Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors

Genetic screens in isogenic mammalian cell lines without single cell cloning

(2020) Peter C. DeWeirdt et al.   Nature Communications

Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets

(2019) Kristen E. Mengwasser et al.   MOLECULAR CELL

Isomerization of BRCA1–BARD1 promotes replication fork protection

(2019) Manuel Daza-Martin et al.   NATURE

PARP Inhibitor Resistance: A Tug-of-War in BRCA-Mutated Cells

(2019) Sylvie M. Noordermeer et al.   TRENDS IN CELL BIOLOGY

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality

(2018) Ewa Gogola et al.   CANCER CELL

The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication

(2018) Hana Hanzlikova et al.   MOLECULAR CELL

RPA and RAD51: fork reversal, fork protection, and genome stability

(2018) Kamakoti P. Bhat et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

(2018) Stephen J. Pettitt et al.   Nature Communications

RPA and RAD51: fork reversal, fork protection, and genome stability

(2018) Kamakoti P. Bhat et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

High speed of fork progression induces DNA replication stress and genomic instability

(2018) Apolinar Maya-Mendoza et al.   NATURE

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

(2018) Michal Zimmermann et al.   NATURE

Isotope-dilution mass spectrometry for exact quantification of noncanonical DNA nucleosides

(2018) Franziska R. Traube et al.   Nature Protocols

Modeling Therapy Resistance in BRCA1/2 -Mutant Cancers

(2017) Amy Dréan et al.   MOLECULAR CANCER THERAPEUTICS

Unresolved recombination intermediates lead to ultra-fine anaphase bridges, chromosome breaks and aberrations

(2017) Ying Wai Chan et al.   NATURE CELL BIOLOGY

Gene Expression and Methylation Analyses Suggest DCTD as a Prognostic Factor in Malignant Glioma

(2017) Huimin Hu et al.   Scientific Reports

Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage

(2016) Yang Yu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

(2016) Y. Pommier et al.   Science Translational Medicine

CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer

(2015) Melania Zauri et al.   NATURE

Protein and Nucleotide Biosynthesis Are Coupled by a Single Rate-Limiting Enzyme, PRPS2, to Drive Cancer

(2014) John T. Cunningham et al.   CELL

Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line

(2014) Patrick Essletzbichler et al.   GENOME RESEARCH

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Coordinated Actions of SLX1-SLX4 and MUS81-EME1 for Holliday Junction Resolution in Human Cells

(2013) Haley D.M. Wyatt et al.   MOLECULAR CELL

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

N6-Substituted AMPs Inhibit Mammalian Deoxynucleotide N-Hydrolase DNPH1

(2013) Claire Amiable et al.   PLoS One

FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress

(2013) Kasper Fugger et al.   Nature Communications

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

(2012) J. Murai et al.   CANCER RESEARCH

On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1

(2012) X. Luo et al.   GENES & DEVELOPMENT

PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees

(2012) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

Loss of 53BP1 Causes PARP Inhibitor Resistance in Brca1 -Mutated Mouse Mammary Tumors

(2012) Janneke E. Jaspers et al.   Cancer Discovery

Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain

(2011) Junjie U. Guo et al.   CELL

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

(2011) Kristine Williams et al.   NATURE

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Genomic rearrangements in BRCA1 and BRCA2: a literature review

(2009) Ingrid Petroni Ewald et al.   GENETICS AND MOLECULAR BIOLOGY

Base Excision by Thymine DNA Glycosylase Mediates DNA-Directed Cytotoxicity of 5-Fluorouracil

(2009) Christophe Kunz et al.   PLOS BIOLOGY

Rcl is a novel ETV1/ER81 target gene upregulated in breast tumors

(2008) Sook Shin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY