Delivery of Periodontopathogenic Extracellular Vesicles to Brain Monocytes and Microglial IL-6 Promotion by RNA Cargo

Microbial extracellular RNAs and their roles in human diseases

(2020) Heon-Jin Lee   EXPERIMENTAL BIOLOGY AND MEDICINE

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

(2019) Stephen S. Dominy et al.   Science Advances

Microbe-Host Communication by Small RNAs in Extracellular Vesicles: Vehicles for Transkingdom RNA Transportation

(2019) Heon-Jin Lee   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research

(2019) Saumya Das et al.   CELL

Toll-like receptors in the pathogenesis of neuroinflammation

(2019) V. Kumar   JOURNAL OF NEUROIMMUNOLOGY

Extracellular vesicle measurements with nanoparticle tracking analysis – An accuracy and repeatability comparison between NanoSight NS300 and ZetaView

(2019) Daniel Bachurski et al.   Journal of Extracellular Vesicles

Extracellular RNAs in periodontopathogenic outer membrane vesicles promote TNF-α production in human macrophages and cross the blood–brain barrier in mice

(2019) Eun-Chong Han et al.   FASEB JOURNAL

TNF-α-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IκB-NFκB and JAK-STAT3 pathways

(2018) Junichi Matsumoto et al.   BRAIN RESEARCH

The Transport Mechanism of Extracellular Vesicles at the Blood-Brain Barrier

(2018) Junichi Matsumoto et al.   CURRENT PHARMACEUTICAL DESIGN

Advances in Meningeal Immunity

(2018) Rejane Rua et al.   TRENDS IN MOLECULAR MEDICINE

Periodontal Pathogens and Associated Intrathecal Antibodies in Early Stages of Alzheimer’s Disease

(2018) Oliver Laugisch et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits

(2018) Yifan Wu et al.   Nature Communications

Tiny RNAs and their voyage via extracellular vesicles: Secretion of bacterial small RNA and eukaryotic microRNA

(2017) Ji-Woong Choi et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Secretable Small RNAs via Outer Membrane Vesicles in Periodontal Pathogens

(2017) J.-W. Choi et al.   JOURNAL OF DENTAL RESEARCH

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Intravital longitudinal wide-area imaging of dynamic bone marrow engraftment and multilineage differentiation through nuclear-cytoplasmic labeling

(2017) Soyeon Ahn et al.   PLoS One

Periodontal pathogenic bacteria, Aggregatibacter actinomycetemcomitans affect non-alcoholic fatty liver disease by altering gut microbiota and glucose metabolism

(2017) Rina Komazaki et al.   Scientific Reports

Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation

(2016) Sivapriya Kailasan Vanaja et al.   CELL

Origin, fate and dynamics of macrophages at central nervous system interfaces

(2016) Tobias Goldmann et al.   NATURE IMMUNOLOGY

Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis

(2016) M. F. Konig et al.   Science Translational Medicine

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

A Novel Mechanism of Host-Pathogen Interaction through sRNA in Bacterial Outer Membrane Vesicles

(2016) Katja Koeppen et al.   PLoS Pathogens

Hall of Fame among Pro-inflammatory Cytokines: Interleukin-6 Gene and Its Transcriptional Regulation Mechanisms

(2016) Yang Luo et al.   Frontiers in Immunology

Uropathogenic Escherichia coli Releases Extracellular Vesicles That Are Associated with RNA

(2016) Cherie Blenkiron et al.   PLoS One

Periodontal Bacteria and Prediabetes Prevalence in ORIGINS

(2015) R.T. Demmer et al.   JOURNAL OF DENTAL RESEARCH

The extracellular RNA complement ofEscherichia coli

(2015) Anubrata Ghosal et al.   MicrobiologyOpen

Functional Advantages of Porphyromonas gingivalis Vesicles

(2015) Meng-Hsuan Ho et al.   PLoS One

Aggregatibacter actinomycetemcomitans Outer Membrane Vesicles Are Internalized in Human Host Cells and Trigger NOD1- and NOD2-Dependent NF-κB Activation

(2014) Bernard Thay et al.   INFECTION AND IMMUNITY

IL-6 in Inflammation, Immunity, and Disease

(2014) T. Tanaka et al.   Cold Spring Harbor Perspectives in Biology

Protein selection and export via outer membrane vesicles

(2013) K.E. Bonnington et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Identification of microRNA-Size, Small RNAs in Escherichia coli

(2013) Sung-Min Kang et al.   CURRENT MICROBIOLOGY

Origin and differentiation of microglia

(2013) Florent Ginhoux et al.   Frontiers in Cellular Neuroscience

Analysis of microRNA-size, small RNAs in Streptococcus mutans by deep sequencing

(2011) Heon-Jin Lee et al.   FEMS MICROBIOLOGY LETTERS

Perinuclear Localization of Internalized Outer Membrane Vesicles Carrying Active Cytolethal Distending Toxin from Aggregatibacter actinomycetemcomitans

(2011) Pramod Kumar Rompikuntal et al.   INFECTION AND IMMUNITY

Novel Characterization of Monocyte-Derived Cell Populations in the Meninges and Choroid Plexus and Their Rates of Replenishment in Bone Marrow Chimeric Mice

(2010) Holly R. Chinnery et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Aggregatibacter (Actinobacillus) actinomycetemcomitans: a triple A* periodontopathogen?

(2010) Brian Henderson et al.   PERIODONTOLOGY 2000

Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window

(2009) Anthony Holtmaat et al.   Nature Protocols