsson Holguin et al.   Spine Journal

Cross talk between Smad transcription factors and TNF-α in intervertebral disc degeneration

(2008) A. Hiyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: Implications for disk degeneration and chordoma formation

(2008) Kyung-Suk Choi et al.   DEVELOPMENTAL DYNAMICS

Postpubertal Architectural Developmental Patterns Differ Between the L3Vertebra and Proximal Tibia in Three Inbred Strains of Mice*

(2008) Helen R Buie et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Age-Related Changes in the Extracellular Matrix of Nucleus Pulposus and Anulus Fibrosus of Human Intervertebral Disc

(2008) Kern Singh et al.   SPINE