Structural conservation of the PIN domain active site across all domains of life

ATP-Dependent Persister Formation in Escherichia coli

(2017) Yue Shan et al.   mBio

Crystal structure of VapC21 from Mycobacterium tuberculosis at 1.31 Å resolution

(2016) Paulo Jardim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Toxin-antitoxin systems in bacterial growth arrest and persistence

(2016) Rebecca Page et al.   Nature Chemical Biology

VapCs of Mycobacterium tuberculosis cleave RNAs essential for translation

(2016) Kristoffer Winther et al.   NUCLEIC ACIDS RESEARCH

Crystallographic Study of Peptidoglycan Biosynthesis Enzyme MurD: Domain Movement Revisited

(2016) Roman Šink et al.   PLoS One

Structural analysis of the active site architecture of the VapC toxin fromShigella flexneri

(2016) Kehan Xu et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structural basis for the regulation of enzymatic activity of Regnase-1 by domain-domain interactions

(2016) Mariko Yokogawa et al.   Scientific Reports

Dormant non-culturable Mycobacterium tuberculosis retains stable low-abundant mRNA

(2015) Dmitriy V. Ignatov et al.   BMC GENOMICS

Structural and functional studies of theMycobacterium tuberculosisVapBC30 toxin-antitoxin system: implications for the design of novel antimicrobial peptides

(2015) In-Gyun Lee et al.   NUCLEIC ACIDS RESEARCH

Growth-regulating Mycobacterium tuberculosis VapC-mt4 toxin is an isoacceptor-specific tRNase

(2015) Jonathan W. Cruz et al.   Nature Communications

Molecular Mechanisms Underlying Bacterial Persisters

(2014) Etienne Maisonneuve et al.   CELL

Crystal structure of the VapBC-15 complex from Mycobacterium tuberculosis reveals a two-metal ion dependent PIN-domain ribonuclease and a variable mode of toxin–antitoxin assembly

(2014) Uddipan Das et al.   JOURNAL OF STRUCTURAL BIOLOGY

CATH: comprehensive structural and functional annotations for genome sequences

(2014) Ian Sillitoe et al.   NUCLEIC ACIDS RESEARCH

RETRACTED: (p)ppGpp Controls Bacterial Persistence by Stochastic Induction of Toxin-Antitoxin Activity

(2013) Etienne Maisonneuve et al.   CELL

A PilT N-terminus domain protein SSO1118 from hyperthemophilic archaeon Sulfolobus solfataricus P2

(2013) Jinsong Xuan et al.   JOURNAL OF BIOMOLECULAR NMR

Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex

(2013) Debora Lika Makino et al.   NATURE

Molecular mechanisms of multiple toxin-antitoxin systems are coordinated to govern the persister phenotype

(2013) R. A. Fasani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and functional analysis of Utp23, a yeast ribosome synthesis factor with degenerate PIN domain

(2013) J. Lu et al.   RNA

VapC20 of Mycobacterium tuberculosis cleaves the Sarcin–Ricin loop of 23S rRNA

(2013) Kristoffer S. Winther et al.   Nature Communications

Bacterial Persistence and Toxin-Antitoxin Loci

(2012) Kenn Gerdes et al.   Annual Review of Microbiology

Extensive Degradation of RNA Precursors by the Exosome in Wild-Type Cells

(2012) Rajani Kanth Gudipati et al.   MOLECULAR CELL

Structural study of MCPIP1 N-terminal conserved domain reveals a PIN-like RNase

(2012) J. Xu et al.   NUCLEIC ACIDS RESEARCH

Regulation of Enteric vapBC Transcription: Induction by VapC Toxin Dimer-Breaking

(2012) Kristoffer S. Winther et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial ribonuclease P structure provides insight into the evolution of catalytic strategies for precursor-tRNA 5' processing

(2012) M. J. Howard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex fromM. tuberculosisreveals a Mg2+ion in the active site and a putative RNA-binding site

(2012) Andrew B. Min et al.   PROTEIN SCIENCE

Genomic analysis of Acidianus hospitalis W1 a host for studying crenarchaeal virus and plasmid life cycles

(2011) Xiao-Yan You et al.   EXTREMOPHILES

Crystal Structure of the VapBC Toxin–Antitoxin Complex from Shigella flexneri Reveals a Hetero-Octameric DNA-Binding Assembly

(2011) Christian Dienemann et al.   JOURNAL OF MOLECULAR BIOLOGY

The Chp1–Tas3 core is a multifunctional platform critical for gene silencing by RITS

(2011) Thomas Schalch et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Utp23p is required for dissociation of snR30 small nucleolar RNP from preribosomal particles

(2011) Coralie Hoareau-Aveilla et al.   NUCLEIC ACIDS RESEARCH

Structural and functional analysis of the archaeal endonuclease Nob1

(2011) Thomas Veith et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of the DNA-bound VapBC2 antitoxin/toxin pair from Rickettsia felis

(2011) María J. Maté et al.   NUCLEIC ACIDS RESEARCH

Enteric virulence associated protein VapC inhibits translation by cleavage of initiator tRNA

(2011) K. S. Winther et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TADB: a web-based resource for Type 2 toxin–antitoxin loci in bacteria and archaea

(2010) Yucheng Shao et al.   NUCLEIC ACIDS RESEARCH

Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism

(2010) R. Tomecki et al.   RNA

Role ofvapBCtoxin–antitoxin loci in the thermal stress response ofSulfolobus solfataricus

(2009) Charlotte R. Cooper et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Structural Basis for mRNA Recognition and Cleavage by the Ribosome-Dependent Endonuclease RelE

(2009) Cajetan Neubauer et al.   CELL

The Yeast Exosome Functions as a Macromolecular Cage to Channel RNA Substrates for Degradation

(2009) Fabien Bonneau et al.   CELL

Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1β mRNA

(2009) Danuta Mizgalska et al.   FEBS Journal

RNA Helicase Prp43 and Its Co-factor Pfa1 Promote 20 to 18 S rRNA Processing Catalyzed by the Endonuclease Nob1

(2009) Brigitte Pertschy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay

(2009) Kazufumi Matsushita et al.   NATURE

The N-terminal PIN domain of the exosome subunit Rrp44 harbors endonuclease activity and tethers Rrp44 to the yeast core exosome

(2009) Claudia Schneider et al.   NUCLEIC ACIDS RESEARCH

The Pfam protein families database

(2009) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

Nob1 binds the single-stranded cleavage site D at the 3'-end of 18S rRNA with its PIN domain

(2009) A. C. Lamanna et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive Functional Analysis of Mycobacterium tuberculosis Toxin-Antitoxin Systems: Implications for Pathogenesis, Stress Responses, and Evolution

(2009) Holly R. Ramage et al.   PLoS Genetics

Structure and Proposed Activity of a Member of the VapBC Family of Toxin-Antitoxin Systems

(2008) Linda Miallau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endonucleolytic RNA cleavage by a eukaryotic exosome

(2008) Alice Lebreton et al.   NATURE

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

(2008) Andrea B Eberle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The exosome contains domains with specific endoribonuclease, exoribonuclease and cytoplasmic mRNA decay activities

(2008) Daneen Schaeffer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of PAE0151 fromPyrobaculum aerophilum, a PIN-domain (VapC) protein from a toxin-antitoxin operon

(2008) Richard D. Bunker et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

An Endoribonuclease Functionally Linked to Perinuclear mRNP Quality Control Associates with the Nuclear Pore Complexes

(2008) Michal Skružný et al.   PLOS BIOLOGY