Compression stress induces nucleus pulposus cell autophagy by inhibition of the PI3K/AKT/mTOR pathway and activation of the JNK pathway

Interleukin-8 as a therapeutic target for chronic low back pain: Upregulation in human cerebrospinal fluid and pre-clinical validation with chronic reparixin in the SPARC-null mouse model

(2019) Emerson Krock et al.   EBioMedicine

Moderate activation of Wnt/β‐catenin signaling promotes the survival of rat nucleus pulposus cells via regulating apoptosis, autophagy, and senescence

(2019) Zhiliang Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

TIGAR impedes compression‐induced intervertebral disc degeneration by suppressing nucleus pulposus cell apoptosis and autophagy

(2019) Zhiliang Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Human cytomegalovirus infection-induced autophagy was associated with the biological behavioral changes of human umbilical vein endothelial cell (HUVEC)

(2018) Jun Zhao et al.   BIOMEDICINE & PHARMACOTHERAPY

LicA induces autophagy through ULK1/Atg13 and ROS pathway in human hepatocellular carcinoma cells

(2018) Qiang Niu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The fatty degeneration of lumbar paraspinal muscles on computed tomography scan according to age and disc level

(2017) Shin Heon Lee et al.   Spine Journal

Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus

(2017) Chao Liu et al.   Scientific Reports

The protective effects of shikonin on hepatic ischemia/reperfusion injury are mediated by the activation of the PI3K/Akt pathway

(2017) Tong Liu et al.   Scientific Reports

Dehydroepiandrosterone triggers autophagic cell death in human hepatoma cell line HepG2 via JNK-mediated p62/SQSTM1 expression

(2016) Rolando Vegliante et al.   CARCINOGENESIS

Autophagy protects ovarian cancer-associated fibroblasts against oxidative stress

(2016) Qian Wang et al.   CELL CYCLE

JNK1 Inhibition Attenuates Hypoxia-Induced Autophagy and Sensitizes to Chemotherapy

(2016) I. A. Vasilevskaya et al.   MOLECULAR CANCER RESEARCH

Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo

(2016) Deheng Chen et al.   Cell Death & Disease

H2O2 treatment or serum deprivation induces autophagy and apoptosis in naked mole-rat skin fibroblasts by inhibiting the PI3K/Akt signaling pathway

(2016) Shanmin Zhao et al.   Oncotarget

Polyphyllin VII Induces an Autophagic Cell Death by Activation of the JNK Pathway and Inhibition of PI3K/AKT/mTOR Pathway in HepG2 Cells

(2016) Chao Zhang et al.   PLoS One

Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways

(2016) Yumei Yan et al.   Scientific Reports

Dihydroartemisinin inhibits catabolism in rat chondrocytes by activating autophagy via inhibition of the NF-κB pathway

(2016) Li-Bo Jiang et al.   Scientific Reports

Current trends in biologics delivery to restore intervertebral disc anabolism

(2015) Gianluca Fontana et al.   ADVANCED DRUG DELIVERY REVIEWS

Mitochondrial ROS Signaling in Organismal Homeostasis

(2015) Gerald S. Shadel et al.   CELL

Quantitative, 3D Visualization of the Initiation and Progression of Vertebral Fractures Under Compression and Anterior Flexion

(2015) Timothy M Jackman et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

Behavioral signs of axial low back pain and motor impairment correlate with the severity of intervertebral disc degeneration in a mouse model

(2015) Magali Millecamps et al.   Spine Journal

Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis by regulating p38 MAPKs and PI3K/AKT signaling pathways

(2015) Bo-Syong Pan et al.   Scientific Reports

Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis

(2014) Yue Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

Autophagy and apoptosis: where do they meet?

(2014) Subhadip Mukhopadhyay et al.   APOPTOSIS

Dual Role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation

(2014) Yongjie Wei et al.   Autophagy

Cell metabolism: Autophagy transcribed

(2014) Carmine Settembre et al.   NATURE

Reactive Oxygen Species Regulation of Autophagy in Skeletal Muscles

(2013) Mashrur Rahman et al.   ANTIOXIDANTS & REDOX SIGNALING

Cell death in intervertebral disc degeneration

(2013) Fan Ding et al.   APOPTOSIS

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy

(2013) Jan R. Dörr et al.   NATURE

Autophagy is activated in compression-induced cell degeneration and is mediated by reactive oxygen species in nucleus pulposus cells exposed to compression

(2013) K.-G. Ma et al.   OSTEOARTHRITIS AND CARTILAGE

Role of mitochondrial pathway in compression-induced apoptosis of nucleus pulposus cells

(2012) Fan Ding et al.   APOPTOSIS

BCL2L11/BIM

(2012) Shouqing Luo et al.   Autophagy

Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation

(2012) Lin Li et al.   CELLULAR SIGNALLING

Cooperative action of JNK and AKT/mTOR in 1-methyl-4-phenylpyridinium-induced autophagy of neuronal PC12 cells

(2012) Jezabel Rodríguez-Blanco et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

The effects of dynamic loading on the intervertebral disc

(2011) Samantha C. W. Chan et al.   EUROPEAN SPINE JOURNAL

Control of autophagy as a therapy for neurodegenerative disease

(2011) Harry Harris et al.   Nature Reviews Neurology

Resveratrol Promotes Autophagic Cell Death in Chronic Myelogenous Leukemia Cells via JNK-Mediated p62/SQSTM1 Expression and AMPK Activation

(2010) A. Puissant et al.   CANCER RESEARCH

Ursolic acid overcomes Bcl-2-mediated resistance to apoptosis in prostate cancer cells involving activation of JNK-induced Bcl-2 phosphorylation and degradation

(2010) Yu-xi Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY