The ribosomal A-site finger is crucial for binding and activation of the stringent factor RelA

Negative allosteric regulation ofEnterococcus faecalissmall alarmone synthetase RelQ by single-stranded RNA

(2017) Jelena Beljantseva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mutagenesis of ppGpp: turning a RelA activator into an inhibitor

(2017) Jelena Beljantseva et al.   Scientific Reports

HPLC-based quantification of bacterial housekeeping nucleotides and alarmone messengers ppGpp and pppGpp

(2017) Vallo Varik et al.   Scientific Reports

The magic dance of the alarmones (p)ppGpp

(2016) Wieland Steinchen et al.   MOLECULAR MICROBIOLOGY

Ribosome-dependent activation of stringent control

(2016) Alan Brown et al.   NATURE

Metabolite concentrations, fluxes and free energies imply efficient enzyme usage

(2016) Junyoung O Park et al.   Nature Chemical Biology

The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis

(2016) Stefan Arenz et al.   NUCLEIC ACIDS RESEARCH

Ribosome•RelA structures reveal the mechanism of stringent response activation

(2016) Anna B Loveland et al.   eLife

The evolutionary and functional diversity of classical and lesser-known cytoplasmic and organellar translational GTPases across the tree of life

(2015) Gemma Atkinson   BMC GENOMICS

Diversity in (p)ppGpp metabolism and effectors

(2015) Kuanqing Liu et al.   CURRENT OPINION IN MICROBIOLOGY

Differential binding of ppGpp and pppGpp toE. coliRNA polymerase: photo-labeling and mass spectral studies

(2015) Kirtimaan Syal et al.   GENES TO CELLS

From (p)ppGpp to (pp)pGpp: Characterization of Regulatory Effects of pGpp Synthesized by the Small Alarmone Synthetase of Enterococcus faecalis

(2015) Anthony O. Gaca et al.   JOURNAL OF BACTERIOLOGY

Effects of amino acid starvation on RelA diffusive behavior in liveEscherichia coli

(2015) Wenting Li et al.   MOLECULAR MICROBIOLOGY

Recent functional insights into the role of (p)ppGpp in bacterial physiology

(2015) Vasili Hauryliuk et al.   NATURE REVIEWS MICROBIOLOGY

Role of a ribosomal RNA phosphate oxygen during the EF-G–triggered GTP hydrolysis

(2015) Miriam Koch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Catalytic mechanism and allosteric regulation of an oligomeric (p)ppGpp synthetase by an alarmone

(2015) Wieland Steinchen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GTP hydrolysis by EF-G synchronizes tRNA movement on small and large ribosomal subunits

(2014) W. Holtkamp et al.   EMBO JOURNAL

Differential regulation by ppGpp versus pppGpp in Escherichia coli

(2013) Undine Mechold et al.   NUCLEIC ACIDS RESEARCH

Secondary structure and domain architecture of the 23S and 5S rRNAs

(2013) Anton S. Petrov et al.   NUCLEIC ACIDS RESEARCH

Positive allosteric feedback regulation of the stringent response enzyme RelA by its product

(2012) Viktoriya Shyp et al.   EMBO REPORTS

Functional Role of the Sarcin–Ricin Loop of the 23S rRNA in the Elongation Cycle of Protein Synthesis

(2012) Xinying Shi et al.   JOURNAL OF MOLECULAR BIOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

GTPases IF2 and EF-G bind GDP and the SRL RNA in a mutually exclusive manner

(2012) Vladimir A. Mitkevich et al.   Scientific Reports

Dependence of RelA-Mediated (p)ppGpp Formation on tRNA Identity

(2011) Roshani Payoe et al.   BIOCHEMISTRY

The RelA/SpoT Homolog (RSH) Superfamily: Distribution and Functional Evolution of ppGpp Synthetases and Hydrolases across the Tree of Life

(2011) Gemma C. Atkinson et al.   PLoS One

Single-molecule investigations of the stringent response machinery in living bacterial cells

(2011) B. P. English et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into the molecular determinants of EF-G catalyzed translocation

(2011) L. Wang et al.   RNA

Molecular Determinants of Microbial Resistance to Thiopeptide Antibiotics

(2010) Sascha Baumann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Atomic mutagenesis reveals A2660 of 23S ribosomal RNA as key to EF-G GTPase activation

(2010) Nina Clementi et al.   Nature Chemical Biology

Resistance to and synthesis of the antibiotic mupirocin

(2010) Christopher M. Thomas et al.   NATURE REVIEWS MICROBIOLOGY

Cleavage of the sarcin-ricin loop of 23S rRNA differentially affects EF-G and EF-Tu binding

(2010) L. Garcia-Ortega et al.   NUCLEIC ACIDS RESEARCH

Guidelines for accurate EC50/IC50 estimation

(2010) J. L. Sebaugh   PHARMACEUTICAL STATISTICS

The Significance of EXDD and RXKD Motif Conservation in Rel Proteins

(2009) Mathew Sajish et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ordered Transcription of RNA Domains Is Not Essential for Ribosome Biogenesis in Escherichia coli

(2009) Kei Kitahara et al.   MOLECULAR CELL

Dynamics of the base of ribosomal A-site finger revealed by molecular dynamics simulations and Cryo-EM

(2009) Kamila Réblová et al.   NUCLEIC ACIDS RESEARCH

Translational Regulation via L11: Molecular Switches on the Ribosome Turned On and Off by Thiostrepton and Micrococcin

(2008) Joerg M. Harms et al.   MOLECULAR CELL