RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis

Shutoff of host transcription triggers a toxin-antitoxin system to cleave phage RNA and abort infection

(2021) Chantal K. Guegler et al.   MOLECULAR CELL

Type II toxin-antitoxin systems: evolution and revolutions

(2020) N. Fraikin et al.   JOURNAL OF BACTERIOLOGY

The C-Terminal RRM/ACT Domain Is Crucial for Fine-Tuning the Activation of ‘Long’ RelA-SpoT Homolog Enzymes by Ribosomal Complexes

(2020) Hiraku Takada et al.   Frontiers in Microbiology

Small-Molecule Acetylation by GCN5-Related N-Acetyltransferases in Bacteria

(2020) Rachel M. Burckhardt et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

A widespread toxin−antitoxin system exploiting growth control via alarmone signaling

(2020) Steffi Jimmy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxin-Antitoxin Gene Pairs Found in Tn3 Family Transposons Appear To Be an Integral Part of the Transposition Module

(2020) Gipsi Lima-Mendez et al.   mBio

A revised mechanism for (p)ppGpp synthesis by Rel proteins: The critical role of the 2’-OH of GTP

(2020) Pratik Rajendra Patil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Primary Physiological Role of Toxin/Antitoxin Systems Is Phage Inhibition

(2020) Sooyeon Song et al.   Frontiers in Microbiology

A nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stems

(2020) Yiming Cai et al.   Science Advances

Complete chemical structures of human mitochondrial tRNAs

(2020) Takeo Suzuki et al.   Nature Communications

(p)ppGpp: the magic governor of bacterial growth economy

(2019) Manlu Zhu et al.   CURRENT GENETICS

Origins and evolution of CRISPR-Cas systems

(2019) Eugene V. Koonin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Intramolecular Interactions Dominate the Autoregulation of Escherichia coli Stringent Factor RelA

(2019) Kathryn Jane Turnbull et al.   Frontiers in Microbiology

An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp

(2019) Shehryar Ahmad et al.   NATURE

Structural basis for (p)ppGpp synthesis by theStaphylococcus aureussmall alarmone synthetase RelP

(2018) Melek Cemre Manav et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toxins, Targets, and Triggers: An Overview of Toxin-Antitoxin Biology

(2018) Alexander Harms et al.   MOLECULAR CELL

The ribosomal A-site finger is crucial for binding and activation of the stringent factor RelA

(2018) Pavel Kudrin et al.   NUCLEIC ACIDS RESEARCH

Antibiotic resistance ABCF proteins reset the peptidyl transferase centre of the ribosome to counter translational arrest

(2018) Victoriia Murina et al.   NUCLEIC ACIDS RESEARCH

Structural and mechanistic divergence of the small (p)ppGpp synthetases RelP and RelQ

(2018) Wieland Steinchen et al.   Scientific Reports

Cap-specific terminal N6-methylation of RNA by an RNA polymerase II–associated methyltransferase

(2018) Shinichiro Akichika et al.   SCIENCE

AtaT blocks translation initiation by N-acetylation of the initiator tRNAfMet

(2017) Dukas Jurėnas et al.   Nature Chemical Biology

Structural conservation of the PIN domain active site across all domains of life

(2017) M. Senissar et al.   PROTEIN SCIENCE

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Prophage-mediated defence against viral attack and viral counter-defence

(2017) Rebekah M. Dedrick et al.   Nature Microbiology

HPLC-based quantification of bacterial housekeeping nucleotides and alarmone messengers ppGpp and pppGpp

(2017) Vallo Varik et al.   Scientific Reports

The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes

(2016) G.C.P. van Zundert et al.   JOURNAL OF MOLECULAR BIOLOGY

A Salmonella Toxin Promotes Persister Formation through Acetylation of tRNA

(2016) Angela M. Cheverton et al.   MOLECULAR CELL

Ribosome-dependent activation of stringent control

(2016) Alan Brown et al.   NATURE

Toxin-antitoxin systems in bacterial growth arrest and persistence

(2016) Rebecca Page et al.   Nature Chemical Biology

The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis

(2016) Stefan Arenz et al.   NUCLEIC ACIDS RESEARCH

Ribosome•RelA structures reveal the mechanism of stringent response activation

(2016) Anna B Loveland et al.   eLife

Diversity in (p)ppGpp metabolism and effectors

(2015) Kuanqing Liu et al.   CURRENT OPINION IN MICROBIOLOGY

Many Means to a Common End: the Intricacies of (p)ppGpp Metabolism and Its Control of Bacterial Homeostasis

(2015) Anthony O. Gaca et al.   JOURNAL OF BACTERIOLOGY

Type II toxin–antitoxin systems are unevenly distributed among Escherichia coli phylogroups

(2015) Krzysztof Fiedoruk et al.   MICROBIOLOGY-SGM

CRP-dependent Positive Autoregulation and Proteolytic Degradation Regulate Competence Activator Sxy ofEscherichia coli

(2015) Milena Jaskólska et al.   MOLECULAR MICROBIOLOGY

Recent functional insights into the role of (p)ppGpp in bacterial physiology

(2015) Vasili Hauryliuk et al.   NATURE REVIEWS MICROBIOLOGY

Catalytic mechanism and allosteric regulation of an oligomeric (p)ppGpp synthetase by an alarmone

(2015) Wieland Steinchen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining the mRNA recognition signature of a bacterial toxin protein

(2015) Marc A. Schureck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth-regulating Mycobacterium tuberculosis VapC-mt4 toxin is an isoacceptor-specific tRNase

(2015) Jonathan W. Cruz et al.   Nature Communications

Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology

(2015) Alexander Harms et al.   Cell Reports

The many faces of Fic: structural and functional aspects of Fic enzymes

(2014) Abel Garcia-Pino et al.   TRENDS IN BIOCHEMICAL SCIENCES

Two Small (p)ppGpp Synthases in Staphylococcus aureus Mediate Tolerance against Cell Envelope Stress Conditions

(2013) T. Geiger et al.   JOURNAL OF BACTERIOLOGY

Identification and Characterization of Type II Toxin-Antitoxin Systems in the Opportunistic Pathogen Acinetobacter baumannii

(2013) M. Jurenaite et al.   JOURNAL OF BACTERIOLOGY

Relaxed Cleavage Specificity within the RelE Toxin Family

(2013) N. Goeders et al.   JOURNAL OF BACTERIOLOGY

MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability

(2013) K. Katoh et al.   MOLECULAR BIOLOGY AND EVOLUTION

The Fic protein Doc uses an inverted substrate to phosphorylate and inactivate EF-Tu

(2013) Daniel Castro-Roa et al.   Nature Chemical Biology

High-Resolution Comparative Modeling with RosettaCM

(2013) Yifan Song et al.   STRUCTURE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

The RelA/SpoT Homolog (RSH) Superfamily: Distribution and Functional Evolution of ppGpp Synthetases and Hydrolases across the Tree of Life

(2011) Gemma C. Atkinson et al.   PLoS One

Enteric virulence associated protein VapC inhibits translation by cleavage of initiator tRNA

(2011) K. S. Winther et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses

(2010) Dawei Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

Mutagenesis and Functional Characterization of the RNA and Protein Components of the toxIN Abortive Infection and Toxin-Antitoxin Locus of Erwinia

(2009) T. R. Blower et al.   JOURNAL OF BACTERIOLOGY