Porphyromonas gingivalis Outer Membrane Vesicles as the Major Driver of and Explanation for Neuropathogenesis, the Cholinergic Hypothesis, Iron Dyshomeostasis, and Salivary Lactoferrin in Alzheimer’s Disease

The Role of Porphyromonas gingivalis Outer Membrane Vesicles in Periodontal Disease and Related Systemic Diseases

(2021) Zhiying Zhang et al.   Frontiers in Cellular and Infection Microbiology

Characterization of Human Genes Modulated by Porphyromonas gingivalis Highlights the Ribosome, Hypothalamus, and Cholinergic Neurons

(2021) Sejal Patel et al.   Frontiers in Immunology

CRISPR‐Cas systems in oral microbiome: From immune defense to physiological regulation

(2020) Tao Gong et al.   Molecular Oral Microbiology

Alzheimer’s Disease-Like Neurodegeneration in Porphyromonas gingivalis Infected Neurons with Persistent Expression of Active Gingipains

(2020) Ursula Haditsch et al.   JOURNAL OF ALZHEIMERS DISEASE

Variation in the Occurrence of fimA Genotypes of Porphyromonas gingivalis in Periodontal Health and Disease

(2020) Manohar Kugaji et al.   International Journal of Environmental Research and Public Health

Decreased salivary lactoferrin levels are specific to Alzheimer's disease

(2020) Marta González-Sánchez et al.   EBioMedicine

Porphyromonas gingivalis, a Long-Range Pathogen: Systemic Impact and Therapeutic Implications

(2020) Hannah Mulhall et al.   Microorganisms

Virulence of the Pathogen Porphyromonas gingivalis Is Controlled by the CRISPR-Cas Protein Cas3

(2020) Jose Solbiati et al.   mSystems

Helicobacter pylori-Derived Outer Membrane Vesicles (OMVs): Role in Bacterial Pathogenesis?

(2020) Miroslaw Jarzab et al.   Microorganisms

The Caribbean‐Hispanic Alzheimer’s brain transcriptome reveals ancestry‐specific disease mechanisms

(2020) Daniel Felsky et al.   Alzheimers & Dementia

Low levels of salivary lactoferrin may affect oral dysbiosis and contribute to Alzheimer’s disease: A hypothesis

(2020) Ingar Olsen et al.   MEDICAL HYPOTHESES

Lipopolysaccharide Recognition in the Crossroads of TLR4 and Caspase-4/11 Mediated Inflammatory Pathways

(2020) Alla Zamyatina et al.   Frontiers in Immunology

Delivery of Periodontopathogenic Extracellular Vesicles to Brain Monocytes and Microglial IL-6 Promotion by RNA Cargo

(2020) Jae Yeong Ha et al.   Frontiers in Molecular Biosciences

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

(2019) Stephen S. Dominy et al.   Science Advances

Microbe-Host Communication by Small RNAs in Extracellular Vesicles: Vehicles for Transkingdom RNA Transportation

(2019) Heon-Jin Lee   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Living at the Extremes: Extremophiles and the Limits of Life in a Planetary Context

(2019) Nancy Merino et al.   Frontiers in Microbiology

Exosomes in Pathogenesis, Diagnosis, and Treatment of Alzheimer’s Disease

(2019) Liqun Jiang et al.   MEDICAL SCIENCE MONITOR

Extracellular RNAs in periodontopathogenic outer membrane vesicles promote TNF-α production in human macrophages and cross the blood–brain barrier in mice

(2019) Eun-Chong Han et al.   FASEB JOURNAL

The Editor recommends this issue's article to the reader

(2019) A. Rønneberg et al.   International Journal of Paediatric Dentistry

Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

(2019) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

Genomic repeats, misassembly and reannotation: a case study with long-read resequencing of Porphyromonas gingivalis reference strains

(2018) Luis Acuña-Amador et al.   BMC GENOMICS

Porphyromonas gingivalis traffics into endoplasmic reticulum-rich-autophagosomes for successful survival in human gingival epithelial cells

(2018) Kyulim Lee et al.   Virulence

Determining the Presence of Periodontopathic Virulence Factors in Short-Term Postmortem Alzheimer's Disease Brain Tissue

(2018) Sophie Poole et al.   JOURNAL OF ALZHEIMERS DISEASE

Active Invasion of Porphyromonas gingivalis and Infection-Induced Complement Activation in ApoE-/- Mice Brains

(2018) Sophie Poole et al.   JOURNAL OF ALZHEIMERS DISEASE

Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice

(2018) Vladimir Ilievski et al.   PLoS One

Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits

(2018) Yifan Wu et al.   Nature Communications

Tiny RNAs and their voyage via extracellular vesicles: Secretion of bacterial small RNA and eukaryotic microRNA

(2017) Ji-Woong Choi et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Secretable Small RNAs via Outer Membrane Vesicles in Periodontal Pathogens

(2017) J.-W. Choi et al.   JOURNAL OF DENTAL RESEARCH

Intranasal Lactoferrin Enhances α-Secretase-Dependent Amyloid Precursor Protein Processing via the ERK1/2-CREB and HIF-1α Pathways in an Alzheimer’s Disease Mouse Model

(2017) Chuang Guo et al.   NEUROPSYCHOPHARMACOLOGY

Outer Membrane Vesicles (OMVs) of Gram-negative Bacteria: A Perspective Update

(2017) Arif Tasleem Jan   Frontiers in Microbiology

Chronic Porphyromonas gingivalis infection accelerates the occurrence of age-related granules in ApoE–/– mice brains

(2017) Sim K. Singhrao et al.   Journal of Oral Microbiology

Porphyromonas gingivalis is the most abundant species detected in coronary and femoral arteries

(2017) J-L. C. Mougeot et al.   Journal of Oral Microbiology

Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes

(2017) Marta Garcia-Contreras et al.   Scientific Reports

Infection of microglia with Porphyromonas gingivalis promotes cell migration and an inflammatory response through the gingipain-mediated activation of protease-activated receptor-2 in mice

(2017) Yicong Liu et al.   Scientific Reports

Role of oral microbiome on oral cancers, a review

(2016) Pourya Gholizadeh et al.   BIOMEDICINE & PHARMACOTHERAPY

Adaptation in CRISPR-Cas Systems

(2016) Samuel H. Sternberg et al.   MOLECULAR CELL

Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA

(2016) Asako Shimoda et al.   Scientific Reports

Metabolic and Non-Cognitive Manifestations of Alzheimer’s Disease: The Hypothalamus as Both Culprit and Target of Pathology

(2015) Makoto Ishii et al.   Cell Metabolism

The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease

(2015) Myles R. Minter et al.   JOURNAL OF NEUROCHEMISTRY

CRISPR-Cas immunity in prokaryotes

(2015) Luciano A. Marraffini   NATURE

The protective effect of lactoferrin on ventral mesencephalon neurons against MPP+ is not connected with its iron binding ability

(2015) Jun Wang et al.   Scientific Reports

The extracellular RNA complement ofEscherichia coli

(2015) Anubrata Ghosal et al.   MicrobiologyOpen

The Hypothalamus in Alzheimer’s Disease

(2014) Stavros J. Baloyannis et al.   American Journal of Alzheimers Disease and Other Dementias

Porphyromonas gingivalis Outer Membrane Vesicles Exclusively Contain Outer Membrane and Periplasmic Proteins and Carry a Cargo Enriched with Virulence Factors

(2014) Paul D. Veith et al.   JOURNAL OF PROTEOME RESEARCH

Genetic Exchange of Fimbrial Alleles Exemplifies the Adaptive Virulence Strategy of Porphyromonas gingivalis

(2014) Jennifer E. Kerr et al.   PLoS One

Distinct Lipid A Moieties Contribute to Pathogen-Induced Site-Specific Vascular Inflammation

(2014) Connie Slocum et al.   PLoS Pathogens

Membrane vesicle production by Chlamydia trachomatis as an adaptive response

(2014) Kyla M. Frohlich et al.   Frontiers in Cellular and Infection Microbiology

CRISPR-Cas systems: new players in gene regulation and bacterial physiology

(2014) Timothy R. Sampson et al.   Frontiers in Cellular and Infection Microbiology

Fimbriae-mediated outer membrane vesicle production and invasion ofPorphyromonas gingivalis

(2014) Chinmay K. Mantri et al.   MicrobiologyOpen

Periodontitis induced by bacterial infection exacerbates features of Alzheimer's disease in transgenic mice

(2013) Naoyuki Ishida et al.   Alzheimers & Dementia

Oral Porphyromonas gingivalis translocates to the liver and regulates hepatic glycogen synthesis through the Akt/GSK-3β signaling pathway

(2013) Makoto Ishikawa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A CRISPR/Cas system mediates bacterial innate immune evasion and virulence

(2013) Timothy R. Sampson et al.   NATURE

Fortifying the barrier: the impact of lipid A remodelling on bacterial pathogenesis

(2013) Brittany D. Needham et al.   NATURE REVIEWS MICROBIOLOGY

Metal Dyshomeostasis and Inflammation in Alzheimer’s and Parkinson’s Diseases: Possible Impact of Environmental Exposures

(2013) Oddvar Myhre et al.   Oxidative Medicine and Cellular Longevity

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Recognition of lipid A variants by the TLR4-MD-2 receptor complex

(2013) Nina Maeshima et al.   Frontiers in Cellular and Infection Microbiology

Identification of essential genes of the periodontal pathogen Porphyromonas gingivalis

(2012) Brian A Klein et al.   BMC GENOMICS

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

(2012) Vijay A.K. Rathinam et al.   CELL

Porphyromonas gingivalis: an invasive and evasive opportunistic oral pathogen

(2012) Nagihan Bostanci et al.   FEMS MICROBIOLOGY LETTERS

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Lactoferrin protects against prion protein-induced cell death in neuronal cells by preventing mitochondrial dysfunction

(2012) YANG-GYU PARK et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Porphyromonas gingivalis as a Potential Community Activist for Disease

(2012) R.P. Darveau et al.   JOURNAL OF DENTAL RESEARCH

The keystone-pathogen hypothesis

(2012) George Hajishengallis et al.   NATURE REVIEWS MICROBIOLOGY

Correction for Li et al., LPS remodeling is an evolved survival strategy for bacteria

(2012)   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Origin of diderm (Gram-negative) bacteria: antibiotic selection pressure rather than endosymbiosis likely led to the evolution of bacterial cells with two membranes

(2011) Radhey S. Gupta   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

Comparison of Gingival Crevicular Fluid Sampling Methods in Patients With Severe Chronic Periodontitis

(2011) Arndt Guentsch et al.   JOURNAL OF PERIODONTOLOGY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Helicobacter pylori versus the Host: Remodeling of the Bacterial Outer Membrane Is Required for Survival in the Gastric Mucosa

(2011) Thomas W. Cullen et al.   PLoS Pathogens

Eating and hypothalamus changes in behavioral-variant frontotemporal dementia

(2010) Olivier Piguet et al.   ANNALS OF NEUROLOGY

Inflammasome Inhibition as a Pathogenic Stealth Mechanism

(2010) Debra J. Taxman et al.   Cell Host & Microbe

Exit of intracellular Porphyromonas gingivalis from gingival epithelial cells is mediated by endocytic recycling pathway

(2010) Hiroki Takeuchi et al.   CELLULAR MICROBIOLOGY

The Lipid A Phosphate Position Determines Differential Host Toll-Like Receptor 4 Responses to Phylogenetically Related Symbiotic and Pathogenic Bacteria

(2010) Stephen R. Coats et al.   INFECTION AND IMMUNITY

“Gum Bug, Leave My Heart Alone!”—Epidemiologic and Mechanistic Evidence Linking Periodontal Infections and Atherosclerosis

(2010) M. Kebschull et al.   JOURNAL OF DENTAL RESEARCH

Deposition of lactoferrin in fibrillar-type senile plaques in the brains of transgenic mouse models of Alzheimer's disease

(2010) Ligang Wang et al.   NEUROSCIENCE LETTERS

Growth control and ribosome biogenesis

(2009) Harri Lempiäinen et al.   CURRENT OPINION IN CELL BIOLOGY

Porphyromonas gingivalis Outer Membrane Vesicles Enter Human Epithelial Cells via an Endocytic Pathway and Are Sorted to Lysosomal Compartments

(2009) N. Furuta et al.   INFECTION AND IMMUNITY

Localization of P. gingivalis in Preterm Delivery Placenta

(2009) J. Katz et al.   JOURNAL OF DENTAL RESEARCH

TNF-α and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects

(2009) Angela R. Kamer et al.   JOURNAL OF NEUROIMMUNOLOGY

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

Long-Distance Delivery of Bacterial Virulence Factors by Pseudomonas aeruginosa Outer Membrane Vesicles

(2009) Jennifer M. Bomberger et al.   PLoS Pathogens

Intracellular survival and vascular cell-to-cell transmission of Porphyromonas gingivalis

(2008) Ling Li et al.   BMC MICROBIOLOGY

Host Innate Immune Receptors and Beyond: Making Sense of Microbial Infections

(2008) Ken J. Ishii et al.   Cell Host & Microbe

Determination of the Genome Sequence of Porphyromonas gingivalis Strain ATCC 33277 and Genomic Comparison with Strain W83 Revealed Extensive Genome Rearrangements in P. gingivalis

(2008) M. Naito et al.   DNA RESEARCH

Porphyromonas gingivalis RgpA-Kgp Proteinase-Adhesin Complexes Penetrate Gingival Tissue and Induce Proinflammatory Cytokines or Apoptosis in a Concentration-Dependent Manner

(2008) N. M. O'Brien-Simpson et al.   INFECTION AND IMMUNITY

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

(2008) Jae Lee et al.   Journal of Neuroinflammation