PI3K functions as a hub in mechanotransduction

Organismal roles for the PI3Kα and β isoforms: their specificity, redundancy or cooperation is context-dependent

(2021) Silvia Arcucci et al.   BIOCHEMICAL JOURNAL

Primary cilium-dependent autophagy drafts PIK3C2A to generate PtdIns3P in response to shear stress

(2020) Asma Boukhalfa et al.   Autophagy

Mechanical regulation of glycolysis via cytoskeleton architecture

(2020) Jin Suk Park et al.   NATURE

Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway

(2020) Antonios Chronopoulos et al.   NATURE MATERIALS

Compression stress induces nucleus pulposus cell autophagy by inhibition of the PI3K/AKT/mTOR pathway and activation of the JNK pathway

(2020) Zhiliang Li et al.   CONNECTIVE TISSUE RESEARCH

Structural and mechanical remodeling of the cytoskeleton maintains tensional homeostasis in 3D microtissues under acute dynamic stretch

(2020) Matthew Walker et al.   Scientific Reports

Pneumatically Actuated Microfluidic Platform for Reconstituting 3D Vascular Tissue Compression

(2020) Jungho Ahn et al.   Applied Sciences-Basel

Mechanical Control of Cell Proliferation Increases Resistance to Chemotherapeutic Agents

(2020) Ilaria Francesca Rizzuti et al.   PHYSICAL REVIEW LETTERS

Solid stress-induced migration is mediated by GDF15 through Akt pathway activation in pancreatic cancer cells

(2019) Maria Kalli et al.   Scientific Reports

The role of PI3K/Akt signaling pathway in non‐physiological shear stress‐induced platelet activation

(2019) Zengsheng Chen et al.   ARTIFICIAL ORGANS

Alpelisib for PIK3CA-Mutated, Hormone Receptor–Positive Advanced Breast Cancer

(2019) Fabrice André et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular profiling establishes genetic features predictive of the efficacy of the p110β inhibitor KIN-193

(2019) Isha Sethi et al.   CANCER RESEARCH

Pancreatic cancer provides testbed for first mechanotherapeutics

(2019) Cormac Sheridan   NATURE BIOTECHNOLOGY

Cell cycle progression in confining microenvironments is regulated by a growth-responsive TRPV4-PI3K/Akt-p27Kip1 signaling axis

(2019) Sungmin Nam et al.   Science Advances

Mechanosensing tensile solid stresses

(2019) Lance L. Munn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hippo pathway integrates PI3K–Akt signals with mechanical and polarity cues to control tissue growth

(2019) Nerea Borreguero-Muñoz et al.   PLOS BIOLOGY

MUC13 promotes intrahepatic cholangiocarcinoma progression via EGFR/PI3K/AKT pathways

(2019) Pei Tiemin et al.   JOURNAL OF HEPATOLOGY

Microfluidic systems for cancer diagnostics

(2019) Jose L Garcia-Cordero et al.   CURRENT OPINION IN BIOTECHNOLOGY

mTORC1 Controls Phase Separation and the Biophysical Properties of the Cytoplasm by Tuning Crowding

(2018) M. Delarue et al.   CELL

PI3K Positively Regulates YAP and TAZ in Mammary Tumorigenesis Through Multiple Signaling Pathways

(2018) Yulei Zhao et al.   MOLECULAR CANCER RESEARCH

Heterogeneity of Phosphatidylinositol-3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin Activation in Cancer: Is PI3K Isoform Specificity Important?

(2018) Célia Cintas et al.   Frontiers in Oncology

Integrin β1 promotes gemcitabine resistance in pancreatic cancer through Cdc42 activation of PI3K p110β signaling

(2018) Dejun Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility

(2018) Ana Angulo-Urarte et al.   Nature Communications

PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease

(2018) Vaibhav B. Patel et al.   Nature Communications

Cell volume change through water efflux impacts cell stiffness and stem cell fate

(2017) Ming Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical compression induces VEGFA overexpression in breast cancer via DNMT3A-dependent miR-9 downregulation

(2017) Baek Gil Kim et al.   Cell Death & Disease

Multiscale cytometry and regulation of 3D cell cultures on a chip

(2017) Sébastien Sart et al.   Nature Communications

Combinatorial Microenvironments Impose a Continuum of Cellular Responses to a Single Pathway-Targeted Anti-cancer Compound

(2017) Chun-Han Lin et al.   Cell Reports

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton

(2016) Hai Hu et al.   CELL

E-cadherin downregulation sensitizes PTEN-mutant tumors to PI3Kβ silencing

(2016) África Millán-Uclés et al.   Oncotarget

Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways

(2016) Wei-Chien Hung et al.   Cell Reports

Adhesion to fibronectin regulates Hippo signaling via the FAK–Src–PI3K pathway

(2015) Nam-Gyun Kim et al.   JOURNAL OF CELL BIOLOGY

A microengineered pathophysiological model of early-stage breast cancer

(2015) Yoonseok Choi et al.   LAB ON A CHIP

Phosphoinositide 3-kinase p110δ promotes lumen formation through the enhancement of apico-basal polarity and basal membrane organization

(2015) Juan Peng et al.   Nature Communications

The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function

(2015) Jessica K. Mountford et al.   Nature Communications

Force Engages Vinculin and Promotes Tumor Progression by Enhancing PI3K Activation of Phosphatidylinositol (3,4,5)-Triphosphate

(2014) Matthew G. Rubashkin et al.   CANCER RESEARCH

Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α

(2014) Romain Baer et al.   GENES & DEVELOPMENT

Classes of phosphoinositide 3-kinases at a glance

(2014) S. Jean et al.   JOURNAL OF CELL SCIENCE

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

(2014) Medha M. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatially distinct roles of class Ia PI3K isoforms in the development and maintenance of PTEN hamartoma tumor syndrome

(2013) Q. Wang et al.   GENES & DEVELOPMENT

Severe osmotic compression triggers a slowdown of intracellular signaling, which can be explained by molecular crowding

(2013) A. Miermont et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro

(2013) K. Alessandri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1

(2013) R. Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

(2012) T. Stylianopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The induction of autophagy by mechanical stress

(2011) Jason S. King et al.   Autophagy

Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor

(2011) Inma M. Berenjeno et al.   BIOCHEMICAL JOURNAL

A versatile valve-enabled microfluidic cell co-culture platform and demonstration of its applications to neurobiology and cancer biology

(2011) Yandong Gao et al.   BIOMEDICAL MICRODEVICES

Mechanical compression drives cancer cells toward invasive phenotype

(2011) J. M. Tse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stromal biology and therapy in pancreatic cancer

(2010) A. Neesse et al.   GUT

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chronic Intermittent Mechanical Stress Increases MUC5AC Protein Expression

(2009) Jin-Ah Park et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

The regulation and function of Class III PI3Ks: novel roles for Vps34

(2008) Jonathan M. Backer   BIOCHEMICAL JOURNAL

The p110  isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110 

(2008) J. Guillermet-Guibert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA