A widespread toxin−antitoxin system exploiting growth control via alarmone signaling

The C-Terminal RRM/ACT Domain Is Crucial for Fine-Tuning the Activation of ‘Long’ RelA-SpoT Homolog Enzymes by Ribosomal Complexes

(2020) Hiraku Takada et al.   Frontiers in Microbiology

Methylobacterium extorquens RSH Enzyme Synthesizes (p)ppGpp and pppApp in vitro and in vivo, and Leads to Discovery of pppApp Synthesis in Escherichia coli

(2019) Michał Sobala et al.   Frontiers in Microbiology

An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp

(2019) Shehryar Ahmad et al.   NATURE

Structural basis for (p)ppGpp synthesis by theStaphylococcus aureussmall alarmone synthetase RelP

(2018) Melek Cemre Manav et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toxins, Targets, and Triggers: An Overview of Toxin-Antitoxin Biology

(2018) Alexander Harms et al.   MOLECULAR CELL

T7 phage factor required for managing RpoS inEscherichia coli

(2018) Aline Tabib-Salazar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The E. coli Global Regulator DksA Reduces Transcription during T4 Infection

(2018) Jennifer Patterson-West et al.   Viruses-Basel

Reassessing the Role of Type II Toxin-Antitoxin Systems in Formation of Escherichia coli Type II Persister Cells

(2018) Frédéric Goormaghtigh et al.   mBio

Structural and mechanistic divergence of the small (p)ppGpp synthetases RelP and RelQ

(2018) Wieland Steinchen et al.   Scientific Reports

AtaT blocks translation initiation by N-acetylation of the initiator tRNAfMet

(2017) Dukas Jurėnas et al.   Nature Chemical Biology

Negative allosteric regulation ofEnterococcus faecalissmall alarmone synthetase RelQ by single-stranded RNA

(2017) Jelena Beljantseva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prophages and Growth Dynamics Confound Experimental Results with Antibiotic-Tolerant Persister Cells

(2017) Alexander Harms et al.   mBio

Prophage-mediated defence against viral attack and viral counter-defence

(2017) Rebekah M. Dedrick et al.   Nature Microbiology

Low-level predation by lytic phage phiIPLA-RODI promotes biofilm formation and triggers the stringent response in Staphylococcus aureus

(2017) Lucía Fernández et al.   Scientific Reports

HPLC-based quantification of bacterial housekeeping nucleotides and alarmone messengers ppGpp and pppGpp

(2017) Vallo Varik et al.   Scientific Reports

PHASTER: a better, faster version of the PHAST phage search tool

(2016) David Arndt et al.   NUCLEIC ACIDS RESEARCH

CDD/SPARCLE: functional classification of proteins via subfamily domain architectures

(2016) Aron Marchler-Bauer et al.   NUCLEIC ACIDS RESEARCH

Recent functional insights into the role of (p)ppGpp in bacterial physiology

(2015) Vasili Hauryliuk et al.   NATURE REVIEWS MICROBIOLOGY

Prediction of Type II Toxin-Antitoxin Loci in Klebsiella pneumoniae Genome Sequences

(2015) Yi-Qing Wei et al.   Interdisciplinary Sciences-Computational Life Sciences

RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies

(2014) Alexandros Stamatakis   BIOINFORMATICS

IQ-TREE: A Fast and Effective Stochastic Algorithm for Estimating Maximum-Likelihood Phylogenies

(2014) Lam-Tung Nguyen et al.   MOLECULAR BIOLOGY AND EVOLUTION

Two Small (p)ppGpp Synthases in Staphylococcus aureus Mediate Tolerance against Cell Envelope Stress Conditions

(2013) T. Geiger et al.   JOURNAL OF BACTERIOLOGY

A Bacterial Toxin Inhibits DNA Replication Elongation through a Direct Interaction with the β Sliding Clamp

(2013) Christopher D. Aakre et al.   MOLECULAR CELL

Complete Genome Sequence of Bacteriophage SSU5 Specific for Salmonella enterica serovar Typhimurium Rough Strains

(2012) M. Kim et al.   JOURNAL OF VIROLOGY

Genomic and Proteomic Characterization of the Broad-Host-Range Salmonella Phage PVP-SE1: Creation of a New Phage Genus

(2011) S. B. Santos et al.   JOURNAL OF VIROLOGY

A processed noncoding RNA regulates an altruistic bacterial antiviral system

(2011) Tim R Blower et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Diversity of bacterial type II toxin–antitoxin systems: a comprehensive search and functional analysis of novel families

(2011) Raphaël Leplae et al.   NUCLEIC ACIDS RESEARCH

The RelA/SpoT Homolog (RSH) Superfamily: Distribution and Functional Evolution of ppGpp Synthetases and Hydrolases across the Tree of Life

(2011) Gemma C. Atkinson et al.   PLoS One

Bacteriophages and their genomes

(2011) Graham F Hatfull et al.   Current Opinion in Virology

A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses

(2010) Dawei Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Molecular Alarmone (p)ppGpp Mediates Stress Responses, Vancomycin Tolerance, and Virulence in Enterococcus faecalis

(2009) J. Abranches et al.   JOURNAL OF BACTERIOLOGY

The Stringent Response and Cell Cycle Arrest in Escherichia coli

(2008) Daniel J. Ferullo et al.   PLoS Genetics