Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders

Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor

(2016) Masaaki Iwata et al.   BIOLOGICAL PSYCHIATRY

The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome

(2016) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior

(2016) Yuyan Cheng et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition

(2016) M-L Wong et al.   MOLECULAR PSYCHIATRY

Therapeutics targeting the inflammasome after central nervous system injury

(2016) Juan Pablo de Rivero Vaccari et al.   Translational Research

Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

(2016) Mausita Karmakar et al.   Nature Communications

Inflammation: Depression Fans the Flames and Feasts on the Heat

(2015) Janice K. Kiecolt-Glaser et al.   AMERICAN JOURNAL OF PSYCHIATRY

Association ofCRPGenetic Variation and CRP Level With Elevated PTSD Symptoms and Physiological Responses in a Civilian Population With High Levels of Trauma

(2015) Vasiliki Michopoulos et al.   AMERICAN JOURNAL OF PSYCHIATRY

Inflammasome-Independent Regulation of IL-1-Family Cytokines

(2015) Mihai G. Netea et al.   Annual Review of Immunology

Thymol produces an antidepressant-like effect in a chronic unpredictable mild stress model of depression in mice

(2015) Xue-Yang Deng et al.   BEHAVIOURAL BRAIN RESEARCH

Long-term effects of early adolescent stress: dysregulation of hypothalamic–pituitary–adrenal axis and central corticotropin releasing factor receptor 1 expression in adult male rats

(2015) Chuting Li et al.   BEHAVIOURAL BRAIN RESEARCH

Stress sounds the alarmin: The role of the danger-associated molecular pattern HMGB1 in stress-induced neuroinflammatory priming

(2015) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

Molecular mechanisms regulating NLRP3 inflammasome activation

(2015) Eun-Kyeong Jo et al.   Cellular & Molecular Immunology

Initiation and perpetuation of NLRP3 inflammasome activation and assembly

(2015) Eric I. Elliott et al.   IMMUNOLOGICAL REVIEWS

Enrichment pathway analysis. The inflammatory genetic background in Bipolar Disorder

(2015) Antonio Drago et al.   JOURNAL OF AFFECTIVE DISORDERS

Exosome-mediated inflammasome signaling after central nervous system injury

(2015) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF NEUROCHEMISTRY

Inflammasome-Induced IL-1  Secretion in Microglia Is Characterized by Delayed Kinetics and Is Only Partially Dependent on Inflammatory Caspases

(2015) S. M. Burm et al.   JOURNAL OF NEUROSCIENCE

Stress Induces the Danger-Associated Molecular Pattern HMGB-1 in the Hippocampus of Male Sprague Dawley Rats: A Priming Stimulus of Microglia and the NLRP3 Inflammasome

(2015) M. D. Weber et al.   JOURNAL OF NEUROSCIENCE

Icariin exerts an antidepressant effect in an unpredictable chronic mild stress model of depression in rats and is associated with the regulation of hippocampal neuroinflammation

(2015) B. Liu et al.   NEUROSCIENCE

Geraniol produces antidepressant-like effects in a chronic unpredictable mild stress mice model

(2015) Xue-Yang Deng et al.   PHYSIOLOGY & BEHAVIOR

Inflammation and Neuroprotection in Traumatic Brain Injury

(2015) Kara N. Corps et al.   JAMA Neurology

Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats

(2014) Ying Pan et al.   BRAIN BEHAVIOR AND IMMUNITY

NLRP3 Inflammasome: A New Target in Major Depressive Disorder

(2014) Elísabet Alcocer-Gómez et al.   CNS Neuroscience & Therapeutics

Ontogeny and Functions of Central Nervous System Macrophages

(2014) Atsuko Katsumoto et al.   JOURNAL OF IMMUNOLOGY

Clearance of Amyloid-Beta in Alzheimer’s Disease: Shifting the Action Site from Center to Periphery

(2014) Yu-Hui Liu et al.   MOLECULAR NEUROBIOLOGY

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Release of Neuronal HMGB1 by Ethanol through Decreased HDAC Activity Activates Brain Neuroimmune Signaling

(2014) Jian Y. Zou et al.   PLoS One

From stress to inflammation and major depressive disorder: A social signal transduction theory of depression.

