Translesion synthesis mechanisms depend on the nature of DNA damage in UV-irradiated human cells

Starvation Promotes REV1 SUMOylation and p53-Dependent Sensitization of Melanoma and Breast Cancer Cells

(2015) H. S. Shim et al.   CANCER RESEARCH

FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress

(2015) Yeran Yang et al.   NUCLEIC ACIDS RESEARCH

The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ

(2015) Kouji Hirota et al.   NUCLEIC ACIDS RESEARCH

DNA repair and recovery of RNA synthesis following exposure to ultraviolet light are delayed in long genes

(2015) Leonardo C. Andrade-Lima et al.   NUCLEIC ACIDS RESEARCH

Three-dimensional microenvironment confers enhanced sensitivity to doxorubicin by reducing p53-dependent induction of autophagy

(2015) L R Gomes et al.   ONCOGENE

Rad51 recombinase prevents Mre11 nuclease-dependent degradation and excessive PrimPol-mediated elongation of nascent DNA after UV irradiation

(2015) María Belén Vallerga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gap-filling and bypass at the replication fork are both active mechanisms for tolerance of low-dose ultraviolet-induced DNA damage in the human genome

(2014) Annabel Quinet et al.   DNA REPAIR

DNA repair diseases: what do they tell us about cancer and aging?

(2014) Carlos FM Menck et al.   GENETICS AND MOLECULAR BIOLOGY

ATR suppresses apoptosis after UVB irradiation by controlling both translesion synthesis and alternative tolerance pathways

(2014) L. C. Andrade-Lima et al.   JOURNAL OF CELL SCIENCE

Redundancy of mammalian Y family DNA polymerases in cellular responses to genomic DNA lesions induced by ultraviolet light

(2014) Jacob G. Jansen et al.   NUCLEIC ACIDS RESEARCH

The CDC13-STN1-TEN1 complex stimulates Pol α activity by promoting RNA priming and primase-to-polymerase switch

(2014) Neal F. Lue et al.   Nature Communications

The Transcription Factor TFII-I Promotes DNA Translesion Synthesis and Genomic Stability

(2014) Farjana J. Fattah et al.   PLoS Genetics

Nucleotide excision repair activity on DNA damage induced by photoactivated methylene blue

(2013) Carolina Maria Berra et al.   FREE RADICAL BIOLOGY AND MEDICINE

PrimPol, an Archaic Primase/Polymerase Operating in Human Cells

(2013) Sara García-Gómez et al.   MOLECULAR CELL

PrimPol breaks replication barriers

(2013) Thomas Helleday   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rev3, the catalytic subunit of Polζ, is required for maintaining fragile site stability in human cells

(2013) Audesh Bhat et al.   NUCLEIC ACIDS RESEARCH

The relative roles of DNA damage induced by UVA irradiation in human cells

(2013) Barbara Cortat et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Temporally distinct translesion synthesis pathways for ultraviolet light-induced photoproducts in the mammalian genome

(2012) Piya Temviriyanukul et al.   DNA REPAIR

The C-terminal domain of human Rev1 contains independent binding sites for DNA polymerase η and Rev7 subunit of polymerase ζ

(2012) Yulia Pustovalova et al.   FEBS LETTERS

DNA Polymerase δ and ζ Switch by Sharing Accessory Subunits of DNA Polymerase δ

(2012) Andrey G. Baranovskiy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Competition, collaboration and coordination - determining how cells bypass DNA damage

(2012) J. E. Sale   JOURNAL OF CELL SCIENCE

CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation

(2012) Ingegerd Elvers et al.   NUCLEIC ACIDS RESEARCH

Both XPA and DNA polymerase eta are necessary for the repair of doxorubicin-induced DNA lesions

(2011) Maria Carolina S. Moraes et al.   CANCER LETTERS

Multiple two-polymerase mechanisms in mammalian translesion DNA synthesis

(2011) Zvi Livneh et al.   CELL CYCLE

The Rev1 translesion synthesis polymerase has multiple distinct DNA binding modes

(2011) Frederik H. de Groote et al.   DNA REPAIR

The Non-canonical Protein Binding Site at the Monomer-Monomer Interface of Yeast Proliferating Cell Nuclear Antigen (PCNA) Regulates the Rev1-PCNA Interaction and Polζ/Rev1-dependent Translesion DNA Synthesis

(2011) Neeru M. Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UV stalled replication forks restart by re-priming in human fibroblasts

(2011) Ingegerd Elvers et al.   NUCLEIC ACIDS RESEARCH

DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity

(2011) Noam Diamant et al.   NUCLEIC ACIDS RESEARCH

PCNA Ubiquitination Is Important, But Not Essential for Translesion DNA Synthesis in Mammalian Cells

(2011) Ayal Hendel et al.   PLoS Genetics

Error-free replicative bypass of (6-4) photoproducts by DNA polymerase   in mouse and human cells

(2010) J.-H. Yoon et al.   GENES & DEVELOPMENT

ATR/Chk1 pathway is essential for resumption of DNA synthesis and cell survival in UV-irradiated XP variant cells

(2010) Emmanuelle Despras et al.   HUMAN MOLECULAR GENETICS

Ubiquitin-dependent DNA damage bypass is separable from genome replication

(2010) Yasukazu Daigaku et al.   NATURE

Postreplication gaps at UV lesions are signals for checkpoint activation

(2010) A. J. Callegari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian polymerase ζ is essential for post-replication repair of UV-induced DNA lesions

(2009) Jacob G. Jansen et al.   DNA REPAIR

Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals

(2009) Sigal Shachar et al.   EMBO JOURNAL

Separate Domains of Rev1 Mediate Two Modes of DNA Damage Bypass in Mammalian Cells

(2009) J. G. Jansen et al.   MOLECULAR AND CELLULAR BIOLOGY

DNA polymerase ζ cooperates with polymerases κ and ι in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients

(2009) Omer Ziv et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PCNA Ubiquitination and REV1 Define Temporally Distinct Mechanisms for Controlling Translesion Synthesis in the Avian Cell Line DT40

(2008) Charlotte E. Edmunds et al.   MOLECULAR CELL

REV1 restrains DNA polymerase ζ to ensure frame fidelity during translesion synthesis of UV photoproducts in vivo

(2008) Dávid Szüts et al.   NUCLEIC ACIDS RESEARCH

CPDs and 6-4PPs play different roles in UV-induced cell death in normal and NER-deficient human cells

(2007) Keronninn Moreno de Lima-Bessa et al.   DNA REPAIR