The Microbiota-Gut-Brain Axis in Health and Disease and Its Implications for Translational Research

Naturalizing mouse models for immunology

(2021) Andrea L. Graham   NATURE IMMUNOLOGY

The gut microbiota and nervous system: Age-defined and age-defying

(2021) Annelise A. Madison et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Rapid gut dysbiosis induced by stroke exacerbates brain infarction in turn

(2021) Kaiyu Xu et al.   GUT

Sex differences in T cell immune responses, gut permeability and outcome after ischemic stroke in aged mice

(2020) Hilda Ahnstedt et al.   BRAIN BEHAVIOR AND IMMUNITY

Age-related shifts in gut microbiota contribute to cognitive decline in aged rats

(2020) Yanli Li et al.   Aging-US

Interaction between microbiota and immunity in health and disease

(2020) Danping Zheng et al.   CELL RESEARCH

Gut Microbiota-Derived Short-Chain Fatty Acids Promote Post-Stroke Recovery in Aged Mice

(2020) Juneyoung Lee et al.   CIRCULATION RESEARCH

Developmental Signatures of Microbiota-Derived Metabolites in the Mouse Brain

(2020) Jonathan R. Swann et al.   Metabolites

Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition

(2020) Emanuela Pasciuto et al.   CELL

New mechanism of neuroinflammation in Alzheimer's disease: The activation of NLRP3 inflammasome mediated by gut microbiota

(2020) Heping Shen et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

GUT DYSBIOSIS AND AGE-RELATED NEUROLOGICAL DISEASES; AN INNOVATIVE APPROACH FOR THERAPEUTIC INTERVENTIONS

(2020) Aleah Holmes et al.   Translational Research

Gut Microbiota in Acute Ischemic Stroke: From Pathophysiology to Therapeutic Implications

(2020) Denise Battaglini et al.   Frontiers in Neurology

Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimer’s disease

(2020) Charlotte Mezö et al.   Acta Neuropathologica Communications

The gut microbiota attenuate neuroinflammation in manganese exposure by inhibiting cerebral NLRP3 inflammasome

(2020) Hui Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Gut–Brain Axis: Role of Gut Microbiota on Neurological Disorders and How Probiotics/Prebiotics Beneficially Modulate Microbial and Immune Pathways to Improve Brain Functions

(2020) Kanmani Suganya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The maternal microbiome modulates fetal neurodevelopment in mice

(2020) Helen E. Vuong et al.   NATURE

Gut Microbiota in Hypertension and Atherosclerosis: A Review

(2020) Barbara J. H. Verhaar et al.   Nutrients

Communications Between Peripheral and the Brain-Resident Immune System in Neuronal Regeneration After Stroke

(2020) Fangxi Liu et al.   Frontiers in Immunology

Myelin as a regulator of development of the microbiota-gut-brain axis

(2020) Ciara E. Keogh et al.   BRAIN BEHAVIOR AND IMMUNITY

Multi-modal Single-Cell Analysis Reveals Brain Immune Landscape Plasticity during Aging and Gut Microbiota Dysbiosis

(2020) Samantha M. Golomb et al.   Cell Reports

Dynamic Changes in the Gut Microbiome at the Acute Stage of Ischemic Stroke in a Pig Model

(2020) Julie Jeon et al.   Frontiers in Neuroscience

Brain-Gut-Microbiota Axis in Alzheimer’s Disease

(2019) Karol Kowalski et al.   Journal of Neurogastroenterology and Motility

Effect of the HDAC Inhibitor, Sodium Butyrate, on Neurogenesis in a Rat Model of Neonatal Hypoxia–Ischemia: Potential Mechanism of Action

(2019) Joanna Jaworska et al.   MOLECULAR NEUROBIOLOGY

Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2019) Catherine Owens Johnson et al.   LANCET NEUROLOGY

Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis

(2019) Qianquan Ma et al.   Journal of Neuroinflammation

Alzheimer’s Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway

(2019) John P. Haran et al.   mBio

Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells

(2019) Annabell Bachem et al.   IMMUNITY

Laboratory mice born to wild mice have natural microbiota and model human immune responses

(2019) Stephan P. Rosshart et al.   SCIENCE

Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression

(2019) Xinyi Wang et al.   CELL RESEARCH

Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer’s disease animal model

(2019) Min-Soo Kim et al.   GUT

The Microbiota-Gut-Brain Axis

(2019) John F. Cryan et al.   PHYSIOLOGICAL REVIEWS

Examining the Role of the Microbiota-Gut-Brain Axis in Stroke

(2019) David J. Durgan et al.   STROKE

Physical Fitness Training in Patients with Subacute Stroke (PHYS-STROKE): multicentre, randomised controlled, endpoint blinded trial

(2019) Alexander H Nave et al.   BMJ-British Medical Journal

The Involvement and Therapy Target of Immune Cells After Ischemic Stroke

(2019) Zhihong Jian et al.   Frontiers in Immunology

Annual Research Review: Critical windows – the microbiota–gut–brain axis in neurocognitive development

(2019) Caitlin S. M. Cowan et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Transplantation of fecal microbiota rich in short chain fatty acids and butyric acid treat cerebral ischemic stroke by regulating gut microbiota

(2019) Runzhi Chen et al.   PHARMACOLOGICAL RESEARCH

Short-Chain Fatty Acids Improve Poststroke Recovery via Immunological Mechanisms

(2019) Rebecca Sadler et al.   JOURNAL OF NEUROSCIENCE

Undulating changes in human plasma proteome profiles across the lifespan

(2019) Benoit Lehallier et al.   NATURE MEDICINE

Dietary Fatty Acids and Microbiota-Brain Communication in Neuropsychiatric Diseases

(2019) Maria Cristina Marrone et al.   Biomolecules

Estimation of clinical trial success rates and related parameters

(2018) Chi Heem Wong et al.   BIOSTATISTICS

Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner

(2018) Morgane Sonia Thion et al.   CELL

Sex, Gut, and Microglia

(2018) Antoine Louveau et al.   DEVELOPMENTAL CELL

Immune system: The “seventh sense”

(2018) Jonathan Kipnis   JOURNAL OF EXPERIMENTAL MEDICINE

Shifts in gut microbiota composition in an APP/PSS1 transgenic mouse model of Alzheimer's disease during lifespan

(2018) C. Bäuerl et al.   LETTERS IN APPLIED MICROBIOLOGY

SLAB51 Probiotic Formulation Activates SIRT1 Pathway Promoting Antioxidant and Neuroprotective Effects in an AD Mouse Model

(2018) Laura Bonfili et al.   MOLECULAR NEUROBIOLOGY

Molecular and functional signatures in a novel Alzheimer’s disease mouse model assessed by quantitative proteomics

(2018) Dong Kyu Kim et al.   Molecular Neurodegeneration

An insight into intestinal mucosal microbiota disruption after stroke

(2018) Dragana Stanley et al.   Scientific Reports

Rapid environmental effects on gut nematode susceptibility in rewilded mice

(2018) Jacqueline M. Leung et al.   PLOS BIOLOGY

The effects of living in an outdoor enclosure on hippocampal plasticity and anxiety-like behavior in response to nematode infection

(2018) Elise C. Cope et al.   HIPPOCAMPUS

Global, Regional, and Country-Specific Lifetime Risks of Stroke, 1990 and 2016

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Maternal Overnutrition Induces Long-Term Cognitive Deficits across Several Generations

(2018) Gitalee Sarker et al.   Nutrients

Chronic colitis induces meninges traffic of gut-derived T cells, unbalances M1 and M2 microglia/macrophage and increases ischemic brain injury in mice

(2018) Yukun Feng et al.   BRAIN RESEARCH

Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer’s Mouse Model

(2017) Carolin Brandscheid et al.   JOURNAL OF ALZHEIMERS DISEASE

Targeting of microbe-derived metabolites to improve human health: The next frontier for drug discovery

(2017) J. Mark Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology

(2017) David Masopust et al.   JOURNAL OF IMMUNOLOGY

Infiltration and persistence of lymphocytes during late-stage cerebral ischemia in middle cerebral artery occlusion and photothrombotic stroke models

(2017) Yan Feng et al.   Journal of Neuroinflammation

Application of 1 H NMR spectroscopy to the metabolic phenotyping of rodent brain extracts: A metabonomic study of gut microbial influence on host brain metabolism

(2017) J.R. Swann et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Strains, functions and dynamics in the expanded Human Microbiome Project

(2017) Jason Lloyd-Price et al.   NATURE

High-avidity IgA protects the intestine by enchaining growing bacteria

(2017) Kathrin Moor et al.   NATURE

Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?

(2017) S.M. O’Mahony et al.   NEUROSCIENCE

Gut dysbiosis is associated with metabolism and systemic inflammation in patients with ischemic stroke

(2017) Kazuo Yamashiro et al.   PLoS One

Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels

(2017) Laura Bonfili et al.   Scientific Reports

Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans

(2016) Ron Sender et al.   CELL

Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome

(2016) Aleksey Chudnovskiy et al.   CELL

Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring

(2016) Shelly A. Buffington et al.   CELL

The Central Nervous System and the Gut Microbiome

(2016) Gil Sharon et al.   CELL

Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response

(2016) Tiffany A. Reese et al.   Cell Host & Microbe

Adult microbiota-deficient mice have distinct dendritic morphological changes: differential effects in the amygdala and hippocampus

(2016) Pauline Luczynski et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke

(2016) V. Singh et al.   JOURNAL OF NEUROSCIENCE

Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration

(2016) Timothy G. Dinan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Accounting for reciprocal host–microbiome interactions in experimental science

(2016) Thaddeus S. Stappenbeck et al.   NATURE

Normalizing the environment recapitulates adult human immune traits in laboratory mice

(2016) Lalit K. Beura et al.   NATURE

Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders

(2016) Monika Fleshner et al.   NEUROPSYCHOPHARMACOLOGY

Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health?

(2016) Megan W. Bourassa et al.   NEUROSCIENCE LETTERS

Autoimmune diseases, gastrointestinal disorders and the microbiome in schizophrenia: more than a gut feeling

(2016) Emily G. Severance et al.   SCHIZOPHRENIA RESEARCH

Transkingdom control of viral infection and immunity in the mammalian intestine

(2016) J. K. Pfeiffer et al.   SCIENCE

The maternal microbiota drives early postnatal innate immune development

(2016) M. Gomez de Aguero et al.   SCIENCE

Microglia development follows a stepwise program to regulate brain homeostasis

(2016) O. Matcovitch-Natan et al.   SCIENCE

Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut

(2016) M. R. Howitt et al.   SCIENCE

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

The Bacterial Microbiome and Virome Milestones of Infant Development

(2016) Efrem S. Lim et al.   TRENDS IN MICROBIOLOGY

Emerging Technologies for Gut Microbiome Research

(2016) Jason W. Arnold et al.   TRENDS IN MICROBIOLOGY

Ly6Chi Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis

(2016) Luisa Möhle et al.   Cell Reports

Regulation of prefrontal cortex myelination by the microbiota

(2016) A E Hoban et al.   Translational Psychiatry

Shotgun Metagenomics of 250 Adult Twins Reveals Genetic and Environmental Impacts on the Gut Microbiome

(2016) Hailiang Xie et al.   Cell Systems

Potential role of antimicrobial peptides in the early onset of Alzheimer's disease

(2015) Mick M. Welling et al.   Alzheimers & Dementia

Adult Hippocampal Neurogenesis Is Regulated by the Microbiome

(2015) Ebere S. Ogbonnaya et al.   BIOLOGICAL PSYCHIATRY

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

Releasing the Brakes on Cancer Immunotherapy

(2015) Dan R. Littman   CELL

Control of Brain Development, Function, and Behavior by the Microbiome

(2015) Timothy R. Sampson et al.   Cell Host & Microbe

Colonic bacterial composition in Parkinson's disease

(2015) Ali Keshavarzian et al.   MOVEMENT DISORDERS

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Manganese-Induced Parkinsonism Is Not Idiopathic Parkinson’s Disease: Environmental and Genetic Evidence

(2015) Tomás R. Guilarte et al.   TOXICOLOGICAL SCIENCES

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Microbiota and host determinants of behavioural phenotype in maternally separated mice

(2015) G. De Palma et al.   Nature Communications

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

(2014) Filipe De Vadder et al.   CELL

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

Kingdom-Agnostic Metagenomics and the Importance of Complete Characterization of Enteric Microbial Communities

(2014) Jason M. Norman et al.   GASTROENTEROLOGY

The Significance of Meaning: Why Do Over 90% of Behavioral Neuroscience Results Fail to Translate to Humans, and What Can We Do to Fix It?

(2014) J. P. Garner   ILAR JOURNAL

Clinical development success rates for investigational drugs

(2014) Michael Hay et al.   NATURE BIOTECHNOLOGY

An integrated catalog of reference genes in the human gut microbiome

(2014) Junhua Li et al.   NATURE BIOTECHNOLOGY

The gut microbiota influences blood-brain barrier permeability in mice

(2014) V. Braniste et al.   Science Translational Medicine

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

The Intestinal Microbiome in Early Life: Health and Disease

(2014) Marie-Claire Arrieta et al.   Frontiers in Immunology

Age-Associated Remodeling of the Intestinal Epithelial Barrier

(2013) L. Tran et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

The gut microbiota — masters of host development and physiology

(2013) Felix Sommer et al.   NATURE REVIEWS MICROBIOLOGY

Effect of HDAC Inhibitors on Neuroprotection and Neurite Outgrowth in Primary Rat Cortical Neurons Following Ischemic Insult

(2013) Mohammad Rakibul Hasan et al.   NEUROCHEMICAL RESEARCH

Conservation and divergence in the transcriptional programs of the human and mouse immune systems

(2013) T. Shay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut–brain axis: how the microbiome influences anxiety and depression

(2013) Jane A. Foster et al.   TRENDS IN NEUROSCIENCES

Butyrate-induced GPR41 Activation Inhibits Histone Acetylation and Cell Growth

(2012) Jin Wu et al.   Journal of Genetics and Genomics

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

(2012) G Clarke et al.   MOLECULAR PSYCHIATRY

The interplay between the intestinal microbiota and the brain

(2012) Stephen M. Collins et al.   NATURE REVIEWS MICROBIOLOGY

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

(2012) John F. Cryan et al.   NATURE REVIEWS NEUROSCIENCE

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

Requirement of adult-born neurons for hippocampus-dependent learning

(2011) Antonia Marín-Burgin et al.   BEHAVIOURAL BRAIN RESEARCH

The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice

(2011) Premysl Bercik et al.   GASTROENTEROLOGY

Normal gut microbiota modulates brain development and behavior

(2011) R. D. Heijtz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial infection causes stress-induced memory dysfunction in mice

(2010) M. G. Gareau et al.   GUT

Valproic Acid Attenuates Blood–Brain Barrier Disruption in a Rat Model of Transient Focal Cerebral Ischemia: The Roles of HDAC and MMP-9 Inhibition

(2010) Zhifei Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Reduced anxiety-like behavior and central neurochemical change in germ-free mice

(2010) K. M. Neufeld et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Composition, variability, and temporal stability of the intestinal microbiota of the elderly

(2010) M. J. Claesson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

‘Too much good news’ – are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease?

(2010) Kathleen R. Zahs et al.   TRENDS IN NEUROSCIENCES

Pulse Inhibition of Histone Deacetylases Induces Complete Resistance to Oxidative Death in Cortical Neurons without Toxicity and Reveals a Role for Cytoplasmic p21waf1/cip1 in Cell Cycle-Independent Neuroprotection

(2008) B. Langley et al.   JOURNAL OF NEUROSCIENCE

Worlds within worlds: evolution of the vertebrate gut microbiota

(2008) Ruth E. Ley et al.   NATURE REVIEWS MICROBIOLOGY