Translesion synthesis inhibitors as a new class of cancer chemotherapeutics

HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis

(2020) Gongshi Bai et al.   MOLECULAR CELL

A stapled POL κ peptide targets REV1 to inhibit mutagenic translesion synthesis

(2020) Nimrat Chatterjee et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Inhibition of the translesion synthesis polymerase REV1 exploits replication gaps as a cancer vulnerability

(2020) Sumeet Nayak et al.   Science Advances

Inactivation of REV7 enhances chemosensitivity and overcomes acquired chemoresistance in testicular germ cell tumors

(2020) Yasutaka Sakurai et al.   CANCER LETTERS

Inhibition of human DNA polymerases eta and kappa by indole-derived molecules occurs through distinct mechanisms

(2019) Amit Ketkar et al.   ACS Chemical Biology

A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy

(2019) Jessica L. Wojtaszek et al.   CELL

Virtual Pharmacophore Screening Identifies Small Molecule Inhibitors of the Rev1‐CT/RIR Protein‐Protein Interaction

(2019) Radha C. Dash et al.   ChemMedChem

Translesion and Repair DNA Polymerases: Diverse Structure and Mechanism

(2018) Wei Yang et al.   Annual Review of Biochemistry

A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells

(2018) Maroof K. Zafar et al.   BIOCHEMISTRY

Small-molecules that bind to the ubiquitin-binding motif of REV1 inhibit REV1 interaction with K164-monoubiquitinated PCNA and suppress DNA damage tolerance

(2018) Murugendra Vanarotti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Small Molecule Scaffolds that Disrupt the Rev1-CT/RIR Protein-Protein Interaction

(2018) Zuleyha Ozen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Rev7 dimerization is important for assembly and function of the Rev1/Polζ translesion synthesis complex

(2018) Alessandro A. Rizzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Approach To Identify a Lead Scaffold That Targets the Translesion Synthesis Polymerase Rev1

(2018) Radha Charan Dash et al.   Journal of Chemical Information and Modeling

Inhibiting translesion DNA synthesis as an approach to combat drug resistance to DNA damaging agents

(2017) Jung-Suk Choi et al.   Oncotarget

Structural insight into inhibition of REV7 protein interaction revealed by docking, molecular dynamics and MM/PBSA studies

(2017) Xiaodong Ren et al.   RSC Advances

Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy?

(2017) Kinrin Yamanaka et al.   PLoS Genetics

Interaction between the Rev1 C-Terminal Domain and the PolD3 Subunit of Polζ Suggests a Mechanism of Polymerase Exchange upon Rev1/Polζ-Dependent Translesion Synthesis

(2016) Yulia Pustovalova et al.   BIOCHEMISTRY

Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction

(2016) Marcelo L. Actis et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics

(2016) Dmitry M. Korzhnev et al.   JOURNAL OF MEDICINAL CHEMISTRY

Roles of mutagenic translesion synthesis in mammalian genome stability, health and disease

(2015) Jacob G. Jansen et al.   DNA REPAIR

REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ζ

(2015) Junya Tomida et al.   NUCLEIC ACIDS RESEARCH

Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells

(2015) Amit Kumar Srivastava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

REV3L, a Promising Target in Regulating the Chemosensitivity of Cervical Cancer Cells

(2015) Li Yang et al.   PLoS One

An Overview of Y-Family DNA Polymerases and a Case Study of Human DNA Polymerase η

(2014) Wei Yang   BIOCHEMISTRY

A site-selective, irreversible inhibitor of the DNA replication auxiliary factor proliferating cell nuclear antigen (PCNA)

(2014) Benjamin J. Evison et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Translesion Polymerase   Is Upregulated by Cancer Therapeutics and Confers Anticancer Drug Resistance

(2014) M. T. Tomicic et al.   CANCER RESEARCH

A Small Molecule Inhibitor of Monoubiquitinated Proliferating Cell Nuclear Antigen(PCNA) Inhibits Repair of Interstrand DNA Cross-link, Enhances DNA Double Strand Break, and Sensitizes Cancer Cells to Cisplatin

(2014) Akira Inoue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antitumor Effects of a Novel Small Molecule Targeting PCNA Chromatin Association in Prostate Cancer

(2014) K. L. Dillehay et al.   MOLECULAR CANCER THERAPEUTICS

N-Aroyl Indole Thiobarbituric Acids as Inhibitors of DNA Repair and Replication Stress Response Polymerases

(2013) Grace E. Coggins et al.   ACS Chemical Biology

Small molecule inhibitors of PCNA/PIP-box interaction suppress translesion DNA synthesis

(2013) Marcelo Actis et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Leukotriene Biosynthesis Inhibitor MK886 Impedes DNA Polymerase Activity

(2013) Amit Ketkar et al.   CHEMICAL RESEARCH IN TOXICOLOGY

NMR Mapping of PCNA Interaction with Translesion Synthesis DNA Polymerase Rev1 Mediated by Rev1-BRCT Domain

(2013) Yulia Pustovalova et al.   JOURNAL OF MOLECULAR BIOLOGY

Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug

(2013) X. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleotide Excision Repair in Eukaryotes

(2013) O. D. Scharer   Cold Spring Harbor Perspectives in Biology

Base Excision Repair

(2013) H. E. Krokan et al.   Cold Spring Harbor Perspectives in Biology

NMR Structure and Dynamics of the C-Terminal Domain from Human Rev1 and Its Complex with Rev1 Interacting Region of DNA Polymerase η

(2012) Alexandra Pozhidaeva et al.   BIOCHEMISTRY

REV1 and DNA polymerase zeta in DNA interstrand crosslink repair

(2012) Shilpy Sharma et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

The C-terminal domain of human Rev1 contains independent binding sites for DNA polymerase η and Rev7 subunit of polymerase ζ

(2012) Yulia Pustovalova et al.   FEBS LETTERS

Structural Basis of Recruitment of DNA Polymerase ζ by Interaction between REV1 and REV7 Proteins

(2012) Sotaro Kikuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Rev1-mediated Assembly of a Quaternary Vertebrate Translesion Polymerase Complex Consisting of Rev1, Heterodimeric Polymerase (Pol) ζ, and Pol κ

(2012) Jessica Wojtaszek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multifaceted Recognition of Vertebrate Rev1 by Translesion Polymerases ζ and κ

(2012) Jessica Wojtaszek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Small Molecule Proliferating Cell Nuclear Antigen (PCNA) Inhibitor That Disrupts Interactions with PIP-box Proteins and Inhibits DNA Replication

(2012) Chandanamali Punchihewa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pinophilins A and B, Inhibitors of Mammalian A-, B-, and Y-Family DNA Polymerases and Human Cancer Cell Proliferation

(2012) Yusuke Myobatake et al.   JOURNAL OF NATURAL PRODUCTS

Y-family DNA polymerases and their role in tolerance of cellular DNA damage

(2012) Julian E. Sale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Comprehensive Strategy to Discover Inhibitors of the Translesion Synthesis DNA Polymerase κ

(2012) Kinrin Yamanaka et al.   PLoS One

Translesion DNA synthesis in the context of cancer research

(2011) Philip A Knobel et al.   Cancer Cell International

REV1 and polymerase ζ facilitate homologous recombination repair

(2011) Shilpy Sharma et al.   NUCLEIC ACIDS RESEARCH

Crystal Structure of Human REV7 in Complex with a Human REV3 Fragment and Structural Implication of the Interaction between DNA Polymerase ζ and REV1

(2010) Kodai Hara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Error-prone translesion synthesis mediates acquired chemoresistance

(2010) K. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of Rev3, the catalytic subunit of Pol , sensitizes drug-resistant lung tumors to chemotherapy

(2010) J. Doles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Penicilliols A and B, novel inhibitors specific to mammalian Y-family DNA polymerases

(2009) Takuma Kimura et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Identification of a novel REV1-interacting motif necessary for DNA polymerase κ function

(2009) Eiji Ohashi et al.   GENES TO CELLS

Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen

(2009) Asami Hishiki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

3-O-Methylfunicone, a Selective Inhibitor of Mammalian Y-Family DNA Polymerases from an Australian Sea Salt Fungal Strain

(2009) Yoshiyuki Mizushina et al.   Marine Drugs

Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

(2009) L. S. Waters et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The Translesion Polymerase Rev3L in the Tolerance of Alkylating Anticancer Drugs

(2009) W. P. Roos et al.   MOLECULAR PHARMACOLOGY

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

DNA Polymerases as Therapeutic Targets†

(2008) Anthony J. Berdis   BIOCHEMISTRY

1-Deoxyrubralactone, a novel specific inhibitor of families X and Y of eukaryotic DNA polymerases from a fungal strain derived from sea algae

(2007) Mitsuki Naganuma et al.   BIOORGANIC & MEDICINAL CHEMISTRY