REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps

Cellular response to endogenous DNA damage: DNA base modifications in gene expression regulation

(2021) Diana L. Bordin et al.   DNA REPAIR

Homology-directed repair protects the replicating genome from metabolic assaults

(2021) Kumar Somyajit et al.   DEVELOPMENTAL CELL

The Multiple Cellular Roles of SMUG1 in Genome Maintenance and Cancer

(2021) Sripriya Raja et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors

(2021) Kasper Fugger et al.   SCIENCE

PrimPol‐mediated repriming facilitates replication traverse of DNA interstrand crosslinks

(2021) Daniel González‐Acosta et al.   EMBO JOURNAL

Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency

(2021) Ke Cong et al.   MOLECULAR CELL

HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis

(2020) Gongshi Bai et al.   MOLECULAR CELL

Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly

(2020) Tanay Thakar et al.   Nature Communications

New insights into abasic site repair and tolerance

(2020) Petria S. Thompson et al.   DNA REPAIR

HMCES Maintains Replication Fork Progression and Prevents Double-Strand Breaks in Response to APOBEC Deamination and Abasic Site Formation

(2020) Kavi P.M. Mehta et al.   Cell Reports

Inhibition of the translesion synthesis polymerase REV1 exploits replication gaps as a cancer vulnerability

(2020) Sumeet Nayak et al.   Science Advances

Trajectory and uniqueness of mutational signatures in yeast mutators

(2020) Sophie Loeillet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translesion synthesis inhibitors as a new class of cancer chemotherapeutics

(2020) Seema M. Patel et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

(2020) Graeme Hewitt et al.   MOLECULAR CELL

PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts

(2020) Ann Liza Piberger et al.   Nature Communications

AKT inhibition impairs PCNA ubiquitylation and triggers synthetic lethality in homologous recombination-deficient cells submitted to replication stress

(2019) Florencia Villafañez et al.   ONCOGENE

53BP1 nuclear bodies enforce replication timing at under-replicated DNA to limit heritable DNA damage

(2019) Julian Spies et al.   NATURE CELL BIOLOGY

Rad5 Recruits Error-Prone DNA Polymerases for Mutagenic Repair of ssDNA Gaps on Undamaged Templates

(2019) David Gallo et al.   MOLECULAR CELL

Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor

(2019) Kenichi Iwai et al.   Science Advances

Comprehensive genomic characterization of breast tumors with BRCA1 and BRCA2 mutations

(2019) Avantika Lal et al.   BMC Medical Genomics

A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy

(2019) Jessica L. Wojtaszek et al.   CELL

Protection of abasic sites during DNA replication by a stable thiazolidine protein-DNA cross-link

(2019) Petria S. Thompson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stimulation of CRISPR-mediated homology-directed repair by an engineered RAD18 variant

(2019) Tarun S. Nambiar et al.   Nature Communications

PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells

(2019) Annabel Quinet et al.   MOLECULAR CELL

The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway

(2019) Joel C. Rosenbaum et al.   Nature Communications

Translesion and Repair DNA Polymerases: Diverse Structure and Mechanism

(2018) Wei Yang et al.   Annual Review of Biochemistry

Uncoupling fork speed and origin activity to identify the primary cause of replicative stress phenotypes

(2018) Sara Rodriguez-Acebes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of MCM2–7 protein phosphorylation in human cancer cells

(2018) Liangru Fei et al.   Cell and Bioscience

HMCES Maintains Genome Integrity by Shielding Abasic Sites in Single-Strand DNA

(2018) Kareem N. Mohni et al.   CELL

DNA repair factor RAD18 and DNA polymerase Polκ confer tolerance of oncogenic DNA replication stress

(2017) Yang Yang et al.   JOURNAL OF CELL BIOLOGY

Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers

(2017) Angelo Taglialatela et al.   MOLECULAR CELL

Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments

(2017) Arun Mouli Kolinjivadi et al.   MOLECULAR CELL

BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination

(2017) Weiran Feng et al.   Nature Communications

MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

(2017) Delphine Lemaçon et al.   Nature Communications

Replication fork reversal triggers fork degradation in BRCA2-defective cells

(2017) Sofija Mijic et al.   Nature Communications

Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy?

(2017) Kinrin Yamanaka et al.   PLoS Genetics

Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1

(2017) Lene Alsøe et al.   Scientific Reports

Interaction between the Rev1 C-Terminal Domain and the PolD3 Subunit of Polζ Suggests a Mechanism of Polymerase Exchange upon Rev1/Polζ-Dependent Translesion Synthesis

(2016) Yulia Pustovalova et al.   BIOCHEMISTRY

Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides

(2016) Kaori Kobayashi et al.   CELL CYCLE

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

(2016) Serena Nik-Zainal et al.   NATURE

Blocking c-Met–mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors

(2016) Yi Du et al.   NATURE MEDICINE

A defect in homologous recombination leads to increased translesion synthesisin E. coli

(2016) Karel Naiman et al.   NUCLEIC ACIDS RESEARCH

Translesion synthesis mechanisms depend on the nature of DNA damage in UV-irradiated human cells

(2016) Annabel Quinet et al.   NUCLEIC ACIDS RESEARCH

PrimPol prevents APOBEC/AID family mediated DNA mutagenesis

(2016) Bas Pilzecker et al.   NUCLEIC ACIDS RESEARCH

Loss of BRCA1 or BRCA2 markedly increases the rate of base substitution mutagenesis and has distinct effects on genomic deletions

(2016) J Zámborszky et al.   ONCOGENE

Functions of Ubiquitin and SUMO in DNA Replication and Replication Stress

(2016) Néstor García-Rodríguez et al.   Frontiers in Genetics

BRCA1 and BRCA2 protect against oxidative DNA damage converted into double-strand breaks during DNA replication

(2015) Ram Fridlich et al.   DNA REPAIR

DNA Polymerase ζ-Dependent Lesion Bypass in Saccharomyces cerevisiae Is Accompanied by Error-Prone Copying of Long Stretches of Adjacent DNA

(2015) Olga V. Kochenova et al.   PLoS Genetics

The need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancer

(2014) Britta Weigelt et al.   ADVANCED DRUG DELIVERY REVIEWS

Replicative Bypass of Abasic Site in Escherichia coli and Human Cells: Similarities and Differences

(2014) Savithri Weerasooriya et al.   PLoS One

BRCA1 haploinsufficiency for replication stress suppression in primary cells

(2014) Shailja Pathania et al.   Nature Communications

hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity

(2013) Li Wan et al.   EMBO REPORTS

PrimPol Bypasses UV Photoproducts during Eukaryotic Chromosomal DNA Replication

(2013) Julie Bianchi et al.   MOLECULAR CELL

PrimPol, an Archaic Primase/Polymerase Operating in Human Cells

(2013) Sara García-Gómez et al.   MOLECULAR CELL

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Repriming of DNA synthesis at stalled replication forks by human PrimPol

(2013) Silvana Mourón et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance

(2013) N. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Homologous recombination rescues ssDNA gaps generated by nucleotide excision repair and reduced translesion DNA synthesis in yeast G2 cells

(2013) W. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hereditary Breast Cancer: The Era of New Susceptibility Genes

(2013) Paraskevi Apostolou et al.   Biomed Research International

NMR Structure and Dynamics of the C-Terminal Domain from Human Rev1 and Its Complex with Rev1 Interacting Region of DNA Polymerase η

(2012) Alexandra Pozhidaeva et al.   BIOCHEMISTRY

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

Insights into the regulation of human Rev1 for translesion synthesis polymerases revealed by the structural studies on its polymerase-interacting domain

(2012) D. Liu et al.   Journal of Molecular Cell Biology

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

The dCMP transferase activity of yeast Rev1 is biologically relevant during the bypass of endogenously generated AP sites

(2011) Nayun Kim et al.   DNA REPAIR

The Rev1 translesion synthesis polymerase has multiple distinct DNA binding modes

(2011) Frederik H. de Groote et al.   DNA REPAIR

BRCA1 Is Required for Postreplication Repair after UV-Induced DNA Damage

(2011) Shailja Pathania et al.   MOLECULAR CELL

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

(2011) Claudia Lukas et al.   NATURE CELL BIOLOGY

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Translesion Synthesis across Abasic Lesions by Human B-Family and Y-Family DNA Polymerases α, δ, η, ι, κ, and REV1

(2010) Jeong-Yun Choi et al.   JOURNAL OF MOLECULAR BIOLOGY

Ubiquitin signalling in DNA replication and repair

(2010) Helle D. Ulrich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

(2010) Peter Bouwman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

(2010) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals

(2009) Sigal Shachar et al.   EMBO JOURNAL

Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

(2009) L. S. Waters et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity

(2008) Alessia Montagnoli et al.   Nature Chemical Biology