The C-Terminal RRM/ACT Domain Is Crucial for Fine-Tuning the Activation of ‘Long’ RelA-SpoT Homolog Enzymes by Ribosomal Complexes

The Rel stringent factor from Thermus thermophilus: crystallization and X-ray analysis

(2019) Katleen Van Nerom et al.   Acta Crystallographica Section F-Structural Biology Communications

The (p)ppGpp-binding GTPase Era promotes rRNA processing and cold adaptation in Staphylococcus aureus

(2019) Alison Wood et al.   PLoS Genetics

Intramolecular Interactions Dominate the Autoregulation of Escherichia coli Stringent Factor RelA

(2019) Kathryn Jane Turnbull et al.   Frontiers in Microbiology

Stringent response protein as a potential target to intervene persistent bacterial infection

(2019) Gajraj Singh Kushwaha et al.   BIOCHIMIE

The Ps and Qs of alarmone synthesis in Staphylococcus aureus

(2019) Ning Yang et al.   PLoS One

Activation of the Stringent Response by Loading of RelA-tRNA Complexes at the Ribosomal A-Site

(2018) Kristoffer Skovbo Winther et al.   MOLECULAR CELL

The ribosomal A-site finger is crucial for binding and activation of the stringent factor RelA

(2018) Pavel Kudrin et al.   NUCLEIC ACIDS RESEARCH

Antibiotic resistance ABCF proteins reset the peptidyl transferase centre of the ribosome to counter translational arrest

(2018) Victoriia Murina et al.   NUCLEIC ACIDS RESEARCH

Regulation of stringent factor by branched-chain amino acids

(2018) Mingxu Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of the opposing (p)ppGpp synthetase and hydrolase activities in a bifunctional RelA/SpoT homologue from Staphylococcus aureus

(2018) Fabio Lino Gratani et al.   PLoS Genetics

ABCF ATPases Involved in Protein Synthesis, Ribosome Assembly and Antibiotic Resistance: Structural and Functional Diversification across the Tree of Life

(2018) Victoriia Murina et al.   JOURNAL OF MOLECULAR BIOLOGY

Regulation of (p)ppGpp hydrolysis by a conserved archetypal regulatory domain

(2018) Séverin Ronneau et al.   NUCLEIC ACIDS RESEARCH

Elimination of Ribosome Inactivating Factors Improves the Efficiency of Bacillus subtilis and Saccharomyces cerevisiae Cell-Free Translation Systems

(2018) Tetiana Brodiazhenko et al.   Frontiers in Microbiology

Negative allosteric regulation ofEnterococcus faecalissmall alarmone synthetase RelQ by single-stranded RNA

(2017) Jelena Beljantseva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribosome dimerization is essential for the efficient regrowth of Bacillus subtilis

(2016) Genki Akanuma et al.   MICROBIOLOGY-SGM

The magic dance of the alarmones (p)ppGpp

(2016) Wieland Steinchen et al.   MOLECULAR MICROBIOLOGY

Ribosome-dependent activation of stringent control

(2016) Alan Brown et al.   NATURE

The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis

(2016) Stefan Arenz et al.   NUCLEIC ACIDS RESEARCH

Ribosome•RelA structures reveal the mechanism of stringent response activation

(2016) Anna B Loveland et al.   eLife

Biochemical studies on Francisella tularensis RelA in (p)ppGpp biosynthesis

(2015) R. C. Wilkinson et al.   BIOSCIENCE REPORTS

Diversity in (p)ppGpp metabolism and effectors

(2015) Kuanqing Liu et al.   CURRENT OPINION IN MICROBIOLOGY

Recent functional insights into the role of (p)ppGpp in bacterial physiology

(2015) Vasili Hauryliuk et al.   NATURE REVIEWS MICROBIOLOGY

The ribosome triggers the stringent response by RelA via a highly distorted tRNA

(2013) Xabier Agirrezabala et al.   EMBO REPORTS

Two Small (p)ppGpp Synthases in Staphylococcus aureus Mediate Tolerance against Cell Envelope Stress Conditions

(2013) T. Geiger et al.   JOURNAL OF BACTERIOLOGY

MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability

(2013) K. Katoh et al.   MOLECULAR BIOLOGY AND EVOLUTION

Positive allosteric feedback regulation of the stringent response enzyme RelA by its product

(2012) Viktoriya Shyp et al.   EMBO REPORTS

ppGpp: magic beyond RNA polymerase

(2012) Zachary D. Dalebroux et al.   NATURE REVIEWS MICROBIOLOGY

Expression of a small (p)ppGpp synthetase, YwaC, in the (p)ppGpp0mutant ofBacillus subtilistriggers YvyD-dependent dimerization of ribosome

(2012) Kazumi Tagami et al.   MicrobiologyOpen

The complex logic of stringent response regulation in Caulobacter crescentus: starvation signalling in an oligotrophic environment

(2011) Cara C. Boutte et al.   MOLECULAR MICROBIOLOGY

The RelA/SpoT Homolog (RSH) Superfamily: Distribution and Functional Evolution of ppGpp Synthetases and Hydrolases across the Tree of Life

(2011) Gemma C. Atkinson et al.   PLoS One

ppGpp Conjures Bacterial Virulence

(2010) Z. D. Dalebroux et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Resistance to and synthesis of the antibiotic mupirocin

(2010) Christopher M. Thomas et al.   NATURE REVIEWS MICROBIOLOGY

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS