Loss of BRCA1 or BRCA2 markedly increases the rate of base substitution mutagenesis and has distinct effects on genomic deletions

Subclonal diversification of primary breast cancer revealed by multiregion sequencing

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Mus81 and converging forks limit the mutagenicity of replication fork breakage

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Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins

(2015) Rohit Prakash et al.   Cold Spring Harbor Perspectives in Biology

Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence

(2015) Maja Sedic et al.   Nature Communications

Tracking the Genomic Evolution of Esophageal Adenocarcinoma through Neoadjuvant Chemotherapy

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SAMBLASTER: fast duplicate marking and structural variant read extraction

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DNA breaks and chromosomal aberrations arise when replication meets base excision repair

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The role of microhomology in genomic structural variation

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BRCA1 haploinsufficiency for replication stress suppression in primary cells

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The Genome of the Chicken DT40 Bursal Lymphoma Cell Line

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Translesion DNA Synthesis and Mutagenesis in Eukaryotes

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Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer

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Ploidy and Large-Scale Genomic Instability Consistently Identify Basal-like Breast Carcinomas with BRCA1/2 Inactivation

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Mutational Processes Molding the Genomes of 21 Breast Cancers

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BRCA Mutation Frequency and Patterns of Treatment Response in BRCA Mutation–Positive Women With Ovarian Cancer: A Report From the Australian Ovarian Cancer Study Group

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Analysis of CPD Ultraviolet Lesion Bypass in Chicken DT40 Cells: Polymerase η and PCNA Ubiquitylation Play Identical Roles

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Telomeric Allelic Imbalance Indicates Defective DNA Repair and Sensitivity to DNA-Damaging Agents

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Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

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Ubiquitin family modifications and template switching

(2011) Dana Branzei   FEBS LETTERS

BRCA1 Is Required for Postreplication Repair after UV-Induced DNA Damage

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CREST maps somatic structural variation in cancer genomes with base-pair resolution

(2011) Jianmin Wang et al.   NATURE METHODS

A dual role of BRCA1 in two distinct homologous recombination mediated repair in response to replication arrest

(2011) Zhihui Feng et al.   NUCLEIC ACIDS RESEARCH

Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells

(2011) H. Konishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Epistatic Relationship between BRCA2 and the Other RAD51 Mediators in Homologous Recombination

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The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

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Enhanced H2AX Phosphorylation, DNA Replication Fork Arrest, and Cell Death in the Absence of Chk1

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Genomic instability — an evolving hallmark of cancer

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PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response

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PCNA Ubiquitination and REV1 Define Temporally Distinct Mechanisms for Controlling Translesion Synthesis in the Avian Cell Line DT40

(2008) Charlotte E. Edmunds et al.   MOLECULAR CELL

Cell-cycle coordination between DNA replication and recombination revealed by a vertebrate N-end rule degron-Rad51

(2008) Xinyi Su et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

REV1 restrains DNA polymerase ζ to ensure frame fidelity during translesion synthesis of UV photoproducts in vivo

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