The Significance of Meaning: Why Do Over 90% of Behavioral Neuroscience Results Fail to Translate to Humans, and What Can We Do to Fix It?
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The Significance of Meaning: Why Do Over 90% of Behavioral Neuroscience Results Fail to Translate to Humans, and What Can We Do to Fix It?
Authors
Keywords
-
Journal
ILAR JOURNAL
Volume 55, Issue 3, Pages 438-456
Publisher
Oxford University Press (OUP)
Online
2014-12-25
DOI
10.1093/ilar/ilu047
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Randomized Block Experimental Designs Can Increase the Power and Reproducibility of Laboratory Animal Experiments
- (2014) M. F. W. Festing ILAR JOURNAL
- Clinical development success rates for investigational drugs
- (2014) Michael Hay et al. NATURE BIOTECHNOLOGY
- Olfactory exposure to males, including men, causes stress and related analgesia in rodents
- (2014) Robert E Sorge et al. NATURE METHODS
- Alzheimer’s disease drug-development pipeline: few candidates, frequent failures
- (2014) Jeffrey L Cummings et al. Alzheimers Research & Therapy
- An automated maze task for assessing hippocampus-sensitive memory in mice
- (2013) Elsa Y. Pioli et al. BEHAVIOURAL BRAIN RESEARCH
- Six red flags for suspect work
- (2013) C. Glenn Begley NATURE
- Reply to: "Reanalysis of Richter et al. (2010) on reproducibility"
- (2013) Hanno Würbel et al. NATURE METHODS
- Energy Reallocation to Breeding Performance through Improved Nest Building in Laboratory Mice
- (2013) Brianna N. Gaskill et al. PLoS One
- Whole Animal Experiments Should Be More Like Human Randomized Controlled Trials
- (2013) Beverly S. Muhlhausler et al. PLOS BIOLOGY
- The naked truth: Breeding performance in nude mice with and without nesting material
- (2012) Brianna N. Gaskill et al. APPLIED ANIMAL BEHAVIOUR SCIENCE
- Raise standards for preclinical cancer research
- (2012) C. Glenn Begley et al. NATURE
- In search of preclinical robustness
- (2012) Ian S. Peers et al. NATURE REVIEWS DRUG DISCOVERY
- Animal systems in the development of treatments for Alzheimer's disease: challenges, methods, and implications
- (2012) Jonathan J. Sabbagh et al. NEUROBIOLOGY OF AGING
- Heat or Insulation: Behavioral Titration of Mouse Preference for Warmth or Access to a Nest
- (2012) Brianna N. Gaskill et al. PLoS One
- Reverse-translational biomarker validation of Abnormal Repetitive Behaviors in mice: An illustration of the 4P's modeling approach
- (2011) Joseph P. Garner et al. BEHAVIOURAL BRAIN RESEARCH
- Erroneous analyses of interactions in neuroscience: a problem of significance
- (2011) Sander Nieuwenhuis et al. NATURE NEUROSCIENCE
- Believe it or not: how much can we rely on published data on potential drug targets?
- (2011) Florian Prinz et al. NATURE REVIEWS DRUG DISCOVERY
- Challenges for pharmaceutical industry: new partnerships for sustainable human health
- (2011) J. Hunter PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
- Effect of Population Heterogenization on the Reproducibility of Mouse Behavior: A Multi-Laboratory Study
- (2011) S. Helene Richter et al. PLoS One
- Environmental and Genetic Activation of a Brain-Adipocyte BDNF/Leptin Axis Causes Cancer Remission and Inhibition
- (2010) Lei Cao et al. CELL
- Hematopoietic Origin of Pathological Grooming in Hoxb8 Mutant Mice
- (2010) Shau-Kwaun Chen et al. CELL
- The standardization-generalization dilemma: a way out
- (2010) F. Josef van der Staay et al. GENES BRAIN AND BEHAVIOR
- Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive–like behaviors in mice
- (2010) Sergey V Shmelkov et al. NATURE MEDICINE
- Systematic variation improves reproducibility of animal experiments
- (2010) S Helene Richter et al. NATURE METHODS
- How to improve R&D productivity: the pharmaceutical industry's grand challenge
- (2010) Steven M. Paul et al. NATURE REVIEWS DRUG DISCOVERY
- Nutritional up-regulation of serotonin paradoxically induces compulsive behavior
- (2010) Brett D. Dufour et al. NUTRITIONAL NEUROSCIENCE
- ‘Too much good news’ – are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease?
- (2010) Kathleen R. Zahs et al. TRENDS IN NEUROSCIENCES
- Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research
- (2010) Carol Kilkenny et al. PLOS BIOLOGY
- Can Animal Models of Disease Reliably Inform Human Studies?
- (2010) H. Bart van der Worp et al. PLOS MEDICINE
- Amyloid precursor protein transgenic mouse models and Alzheimer's disease: Understanding the paradigms, limitations, and contributions
- (2009) Tyler A. Kokjohn et al. Alzheimers & Dementia
- N-Acetylcysteine, a Glutamate Modulator, in the Treatment of Trichotillomania
- (2009) Jon E. Grant et al. ARCHIVES OF GENERAL PSYCHIATRY
- Of Mice and Men
- (2009) Hugo Geerts CNS DRUGS
- Reverse translational strategies for developing animal models of bipolar disorder
- (2009) O. Malkesman et al. Disease Models & Mechanisms
- Environmental standardization: cure or cause of poor reproducibility in animal experiments?
- (2009) S Helene Richter et al. NATURE METHODS
- Survey of the Quality of Experimental Design, Statistical Analysis and Reporting of Research Using Animals
- (2009) Carol Kilkenny et al. PLoS One
- Social isolation dysregulates endocrine and behavioral stress while increasing malignant burden of spontaneous mammary tumors
- (2009) Gretchen L. Hermes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Some like it hot: Mouse temperature preferences in laboratory housing
- (2008) Brianna N. Gaskill et al. APPLIED ANIMAL BEHAVIOUR SCIENCE
- Standards for the publication of mouse mutant studies
- (2008) W. E. Crusio et al. GENES BRAIN AND BEHAVIOR
- Reciprocal Affiliation Among Adolescent Rats During a Mild Group Stressor Predicts Mammary Tumors and Lifespan
- (2008) Jason R. Yee et al. PSYCHOSOMATIC MEDICINE
- Evidence for the Efficacy of NXY-059 in Experimental Focal Cerebral Ischaemia Is Confounded by Study Quality
- (2008) Malcolm R. Macleod et al. STROKE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started