Targeting of microbe-derived metabolites to improve human health: The next frontier for drug discovery
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Targeting of microbe-derived metabolites to improve human health: The next frontier for drug discovery
Authors
Keywords
-
Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 292, Issue 21, Pages 8560-8568
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2017-04-08
DOI
10.1074/jbc.r116.765388
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Glucuronides in the gut: Sugar-driven symbioses between microbe and host
- (2017) Samuel J. Pellock et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dietary phosphatidylcholine and risk of all-cause and cardiovascular-specific mortality among US women and men
- (2016) Yan Zheng et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis
- (2016) Karolina Skagen et al. ATHEROSCLEROSIS
- L-Carnitine intake and high trimethylamine N-oxide plasma levels correlate with low aortic lesions in ApoE−/− transgenic mice expressing CETP
- (2016) Heidi L. Collins et al. ATHEROSCLEROSIS
- Toward Accurate and Quantitative Comparative Metagenomics
- (2016) Stephen Nayfach et al. CELL
- Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring
- (2016) Shelly A. Buffington et al. CELL
- Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk
- (2016) Weifei Zhu et al. CELL
- Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels
- (2016) M. Dambrova et al. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
- Brief Report
- (2016) P. Elliott Miller et al. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
- Sex steroid deficiency–associated bone loss is microbiota dependent and prevented by probiotics
- (2016) Jau-Yi Li et al. JOURNAL OF CLINICAL INVESTIGATION
- Plasma Trimethylamine N -Oxide, a Gut Microbe–Generated Phosphatidylcholine Metabolite, Is Associated With Atherosclerotic Burden
- (2016) Vichai Senthong et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- TrimethylamineN-Oxide and Cardiovascular Events in Hemodialysis Patients
- (2016) Tariq Shafi et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Advanced chronic kidney disease populations have elevated trimethylamine N-oxide levels associated with increased cardiovascular events
- (2016) Richard B. Kim et al. KIDNEY INTERNATIONAL
- Diet–microbiota interactions as moderators of human metabolism
- (2016) Justin L. Sonnenburg et al. NATURE
- Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor
- (2016) Veit Rothhammer et al. NATURE MEDICINE
- Emerging applications of metabolomics in drug discovery and precision medicine
- (2016) David S. Wishart NATURE REVIEWS DRUG DISCOVERY
- Emerging new strategies for successful metabolite identification in metabolomics
- (2016) Kerem Bingol et al. Bioanalysis
- Resveratrol Attenuates Trimethylamine- N -Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota
- (2016) Ming-liang Chen et al. mBio
- Characterization of the Gut Microbiome Using 16S or Shotgun Metagenomics
- (2016) Juan Jovel et al. Frontiers in Microbiology
- Intestinal Microbiota‐Generated Metabolite Trimethylamine‐N‐Oxide and 5‐Year Mortality Risk in Stable Coronary Artery Disease: The Contributory Role of Intestinal Microbiota in a COURAGE‐Like Patient Cohort
- (2016) Vichai Senthong et al. Journal of the American Heart Association
- Microbiota‐Dependent Metabolite Trimethylamine N‐Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA)
- (2016) Katie A. Meyer et al. Journal of the American Heart Association
- Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB
- (2016) Marcus M. Seldin et al. Journal of the American Heart Association
- Serum Trimethylamine-N-Oxide Is Strongly Related to Renal Function and Predicts Outcome in Chronic Kidney Disease
- (2016) Catharina Missailidis et al. PLoS One
- Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults
- (2016) Yu-ming Chen et al. Scientific Reports
- Relationship of Serum Trimethylamine N-Oxide (TMAO) Levels with early Atherosclerosis in Humans
- (2016) Elko Randrianarisoa et al. Scientific Reports
- The Gut Microbial Endocrine Organ: Bacterially Derived Signals Driving Cardiometabolic Diseases
- (2015) J. Mark Brown et al. Annual Review of Medicine
- Microbiology Meets Big Data: The Case of Gut Microbiota–Derived Trimethylamine
- (2015) Gwen Falony et al. Annual Review of Microbiology
- The Relationship Between Trimethylamine-N-Oxide and Prevalent Cardiovascular Disease in a Multiethnic Population Living in Canada
- (2015) Andrew Mente et al. CANADIAN JOURNAL OF CARDIOLOGY
- Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis
- (2015) Zeneng Wang et al. CELL
- Choline Diet and Its Gut Microbe–Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload–Induced Heart FailureCLINICAL PERSPECTIVE
- (2015) Chelsea L. Organ et al. Circulation-Heart Failure
- Associations among serum trimethylamine-N-oxide (TMAO) levels, kidney function and infarcted coronary artery number in patients undergoing cardiovascular surgery: a cross-sectional study
- (2015) Aki Mafune et al. Clinical and Experimental Nephrology
- Role of the Gut Microbiome in Obstructive Sleep Apnea–Induced Hypertension
- (2015) David J. Durgan et al. HYPERTENSION
- Intestinal Microbiota-Dependent Phosphatidylcholine Metabolites, Diastolic Dysfunction, and Adverse Clinical Outcomes in Chronic Systolic Heart Failure
- (2015) W.H. Wilson Tang et al. JOURNAL OF CARDIAC FAILURE
- Plasma Concentrations of Trimethylamine-N-oxide Are Directly Associated with Dairy Food Consumption and Low-Grade Inflammation in a German Adult Population
- (2015) Sabine Rohrmann et al. JOURNAL OF NUTRITION
- Serum Trimethylamine-N-Oxide is Elevated in CKD and Correlates with Coronary Atherosclerosis Burden
- (2015) J. R. Stubbs et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- A community-based approach to new antibiotic discovery
- (2015) Matthew A. Cooper NATURE REVIEWS DRUG DISCOVERY
- Short-term high-fat diet increases postprandial trimethylamine- N -oxide in humans
- (2015) Nabil E. Boutagy et al. NUTRITION RESEARCH
- Illuminating the dark matter in metabolomics: Fig. 1.
- (2015) Ricardo R. da Silva et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Intestinal Microbiota Composition Modulates Choline Bioavailability from Diet and Accumulation of the Proatherogenic Metabolite Trimethylamine- N -Oxide
- (2015) Kymberleigh A. Romano et al. mBio
- Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis
- (2015) Ji Miao et al. Nature Communications
- In Vivo Single-Cell Detection of Metabolic Oscillations in Stem Cells
- (2015) Chiara Stringari et al. Cell Reports
- Dysbiosis of Gut Microbiota With Reduced Trimethylamine‐N‐Oxide Level in Patients With Large‐Artery Atherosclerotic Stroke or Transient Ischemic Attack
- (2015) Jia Yin et al. Journal of the American Heart Association
- Trimethylamine-N-Oxide: A Carnitine-Derived Metabolite That Prolongs the Hypertensive Effect of Angiotensin II in Rats
- (2014) Marcin Ufnal et al. CANADIAN JOURNAL OF CARDIOLOGY
- γ-Butyrobetaine Is a Proatherogenic Intermediate in Gut Microbial Metabolism of L -Carnitine to TMAO
- (2014) Robert A. Koeth et al. Cell Metabolism
- Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide
- (2014) Z. Wang et al. EUROPEAN HEART JOURNAL
- Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation
- (2014) Jill C. Gregory et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet
- (2014) Xiang Gao et al. JOURNAL OF BIOSCIENCE AND BIOENGINEERING
- The contributory role of gut microbiota in cardiovascular disease
- (2014) W.H. Wilson Tang et al. JOURNAL OF CLINICAL INVESTIGATION
- Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure
- (2014) M. Trøseid et al. JOURNAL OF INTERNAL MEDICINE
- Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis
- (2014) Diana M. Shih et al. JOURNAL OF LIPID RESEARCH
- Prognostic Value of Elevated Levels of Intestinal Microbe-Generated Metabolite Trimethylamine-N-Oxide in Patients With Heart Failure
- (2014) W.H. Wilson Tang et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity
- (2014) Manon D. Schulz et al. NATURE
- Betaine and Trimethylamine-N-Oxide as Predictors of Cardiovascular Outcomes Show Different Patterns in Diabetes Mellitus: An Observational Study
- (2014) Michael Lever et al. PLoS One
- Survey of variants of human flavin-containing monooxygenase 3 (FMO3) and their drug oxidation activities
- (2013) Hiroshi Yamazaki et al. BIOCHEMICAL PHARMACOLOGY
- Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders
- (2013) Elaine Y. Hsiao et al. CELL
- Altered profile of human gut microbiome is associated with cirrhosis and its complications
- (2013) Jasmohan S. Bajaj et al. JOURNAL OF HEPATOLOGY
- A Combined Epidemiologic and Metabolomic Approach Improves CKD Prediction
- (2013) E. P. Rhee et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
- (2013) Shin Yoshimoto et al. NATURE
- Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
- (2013) Robert A Koeth et al. NATURE MEDICINE
- Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk
- (2013) W.H. Wilson Tang et al. NEW ENGLAND JOURNAL OF MEDICINE
- Human Trace Amine-Associated Receptor TAAR5 Can Be Activated by Trimethylamine
- (2013) Ivonne Wallrabenstein et al. PLoS One
- Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation
- (2013) Jennifer L. Pluznick et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Human Microbiome: Our Second Genome
- (2012) Elizabeth A. Grice et al. Annual Review of Genomics and Human Genetics
- The Impact of the Gut Microbiota on Human Health: An Integrative View
- (2012) Jose C. Clemente et al. CELL
- Synchronous Evolution of an Odor Biosynthesis Pathway and Behavioral Response
- (2012) Qian Li et al. CURRENT BIOLOGY
- The gut microbiota regulates bone mass in mice
- (2012) Klara Sjögren et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Diversity, stability and resilience of the human gut microbiota
- (2012) Catherine A. Lozupone et al. NATURE
- Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
- (2012) Jorge Henao-Mejia et al. NATURE
- Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota
- (2012) J. C. Arthur et al. SCIENCE
- Symptomatic atherosclerosis is associated with an altered gut metagenome
- (2012) Fredrik H. Karlsson et al. Nature Communications
- Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination
- (2011) Kerstin Berer et al. NATURE
- Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
- (2011) Zeneng Wang et al. NATURE
- Enterotypes of the human gut microbiome
- (2011) Manimozhiyan Arumugam et al. NATURE
- Enteric dysbiosis associated with a mouse model of alcoholic liver disease
- (2010) Arthur W. Yan et al. HEPATOLOGY
- A human gut microbial gene catalogue established by metagenomic sequencing
- (2010) Junjie Qin et al. NATURE
- Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis
- (2010) Y. K. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Human oral, gut, and plaque microbiota in patients with atherosclerosis
- (2010) O. Koren et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme
- (2010) B. D. Wallace et al. SCIENCE
- A core gut microbiome in obese and lean twins
- (2008) Peter J. Turnbaugh et al. NATURE
- Innate immunity and intestinal microbiota in the development of Type 1 diabetes
- (2008) Li Wen et al. NATURE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search