(2014) George M. Slavich et al.   PSYCHOLOGICAL BULLETIN

Epilepsy and Inflammation in the Brain: Overview and Pathophysiology

(2014) Annamaria Vezzani   Epilepsy Currents

Stress-induced glucocorticoids as a neuroendocrine alarm signal of danger

(2013) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder

(2013) Elísabet Alcocer-Gómez et al.   BRAIN BEHAVIOR AND IMMUNITY

Interpersonal violence, PTSD, and inflammation: Potential psychogenic pathways to higher C-reactive protein levels

(2013) Nicole M. Heath et al.   CYTOKINE

The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis

(2013) Huan Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Assessment of the Performance of Three Multiplex Array Panels for the Detection of Circulating Cytokines and Chemokines in Naive, LPS, and SEB-treated Cynomolgus Macaques

(2013) Ching He et al.   TOXICOLOGIC PATHOLOGY

When grief makes you sick: Bereavement induced systemic inflammation is a question of genotype

(2012) Christian R. Schultze-Florey et al.   BRAIN BEHAVIOR AND IMMUNITY

Stress-evoked sterile inflammation, danger associated molecular patterns (DAMPs), microbial associated molecular patterns (MAMPs) and the inflammasome

(2012) Monika Fleshner   BRAIN BEHAVIOR AND IMMUNITY

The inflammasome and danger associated molecular patterns (DAMPs) are implicated in cytokine and chemokine responses following stressor exposure

(2012) Thomas Maslanik et al.   BRAIN BEHAVIOR AND IMMUNITY

Immune-neural connections: how the immune system's response to infectious agents influences behavior

(2012) R. H. McCusker et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

(2012) Emilie Venereau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRP3 Inflammasome Activity Is Negatively Controlled by miR-223

(2012) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

HMGB1 in Development and Diseases of the Central Nervous System

(2012) Ping Fang et al.   MOLECULAR NEUROBIOLOGY

Commensal Bacteria and MAMPs Are Necessary for Stress-Induced Increases in IL-1β and IL-18 but Not IL-6, IL-10 or MCP-1

(2012) Thomas Maslanik et al.   PLoS One

Stress-induced facilitation of host response to bacterial challenge in F344 rats is dependent on extracellular heat shock protein 72 and independent of alpha beta T cells

(2012) Jay Campisi et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

The impact of acute-stressor exposure on splenic innate immunity: A gene expression analysis

(2011) Thomas Maslanik et al.   BRAIN BEHAVIOR AND IMMUNITY

Maintenance of a positive outlook during acute stress protects against pro-inflammatory reactivity and future depressive symptoms

(2011) K. Aschbacher et al.   BRAIN BEHAVIOR AND IMMUNITY

Increased peripheral NF-κB pathway activity in women with childhood abuse-related posttraumatic stress disorder

(2011) Thaddeus W.W. Pace et al.   BRAIN BEHAVIOR AND IMMUNITY

Sensing damage by the NLRP3 inflammasome

(2011) Jaklien C. Leemans et al.   IMMUNOLOGICAL REVIEWS

Innate and adaptive immune responses to cell death

(2011) Kenneth L. Rock et al.   IMMUNOLOGICAL REVIEWS

Hemorrhagic Shock Activation of NLRP3 Inflammasome in Lung Endothelial Cells

(2011) M. Xiang et al.   JOURNAL OF IMMUNOLOGY

 -Adrenergic Receptor Antagonism Prevents Anxiety-Like Behavior and Microglial Reactivity Induced by Repeated Social Defeat

(2011) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

Immune system to brain signaling: Neuropsychopharmacological implications

(2011) Lucile Capuron et al.   PHARMACOLOGY & THERAPEUTICS

Autophagy and ATP-induced anti-apoptosis in antigen presenting cells (APC) follows the cytokine storm in patients after major trauma

(2011) E. Marion Schneider et al.   Journal of Cell Communication and Signaling

The Sterile Inflammatory Response

(2010) Kenneth L. Rock et al.   Annual Review of Immunology

Molecular Mechanism of NLRP3 Inflammasome Activation

(2010) Chengcheng Jin et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The myeloid cells of the central nervous system parenchyma

(2010) Richard M. Ransohoff et al.   NATURE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Therapeutic Neutralization of the NLRP1 Inflammasome Reduces the Innate Immune Response and Improves Histopathology after Traumatic Brain Injury

(2009) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Environmental Enrichment Restores Memory Functioning in Mice with Impaired IL-1 Signaling via Reinstatement of Long-Term Potentiation and Spine Size Enlargement

(2009) I. Goshen et al.   JOURNAL OF NEUROSCIENCE

Close relationships, inflammation, and health

(2009) Janice K. Kiecolt-Glaser et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Cognitive appraisals and emotions predict cortisol and immune responses: A meta-analysis of acute laboratory social stressors and emotion inductions.

(2009) Thomas F. Denson et al.   PSYCHOLOGICAL BULLETIN

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

(2009) M Bryant Howren et al.   PSYCHOSOMATIC MEDICINE

Elevated Inflammation Levels in Depressed Adults With a History of Childhood Maltreatment

(2008) Andrea Danese et al.   ARCHIVES OF GENERAL PSYCHIATRY

Inhibition of the Inflammasome Complex Reduces the Inflammatory Response after Thromboembolic Stroke in Mice

(2008) Denise P Abulafia et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A Molecular Platform in Neurons Regulates Inflammation after Spinal Cord Injury

(2008) J. P. de Rivero Vaccari et al.   JOURNAL OF NEUROSCIENCE