Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance
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Title
Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance
Authors
Keywords
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Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 110, Issue 42, Pages 17041-17046
Publisher
Proceedings of the National Academy of Sciences
Online
2013-10-02
DOI
10.1073/pnas.1305170110
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- 53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks
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- 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
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- PALB2 Functionally Connects the Breast Cancer Susceptibility Proteins BRCA1 and BRCA2
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- Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90
- (2009) F. A. Dungey et al. MOLECULAR CANCER THERAPEUTICS
- CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle
- (2009) Maximina H. Yun et al. NATURE
- Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers
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- PALB2 is an integral component of the BRCA complex required for homologous recombination repair
- (2009) S. M. H. Sy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Secondary BRCA1 Mutations in BRCA1-Mutated Ovarian Carcinomas with Platinum Resistance
- (2008) E. M. Swisher et al. CANCER RESEARCH
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