PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease

2-Deoxyadenosine triphosphate restores the contractile function of cardiac myofibril from adult dogs with naturally occurring dilated cardiomyopathy

(2016) Yuanhua Cheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Type 1 Diabetes Genetic Risk Score: A Novel Tool to Discriminate Monogenic and Type 1 Diabetes

(2016) Kashyap A. Patel et al.   DIABETES

Mechanisms and Functions of Vinculin Interactions with Phospholipids at Cell Adhesion Sites

(2016) Tina Izard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PI3Kα is essential for the recovery from Cre/tamoxifen cardiotoxicity and in myocardial insulin signalling but is not required for normal myocardial contractility in the adult heart

(2015) Brent A. McLean et al.   CARDIOVASCULAR RESEARCH

Molecules in medicine mini-review: isoforms of PI3K in biology and disease

(2015) Bart Vanhaesebroeck et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

2013 ACCF/AHA Guideline for the Management of Heart Failure: Executive Summary

(2013) Clyde W. Yancy et al.   CIRCULATION

Loss of p47 phox Subunit Enhances Susceptibility to Biomechanical Stress and Heart Failure Because of Dysregulation of Cortactin and Actin Filaments

(2013) Vaibhav B. Patel et al.   CIRCULATION RESEARCH

Dynamic Localization of G-Actin during Membrane Protrusion in Neuronal Motility

(2013) Chi Wai Lee et al.   CURRENT BIOLOGY

Comparative molecular dynamics simulation studies for determining factors contributing to the thermostability of chemotaxis protein “CheY”

(2013) Manish Paul et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Genetic mutations and mechanisms in dilated cardiomyopathy

(2013) Elizabeth M. McNally et al.   JOURNAL OF CLINICAL INVESTIGATION

Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and induciblePIK3CDpromoter

(2012) Maria A. Whitehead et al.   BIOCHEMICAL JOURNAL

Loss of Angiotensin-Converting Enzyme-2 Exacerbates Diabetic Cardiovascular Complications and Leads to Systolic and Vascular Dysfunction

(2012) Vaibhav B. Patel et al.   CIRCULATION RESEARCH

Phosphoinositide 3-Kinase p110α Is a Master Regulator of Exercise-Induced Cardioprotection and PI3K Gene Therapy Rescues Cardiac Dysfunction

(2012) Kate L. Weeks et al.   Circulation-Heart Failure

Cardioprotective Effects Mediated by Angiotensin II Type 1 Receptor Blockade and Enhancing Angiotensin 1-7 in Experimental Heart Failure in Angiotensin-Converting Enzyme 2–Null Mice

(2012) Vaibhav B. Patel et al.   HYPERTENSION

Activation of Moesin, a Protein That Links Actin Cytoskeleton to the Plasma Membrane, Occurs by Phosphatidylinositol 4,5-bisphosphate (PIP2) Binding Sequentially to Two Sites and Releasing an Autoinhibitory Linker

(2012) Khadija Ben-Aissa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Truncations of Titin Causing Dilated Cardiomyopathy

(2012) Daniel S. Herman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Uncoupling between enhanced excitation–contraction coupling and the response to heart disease: Lessons from the PI3Kγ knockout murine model

(2011) Danny Guo et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Intercellular and extracellular mechanotransduction in cardiac myocytes

(2011) J. Yasha Kresh et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

PI3Ks Maintain the Structural Integrity of T-Tubules in Cardiac Myocytes

(2011) Chia-Yen C. Wu et al.   PLoS One

ADP-Ribosylation of Cross-Linked Actin Generates Barbed-End Polymerization-Deficient F-Actin Oligomers

(2010) Alexandru A. Perieteanu et al.   BIOCHEMISTRY

Angiotensin-Converting Enzyme 2 Suppresses Pathological Hypertrophy, Myocardial Fibrosis, and Cardiac Dysfunction

(2010) JiuChang Zhong et al.   CIRCULATION

Loss of PI3Kγ Enhances cAMP-Dependent MMP Remodeling of the Myocardial N-Cadherin Adhesion Complexes and Extracellular Matrix in Response to Early Biomechanical Stress

(2010) Danny Guo et al.   CIRCULATION RESEARCH

Nebulette Mutations Are Associated With Dilated Cardiomyopathy and Endocardial Fibroelastosis

(2010) Enkhsaikhan Purevjav et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Multifunctional roles of gelsolin in health and diseases

(2010) Guo Hua Li et al.   MEDICINAL RESEARCH REVIEWS

Cardiac regulation by phosphoinositide 3-kinases and PTEN

(2009) G. Y. Oudit et al.   CARDIOVASCULAR RESEARCH

Gelsolin and Cardiac Myocyte Apoptosis

(2009) Ryosuke Nishio et al.   CIRCULATION RESEARCH

FAK, PIP5KI  and gelsolin cooperatively mediate force-induced expression of  -smooth muscle actin

(2009) M. W. C. Chan et al.   JOURNAL OF CELL SCIENCE

Advanced Heart Failure Treated with Continuous-Flow Left Ventricular Assist Device

(2009) Mark S. Slaughter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin

(2009) S. Nag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress

(2008) G. Y. Oudit et al.   CARDIOVASCULAR RESEARCH

Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration

(2008) Mariona Graupera et al.   NATURE

Cardiac Plasticity

(2008) Joseph A. Hill et al.   NEW ENGLAND JOURNAL OF MEDICINE

The p110  isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110 

(2008) J. Guillermet-Guibert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA